First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of BMS-986141, a novel, reversible, small-molecule, PAR4 agonist in non-Japanese and Japanese healthy participants
This study found BMS-986141 was safe and well tolerated, with dose-proportional pharmacokinetics and concentration-dependent pharmacodynamics in healthy participants over a wide dose range. ClinicalTrials.gov ID: NCT02341638.PMID:37394920 | DOI:10.1080/09537104.2023.2222846 (Source: Platelets)
Source: Platelets - July 3, 2023 Category: Hematology Authors: Samira Merali Zhaoqing Wang Charles Frost Stephanie Meadows-Shropshire Dara Hawthorne Jing Yang Dietmar Seiffert Source Type: research
Assessing learning and memory among patients with pediatric brain tumor (PBT): a comparison of measures
Child Neuropsychol. 2023 Jul 3:1-12. doi: 10.1080/09297049.2023.2229026. Online ahead of print.ABSTRACTPatients with pediatric brain tumor (PBT) can have memory deficits due to tumor location, medical complications, and treatment. The main objective of this study was to investigate whether the California Verbal Learning Test-Children's Version (CVLT-C; 1994) and briefer Child and Adolescent Memory Profile (ChAMP; 2015) similarly identify such deficits. Seventy-five patients with PBT ages 8-16 (x‾ = 13.1 years, SD = 2.1) were administered the ChAMP or CVLT-C. Rote verbal learning, long-term retrieval, and recognition were...
Source: Child Neuropsychology - July 3, 2023 Category: Child Development Authors: Ashley M Whitaker Zachary B Wood Kelsey Hawthorne Leanne Mendoza Source Type: research
First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of BMS-986141, a novel, reversible, small-molecule, PAR4 agonist in non-Japanese and Japanese healthy participants
This study found BMS-986141 was safe and well tolerated, with dose-proportional pharmacokinetics and concentration-dependent pharmacodynamics in healthy participants over a wide dose range. ClinicalTrials.gov ID: NCT02341638.PMID:37394920 | DOI:10.1080/09537104.2023.2222846 (Source: Platelets)
Source: Platelets - July 3, 2023 Category: Hematology Authors: Samira Merali Zhaoqing Wang Charles Frost Stephanie Meadows-Shropshire Dara Hawthorne Jing Yang Dietmar Seiffert Source Type: research
Physicochemical properties and Pb < sup > 2+ < /sup > adsorption capacity of freeze-dried hawthorn pectin fractions by gradient ethanol precipitation
Int J Biol Macromol. 2023 Jun 27:125581. doi: 10.1016/j.ijbiomac.2023.125581. Online ahead of print.ABSTRACTThree fractions of FHP20, FHP40 and FHP60 were obtained from freeze-dried hawthorn pectin by gradient ethanol precipitation (20-60 %), and their physicochemical properties and adsorption performance on Pb2+ were investigated. It was found that the content of galacturonic acid (GalA) and esterification of FHP fractions gradually reduced with the increase of ethanol concentration. FHP60 had the lowest molecular weight (60.69 × 103 Da), and the composition and proportion of monosaccharides were significantly different....
Source: International Journal of Biological Macromolecules - June 29, 2023 Category: Biochemistry Authors: Zhixin Li Xiaoyan Zhang Chuanhe Zhu Source Type: research
Physicochemical properties and Pb < sup > 2+ < /sup > adsorption capacity of freeze-dried hawthorn pectin fractions by gradient ethanol precipitation
Int J Biol Macromol. 2023 Jun 27;245:125581. doi: 10.1016/j.ijbiomac.2023.125581. Online ahead of print.ABSTRACTThree fractions of FHP20, FHP40 and FHP60 were obtained from freeze-dried hawthorn pectin by gradient ethanol precipitation (20-60 %), and their physicochemical properties and adsorption performance on Pb2+ were investigated. It was found that the content of galacturonic acid (GalA) and esterification of FHP fractions gradually reduced with the increase of ethanol concentration. FHP60 had the lowest molecular weight (60.69 × 103 Da), and the composition and proportion of monosaccharides were significantly differ...
