A case of Hashimoto's thyroiditis with multiple drug resistance and high expression of efflux transporters.
CONCLUSIONS: High expression and accelerated efflux transporter activity of ABCG2/BCRP in the small intestine are expected to contribute to the ineffectiveness of orally administered intact tablets in cases with treatment-resistant Hashimoto's thyroiditis, and crushed tablets can be more effective for some of these patients. PMID: 31614366 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - October 16, 2019 Category: Endocrinology Authors: Yoshida T, Nakayama A, Tamura A, Higuchi S, Sakuma I, Nagano H, Felizola SJA, Hashimoto N, Takemoto M, Tatsuno I, Koide H, Yokote K, Tanaka T Tags: J Clin Endocrinol Metab Source Type: research

Prevalence of undifferentiated inflammatory arthropathy in patients with Hashimoto's thyroiditis in an endocrinology clinic
ConclusionsAlmost 1 in 4 patients with HT had no definite rheumatic disease present with UIA. An early identification of concurrent arthritis in HT patients is necessary for thorough differential diagnosis and prompt treatment initiation to halt potential joint damage and disability. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 16, 2019 Category: Rheumatology Authors: Luis M. Valderrama ‐Hinds, Eliangel García‐Carrión, Evelyn Hernández, María I. Agostini, Omar R. Reyes‐Morales, Liliana Fung, Soham Al Snih, Martin A. Rodríguez Tags: ORIGINAL ARTICLE Source Type: research

Potential role of IL-37 signaling pathway in feedback regulation of autoimmune Hashimoto thyroiditis
AbstractIL-37, the anti-inflammatory cytokine of the IL-1 family, plays several key roles in the regulation of autoimmune diseases. Yet, its role in Hashimoto ’s thyroiditis (HT) is not clear. In the present study, we found that, in tissues from HT patients, most of the follicular epithelial cells were positive for both IL-37 and single Ig IL-1-related receptor (SIGIRR) by immunohistochemical staining, while the infiltrating lymphocytes and other inflam matory cells hardly expressed any. Meanwhile, mRNA expression levels of IL-37 in peripheral blood mononuclear cells (PBMC) of HT patients were significantly higher th...
Source: Histochemistry and Cell Biology - October 4, 2019 Category: Biomedical Science Source Type: research

Successful Treatment of Amiodarone-induced Thyrotoxicosis Type 1 in Combination with Methimazole and Potassium Iodide in a Patient with Hashimoto's Thyroiditis: A Case Report.
Authors: Katoh D, Yoshino H, Ikehara K, Kumashiro N, Uchino H, Tsuboi K, Hirose T Abstract A patient with underlying Hashimoto's thyroiditis developed amiodarone-induced thyrotoxicosis type 1 that was successfully treated using methimazole in combination with potassium iodide. A 35-year-old woman admitted for perinatal care of twin-to-twin transfusion syndrome was given amiodarone for 7 days for paroxysmal ventricular contraction following pulseless ventricular tachycardia 1 day after delivery. She developed thyrotoxicosis one month after the discontinuation of amiodarone therapy and was negative for thyroid-stimul...
Source: Internal Medicine - September 28, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Interaction of Genetic Variations in NFE2L2 and SELENOS Modulates the Risk of Hashimoto's Thyroiditis
Thyroid,Volume 29, Issue 9, Page 1302-1315, September 2019. (Source: Thyroid)
Source: Thyroid - September 17, 2019 Category: Endocrinology Authors: Liliana R. Santos Cec ília Durães Panos G. Ziros Ana Pestana C ésar Esteves Celestino Neves Davide Carvalho Massimo Bongiovanni C édric O. Renaud Dionysios V. Chartoumpekis Ioannis G. Habeos Manuel Sobrinho Sim ões Paula Soares Gerasimos P. Sykiotis Source Type: research

Is ultrasound combined with computed tomography useful for distinguishing between primary thyroid lymphoma and Hashimot's thyroiditis?
Abstract INTRODUCTION: The aim of the study is to investigate the usefulness of ultrasound combined with computed tomography (CT) for distinguishing between primary thyroid lymphoma (PTL) and Hashimoto's thyroiditis (HT). MATERIAL AND METHODS: The investigation was conducted retrospectively in 80 patients from January 2000 to July 2018. All patients underwent pathological test to be classified into two groups: PTL group and HT group. The cut-off value of CT density was determined using receiver-operating characteristic (ROC) curve analysis. The accuracy, sensitivity, specificity, positive predictive value (PP...
Source: Endokrynologia Polska - September 17, 2019 Category: Endocrinology Authors: Luo J, Huang F, Zhou P, Chen J, Sun Y, Xu F, Wu L, Huang P Tags: Endokrynol Pol Source Type: research

