An economic evaluation of eptinezumab for the preventive treatment of migraine in the UK, with consideration for natural history and work productivity
ConclusionsThis economic evaluation shows that from a societal perspective, eptinezumab is a cost-effective treatment in patients with ≥ 4 migraine days per month and for whom ≥ 3 other preventive migraine treatments have failed.Trial registrationN/A.Graphical Abstract (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - April 18, 2024 Category: Neurology Source Type: research
Dynamic fluctuations of salivary CGRP levels during migraine attacks: association with clinical variables and phenotypic characterization
ConclusionsOur study underscores the dynamic nature of migraine at a molecular level and emphasizes the importance of integrating clinical variables, such as depressive symptoms, in understanding its pathophysiology. The identification of distinct migraine subtypes based on CGRP dependence suggests potential opportunities for personalized treatment approaches. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - April 18, 2024 Category: Neurology Source Type: research
Genetic and Phenotypic Profiling of Triptan Users in a Swedish Cluster Headache Cohort
AbstractUp to 25% of individuals who live with cluster headache (CH), an extremely painful primary headache disorder, do not adequately respond to the first-line treatment, triptans. Studies have indicated that genetic variants can play a role in treatment response. Likewise, differences in clinical characteristics can give clues to mechanisms underlying triptan non-response. Our aim was to investigate five genetic variants previously implicated in triptan response and their relation to triptan usage in our Swedish CH cohort and to investigate potential distinctions in clinical characteristics. 545 CH patients were screene...
Source: Journal of Molecular Neuroscience - April 18, 2024 Category: Neuroscience Source Type: research
Focused Update on Migraine and Vertigo Comorbidity
AbstractPurpose of ReviewTo provide an update on comorbidity of vestibular symptoms and migraine.Recent FindingsMultisensory processing and integration is a key concept for understanding mixed presentation of migraine and vestibular symptoms. Here, we discuss how vestibular migraine should be distinguished from a secondary migraine phenomenon in which migraine symptoms may coincide with or triggered by another vestibular disorder. We also have some updates on the diagnostic criteria of vestibular migraine, its pathophysiology, and common approaches used for its treatment.SummaryAs a common clinical presentation of migraine...
Source: Current Pain and Headache Reports - April 18, 2024 Category: Neurology Source Type: research
Durable Effects of Acupuncture for Knee Osteoarthritis: A Systematic Review and Meta-analysis
AbstractPurpose of ReviewKnee osteoarthritis (KOA) is a degenerative joint disease which can result in chronic pain and disability. The current interventions available for KOA often fail to provide long-lasting effects, highlighting the need for new treatment options that can offer durable benefits. Previous studies have suggested the efficacy of acupuncture for knee osteoarthritis (KOA) with its durability remaining uncertain. In this review, we aimed to investigate the durability of the efficacy after completion of treatment.Recent FindingsWe performed thorough searches of PubMed, EMBASE, Web of Science, and Cochrane Cen...
Source: Current Pain and Headache Reports - April 18, 2024 Category: Neurology Source Type: research
Sudden unexpected death in a middle-aged woman
Clinical presentation The patient was a woman in her 50s with a history of migraine and Raynaud’s disease. She had episodes of severe migraine that only partially responded to triptans, and worsened during pregnancy approximately 14 years prior, and also during the perimenopausal period approximately 2 years ago. After menopause, her migraines improved, occurred once a month, and responded well to triptans. She had elevated cholesterol. She had no known history of hypertension, diabetes mellitus, coronary artery disease, myocardial infarction, stroke, autoimmune disease or connective tissue disease. She was not on ho...
