Real-time monitoring of endogenous cysteine in LPS-induced oxidative stress process with a novel lysosome-targeted fluorescent probe
Anal Chim Acta. 2023 Oct 23;1279:341819. doi: 10.1016/j.aca.2023.341819. Epub 2023 Sep 13.ABSTRACTCysteine (Cys), one of essential small-molecule-based biothiols in the human body, contributes to the regulation of redox reactions and is closely associated with many physiological and pathological metabolic processes. Herein, a novel fluorescent probe, hydroxyphenyl-conjugated benzothiazole (HBT-Cys) capable of detecting Cys was constructed, where acrylate served as the recognition group and hydroxyphenyl-linked benzothiazole acted as the fluorophore. The fluorescence of the probe was negligible in the absence of Cys, and an...
Source: Analytica Chimica Acta - October 12, 2023 Category: Chemistry Authors: Zhiqiang Yang Jia Li Sining Li Jingxi Zhou Zhixing Cao Longxuan Li Dongbin Zheng Xuan Zhao Wei Wang Yun Deng Yuyu Fang Source Type: research
Real-time monitoring of endogenous cysteine in LPS-induced oxidative stress process with a novel lysosome-targeted fluorescent probe
Anal Chim Acta. 2023 Oct 23;1279:341819. doi: 10.1016/j.aca.2023.341819. Epub 2023 Sep 13.ABSTRACTCysteine (Cys), one of essential small-molecule-based biothiols in the human body, contributes to the regulation of redox reactions and is closely associated with many physiological and pathological metabolic processes. Herein, a novel fluorescent probe, hydroxyphenyl-conjugated benzothiazole (HBT-Cys) capable of detecting Cys was constructed, where acrylate served as the recognition group and hydroxyphenyl-linked benzothiazole acted as the fluorophore. The fluorescence of the probe was negligible in the absence of Cys, and an...
Source: Analytica Chimica Acta - October 12, 2023 Category: Chemistry Authors: Zhiqiang Yang Jia Li Sining Li Jingxi Zhou Zhixing Cao Longxuan Li Dongbin Zheng Xuan Zhao Wei Wang Yun Deng Yuyu Fang Source Type: research
Real-time monitoring of endogenous cysteine in LPS-induced oxidative stress process with a novel lysosome-targeted fluorescent probe
Anal Chim Acta. 2023 Oct 23;1279:341819. doi: 10.1016/j.aca.2023.341819. Epub 2023 Sep 13.ABSTRACTCysteine (Cys), one of essential small-molecule-based biothiols in the human body, contributes to the regulation of redox reactions and is closely associated with many physiological and pathological metabolic processes. Herein, a novel fluorescent probe, hydroxyphenyl-conjugated benzothiazole (HBT-Cys) capable of detecting Cys was constructed, where acrylate served as the recognition group and hydroxyphenyl-linked benzothiazole acted as the fluorophore. The fluorescence of the probe was negligible in the absence of Cys, and an...
Source: Analytica Chimica Acta - October 12, 2023 Category: Chemistry Authors: Zhiqiang Yang Jia Li Sining Li Jingxi Zhou Zhixing Cao Longxuan Li Dongbin Zheng Xuan Zhao Wei Wang Yun Deng Yuyu Fang Source Type: research
Real-time monitoring of endogenous cysteine in LPS-induced oxidative stress process with a novel lysosome-targeted fluorescent probe
Anal Chim Acta. 2023 Oct 23;1279:341819. doi: 10.1016/j.aca.2023.341819. Epub 2023 Sep 13.ABSTRACTCysteine (Cys), one of essential small-molecule-based biothiols in the human body, contributes to the regulation of redox reactions and is closely associated with many physiological and pathological metabolic processes. Herein, a novel fluorescent probe, hydroxyphenyl-conjugated benzothiazole (HBT-Cys) capable of detecting Cys was constructed, where acrylate served as the recognition group and hydroxyphenyl-linked benzothiazole acted as the fluorophore. The fluorescence of the probe was negligible in the absence of Cys, and an...
Source: Analytica Chimica Acta - October 12, 2023 Category: Chemistry Authors: Zhiqiang Yang Jia Li Sining Li Jingxi Zhou Zhixing Cao Longxuan Li Dongbin Zheng Xuan Zhao Wei Wang Yun Deng Yuyu Fang Source Type: research
Real-time monitoring of endogenous cysteine in LPS-induced oxidative stress process with a novel lysosome-targeted fluorescent probe
Anal Chim Acta. 2023 Oct 23;1279:341819. doi: 10.1016/j.aca.2023.341819. Epub 2023 Sep 13.ABSTRACTCysteine (Cys), one of essential small-molecule-based biothiols in the human body, contributes to the regulation of redox reactions and is closely associated with many physiological and pathological metabolic processes. Herein, a novel fluorescent probe, hydroxyphenyl-conjugated benzothiazole (HBT-Cys) capable of detecting Cys was constructed, where acrylate served as the recognition group and hydroxyphenyl-linked benzothiazole acted as the fluorophore. The fluorescence of the probe was negligible in the absence of Cys, and an...
