Treating autoimmune hepatitis – More science, more progress, better therapy
People living with autoimmune diseases frequently have impaired quality and quantity of life, and usually a chronic disease course.1 Physicians usually focus on their own areas of interest but taking the ‘patient helicopter’ view is important to challenge our current management paradigms. Patients may fairly ask what do autoimmune hepatitis (AIH), rheumatoid arthritis, multiple sclerosis, psoriasis, and inflammatory bowel diseases have in common? All are immune-mediated diseases, whose exact aet iology is unknown, all may lead to acute flares that can be effectively managed by corticosteroid therapy, all require long-t...
Source: Journal of Hepatology - February 1, 2024 Category: Gastroenterology Authors: Gideon M. Hirschfield, Ansgar W. Lohse Tags: Editorial Source Type: research
Heat stability of foodborne viruses - Findings, methodological challenges and current developments
Int J Food Microbiol. 2024 Mar 2;413:110582. doi: 10.1016/j.ijfoodmicro.2024.110582. Epub 2024 Jan 25.ABSTRACTHeat treatment of food represents an important measure to prevent pathogen transmission. Thus far, evaluation of heat treatment processes is mainly based on data from bacteria. However, foodborne viruses have gained increasing attention during the last decades. Here, the published literature on heat stability and inactivation of human norovirus (NoV), hepatitis A virus (HAV) and hepatitis E virus (HEV) was reviewed. Data for surrogate viruses were not included. As stability assessment for foodborne viruses is often...
Source: International Journal of Food Microbiology - January 30, 2024 Category: Food Science Authors: Reimar Johne Johannes Scholz Alexander Falkenhagen Source Type: research
Plant stanol consumption increases anti-COVID-19 antibody responses, independent of changes in serum cholesterol concentrations: a randomized controlled trial
CONCLUSIONS: Consuming plant stanols (4 g/d) affects immune responses to COVID-19 vaccinations, translating into increased serum anti-COVID-19 IgM concentrations in subjects with overweight/obesity. Only in IgG seroconverted subjects, serum anti-COVID-19 IgG concentrations also increases. These effects are independent of reductions in LDL cholesterol. These results suggest that this high-risk group for COVID-19 complications could benefit from plant stanol consumption. This trial was registered at clinicaltrials.gov as NCT04844346.PMID:38278364 | DOI:10.1016/j.ajcnut.2024.01.017 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - January 26, 2024 Category: Nutrition Authors: Lieve van Brakel Ronald P Mensink Dieter L ütjohann Jogchum Plat Source Type: research
Plant stanol consumption increases anti-COVID-19 antibody responses, independent of changes in serum cholesterol concentrations: a randomized controlled trial
CONCLUSIONS: Consuming plant stanols (4 g/d) affects immune responses to COVID-19 vaccinations, translating into increased serum anti-COVID-19 IgM concentrations in subjects with overweight/obesity. Only in IgG seroconverted subjects, serum anti-COVID-19 IgG concentrations also increases. These effects are independent of reductions in LDL cholesterol. These results suggest that this high-risk group for COVID-19 complications could benefit from plant stanol consumption. This trial was registered at clinicaltrials.gov as NCT04844346.PMID:38278364 | DOI:10.1016/j.ajcnut.2024.01.017 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - January 26, 2024 Category: Nutrition Authors: Lieve van Brakel Ronald P Mensink Dieter L ütjohann Jogchum Plat Source Type: research
Meta-analysis of the prevalence of norovirus and hepatitis a virus in berries
Int J Food Microbiol. 2024 Mar 2;413:110577. doi: 10.1016/j.ijfoodmicro.2024.110577. Epub 2024 Jan 17.ABSTRACTNorovirus (NoV) and hepatitis A virus (HAV) stand as the predominant agents associated with viral foodborne infections. Outbreaks have been documented to be caused by various types of food items, including fresh and/or frozen berries. Comprehensive data concerning crucial viral pathogens in berries remain limited and are not currently available in aggregate form. Consequently, the present study aimed to compile the existing information regarding the prevalence of NoV and HAV in this matrix. Records of foodborne vir...
