Inhibition of hepatitis B virus < em > via < /em > selective apoptosis modulation by Chinese patent medicine Liuweiwuling Tablet
CONCLUSION: Preliminary results suggest that LWWL exerts a potent inhibitory effect on wild-type and drug-resistant HBV, potentially involving selective regulation of apoptosis. These findings offer novel insights into the anti-HBV activities of LWWL and present a novel mechanism for the development of anti-HBV medications.PMID:38659485 | PMC:PMC11036500 | DOI:10.3748/wjg.v30.i13.1911 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Fei-Lin Ge Yan Yang Lan-Lan Si Yuan-Hua Li Meng-Zhen Cao Jun Wang Zhao-Fang Bai Zhi-Gang Ren Xiao-He Xiao Yan Liu Source Type: research
Interim analysis of the PARADISE study: benefits of add-on peginterferon- α in NA-treated patients with CHB
This study aimed to investigate whether peginterferon-α (IFN) add-on nucleos(t)ide analogs(NAs) can further reduce hepatocellular carcinoma(HCC) risk compared with NAs monotherapy in NA-treated patients with chronic hepatitis B(CHB). In this multi-center randomized controlled trial "PARADISE study" (NCT05671315), CHB patients with intermediate to high risk of HCC after more than 24-week NAs pretreatment were recruited, randomized to two groups at a ratio of 1:2 and followed up for 240 weeks. NAs group maintained NAs monotherapy, while IFN+NAs group received IFN add-on NAs therapy for 48 weeks, then switched to NAs monothe...
Source: Antiviral Research - April 25, 2024 Category: Virology Authors: Shaowen Jiang Simin Guo Yan Huang Jie Xu Yi Li Yilan Zeng Yuan Guo Lijuan Ouyang Chuanwu Zhu Weifeng Zhao Qin Zhang Qing Guo Haiguang Xin Qing Xie Source Type: research
Synthesis and evaluation of pentacyclic triterpenoids conjugates as novel HBV entry inhibitors targeting NTCP receptor
In this study, pentacyclic triterpenoids (PTs) including glycyrrhetinic acid (GA), oleanolic acid (OA), ursolic acid (UA) and betulinic acid (BA) were modified via molecular hybridization with podophyllotoxin respectively, and resulted in thirty-two novel conjugates. The anti-HBV activities of conjugates were evaluated in HepG2.2.15 cells. The results showed that 66% of the conjugates exhibited lower toxicity to the host cells and had significant inhibitory effects on the two HBV antigens, especially HBsAg. Notably, the compounds BA-PPT1, BA-PPT3, BA-PPT4, and UA-PPT3 not only inhibited the secretion of HBsAg but also supp...
Source: Bioorganic Chemistry - April 25, 2024 Category: Chemistry Authors: Yixin Chen Meitao Duan Xiangwan Wang Jianling Xu Shuo Tian Xiaotian Xu Ao Duan Ahmed Mahal Yongyan Zhu Quanhong Zhu Source Type: research
Inhibition of hepatitis B virus < em > via < /em > selective apoptosis modulation by Chinese patent medicine Liuweiwuling Tablet
CONCLUSION: Preliminary results suggest that LWWL exerts a potent inhibitory effect on wild-type and drug-resistant HBV, potentially involving selective regulation of apoptosis. These findings offer novel insights into the anti-HBV activities of LWWL and present a novel mechanism for the development of anti-HBV medications.PMID:38659485 | PMC:PMC11036500 | DOI:10.3748/wjg.v30.i13.1911 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Fei-Lin Ge Yan Yang Lan-Lan Si Yuan-Hua Li Meng-Zhen Cao Jun Wang Zhao-Fang Bai Zhi-Gang Ren Xiao-He Xiao Yan Liu Source Type: research
Inhibition of hepatitis B virus < em > via < /em > selective apoptosis modulation by Chinese patent medicine Liuweiwuling Tablet
CONCLUSION: Preliminary results suggest that LWWL exerts a potent inhibitory effect on wild-type and drug-resistant HBV, potentially involving selective regulation of apoptosis. These findings offer novel insights into the anti-HBV activities of LWWL and present a novel mechanism for the development of anti-HBV medications.PMID:38659485 | PMC:PMC11036500 | DOI:10.3748/wjg.v30.i13.1911 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Fei-Lin Ge Yan Yang Lan-Lan Si Yuan-Hua Li Meng-Zhen Cao Jun Wang Zhao-Fang Bai Zhi-Gang Ren Xiao-He Xiao Yan Liu Source Type: research
Risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection: A systematic review
CONCLUSION: Although, studies have shown that HCV genotype-3 infection is an independent risk factor for end-stage liver disease, HCC, and liver-related death, there is a lack of evidence for specific risk factors for HCC secondary to HCV genotype-3. Only cirrhosis and age have demonstrated an association; however, the number of studies is very small, and more research is required to investigate risk factors for HCC secondary to HCV genotype-3.PMID:38660636 | PMC:PMC11037048 | DOI:10.4251/wjgo.v16.i4.1596 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Hamzah Z Farooq Michael James Jane Abbott Patrick Oyibo Pip Divall Naheed Choudhry Graham R Foster Source Type: research
Development and validation of a nomogram for assessing hepatocellular carcinoma risk after SVR in hepatitis C patients with advanced fibrosis and cirrhosis
Hepatitis C patients with advanced fibrosis or cirrhosis are at high risk of developing hepatocellular carcinoma (HCC), even after sustained virological response (SVR). Clinical recommendations impose a signif... (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Shanshan Xu, Lixia Qiu, Liang Xu, Yali Liu and Jing Zhang Tags: Research Source Type: research
