Eucalyptus-derived essential oils alleviate microbes and modulate inflammation by suppressing superoxide and elastase release
The Eucalyptus tree, belonging to the myrtle family, grows all over the world for its pharmaceutical and industrial benefits. In this article, we present a comparative analysis of the chemical composition of the hydrodistilled oils obtained from three different Eucalyptus species growing in Egypt viz. E. citriodora, E. camaldulensis, and E. ficifolia. Gas Chromatography-Mass Spectrometric guided analysis resulted in the identification of a total of 20 metabolites in E. citriodora oil with citronellal (54.9%) and citronellol (25.4%) being the most dominant components. β-cymene (12.7%) and 1,8-cineole (11.7%) were the major...
Source: Frontiers in Pharmacology - November 21, 2023 Category: Drugs & Pharmacology Source Type: research
Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair
Autophagy. 2023 Nov 18:1-22. doi: 10.1080/15548627.2023.2281156. Online ahead of print.ABSTRACTMacroautophagy/autophagy contributes to maladaptive kidney repair by inducing pro-fibrotic factors such as FGF2 (fibroblast growth factor 2), but the underlying mechanism remains elusive. Here, we show that EGR1 (early growth response 1) was induced in injured proximal tubules after ischemic acute kidney injury (AKI) and this induction was suppressed by autophagy deficiency in inducible, renal tubule-specific atg7 (autophagy related 7) knockout (iRT-atg7 KO) mice. In cultured proximal tubular cells, TGFB1 (transforming growth fac...
Source: Autophagy - November 18, 2023 Category: Cytology Authors: Man J Livingston Ming Zhang Sang-Ho Kwon Jian-Kang Chen Honglin Li Santhakumar Manicassamy Zheng Dong Source Type: research
Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair
Autophagy. 2023 Nov 18:1-22. doi: 10.1080/15548627.2023.2281156. Online ahead of print.ABSTRACTMacroautophagy/autophagy contributes to maladaptive kidney repair by inducing pro-fibrotic factors such as FGF2 (fibroblast growth factor 2), but the underlying mechanism remains elusive. Here, we show that EGR1 (early growth response 1) was induced in injured proximal tubules after ischemic acute kidney injury (AKI) and this induction was suppressed by autophagy deficiency in inducible, renal tubule-specific atg7 (autophagy related 7) knockout (iRT-atg7 KO) mice. In cultured proximal tubular cells, TGFB1 (transforming growth fac...
Source: Autophagy - November 18, 2023 Category: Cytology Authors: Man J Livingston Ming Zhang Sang-Ho Kwon Jian-Kang Chen Honglin Li Santhakumar Manicassamy Zheng Dong Source Type: research
Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair
Autophagy. 2023 Nov 18:1-22. doi: 10.1080/15548627.2023.2281156. Online ahead of print.ABSTRACTMacroautophagy/autophagy contributes to maladaptive kidney repair by inducing pro-fibrotic factors such as FGF2 (fibroblast growth factor 2), but the underlying mechanism remains elusive. Here, we show that EGR1 (early growth response 1) was induced in injured proximal tubules after ischemic acute kidney injury (AKI) and this induction was suppressed by autophagy deficiency in inducible, renal tubule-specific atg7 (autophagy related 7) knockout (iRT-atg7 KO) mice. In cultured proximal tubular cells, TGFB1 (transforming growth fac...
Source: Autophagy - November 18, 2023 Category: Cytology Authors: Man J Livingston Ming Zhang Sang-Ho Kwon Jian-Kang Chen Honglin Li Santhakumar Manicassamy Zheng Dong Source Type: research
Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair
Autophagy. 2023 Nov 18:1-22. doi: 10.1080/15548627.2023.2281156. Online ahead of print.ABSTRACTMacroautophagy/autophagy contributes to maladaptive kidney repair by inducing pro-fibrotic factors such as FGF2 (fibroblast growth factor 2), but the underlying mechanism remains elusive. Here, we show that EGR1 (early growth response 1) was induced in injured proximal tubules after ischemic acute kidney injury (AKI) and this induction was suppressed by autophagy deficiency in inducible, renal tubule-specific atg7 (autophagy related 7) knockout (iRT-atg7 KO) mice. In cultured proximal tubular cells, TGFB1 (transforming growth fac...