Source: International Journal of Biological Macromolecules - June 29, 2023 Category: Biochemistry Authors: Zhixin Li Xiaoyan Zhang Chuanhe Zhu Source Type: research
Human rotator cuff tears demonstrate an age-dependent increase in markers of cellular senescence and selective removal of senescent cells with dasatinib+quercetin increases genetic expression of COL1A1 in vitro
To quantify cellular senescence in supraspinatus tendon and subacromial bursa of humans with rotator cuff tears and to investigate the in vitro efficacy of the senolytic dasatinib+quercetin (D+Q) to eliminate senescent cells and alter tenogenic differentiation. (Source: Arthroscopy - Journal of Arthroscopic and Related Surgery)
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - June 22, 2023 Category: Surgery Authors: Benjamin C. Hawthorne, Ian J. Wellington, Joshua T. Sabitsky, Kyle V. Murphy, Owen P. Karsmarski, Rohin O. Thomas, Matthew R. LeVasseur, Michael R. Mancini, Maxwell T. Trudeau, Sagar Gulati, Mary Beth R. McCarthy, Mark P. Cote, Ming Xu, Augustus D. Mazzoc Source Type: research
Human Rotator Cuff Tears Reveal an Age-Dependent Increase in Markers of Cellular Senescence and Selective Removal of Senescent Cells With Dasatinib + Quercetin Increases Genetic Expression of COL1A1 In Vitro
To quantify cellular senescence in supraspinatus tendon and subacromial bursa of humans with rotator cuff tears and to investigate the in vitro efficacy of the senolytic dasatinib + quercetin (D+Q) to eliminate senescent cells and alter tenogenic differentiation. (Source: Arthroscopy - Journal of Arthroscopic and Related Surgery)
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - June 22, 2023 Category: Surgery Authors: Benjamin C. Hawthorne, Ian J. Wellington, Joshua T. Sabitsky, Kyle V. Murphy, Owen P. Karsmarski, Rohin O. Thomas, Matthew R. LeVasseur, Michael R. Mancini, Maxwell T. Trudeau, Sagar Gulati, Mary Beth R. McCarthy, Mark P. Cote, Ming Xu, Augustus D. Mazzoc Tags: Original Article Source Type: research
Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn ( < em > Crataegus anamesa < /em > Sarg.) extracts in cardiovascular diseases
This study aimed to review the vascular protective effects and molecular mechanisms of hawthorn and its extracts on cardiovascular diseases (CVDs). Hawthorn has a wide range of biological functions. Evidence suggests that the active components of HE reduce oxidative stress and inflammation, regulate lipid levels to prevent lipid accumulation, and inhibit free cholesterol accumulation in macrophages and foam cell formation. Additionally, hawthorn extract (HE) can protect vascular endothelial function, regulate endothelial dysfunction, and promote vascular endothelial relaxation. It has also been reported that the effective ...
Source: Atherosclerosis - June 20, 2023 Category: Cardiology Authors: Mengkai Lu Lei Zhang Jinyuan Pan Huishan Shi Muxin Zhang Chao Li Source Type: research
Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn ( < em > Crataegus anamesa < /em > Sarg.) extracts in cardiovascular diseases
This study aimed to review the vascular protective effects and molecular mechanisms of hawthorn and its extracts on cardiovascular diseases (CVDs). Hawthorn has a wide range of biological functions. Evidence suggests that the active components of HE reduce oxidative stress and inflammation, regulate lipid levels to prevent lipid accumulation, and inhibit free cholesterol accumulation in macrophages and foam cell formation. Additionally, hawthorn extract (HE) can protect vascular endothelial function, regulate endothelial dysfunction, and promote vascular endothelial relaxation. It has also been reported that the effective ...
