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Evaluation of a new automated viral RNA extraction platform for hepatitis A virus and human norovirus in testing of berries, lettuce, and oysters
Int J Food Microbiol. 2024 Mar 7;416:110664. doi: 10.1016/j.ijfoodmicro.2024.110664. Online ahead of print.ABSTRACTFruits, vegetables, and shellfish are often associated with outbreaks of illness caused particularly by human norovirus (HuNoV) and hepatitis A virus (HAV), the leading causative agents of foodborne illness worldwide. The aim of this study was to evaluate a new automated nucleic acid extraction platform (EGENE-UP EASYPREP) for enteric viruses in several at-risk food matrices and to test its limit of detection in comparison to a semi-automated method (EGENE-UP) using Boom methodology for nucleic acid extraction...
Source: International Journal of Food Microbiology - March 16, 2024 Category: Food Science Authors: Mathilde Trudel-Ferland Marie- Ève Collard Val érie Goulet-Beaulieu Eric Jubinville Fabienne Hamon Julie Jean Source Type: research

Investigating animal reservoirs for hepatitis E virus in Bangui, Central African Republic
ConclusionThis study confirms that pigs constitute an HEV reservoir, with genotype 3 being the major circulating strain. Further studies are needed to investigate other local reservoirs and to improve knowledge of the molecular epidemiology of HEV in CAR. (Source: PLoS One)
Source: PLoS One - March 15, 2024 Category: Biomedical Science Authors: Marina Prisca de Marguerite Nombot-Yazenguet Source Type: research

Germline HAVCR2/TIM-3 Checkpoint Inhibitor Receptor Deficiency in Recurrent Autoinflammatory Myocarditis
AbstractMyocarditis can be caused by viral infection, drug reaction or general inflammatory condition. To provide understanding on inflammatory myocarditis, we describe clinical, genetic, and immunological properties of a young male patient who suffered from recurrent myocarditis episodes since the age of four years. Electrocardiography, troponin I/T, echocardiography, myocardial magnetic resonance imaging and histological findings were consistent with recurrent myocarditis episodes. Homozygous c.245 A > G p.Tyr82Cys pathogenic variant in Hepatitis A Virus Cellular Receptor 2 (HAVCR2) gene encoding T cell immunog...
Source: Journal of Clinical Immunology - March 15, 2024 Category: Allergy & Immunology Source Type: research

Nurse Practitioners ’ Knowledge, Attitudes, and Practices Surrounding Adult Hepatitis Vaccination
An online survey was conducted to investigate knowledge, attitudes, and practices regarding hepatitis A and hepatitis B vaccination among 409 nurse practitioners (NPs). While most NPs (>80%) were knowledgeable about the Centers for Disease Control and Prevention ’s Advisory Committee on Immunization Practices recommendations for adult hepatitis A and hepatitis B vaccination, self-reported adherence to guidelines was suboptimal. Among NPs, 25% to 45% reported having no recent vaccination training, and>80% were interested in receiving training. (Source: The Journal for Nurse Practitioners)
Source: The Journal for Nurse Practitioners - March 12, 2024 Category: Nursing Authors: Emily K. Horn, Oscar Herrera-Restrepo, Neil P. Huyck, Anna M. Acosta, Andrea J. Harmelink, Jasjit K. Multani, Zifan Zhou, Annie Krishnan, Rifat Tuly, LiuCheng Shi, Chi-Chang Chen Tags: Original Research Source Type: research

Viral hepatitis –induced acute liver failure
AbstractViral hepatitis –induced acute liver failure (ALF) is a preventable cause for liver-related mortality worldwide. Viruses are the most common cause for ALF in developing nations in contrast to the west, where acetaminophen is largely responsible. Viruses may be hepatotropic or affect the liver secondary to a syste mic infection. In tropical countries, infections such as leptospirosis, scrub typhus and malaria can mimic the symptoms of ALF. Differentiating these ALF mimics is crucial because they require etiology-specific therapy. Treatment of viral hepatitis-induced ALF is two-pronged and directed towards pro vidi...
Source: Indian Journal of Gastroenterology - March 7, 2024 Category: Gastroenterology Source Type: research

Point-of-care ultrasound to inform antiviral treatment initiation in chronic hepatitis B virus infection in low-resource settings – the PUSH protocol
ConclusionUltrasound can facilitate same-day initiation of antiviral therapy for chronic HBV monoinfection in a resource-limited setting and a streamlined protocol-driven liver ultrasound can be feasibly used by front line clinicians managing HBV. (Source: Critical Ultrasound Journal)
Source: Critical Ultrasound Journal - March 4, 2024 Category: Radiology Source Type: research

"PROTAC" modified Dihydroquinolizinones (DHQs) that causes degradation of PAPD-5 and inhibition of hepatitis a virus and hepatitis B virus, in vitro
In this report, we describe RG7834-based Proteolysis Targeting Chimeras (PROTACs), such as compound 12b, (6S)-9-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-21-oxo-3,6,9,12,15,18-hexaoxa-22-azapentacosan-25-yl)oxy)-6-isopropyl-10-methoxy-2-oxo-6,7-dihydro-2H-pyrido[2,1-a]isoquinoline-3-carboxylic acid. The PROTAC DHQs described here inhibited an HAV reporter virus in vitro with an IC50 of 277 nM. Although the PROTAC DHQs were also inhibitory to HBV, their activities were substantially less potent against HBV in vitro, being in the 10 to 20 µM range, based on the reduction of HBsAg and HBV mRNA levels....
Source: Bioorganic and Medicinal Chemistry Letters - March 1, 2024 Category: Chemistry Authors: You Li Nicky Hwang Andrew Snedeker Stanley Lemon Daisy Noe Liren Sun Jason A Clement Tianlun Zhou Liudi Tang Timothy Block Yanming Du Source Type: research

"PROTAC" modified Dihydroquinolizinones (DHQs) that causes degradation of PAPD-5 and inhibition of hepatitis a virus and hepatitis B virus, in vitro
In this report, we describe RG7834-based Proteolysis Targeting Chimeras (PROTACs), such as compound 12b, (6S)-9-((1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-21-oxo-3,6,9,12,15,18-hexaoxa-22-azapentacosan-25-yl)oxy)-6-isopropyl-10-methoxy-2-oxo-6,7-dihydro-2H-pyrido[2,1-a]isoquinoline-3-carboxylic acid. The PROTAC DHQs described here inhibited an HAV reporter virus in vitro with an IC50 of 277 nM. Although the PROTAC DHQs were also inhibitory to HBV, their activities were substantially less potent against HBV in vitro, being in the 10 to 20 µM range, based on the reduction of HBsAg and HBV mRNA levels....
Source: Bioorganic and Medicinal Chemistry Letters - March 1, 2024 Category: Chemistry Authors: You Li Nicky Hwang Andrew Snedeker Stanley M Lemon Daisy Noe Liren Sun Jason A Clement Tianlun Zhou Liudi Tang Timothy Block Yanming Du Source Type: research

Liver Transplant in Patients With Autoimmune Hepatitis: A Large Single-Center Study
CONCLUSIONS: Liver transplant in patients with autoimmune hepatitis is safe and is associated with good outcomes.PMID:38385406 | DOI:10.6002/ect.MESOT2023.P65 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Amir Kasraianfard Ali Mohammad Moradi Mohssen Nassiri-Toosi Ali Jafarian Source Type: research