The Risk For Malignancy of the Thyroid Nodule is Modulated by Gender, Echotexture, and Intranodular Lymphocytic Thyroiditis
Horm Metab Res 2019; 51: 559-567 DOI: 10.1055/a-0994-0489Based on the American (Bethesda, 2017) or Italian (SIAPEC 2014) cytological categories of thyroid nodules, the risk of malignancy and management vary. This risk is 5–10% or
Source: Hormone and Metabolic Research - September 10, 2019 Category: Endocrinology Authors: Arena, Salvatore Benvenga, Salvatore Tags: Endocrine Care Source Type: research

Comprehensive research on thyroid diseases associated with autoimmunity: autoimmune thyroid diseases, thyroid diseases during immune-checkpoint inhibitors therapy, and immunoglobulin-G4-associated thyroid diseases.
Authors: Inaba H, Ariyasu H, Takeshima K, Iwakura H, Akamizu T Abstract Various thyroid diseases are associated with autoimmunity. Major autoimmune thyroid diseases are Graves' disease (GD) and Hashimoto's thyroiditis (HT). Thyrotropin receptor is an autoantigen in GD, and its immunogenicity has been examined. Immune-checkpoint inhibitor (ICI) is recently widely used for treatment of malignant tumors, but cases of thyroid diseases during ICI treatment have been increasing. Thyroid diseases during ICI therapy have been investigated in immunological and clinical aspects, and their Japanese official diagnostic guideli...
Source: Endocrine Journal - August 24, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Antithyroid Peroxidase Antibodies in Multinodular Hashimoto's Thyroiditis Indicate a Variant Etiology.
This study analyzes the clinical features and the correlation of anti-TPO levels with diffuse and multinodular forms of HT. Material and Methods: This study was conducted in the Department of General Surgery in a tertiary care hospital in south Tamil Nadu. Patients presenting with clinical features of a thyroid disorder were interviewed and given a detailed clinical, radiological examination and guided FNAC. Those patients diagnosed by FNAC as HT were registered and a sample of 3cc of blood was drawn for T3, T4, TSH, and anti-TPO analysis. All the data were tabulated. Results and Discussion: Of the 212 patients who...
Source: Journal of Thyroid Research - August 22, 2019 Category: Endocrinology Tags: J Thyroid Res Source Type: research

Interaction of genetic variations in < i > NFE2L2 < /i > and < i > SELENOS < /i > modulates the risk of Hashimoto's thyroiditis.
Conclusions: The NFE2L2 promoter genotype interacts with the SELENOS promoter genotype to modulate the risk of HT in a Portuguese population. This interaction may be due to a bidirectional positive feedback between the Nrf2 and SelS pathways. PMID: 31426718 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - August 21, 2019 Category: Endocrinology Tags: Thyroid Source Type: research

Ocular surface evaluation in pediatric Hashimoto's thyroiditis without thyroid-associated ophthalmopathy
Conclusions: The study demonstrates several ocular surface changes in children with Hashimoto's thyroiditis. These findings may indicate a tendency for dry eye in pediatric Hashimoto's thyroiditis patien ts without clinical evidence of thyroid-associated ophthalmopathy.RESUMO Objetivo: Avaliar as caracter ísticas da superfície ocular em crianças com tireoidite de Hashimoto sem oftalmopatia associada à tireoide e comparar os resultados com aqueles de crianças saudáveis. Métodos: Vinte e duas crianças com tireoidite de Hashimoto (Grupo 1) e 20 crianças saud&aacut...
Source: Arquivos Brasileiros de Oftalmologia - August 20, 2019 Category: Opthalmology Source Type: research