Source: Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Casimero, F. V. C., Patalas, E. D., Stone, J. R. Tags: Grand rounds Source Type: research
Rare vermian pilocytic astrocytoma with recurrent spontaneous hemorrhage in the elderly: A case report and review of literature
CONCLUSION: PA in the elderly is a rare disease with distinct histologic and genetic peculiarities. This case review showed one of the oldest cases of cerebellar vermian PA presenting with recurrent spontaneous intratumoral hemorrhage, an extremely rare occurrence in benign glioma. Although complete surgical excision is recommended, partial resection is advocated for morbidly adherent tumors. Overall prognosis is worse in elderly PA.PMID:38628526 | PMC:PMC11021065 | DOI:10.25259/SNI_978_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Campbell Chukwuebuka Francis Kohei Kanaya Kohei Nagamine Tetsuya Goto Tetsuyoshi Horiuchi Samuel Chukwunonyerem Ohaegbulam Source Type: research
Secondary normal pressure hydrocephalus following pituitary apoplexy: A case report
CONCLUSION: This case suggests that sNPH can develop even after a small subarachnoid hemorrhage caused by a pituitary apoplexy in LOVA patients. If the aqueduct of Sylvius is open, sNPH with a LOVA background can be successfully treated with LPS placement.PMID:38628523 | PMC:PMC11021090 | DOI:10.25259/SNI_32_2024 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Yusuke Tomita Shoichi Fukuda Aiko Kobashi Yoshihiro Okada Keigo Makino Naoya Kidani Kenichiro Muraoka Nobuyuki Hirotsune Shigeki Nishino Source Type: research
Spontaneous thrombosis and calcification of giant cavernous carotid artery aneurysm: A rare case and management insights
CONCLUSION: This case highlights the complex interplay between thrombosed giant aneurysms and affected vessels, with unique features such as cross-flow, calcification, and bone erosion. We advocate conservative management for stable cases, supported by literature, emphasizing vigilant follow-up. This expands the spectrum of aneurysm presentations and encourages further research into their dynamics.PMID:38628510 | PMC:PMC11021061 | DOI:10.25259/SNI_805_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Vikas Chandra Jha Rahul Jain Vivek Saran Sinha Nitish Kumar Gaurav Verma Nikhil Dhage Source Type: research
Penetrating head trauma resulting from vigilante street justice
CONCLUSION: Proper handling and rapid transport of patients to the advanced trauma center are crucial for victims of PBI. Timely and skilled interventions could prevent further nervous tissue damage and any related neurological dysfunction.PMID:38628506 | PMC:PMC11021100 | DOI:10.25259/SNI_1031_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Sylvery Mwesige Maxigama Ndossi Nicephorus Rutabasibwa Laurent Lemeri Source Type: research
Rare vermian pilocytic astrocytoma with recurrent spontaneous hemorrhage in the elderly: A case report and review of literature
CONCLUSION: PA in the elderly is a rare disease with distinct histologic and genetic peculiarities. This case review showed one of the oldest cases of cerebellar vermian PA presenting with recurrent spontaneous intratumoral hemorrhage, an extremely rare occurrence in benign glioma. Although complete surgical excision is recommended, partial resection is advocated for morbidly adherent tumors. Overall prognosis is worse in elderly PA.PMID:38628526 | PMC:PMC11021065 | DOI:10.25259/SNI_978_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Campbell Chukwuebuka Francis Kohei Kanaya Kohei Nagamine Tetsuya Goto Tetsuyoshi Horiuchi Samuel Chukwunonyerem Ohaegbulam Source Type: research
Secondary normal pressure hydrocephalus following pituitary apoplexy: A case report
CONCLUSION: This case suggests that sNPH can develop even after a small subarachnoid hemorrhage caused by a pituitary apoplexy in LOVA patients. If the aqueduct of Sylvius is open, sNPH with a LOVA background can be successfully treated with LPS placement.PMID:38628523 | PMC:PMC11021090 | DOI:10.25259/SNI_32_2024 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Yusuke Tomita Shoichi Fukuda Aiko Kobashi Yoshihiro Okada Keigo Makino Naoya Kidani Kenichiro Muraoka Nobuyuki Hirotsune Shigeki Nishino Source Type: research
Spontaneous thrombosis and calcification of giant cavernous carotid artery aneurysm: A rare case and management insights
CONCLUSION: This case highlights the complex interplay between thrombosed giant aneurysms and affected vessels, with unique features such as cross-flow, calcification, and bone erosion. We advocate conservative management for stable cases, supported by literature, emphasizing vigilant follow-up. This expands the spectrum of aneurysm presentations and encourages further research into their dynamics.PMID:38628510 | PMC:PMC11021061 | DOI:10.25259/SNI_805_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Vikas Chandra Jha Rahul Jain Vivek Saran Sinha Nitish Kumar Gaurav Verma Nikhil Dhage Source Type: research
Penetrating head trauma resulting from vigilante street justice
CONCLUSION: Proper handling and rapid transport of patients to the advanced trauma center are crucial for victims of PBI. Timely and skilled interventions could prevent further nervous tissue damage and any related neurological dysfunction.PMID:38628506 | PMC:PMC11021100 | DOI:10.25259/SNI_1031_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Sylvery Mwesige Maxigama Ndossi Nicephorus Rutabasibwa Laurent Lemeri Source Type: research
Rare vermian pilocytic astrocytoma with recurrent spontaneous hemorrhage in the elderly: A case report and review of literature
CONCLUSION: PA in the elderly is a rare disease with distinct histologic and genetic peculiarities. This case review showed one of the oldest cases of cerebellar vermian PA presenting with recurrent spontaneous intratumoral hemorrhage, an extremely rare occurrence in benign glioma. Although complete surgical excision is recommended, partial resection is advocated for morbidly adherent tumors. Overall prognosis is worse in elderly PA.PMID:38628526 | PMC:PMC11021065 | DOI:10.25259/SNI_978_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Campbell Chukwuebuka Francis Kohei Kanaya Kohei Nagamine Tetsuya Goto Tetsuyoshi Horiuchi Samuel Chukwunonyerem Ohaegbulam Source Type: research