Source: Analytica Chimica Acta - October 12, 2023 Category: Chemistry Authors: Zhiqiang Yang Jia Li Sining Li Jingxi Zhou Zhixing Cao Longxuan Li Dongbin Zheng Xuan Zhao Wei Wang Yun Deng Yuyu Fang Source Type: research
Carboxy-Functionalized Covalent Organic Framework as a Carrier for Lipase Immobilization and Its Application in Inhibitors Screening
Appl Biochem Biotechnol. 2023 Oct 11. doi: 10.1007/s12010-023-04725-1. Online ahead of print.ABSTRACTCovalent organic frameworks (COFs) with large specific surface areas, high porosity, good stability, and designable structure are promising carriers for immobilized enzymes. It is important to explore lipase inhibitors from natural foods as lipase inhibitors are closely related to the treatment of obesity. In this work, a carboxyl functionalized covalent organic framework (TpBD-3COOH) was prepared by solvothermal method for covalent immobilization of porcine pancreatic lipase (PPL) and obtained the enzyme-decorated COF (PPL...
Source: Applied Biochemistry and Biotechnology - October 11, 2023 Category: Biochemistry Authors: Xue Liu Jiaqi Wu Shan Yang Lingyu Li Yibing Ji Source Type: research
Carboxy-Functionalized Covalent Organic Framework as a Carrier for Lipase Immobilization and Its Application in Inhibitors Screening
Appl Biochem Biotechnol. 2023 Oct 11. doi: 10.1007/s12010-023-04725-1. Online ahead of print.ABSTRACTCovalent organic frameworks (COFs) with large specific surface areas, high porosity, good stability, and designable structure are promising carriers for immobilized enzymes. It is important to explore lipase inhibitors from natural foods as lipase inhibitors are closely related to the treatment of obesity. In this work, a carboxyl functionalized covalent organic framework (TpBD-3COOH) was prepared by solvothermal method for covalent immobilization of porcine pancreatic lipase (PPL) and obtained the enzyme-decorated COF (PPL...
Source: Applied Biochemistry and Biotechnology - October 11, 2023 Category: Biochemistry Authors: Xue Liu Jiaqi Wu Shan Yang Lingyu Li Yibing Ji Source Type: research
Carboxy-Functionalized Covalent Organic Framework as a Carrier for Lipase Immobilization and Its Application in Inhibitors Screening
Appl Biochem Biotechnol. 2023 Oct 11. doi: 10.1007/s12010-023-04725-1. Online ahead of print.ABSTRACTCovalent organic frameworks (COFs) with large specific surface areas, high porosity, good stability, and designable structure are promising carriers for immobilized enzymes. It is important to explore lipase inhibitors from natural foods as lipase inhibitors are closely related to the treatment of obesity. In this work, a carboxyl functionalized covalent organic framework (TpBD-3COOH) was prepared by solvothermal method for covalent immobilization of porcine pancreatic lipase (PPL) and obtained the enzyme-decorated COF (PPL...
Source: Applied Biochemistry and Biotechnology - October 11, 2023 Category: Biochemistry Authors: Xue Liu Jiaqi Wu Shan Yang Lingyu Li Yibing Ji Source Type: research
Carboxy-Functionalized Covalent Organic Framework as a Carrier for Lipase Immobilization and Its Application in Inhibitors Screening
Appl Biochem Biotechnol. 2023 Oct 11. doi: 10.1007/s12010-023-04725-1. Online ahead of print.ABSTRACTCovalent organic frameworks (COFs) with large specific surface areas, high porosity, good stability, and designable structure are promising carriers for immobilized enzymes. It is important to explore lipase inhibitors from natural foods as lipase inhibitors are closely related to the treatment of obesity. In this work, a carboxyl functionalized covalent organic framework (TpBD-3COOH) was prepared by solvothermal method for covalent immobilization of porcine pancreatic lipase (PPL) and obtained the enzyme-decorated COF (PPL...
Source: Applied Biochemistry and Biotechnology - October 11, 2023 Category: Biochemistry Authors: Xue Liu Jiaqi Wu Shan Yang Lingyu Li Yibing Ji Source Type: research
Carboxy-Functionalized Covalent Organic Framework as a Carrier for Lipase Immobilization and Its Application in Inhibitors Screening
Appl Biochem Biotechnol. 2023 Oct 11. doi: 10.1007/s12010-023-04725-1. Online ahead of print.ABSTRACTCovalent organic frameworks (COFs) with large specific surface areas, high porosity, good stability, and designable structure are promising carriers for immobilized enzymes. It is important to explore lipase inhibitors from natural foods as lipase inhibitors are closely related to the treatment of obesity. In this work, a carboxyl functionalized covalent organic framework (TpBD-3COOH) was prepared by solvothermal method for covalent immobilization of porcine pancreatic lipase (PPL) and obtained the enzyme-decorated COF (PPL...
