Estimating the Allocation of the Economic Value Generated by Utilization of All-Oral Direct-Acting Antivirals for Hepatitis C in the United States, 2015 –2019
Between 2013 –2019, several all-oral direct-acting antivirals (DAAs) were launched with the potential to cure patients with hepatitis C virus (HCV). They generated economic value in terms of the health gains for patients and cost-savings for the US healthcare system. We estimated the share of this value alloca ted to four manufacturers vs society. (Source: Value in Health)
Source: Value in Health - April 22, 2024 Category: International Medicine & Public Health Authors: Louis P. Garrison, Boshen Jiao, Zizi Elsisi, Alon Yehoshua, Roy Koruth, Bruce Kreter, Jens Grueger Source Type: research
Cancers, Vol. 16, Pages 1606: Seroprevalence of SARS-CoV-2 and Hepatitis B Virus Coinfections among Ethiopians with Acute Leukemia
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Rawleigh Howe
SARS-CoV-2 and blood-borne viral coinfections are well reported. Nevertheless, little is known regarding the seroprevalence of SARS-CoV-2 and coinfection with blood-borne viruses in hematologic malignancy patients in Ethiopia. We aimed to assess the seroprevalence of SARS-CoV-2 and associated infections with hepatitis B and other viruses among adolescent and adult acute leukemia patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. A cross-sectional study was conducted from July 2020 to June 2021. Blood samples were tested for the presence of anti-SARS-CoV-2, HBV, HCV, and HIV with ...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Jemal Alemu Balako Gumi Aster Tsegaye Ziyada Rahimeto Dessalegn Fentahun Fozia Ibrahim Abdulaziz Abubeker Amha Gebremedhin Tesfaye Gelanew Rawleigh Howe Tags: Article Source Type: research
Elevated serum HE4 levels as a novel biomarker of disease severity and hepatic fibrosis in autoimmune hepatitis
CONCLUSIONS: Serum HE4 levels were found to be elevated in AIH-LC patients and exhibited a strong correlation with the severity of hepatic fibrosis, thus supporting their potential clinical value as a novel biomarker of disease severity and hepatic fibrosis in AIH.PMID:38643819 | DOI:10.1016/j.cca.2024.119682 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 21, 2024 Category: Chemistry Authors: Zhi Yu Caina Nian Wenmei Sun Xinhua Liu Xueyuan Nian Source Type: research
Viruses, Vol. 16, Pages 644: Accumulation Dynamics of Defective Genomes during Experimental Evolution of Two Betacoronaviruses
In conclusion, our study illustrates the widespread formation of DVGs during betacoronavirus evolution, influenced by MOI and cell- and virus-specific factors. (Source: Viruses)
Source: Viruses - April 20, 2024 Category: Virology Authors: Julia Hillung Mar ía J. Olmo-Uceda Juan C. Mu ñoz-Sánchez Santiago F. Elena Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1582: Hepatocellular Carcinoma: Current Drug Therapeutic Status, Advances and Challenges
Wanjin Hong
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for ~90% of liver neoplasms. It is the second leading cause of cancer-related deaths and the seventh most common cancer worldwide. Although there have been rapid developments in the treatment of HCC over the past decade, the incidence and mortality rates of HCC remain a challenge. With the widespread use of the hepatitis B vaccine and antiviral therapy, the etiology of HCC is shifting more toward metabolic-associated steatohepatitis (MASH). Early-stage HCC can be treated with potentially curative strategies such as surgical...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Shunzhen Zheng Siew Wee Chan Fei Liu Jun Liu Pierce Kah Hoe Chow Han Chong Toh Wanjin Hong Tags: Review Source Type: research
Jian Gan powder ameliorates immunological liver injury in mice by modulating the gut microbiota and metabolic profiles
ConclusionsJGP intervention improves ILI by restoring gut microbiota and modifying its metabolic profiles. These results provide a novel insight into the mechanism of JGP in treating ILI and the scientific basis to support its clinical application. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research
Fonction de l'ARNnc exosomal HEIH dans le carcinome h épatocellulaire associé au virus de l'hépatite B
This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the ...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Tao Yu Huiming Li Guijia Shen Qifang Wu Source Type: research
Communicable Disease Screening and Human Immunodeficiency Virus Prevention in the Emergency Department
Emerg Med Clin North Am. 2024 May;42(2):369-389. doi: 10.1016/j.emc.2024.02.007. Epub 2024 Mar 19.ABSTRACTEmergency departments (ED) provide care to populations with high rates of communicable diseases, like HIV, hepatitis C virus, and syphilis. For many patients, the ED is their sole entry point into the healthcare system and they do not routinely access screening and prevention services elsewhere. As such, the ED can serve an important public health role through communicable disease identification, treatment, and prevention. In this article, we examine national recommendations, peer-reviewed literature, and expert consen...