Source: International Journal of Food Microbiology - January 23, 2024 Category: Food Science Authors: Camila Miotti Marcelo Lisandro Signorini Juan Mart ín Oteiza Ver ónica Emilse Prez Patricia Ang élica Barril Source Type: research
CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function
Innate Immun. 2024 Jan 23:17534259231225611. doi: 10.1177/17534259231225611. Online ahead of print.ABSTRACTInterferon Stimulated Gene (ISG) expression plays a key role in the control of viral replication and development of a robust adaptive response. Understanding this dynamic relationship between the pathogen and host is critical to our understanding of viral life-cycles and development of potential novel anti-viral strategies. Traditionally, plasmid based exogenous prompter driven expression of ISGs has been used to investigate anti-viral ISG function, however there are deficiencies in this approach. To overcome this, we...
Source: Innate Immunity - January 23, 2024 Category: Allergy & Immunology Authors: Emily N Kirby Xavier B Montin Timothy P Allen Jaslan Densumite Brooke N Trowbridge Michael R Beard Source Type: research
CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function
Innate Immun. 2024 Jan 23:17534259231225611. doi: 10.1177/17534259231225611. Online ahead of print.ABSTRACTInterferon Stimulated Gene (ISG) expression plays a key role in the control of viral replication and development of a robust adaptive response. Understanding this dynamic relationship between the pathogen and host is critical to our understanding of viral life-cycles and development of potential novel anti-viral strategies. Traditionally, plasmid based exogenous prompter driven expression of ISGs has been used to investigate anti-viral ISG function, however there are deficiencies in this approach. To overcome this, we...
Source: Innate Immunity - January 23, 2024 Category: Allergy & Immunology Authors: Emily N Kirby Xavier B Montin Timothy P Allen Jaslan Densumite Brooke N Trowbridge Michael R Beard Source Type: research
CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function
Innate Immun. 2024 Jan 23:17534259231225611. doi: 10.1177/17534259231225611. Online ahead of print.ABSTRACTInterferon Stimulated Gene (ISG) expression plays a key role in the control of viral replication and development of a robust adaptive response. Understanding this dynamic relationship between the pathogen and host is critical to our understanding of viral life-cycles and development of potential novel anti-viral strategies. Traditionally, plasmid based exogenous prompter driven expression of ISGs has been used to investigate anti-viral ISG function, however there are deficiencies in this approach. To overcome this, we...
Source: Innate Immunity - January 23, 2024 Category: Allergy & Immunology Authors: Emily N Kirby Xavier B Montin Timothy P Allen Jaslan Densumite Brooke N Trowbridge Michael R Beard Source Type: research
CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function
Innate Immun. 2024 Jan 23:17534259231225611. doi: 10.1177/17534259231225611. Online ahead of print.ABSTRACTInterferon Stimulated Gene (ISG) expression plays a key role in the control of viral replication and development of a robust adaptive response. Understanding this dynamic relationship between the pathogen and host is critical to our understanding of viral life-cycles and development of potential novel anti-viral strategies. Traditionally, plasmid based exogenous prompter driven expression of ISGs has been used to investigate anti-viral ISG function, however there are deficiencies in this approach. To overcome this, we...
Source: Innate Immunity - January 23, 2024 Category: Allergy & Immunology Authors: Emily N Kirby Xavier B Montin Timothy P Allen Jaslan Densumite Brooke N Trowbridge Michael R Beard Source Type: research
CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function
Innate Immun. 2024 Jan 23:17534259231225611. doi: 10.1177/17534259231225611. Online ahead of print.ABSTRACTInterferon Stimulated Gene (ISG) expression plays a key role in the control of viral replication and development of a robust adaptive response. Understanding this dynamic relationship between the pathogen and host is critical to our understanding of viral life-cycles and development of potential novel anti-viral strategies. Traditionally, plasmid based exogenous prompter driven expression of ISGs has been used to investigate anti-viral ISG function, however there are deficiencies in this approach. To overcome this, we...
