Human rotator cuff tears demonstrate an age-dependent increase in markers of cellular senescence and selective removal of senescent cells with dasatinib+quercetin increases genetic expression of COL1A1 in vitro

To quantify cellular senescence in supraspinatus tendon and subacromial bursa of humans with rotator cuff tears and to investigate the in vitro efficacy of the senolytic dasatinib+quercetin (D+Q) to eliminate senescent cells and alter tenogenic differentiation.

Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - June 22, 2023 Category: Surgery Authors: Benjamin C. Hawthorne, Ian J. Wellington, Joshua T. Sabitsky, Kyle V. Murphy, Owen P. Karsmarski, Rohin O. Thomas, Matthew R. LeVasseur, Michael R. Mancini, Maxwell T. Trudeau, Sagar Gulati, Mary Beth R. McCarthy, Mark P. Cote, Ming Xu, Augustus D. Mazzoc Source Type: research