Source: Atherosclerosis - June 20, 2023 Category: Cardiology Authors: Mengkai Lu Lei Zhang Jinyuan Pan Huishan Shi Muxin Zhang Chao Li Source Type: research
Supplements for Lipid Lowering: What Does the Evidence Show?
AbstractPurposeIn this review, the regulation, proposed hypolipidemic mechanism, and efficacy of common dietary supplements (DSs) marketed for cardiovascular health are discussed.Recent FindingsData demonstrate modest but inconsistent lipid-lowering effects with common DSs such as probiotics, soluble fibers, plant sterols, green tea, berberine, guggul, niacin, and garlic. Furthermore, data is limited regarding turmeric, hawthorn, and cinnamon. Red yeast rice has shown to be a beneficial DS, but its safety and efficacy are dependent upon its production quality and monacolin K content, respectively. Finally, soy proteins and...
Source: Current Cardiology Reports - June 10, 2023 Category: Cardiology Source Type: research
Evaluation of probiotic properties of Levilactobacillus brevis isolated from hawthorn vinegar
Arch Microbiol. 2023 Jun 8;205(7):258. doi: 10.1007/s00203-023-03599-5.ABSTRACTProbiotic microorganisms are increasing their interest today due to the benefits they provide to humans. Vinegar is the process of processing foods containing carbohydrates that can be fermented by acetic acid bacteria and yeasts. Hawthorn vinegar is also important in terms of amino acids, aromatic compounds, organic acids, vitamins and minerals it contains. Depending on the variety of microorganisms in it, the content of hawthorn vinegar changes, especially its biological activity. Bacteria were isolated from handmade hawthorn vinegar obtained ...
Source: Archives of Microbiology - June 7, 2023 Category: Microbiology Authors: Samet Kocabay Source Type: research
Anti-Obesity Actions of Two Separated Aqueous Extracts From Arbutus ( < em > Arbutus unedo < /em > ) and Hawthorn ( < em > Crataegus monogyna < /em > ) Fruits Against High-Fat Diet in Rats via Potent Antioxidant Target
Dose Response. 2023 May 30;21(2):15593258231179904. doi: 10.1177/15593258231179904. eCollection 2023 Apr-Jun.ABSTRACTArbutus unedo and Crataegus monogyna are widely distributed throughout the Mediterranean basin and commonly used in folk medicine against a wide range of diseases. Therefore, the present study has been designed to evaluate the anti-obesity potential of two aqueous extracts of the fruits of A. unedo (AUAE) and C. monogyna (CMAE). Male Wistar rats were supplied with a standard diet (SD), high-fat diet (HFD), HFD with the two separated extracts at the same dose (300 mg/kg, BW, p. o.), or HFD with atorvastatin-(...
Source: Dose Response - June 5, 2023 Category: Drugs & Pharmacology Authors: Soumaya Wahabi Kais Rtibi Amal Atouani Hichem Sebai Source Type: research
Anti-Obesity Actions of Two Separated Aqueous Extracts From Arbutus ( < em > Arbutus unedo < /em > ) and Hawthorn ( < em > Crataegus monogyna < /em > ) Fruits Against High-Fat Diet in Rats via Potent Antioxidant Target
Dose Response. 2023 May 30;21(2):15593258231179904. doi: 10.1177/15593258231179904. eCollection 2023 Apr-Jun.ABSTRACTArbutus unedo and Crataegus monogyna are widely distributed throughout the Mediterranean basin and commonly used in folk medicine against a wide range of diseases. Therefore, the present study has been designed to evaluate the anti-obesity potential of two aqueous extracts of the fruits of A. unedo (AUAE) and C. monogyna (CMAE). Male Wistar rats were supplied with a standard diet (SD), high-fat diet (HFD), HFD with the two separated extracts at the same dose (300 mg/kg, BW, p. o.), or HFD with atorvastatin-(...
Source: Dose Response - June 5, 2023 Category: Drugs & Pharmacology Authors: Soumaya Wahabi Kais Rtibi Amal Atouani Hichem Sebai Source Type: research