Source: Autophagy - November 18, 2023 Category: Cytology Authors: Man J Livingston Ming Zhang Sang-Ho Kwon Jian-Kang Chen Honglin Li Santhakumar Manicassamy Zheng Dong Source Type: research
PrEP2U: a novel community partnership HIV pre-exposure prophylaxis clinic
Broadening the access of HIV–pre-exposure prophylaxis (HIV-PrEP) prevents HIV transmission.1 In Brighton, we partnership with The Terrence Higgins Trust to deliver a community-based HIV-PrEP service (PrEP2U).2 PrEP2U operates weekly, offering comprehensive STI/HIV testing, HIV-PrEP monitoring and hepatitis A & B and human papilloma virus vaccinations. We aimed to explore whether PrEP2U is providing HIV-PrEP to a different population compared with our clinic. Eighty-two individuals attended PrEP2U between August and December 2022, 66 (80%) identified as cis-male, 5 (6%) cis-female, 5 (6%) trans-feminine, 2 (2%) tr...
Source: Sexually Transmitted Infections - November 17, 2023 Category: Sexual Medicine Authors: Frem, J. A., Russell, A., Nichols, K., Buonsenno, L., Tweed, M., Fitzpatrick, C., Darking, M., Whetham, J., Richardson, D. Tags: PostScript Source Type: research
Pemetrexed ameliorates Con A-induced hepatic injury by restricting M1 macrophage activation
Int Immunopharmacol. 2023 Nov 3;125(Pt A):111158. doi: 10.1016/j.intimp.2023.111158. Online ahead of print.ABSTRACTAutoimmune hepatitis (AIH), characterized by immune-driven liver destruction and cytokine production, is a progressive inflammatory liver condition that may progress to hepatic cirrhosis or tumors. However, the underlying mechanism is not well understood, and the treatment options for this disease are limited. Pemetrexed (PEM), a clinically used anti-folate drug for treating various tumors, was found to inhibit the nuclear factor (NF)-κB signaling pathways that exert an important role in the development of AI...
Source: International Immunopharmacology - November 5, 2023 Category: Allergy & Immunology Authors: Zhaiyi Liu Zhiyue Bao Bo Yu Lihong Chen Guangrui Yang Source Type: research
Bacillus cereus Sepsis in a Patient with Severe Alcoholic Hepatitis: A Case Report
Intern Med. 2023 Nov 6. doi: 10.2169/internalmedicine.2553-23. Online ahead of print.ABSTRACTA 57-year-old woman with a liver injury was referred to our hospital. She had a history of heavy alcohol consumption and had developed severe alcoholic hepatitis. Blood cultures revealed bacteremia caused by Bacillus cereus. The patient was treated with short-term steroid therapy for liver injury and vancomycin administration for B. cereus sepsis, which led to recovery. The findings in the present case suggest the need for empirical therapy with vancomycin in patients with severe alcoholic hepatitis and suspected B. cereus infectio...
Source: Internal Medicine - November 5, 2023 Category: Internal Medicine Authors: Kazuto Suto Manabu Hayashi Masashi Fujita Kazumichi Abe Atsushi Takahashi Hiromasa Ohira Source Type: research
Pemetrexed ameliorates Con A-induced hepatic injury by restricting M1 macrophage activation
Int Immunopharmacol. 2023 Nov 3;125(Pt A):111158. doi: 10.1016/j.intimp.2023.111158. Online ahead of print.ABSTRACTAutoimmune hepatitis (AIH), characterized by immune-driven liver destruction and cytokine production, is a progressive inflammatory liver condition that may progress to hepatic cirrhosis or tumors. However, the underlying mechanism is not well understood, and the treatment options for this disease are limited. Pemetrexed (PEM), a clinically used anti-folate drug for treating various tumors, was found to inhibit the nuclear factor (NF)-κB signaling pathways that exert an important role in the development of AI...
Source: International Immunopharmacology - November 5, 2023 Category: Allergy & Immunology Authors: Zhaiyi Liu Zhiyue Bao Bo Yu Lihong Chen Guangrui Yang Source Type: research
Bacillus cereus Sepsis in a Patient with Severe Alcoholic Hepatitis: A Case Report
Intern Med. 2023 Nov 6. doi: 10.2169/internalmedicine.2553-23. Online ahead of print.ABSTRACTA 57-year-old woman with a liver injury was referred to our hospital. She had a history of heavy alcohol consumption and had developed severe alcoholic hepatitis. Blood cultures revealed bacteremia caused by Bacillus cereus. The patient was treated with short-term steroid therapy for liver injury and vancomycin administration for B. cereus sepsis, which led to recovery. The findings in the present case suggest the need for empirical therapy with vancomycin in patients with severe alcoholic hepatitis and suspected B. cereus infectio...
Source: Internal Medicine - November 5, 2023 Category: Internal Medicine Authors: Kazuto Suto Manabu Hayashi Masashi Fujita Kazumichi Abe Atsushi Takahashi Hiromasa Ohira Source Type: research
