Effect and interactions of BRAF on lymph node metastasis in papillary thyroid carcinoma with Hashimoto's thyroiditis
CONCLUSION: BRAF is a risk factor for LN metastasis in PTC with HT. Meanwhile, BRAF can interacts with age, BMI, hypertension, and calcification which together influence LN metastasis.PMID:37967234 | DOI:10.1210/clinem/dgad667 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 15, 2023 Category: Endocrinology Authors: Pengyu Li Yang Liu Tao Wei Xiaofei Wang Jingqiang Zhu Rui Yang Yanping Gong Wanjun Zhao Source Type: research
Effect and interactions of BRAF on lymph node metastasis in papillary thyroid carcinoma with Hashimoto's thyroiditis
CONCLUSION: BRAF is a risk factor for LN metastasis in PTC with HT. Meanwhile, BRAF can interacts with age, BMI, hypertension, and calcification which together influence LN metastasis.PMID:37967234 | DOI:10.1210/clinem/dgad667 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 15, 2023 Category: Endocrinology Authors: Pengyu Li Yang Liu Tao Wei Xiaofei Wang Jingqiang Zhu Rui Yang Yanping Gong Wanjun Zhao Source Type: research
HT-RCM: Hashimoto's Thyroiditis Ultrasound Image Classification Model based on Res-FCT and Res-CAM
IEEE J Biomed Health Inform. 2023 Nov 10;PP. doi: 10.1109/JBHI.2023.3331944. Online ahead of print.ABSTRACTThe early lesions of Hashimoto's thyroiditis are inconspicuous, and the ultrasonic features of these early lesions are indistinguishable from other thyroid diseases. This paper proposes a Hashimoto Thyroiditis ultrasound image classification model HT-RCM which consists of a Residual Full Convolution Transformer (Res-FCT) model and a Residual Channel Attention Module (Res-CAM). To collect the low-order information caused by hypoechoic signals accurately, the residual connection is injected between FCTs to form Res-FCT ...
Source: Biomed Res - November 10, 2023 Category: Research Authors: Wenchao Jiang Kang Chen Zhipeng Liang Tianchun Luo Guanghui Yue Zhiming Zhao Wei Song Ling Zhao Jianxuan Wen Source Type: research
HT-RCM: Hashimoto's Thyroiditis Ultrasound Image Classification Model based on Res-FCT and Res-CAM
IEEE J Biomed Health Inform. 2023 Nov 10;PP. doi: 10.1109/JBHI.2023.3331944. Online ahead of print.ABSTRACTThe early lesions of Hashimoto's thyroiditis are inconspicuous, and the ultrasonic features of these early lesions are indistinguishable from other thyroid diseases. This paper proposes a Hashimoto Thyroiditis ultrasound image classification model HT-RCM which consists of a Residual Full Convolution Transformer (Res-FCT) model and a Residual Channel Attention Module (Res-CAM). To collect the low-order information caused by hypoechoic signals accurately, the residual connection is injected between FCTs to form Res-FCT ...
Source: Biomed Res - November 10, 2023 Category: Research Authors: Wenchao Jiang Kang Chen Zhipeng Liang Tianchun Luo Guanghui Yue Zhiming Zhao Wei Song Ling Zhao Jianxuan Wen Source Type: research
Network Pharmacology Studies on the Molecular Mechanism of Hashimoto's Thyroiditis Treated with Shutiao Qiji Decoction
CONCLUSION: It is verified by molecular docking results that Shutiao Qiji Decoction has a potential therapeutic effect on Hashimoto's thyroiditis in the MAPK/TSHR/NOTCH signal pathway, and that the main components, mairin, stigmasterol, poriferast-5-en-3beta-ol, and chryseriol play a role in it. SQD has been shown to have a good therapeutic effect on Hashimoto's thyroiditis.PMID:37929726 | DOI:10.2174/0113862073259714231012070100 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 6, 2023 Category: Chemistry Authors: Shuang Guo Yan Lv Junyu Shen Rong Li Haipeng Liu Yuan Fan Chunhong Tian Source Type: research
Network Pharmacology Studies on the Molecular Mechanism of Hashimoto's Thyroiditis Treated with Shutiao Qiji Decoction
CONCLUSION: It is verified by molecular docking results that Shutiao Qiji Decoction has a potential therapeutic effect on Hashimoto's thyroiditis in the MAPK/TSHR/NOTCH signal pathway, and that the main components, mairin, stigmasterol, poriferast-5-en-3beta-ol, and chryseriol play a role in it. SQD has been shown to have a good therapeutic effect on Hashimoto's thyroiditis.PMID:37929726 | DOI:10.2174/0113862073259714231012070100 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 6, 2023 Category: Chemistry Authors: Shuang Guo Yan Lv Junyu Shen Rong Li Haipeng Liu Yuan Fan Chunhong Tian Source Type: research
Network Pharmacology Studies on the Molecular Mechanism of Hashimoto's Thyroiditis Treated with Shutiao Qiji Decoction
CONCLUSION: It is verified by molecular docking results that Shutiao Qiji Decoction has a potential therapeutic effect on Hashimoto's thyroiditis in the MAPK/TSHR/NOTCH signal pathway, and that the main components, mairin, stigmasterol, poriferast-5-en-3beta-ol, and chryseriol play a role in it. SQD has been shown to have a good therapeutic effect on Hashimoto's thyroiditis.PMID:37929726 | DOI:10.2174/0113862073259714231012070100 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 6, 2023 Category: Chemistry Authors: Shuang Guo Yan Lv Junyu Shen Rong Li Haipeng Liu Yuan Fan Chunhong Tian Source Type: research