Source: The Medical Clinics of North America - April 19, 2024 Category: General Medicine Authors: Douglas A E White Rachel E Solnick Source Type: research
Fonction de l'ARNnc exosomal HEIH dans le carcinome h épatocellulaire associé au virus de l'hépatite B
This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the ...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Tao Yu Huiming Li Guijia Shen Qifang Wu Source Type: research
Communicable Disease Screening and Human Immunodeficiency Virus Prevention in the Emergency Department
Emerg Med Clin North Am. 2024 May;42(2):369-389. doi: 10.1016/j.emc.2024.02.007. Epub 2024 Mar 19.ABSTRACTEmergency departments (ED) provide care to populations with high rates of communicable diseases, like HIV, hepatitis C virus, and syphilis. For many patients, the ED is their sole entry point into the healthcare system and they do not routinely access screening and prevention services elsewhere. As such, the ED can serve an important public health role through communicable disease identification, treatment, and prevention. In this article, we examine national recommendations, peer-reviewed literature, and expert consen...
Source: The Medical Clinics of North America - April 19, 2024 Category: General Medicine Authors: Douglas A E White Rachel E Solnick Source Type: research
Fonction de l'ARNnc exosomal HEIH dans le carcinome h épatocellulaire associé au virus de l'hépatite B
This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the ...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Tao Yu Huiming Li Guijia Shen Qifang Wu Source Type: research
Communicable Disease Screening and Human Immunodeficiency Virus Prevention in the Emergency Department
Emerg Med Clin North Am. 2024 May;42(2):369-389. doi: 10.1016/j.emc.2024.02.007. Epub 2024 Mar 19.ABSTRACTEmergency departments (ED) provide care to populations with high rates of communicable diseases, like HIV, hepatitis C virus, and syphilis. For many patients, the ED is their sole entry point into the healthcare system and they do not routinely access screening and prevention services elsewhere. As such, the ED can serve an important public health role through communicable disease identification, treatment, and prevention. In this article, we examine national recommendations, peer-reviewed literature, and expert consen...
Source: The Medical Clinics of North America - April 19, 2024 Category: General Medicine Authors: Douglas A E White Rachel E Solnick Source Type: research
Fonction de l'ARNnc exosomal HEIH dans le carcinome h épatocellulaire associé au virus de l'hépatite B
This study aimed to investigate the expression of exosomal lncRNA-HEIH in B-HCC patients and explore its clinical significance. We collected blood samples from 60 B-HCC patients, 60 non-hepatitis virus-associated HCC (N-HCC) patients, and 50 healthy volunteers. Exosomal lncRNA-HEIH levels were measured by real-time PCR and analyzed for their correlation with patient prognosis using Kaplan-Meier analysis. Multivariate COX regression analysis was conducted to identify factors affecting patient outcomes. The effects of lncRNA-HEIH on carcinogenesis were also investigated by constructing a Huh7 cell line stably expressing the ...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Tao Yu Huiming Li Guijia Shen Qifang Wu Source Type: research
Communicable Disease Screening and Human Immunodeficiency Virus Prevention in the Emergency Department
Emerg Med Clin North Am. 2024 May;42(2):369-389. doi: 10.1016/j.emc.2024.02.007. Epub 2024 Mar 19.ABSTRACTEmergency departments (ED) provide care to populations with high rates of communicable diseases, like HIV, hepatitis C virus, and syphilis. For many patients, the ED is their sole entry point into the healthcare system and they do not routinely access screening and prevention services elsewhere. As such, the ED can serve an important public health role through communicable disease identification, treatment, and prevention. In this article, we examine national recommendations, peer-reviewed literature, and expert consen...
Source: The Medical Clinics of North America - April 19, 2024 Category: General Medicine Authors: Douglas A E White Rachel E Solnick Source Type: research
Trends in Mortality Related to Hepatitis B and C from 1990 to 2019 in the Western Pacific Region
CONCLUSIONS: : Although the mortality rate from hepatitis B and C decreased from 1990 to 2019, notable variation was observed among 27 Western Pacific countries. Efforts targeting hepatitis B and C prevention and treatment are still required in this region, especially for the pandemic countries.PMID:38638100 | DOI:10.5009/gnl230023 (Source: Gut and Liver)
Source: Gut and Liver - April 19, 2024 Category: Gastroenterology Authors: Hua Zhou Mengxia Yan Datian Che Bin Wu Source Type: research