Local Ocular Surface Alterations in Children with Hashimoto's Thyroiditis.
This study included 51 children with HT and 53 control subjects. The ocular surface characteristics of participants were assessed via Schirmer's test, TBUT, and CIC. Conjunctival samples were examined cytologically according to the Nelson grading system. Results: Schirmer's and TBUT results were significantly lower in HT group (p
Source: Ocular Immunology and Inflammation - August 16, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Effect of chronic lymphocytic thyroiditis on the efficacy and safety of ultrasound ‐guided radiofrequency ablation for papillary thyroid microcarcinoma
ConclusionsRFA was effective in patients with PTMC+CLT, and its therapeutic efficacy and safety were similar to those in patients with PTMC without CLT. (Source: Cancer Medicine)
Source: Cancer Medicine - July 30, 2019 Category: Cancer & Oncology Authors: Yan Zhang, Ming ‐bo Zhang, Yu‐kun Luo, Jie Li, Ying Zhang, Jie Tang Tags: ORIGINAL RESEARCH Source Type: research

Evaluation of trace metals in thyroid tissues: Comparative analysis with benign and malignant thyroid diseases.
Abstract Evaluation of trace metals at level of solid tissue can provide better information than blood or urine and, therefore, could highlight the role of metals in the etiology of organ-specific disease. The current study aimed to establish the baseline content of four essential (Mn, Cu, Zn, Se) and four toxic metals (As, Cd, Pb, U) in the healthy thyroid tissues (HTTs) by considering sex, age and smoking habits. A further aim was to examine whether differences in the content of metals exist in regard to the thyroid diseases, such as benign tumor (BT), Hashimoto's thyroiditis (HT), multinodular goiter (MNG) and ...
Source: Ecotoxicology and Environmental Safety - July 28, 2019 Category: Environmental Health Authors: Stojsavljević A, Rovčanin B, Krstić Đ, Borković-Mitić S, Paunović I, Kodranov I, Gavrović-Jankulović M, Manojlović D Tags: Ecotoxicol Environ Saf Source Type: research

Stress-induced hashitoxicosis: case report and relative HLA serotype and genotype
CONCLUSION This case demonstrates that, similarly to Graves ’ disease, Hashitoxicosis can also be triggered by stressful life events.RESUMO OBJETIVO Mesmo que o estresse seja conhecido h á muito tempo como um fator provocativo para a doença de Graves, sua relação com a tireoidite de Hashimoto é mais controversa. Estudos sobre esse tema são escassos. O objetivo deste artigo é relatar um caso de Hashitoxicose induzida por estresse. RESULTADOS Aqui nós relatamos um caso de Has hitoxicose induzido por um evento psicológico estressante em uma mulher de 28 anos...
Source: Revista da Associacao Medica Brasileira - July 23, 2019 Category: General Medicine Source Type: research

Neurofibromatosis Type 1 Associated with Hashimoto's Thyroiditis.
Authors: Kumar SSS, Palaniandavan S, Bhargavi MV, Gambeer AS, Nithyalakshmi G Abstract Hashimoto's thyroiditis is a common form of chronic autoimmune thyroid disease (AITD) and it often coexists with other autoimmune diseases, but Hashimoto's thyroiditis associated with an autosomal dominant neurofibromatosis type 1 is exceedingly rare. A 30-year-old woman presented with complaints of headache for 1 year on and off. Physical examination revealed nodular swelling in the neck, cafe-au-lait spots, and neurofibromas covering the entire surface of her body. Her thyroid hormones were within normal limits. Thyroid ultraso...
Source: Journal of the Association of Physicians of India - July 22, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Clock gene PERIOD3 polymorphism is associated with susceptibility to Graves' disease but not to Hashimoto's thyroiditis.
In conclusion, this study provides the first evidence for a genetic association between GD and the PER3 gene, highlighting the possible relevance of polymorphisms in clock genes in the etiopathogenesis of AITD. However, functional studies to identify the underlying molecular mechanisms of this association are needed to translate these findings to clinical applications. PMID: 31328557 [PubMed - as supplied by publisher] (Source: Chronobiology International)
Source: Chronobiology International - July 22, 2019 Category: Biology Authors: Helvaci N, Oguz SH, Kabacam S, Karabulut E, Akbiyik F, Alikasifoglu M, Gurlek A Tags: Chronobiol Int Source Type: research