Network Pharmacology Studies on the Molecular Mechanism of Hashimoto's Thyroiditis Treated with Shutiao Qiji Decoction
CONCLUSION: It is verified by molecular docking results that Shutiao Qiji Decoction has a potential therapeutic effect on Hashimoto's thyroiditis in the MAPK/TSHR/NOTCH signal pathway, and that the main components, mairin, stigmasterol, poriferast-5-en-3beta-ol, and chryseriol play a role in it. SQD has been shown to have a good therapeutic effect on Hashimoto's thyroiditis.PMID:37929726 | DOI:10.2174/0113862073259714231012070100 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 6, 2023 Category: Chemistry Authors: Shuang Guo Yan Lv Junyu Shen Rong Li Haipeng Liu Yuan Fan Chunhong Tian Source Type: research
Clinical and molecular impact of concurrent thyroid autoimmune disease and thyroid cancer: From the bench to bedside
Rev Endocr Metab Disord. 2023 Oct 27. doi: 10.1007/s11154-023-09846-w. Online ahead of print.ABSTRACTThe recent incorporation of immune checkpoint inhibitors targeting the PD-1 (programmed cell death receptor 1) and CTLA-4 (cytotoxic T lymphocyte antigen 4) pathways into the therapeutic armamentarium of cancer has increased the need to understand the correlation between the immune system, autoimmunity, and malignant neoplasms. Both autoimmune thyroid diseases and thyroid cancer are common clinical conditions. The molecular pathology of autoimmune thyroid diseases is characterized by the important impact of the PD-1/PD-L1 a...
Source: ENDOCR REV - October 27, 2023 Category: Endocrinology Authors: Victor Alexandre Dos Santos Valsecchi Felipe Rodrigues Betoni Laura Sterian Ward Lucas Leite Cunha Source Type: research
Clinical and molecular impact of concurrent thyroid autoimmune disease and thyroid cancer: From the bench to bedside
Rev Endocr Metab Disord. 2023 Oct 27. doi: 10.1007/s11154-023-09846-w. Online ahead of print.ABSTRACTThe recent incorporation of immune checkpoint inhibitors targeting the PD-1 (programmed cell death receptor 1) and CTLA-4 (cytotoxic T lymphocyte antigen 4) pathways into the therapeutic armamentarium of cancer has increased the need to understand the correlation between the immune system, autoimmunity, and malignant neoplasms. Both autoimmune thyroid diseases and thyroid cancer are common clinical conditions. The molecular pathology of autoimmune thyroid diseases is characterized by the important impact of the PD-1/PD-L1 a...
Source: ENDOCR REV - October 27, 2023 Category: Endocrinology Authors: Victor Alexandre Dos Santos Valsecchi Felipe Rodrigues Betoni Laura Sterian Ward Lucas Leite Cunha Source Type: research
Clinical and molecular impact of concurrent thyroid autoimmune disease and thyroid cancer: From the bench to bedside
Rev Endocr Metab Disord. 2023 Oct 27. doi: 10.1007/s11154-023-09846-w. Online ahead of print.ABSTRACTThe recent incorporation of immune checkpoint inhibitors targeting the PD-1 (programmed cell death receptor 1) and CTLA-4 (cytotoxic T lymphocyte antigen 4) pathways into the therapeutic armamentarium of cancer has increased the need to understand the correlation between the immune system, autoimmunity, and malignant neoplasms. Both autoimmune thyroid diseases and thyroid cancer are common clinical conditions. The molecular pathology of autoimmune thyroid diseases is characterized by the important impact of the PD-1/PD-L1 a...
Source: ENDOCR REV - October 27, 2023 Category: Endocrinology Authors: Victor Alexandre Dos Santos Valsecchi Felipe Rodrigues Betoni Laura Sterian Ward Lucas Leite Cunha Source Type: research
Clinical and molecular impact of concurrent thyroid autoimmune disease and thyroid cancer: From the bench to bedside
AbstractThe recent incorporation of immune checkpoint inhibitors targeting the PD-1 (programmed cell death receptor 1) and CTLA-4 (cytotoxic T lymphocyte antigen 4) pathways into the therapeutic armamentarium of cancer has increased the need to understand the correlation between the immune system, autoimmunity, and malignant neoplasms. Both autoimmune thyroid diseases and thyroid cancer are common clinical conditions. The molecular pathology of autoimmune thyroid diseases is characterized by the important impact of the PD-1/PD-L1 axis, an important inhibitory pathway involved in the regulation of T-cell responses. Insuffic...
Source: Reviews in Endocrine and Metabolic Disorders - October 27, 2023 Category: Endocrinology Source Type: research
Effects of block-replace regimen in patients with autoimmune hypothyroidism converted to Graves' disease
CONCLUSION: Spontaneous autoimmune conversion of hypothyroidism to hyperthyroidism can occur at any time: it is important to promptly identify these cases so as to manage them effectively.PMID:37831339 | DOI:10.1007/s42000-023-00496-w (Source: Hormones)
Source: Hormones - October 13, 2023 Category: Endocrinology Authors: Ana-Maria Stancu Daniela Alexandrescu Corin Badiu Source Type: research
