Cancers, Vol. 15, Pages 4849: Mistletoe Extracts from Different Host Trees Disparately Inhibit Bladder Cancer Cell Growth and Proliferation

Cancers, Vol. 15, Pages 4849: Mistletoe Extracts from Different Host Trees Disparately Inhibit Bladder Cancer Cell Growth and Proliferation Cancers doi: 10.3390/cancers15194849 Authors: Eva Juengel Jochen Rutz Moritz Meiborg Sascha D. Markowitsch Sebastian Maxeiner Timothy Grein Anita Thomas Felix K.-H. Chun Axel Haferkamp Igor Tsaur Olesya Vakhrusheva Roman A. Blaheta Extracts of European mistletoe (Viscum album) are popular as a complementary treatment for patients with many different cancer types. However, whether these extracts actually block bladder cancer progression remains unknown. The influence of different mistletoe extracts on bladder cancer cell growth and proliferation was investigated by exposing RT112, UMUC3, and TCCSup cells to mistletoe from hawthorn (Crataegi), lime trees (Tiliae), willow trees (Salicis), or poplar trees (Populi). The tumor cell growth and proliferation, apoptosis induction, and cell cycle progression were then evaluated. Alterations in integrin α and β subtype expression as well as CD44 standard (CD44s) and CD44 variant (CD44v) expressions were evaluated. Cell cycle-regulating proteins (CDK1 and 2, Cyclin A and B) were also investigated. Blocking and knock-down studies served to correlate protein alterations with cell growth. All extracts significantly down-regulated the growth and proliferation of all bladder cancer cell lines, most strongly in RT112 and UMUC3 cells. Alterations in C...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research