Investigation of blood groups in benign thyroid diseases in Turkey.
The objective of our study is to investigate how often ABO and Rh blood groups are seen in benign thyroid diseases, especially in autoimmune-mediated thyroid diseases, and hence whether there is an association between blood groups and thyroid diseases. A total of 958 patients who were followed due to any benign thyroid disease were included in the study. The study population comprised 958 patients, 550 with Hashimoto's hypothyroidism, 160 with non-Hashimoto's hypothyroidism, 103 with iatrogenic hypothyroidism, 93 with central hypothyroidism, and 28 with Graves' and 24 with non-Graves' hyperthyroidism. Of the patients, 47.1...
Source: Endocrine Journal - July 18, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Thyroid blood flow in inferior thyroid artery as predictor for increase in levothyroxine dosage during pregnancy in women with Hashimoto's thyroiditis - a retrospective study
We examined whether inferior thyroid artery peak systolic velocity (ITA-PSV) predicts an increase in levothyroxine (LT4) dosage in pregnant women with Hashimoto ’s thyroiditis. (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - July 5, 2019 Category: OBGYN Authors: Masafumi Kurajoh, Akiyo Yamasaki, Toshiki Nagasaki, Yuki Nagata, Shinsuke Yamada, Yasuo Imanishi, Masanori Emoto, Kanae Takahashi, Kouji Yamamoto, Ayumi Shintani and Masaaki Inaba Tags: Research article Source Type: research

The Role of Surgery in Autoimmune Conditions of the Thyroid.
Abstract The two most common autoimmune conditions of the thyroid include chronic lymphocytic (Hashimoto's) thyroiditis and Graves' disease. Both conditions can be treated medically, but surgery plays an important role. Hashimoto's thyroiditis and Graves' disease are mediated by autoantibodies that interact directly with the thyroid, creating inflammation and impacting thyroid function. Patients may develop large goiters with compressive symptoms or malignancy requiring surgical intervention. In addition, there are several surgical indications specific to Hashimoto's and Graves' Disease. PMID: 31255196 [PubMe...
Source: The Surgical Clinics of North America - July 1, 2019 Category: Surgery Authors: Gan T, Randle RW Tags: Surg Clin North Am Source Type: research

Acute exacerbation of Hashimoto's thyroiditis in a patient treated with dimethyl fumarate for multiple sclerosis: A case report: Erratum
No abstract available (Source: Medicine)
Source: Medicine - July 1, 2019 Category: Internal Medicine Tags: Erratum Source Type: research

Uterus globulin associated protein 1 (UGRP1) is a potential marker of progression of Graves' disease into hypothyroidism
Publication date: Available online 27 June 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Zheng Zhou, Chun-Lin Zuo, Xue-Song Li, Xiao-Ping Ye, Qian-Yue Zhang, Ping Wang, Rong-Xin Zhang, Gang Chen, Jia-Lin Yang, Yue Chen, Qin-Yun Ma, Huai-Dong SongAbstractApproximately 20% of Graves' disease (GD) patients may result eventually in hypothyroidism in their natural course. Uterus globulin-associated protein 1 (UGRP1) was associated with GD in our previous study. Here we investigated the role of UGRP1 in the development of autoimmune thyroid disease (AITD). The results showed that UGRP1 was expressed in the thyrocyte...
Source: Molecular and Cellular Endocrinology - June 28, 2019 Category: Endocrinology Source Type: research

Liver dysfunction induced by Levothyroxine Sodium Tablets (Euthyrox ®) in a hypothyroid patient with Hashimoto's thyroiditis: case report and literature review.
Liver dysfunction induced by Levothyroxine Sodium Tablets (Euthyrox®) in a hypothyroid patient with Hashimoto's thyroiditis: case report and literature review. Endocr J. 2019 Jun 18;: Authors: Yu H, Zhang W, Shen C, Zhang H, Zhang H, Zhang Y, Zou D, Gong X Abstract A 49-year-old woman with hypothyroidism developed liver dysfunction after increasing dose of levothyroxine (L-T4) (Euthyrox®) from 25 μg to 50 μg. Viral hepatitis, autoimmune hepatitis and non-alcoholic steatohepatitis (NASH) were ruled out with examinations. She had no concurrent medication and had no history of infectious, ch...
Source: Endocrine Journal - June 22, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