Association between hepatitis A seropositivity and bone mineral density in adolescents and adults: a cross-sectional study using NHANES data
CONCLUSIONS: This study confirmed that both adolescent and adult individuals seropositive for Hepatitis A antibodies had reduced BMD among both adolescents and adults, especially in the adult group. This finding suggests a possible link between Hepatitis A infection and risk of osteoporosis.PMID:38655984 | DOI:10.1590/1516-3180.2023.0266.R1.08022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: Zhuowen Yu Gunchu Hu Jiajie Wang Zhihong Li Source Type: research
Association between hepatitis A seropositivity and bone mineral density in adolescents and adults: a cross-sectional study using NHANES data
CONCLUSIONS: This study confirmed that both adolescent and adult individuals seropositive for Hepatitis A antibodies had reduced BMD among both adolescents and adults, especially in the adult group. This finding suggests a possible link between Hepatitis A infection and risk of osteoporosis.PMID:38655984 | DOI:10.1590/1516-3180.2023.0266.R1.08022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: Zhuowen Yu Gunchu Hu Jiajie Wang Zhihong Li Source Type: research
Association between hepatitis A seropositivity and bone mineral density in adolescents and adults: a cross-sectional study using NHANES data
CONCLUSIONS: This study confirmed that both adolescent and adult individuals seropositive for Hepatitis A antibodies had reduced BMD among both adolescents and adults, especially in the adult group. This finding suggests a possible link between Hepatitis A infection and risk of osteoporosis.PMID:38655984 | DOI:10.1590/1516-3180.2023.0266.R1.08022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: Zhuowen Yu Gunchu Hu Jiajie Wang Zhihong Li Source Type: research
Association between hepatitis A seropositivity and bone mineral density in adolescents and adults: a cross-sectional study using NHANES data
CONCLUSIONS: This study confirmed that both adolescent and adult individuals seropositive for Hepatitis A antibodies had reduced BMD among both adolescents and adults, especially in the adult group. This finding suggests a possible link between Hepatitis A infection and risk of osteoporosis.PMID:38655984 | DOI:10.1590/1516-3180.2023.0266.R1.08022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: Zhuowen Yu Gunchu Hu Jiajie Wang Zhihong Li Source Type: research
Association between hepatitis A seropositivity and bone mineral density in adolescents and adults: a cross-sectional study using NHANES data
CONCLUSIONS: This study confirmed that both adolescent and adult individuals seropositive for Hepatitis A antibodies had reduced BMD among both adolescents and adults, especially in the adult group. This finding suggests a possible link between Hepatitis A infection and risk of osteoporosis.PMID:38655984 | DOI:10.1590/1516-3180.2023.0266.R1.08022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: Zhuowen Yu Gunchu Hu Jiajie Wang Zhihong Li Source Type: research
Hepatitis E and diaphragmatic dysfunction: Case series and review of the literature
CONCLUSION: NA that shows involvement of the phrenic nerve resulting in diaphragmatic dysfunction and dyspnoea, may be associated with HEV infection. The observation of 13 patients with diaphragmatic dysfunctions and HEV infection within a period of three years indicates a high number of undetected HEV-associated diaphragmatic dysfunction in the population, especially in the absence of NA symptoms. Therefore, even in diaphragmatic dysfunction without NA symptoms and causative damaging event, HEV infection should be considered, as it may represent a subform of NA with only phrenic nerve involvement. Therapy of HEV-associate...
Source: Pneumologie - April 24, 2024 Category: Respiratory Medicine Authors: Michael Westhoff Andres Arias Patric Litterst Source Type: research
Association between hepatitis A seropositivity and bone mineral density in adolescents and adults: a cross-sectional study using NHANES data
CONCLUSIONS: This study confirmed that both adolescent and adult individuals seropositive for Hepatitis A antibodies had reduced BMD among both adolescents and adults, especially in the adult group. This finding suggests a possible link between Hepatitis A infection and risk of osteoporosis.PMID:38655984 | DOI:10.1590/1516-3180.2023.0266.R1.08022024 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 24, 2024 Category: General Medicine Authors: Zhuowen Yu Gunchu Hu Jiajie Wang Zhihong Li Source Type: research
Hepatitis E and diaphragmatic dysfunction: Case series and review of the literature
CONCLUSION: NA that shows involvement of the phrenic nerve resulting in diaphragmatic dysfunction and dyspnoea, may be associated with HEV infection. The observation of 13 patients with diaphragmatic dysfunctions and HEV infection within a period of three years indicates a high number of undetected HEV-associated diaphragmatic dysfunction in the population, especially in the absence of NA symptoms. Therefore, even in diaphragmatic dysfunction without NA symptoms and causative damaging event, HEV infection should be considered, as it may represent a subform of NA with only phrenic nerve involvement. Therapy of HEV-associate...
Source: Pneumologie - April 24, 2024 Category: Respiratory Medicine Authors: Michael Westhoff Andres Arias Patric Litterst Source Type: research