Source: Applied Biochemistry and Biotechnology - October 11, 2023 Category: Biochemistry Authors: Xue Liu Jiaqi Wu Shan Yang Lingyu Li Yibing Ji Source Type: research
Forgotten Perfumery Plants - Part II: New Insights into the Development of Novel Fragrant Ingredients - Hawthorn Case Study
Chem Biodivers. 2023 Oct 10:e202301020. doi: 10.1002/cbdv.202301020. Online ahead of print.ABSTRACTNaturalness is gaining ground among perfumers and the use of natural raw materials is spreading in perfumery. Forgotten perfumery plants are of concern to develop innovative and natural ingredients for modern perfume industries. The main purpose of this study was to evaluate the potential interest of Crataegus monogyna Jacq. extracts as fragrance ingredient. To this end, various extractions, phytochemical characterizations and organoleptic evaluations of hawthorn were conducted on fresh, frozen, and dried flowering aerial par...
Source: Chemistry and Biodiversity - October 10, 2023 Category: Biochemistry Authors: Anne-Sophie Bouville Kevin da Fonte Pascal Portes Jean-Charles Lhommet St éphane Azoulay Xavier Fernandez Source Type: research
Forgotten Perfumery Plants - Part II: New Insights into the Development of Novel Fragrant Ingredients - Hawthorn Case Study
Chem Biodivers. 2023 Oct 10:e202301020. doi: 10.1002/cbdv.202301020. Online ahead of print.ABSTRACTNaturalness is gaining ground among perfumers and the use of natural raw materials is spreading in perfumery. Forgotten perfumery plants are of concern to develop innovative and natural ingredients for modern perfume industries. The main purpose of this study was to evaluate the potential interest of Crataegus monogyna Jacq. extracts as fragrance ingredient. To this end, various extractions, phytochemical characterizations and organoleptic evaluations of hawthorn were conducted on fresh, frozen, and dried flowering aerial par...
Source: Chemistry and Biodiversity - October 10, 2023 Category: Biochemistry Authors: Anne-Sophie Bouville Kevin da Fonte Pascal Portes Jean-Charles Lhommet St éphane Azoulay Xavier Fernandez Source Type: research
Measuring the observer (Hawthorne) effect on adenoma detection rates
Conclusions The presence of an independent observer documenting colonoscopy quality metrics and video recording the colonoscopy resulted in a significant increase in ADR and other quality metrics. The Hawthorne effect should be considered an alternative strategy to advanced devices to improve colonoscopy quality in practice. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - October 6, 2023 Category: Gastroenterology Authors: Taghiakbari, Mahsa Coman, Diana Elena Takla, Mark Barkun, Alan Bouin, Mickael Bouchard, Simon Deslandres, Eric Sidani, Sacha von Renteln, Daniel Tags: Original article Source Type: research
Cancers, Vol. 15, Pages 4849: Mistletoe Extracts from Different Host Trees Disparately Inhibit Bladder Cancer Cell Growth and Proliferation
heva
Roman A. Blaheta
Extracts of European mistletoe (Viscum album) are popular as a complementary treatment for patients with many different cancer types. However, whether these extracts actually block bladder cancer progression remains unknown. The influence of different mistletoe extracts on bladder cancer cell growth and proliferation was investigated by exposing RT112, UMUC3, and TCCSup cells to mistletoe from hawthorn (Crataegi), lime trees (Tiliae), willow trees (Salicis), or poplar trees (Populi). The tumor cell growth and proliferation, apoptosis induction, and cell cycle progression were then evaluated. Alt...
Source: Cancers - October 4, 2023 Category: Cancer & Oncology Authors: Eva Juengel Jochen Rutz Moritz Meiborg Sascha D. Markowitsch Sebastian Maxeiner Timothy Grein Anita Thomas Felix K.-H. Chun Axel Haferkamp Igor Tsaur Olesya Vakhrusheva Roman A. Blaheta Tags: Article Source Type: research
Gelanxinning capsule improves coronary microvascular dysfunction by inhibiting inflammation and restoring endothelial function
CONCLUSIONS: In conclusion, GXSC could improve CMD by inhibiting inflammation and restoring endothelial function. GXSC might be an effective drug in CAD patients without obstructive epicardial coronary arteries but suffering from angina.PMID:37782173 | DOI:10.26355/eurrev_202309_33782 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - October 2, 2023 Category: Drugs & Pharmacology Authors: M-Y Dong H-Y Jiang Y-Y Wang H Zhao R-J Jiang C-Y Liang J Zhang S Jia B-L Hsu W Fang G Cheng Source Type: research