Source: Innate Immunity - January 23, 2024 Category: Allergy & Immunology Authors: Emily N Kirby Xavier B Montin Timothy P Allen Jaslan Densumite Brooke N Trowbridge Michael R Beard Source Type: research
CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function
Innate Immun. 2024 Jan 23:17534259231225611. doi: 10.1177/17534259231225611. Online ahead of print.ABSTRACTInterferon Stimulated Gene (ISG) expression plays a key role in the control of viral replication and development of a robust adaptive response. Understanding this dynamic relationship between the pathogen and host is critical to our understanding of viral life-cycles and development of potential novel anti-viral strategies. Traditionally, plasmid based exogenous prompter driven expression of ISGs has been used to investigate anti-viral ISG function, however there are deficiencies in this approach. To overcome this, we...
Source: Innate Immunity - January 23, 2024 Category: Allergy & Immunology Authors: Emily N Kirby Xavier B Montin Timothy P Allen Jaslan Densumite Brooke N Trowbridge Michael R Beard Source Type: research
CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function
Innate Immun. 2024 Jan 23:17534259231225611. doi: 10.1177/17534259231225611. Online ahead of print.ABSTRACTInterferon Stimulated Gene (ISG) expression plays a key role in the control of viral replication and development of a robust adaptive response. Understanding this dynamic relationship between the pathogen and host is critical to our understanding of viral life-cycles and development of potential novel anti-viral strategies. Traditionally, plasmid based exogenous prompter driven expression of ISGs has been used to investigate anti-viral ISG function, however there are deficiencies in this approach. To overcome this, we...
Source: Innate Immunity - January 23, 2024 Category: Allergy & Immunology Authors: Emily N Kirby Xavier B Montin Timothy P Allen Jaslan Densumite Brooke N Trowbridge Michael R Beard Source Type: research
CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function
Innate Immun. 2024 Jan 23:17534259231225611. doi: 10.1177/17534259231225611. Online ahead of print.ABSTRACTInterferon Stimulated Gene (ISG) expression plays a key role in the control of viral replication and development of a robust adaptive response. Understanding this dynamic relationship between the pathogen and host is critical to our understanding of viral life-cycles and development of potential novel anti-viral strategies. Traditionally, plasmid based exogenous prompter driven expression of ISGs has been used to investigate anti-viral ISG function, however there are deficiencies in this approach. To overcome this, we...
Source: Innate Immunity - January 23, 2024 Category: Allergy & Immunology Authors: Emily N Kirby Xavier B Montin Timothy P Allen Jaslan Densumite Brooke N Trowbridge Michael R Beard Source Type: research
CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function
Innate Immun. 2024 Jan 23:17534259231225611. doi: 10.1177/17534259231225611. Online ahead of print.ABSTRACTInterferon Stimulated Gene (ISG) expression plays a key role in the control of viral replication and development of a robust adaptive response. Understanding this dynamic relationship between the pathogen and host is critical to our understanding of viral life-cycles and development of potential novel anti-viral strategies. Traditionally, plasmid based exogenous prompter driven expression of ISGs has been used to investigate anti-viral ISG function, however there are deficiencies in this approach. To overcome this, we...
Source: Innate Immunity - January 23, 2024 Category: Allergy & Immunology Authors: Emily N Kirby Xavier B Montin Timothy P Allen Jaslan Densumite Brooke N Trowbridge Michael R Beard Source Type: research
CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function
Innate Immun. 2024 Jan 23:17534259231225611. doi: 10.1177/17534259231225611. Online ahead of print.ABSTRACTInterferon Stimulated Gene (ISG) expression plays a key role in the control of viral replication and development of a robust adaptive response. Understanding this dynamic relationship between the pathogen and host is critical to our understanding of viral life-cycles and development of potential novel anti-viral strategies. Traditionally, plasmid based exogenous prompter driven expression of ISGs has been used to investigate anti-viral ISG function, however there are deficiencies in this approach. To overcome this, we...
Source: Innate Immunity - January 23, 2024 Category: Allergy & Immunology Authors: Emily N Kirby Xavier B Montin Timothy P Allen Jaslan Densumite Brooke N Trowbridge Michael R Beard Source Type: research