The subclinical Myocardial Dysfunction in Children with Euthyroid Hashimoto's Thyroiditis Demonstrated by Speckle Tracking Echocardiography
Conclusions: Conventional echocardiography does not exclude subclinical LV wall motion abnormalities in asymptomatic patients with eHT. The results show that myocardial function in children with eHT has impaired in the absence of any clinical symptoms and conventional echocardiography is inadequate to determine these changes. PMID: 31218876 [PubMed - as supplied by publisher] (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - June 22, 2019 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

18F-FCH PET/CT for patients with uremic hyperparathyroidism
Conclusion: The results of this study showed that 18F-FCH PET/CT was superior to US and MIBI in the preoperative diagnosis of uHPT, especially for lesions diagnosed as the thyroid nodule by US. Nevertheless, larger trials are needed in future to confirm the superiority of FCH PET/CT. Fig 1: Images in a 62-year-old woman with three parathyroid hyperplasia, the later 90 minute planar 99mTc-MIBI SPECT/CT image(a),the axial CT image (not shown) and fusion image(c) cannot present all three lesions clearly because of Hashimoto's thyroiditis. Although the planar 18F-FCH PET image (b) is a little messy because of renal osteopathy,...
Source: Journal of Nuclear Medicine - May 21, 2019 Category: Nuclear Medicine Authors: Xue, Y. Tags: Thyroid and Para-Thyroid Source Type: research

The Role of Surgery in Autoimmune Conditions of the Thyroid
The two most common autoimmune conditions of the thyroid include chronic lymphocytic (Hashimoto's) thyroiditis and Graves ’ disease. Both conditions can be treated medically, but surgery plays an important role. Hashimoto's thyroiditis and Graves’ disease are mediated by autoantibodies that interact directly with the thyroid, creating inflammation and impacting thyroid function. Patients may develop large goiters w ith compressive symptoms or malignancy requiring surgical intervention. In addition, there are several surgical indications specific to Hashimoto's and Graves’ Disease. (Source: Surgical Clinics of North America)
Source: Surgical Clinics of North America - May 9, 2019 Category: Surgery Authors: Tong Gan, Reese W. Randle Source Type: research

Spontaneous intracranial hypotension in Hashimoto's thyroiditis: A case report
Rationale: Autoimmune thyroid diseases (ATDs) seldom affect intracranial pressure. Here, we describe a case of spontaneous intracranial hypotension (SIH) related to Hashimoto's thyroiditis (HT), which has never been previously published. Patient concerns: A 54-year-old woman was admitted to our hospital due to sudden-onset postural headache, neck pain stiffness, visual blurring, nausea and vomiting. The headache was aggravated when the patient sat or stood up yet rapidly resolved within 1 minute after recumbency. Diagnosis: The patient had a grade 1a diffusely palpable thyroid gland and the laboratory report reveal...
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Hypothyroidism as a Predictor of Surgical Outcomes in the Elderly
Marco Vacante1, Antonio Biondi1, Francesco Basile1, Roberto Ciuni1, Salvatore Luca1, Salomone Di Saverio2, Carola Buscemi3, Enzo Saretto Dante Vicari3 and Antonio Maria Borzì3* 1Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy 2Cambridge Colorectal Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom 3Department of Clinical and Experimental Medicine, Specialization School in Geriatrics, University of Catania, Catania, Italy There is a high prevalence of hypothyroidism in the elderly population, mainly among women. The mo...
Source: Frontiers in Endocrinology - April 24, 2019 Category: Endocrinology Source Type: research

Angiotensinogen gene T174M polymorphism is related to Hashimoto's thyroiditis.
Authors: Abstract OBJECTIVES: The Hashimoto thyroiditis is found to be Th1-related autoimmunity. Recently, it has been proved that the renin-angiotensin-aldosterone system (RAAS) may be involved in promoting Th1-mediated autoimmune diseases. However, the role of RAAS in HT pathogenesis remains still unknown. The aim of this study was to determine whether the polymorphisms of ACE, AGTR1 and AGT genes are associated with HT. MATERIAL AND METHODS: Polymerase Chain Reaction (PCR) was performed to determine ACE I/D, AGTR1 A1166C and AGT T174M polymorphisms and next chi-square test was used to compare allele frequen...
Source: Neuroendocrinology Letters - April 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The association between thyroid echogenicity and thyroid function in pediatric and adolescent Hashimoto's thyroiditis
In this study, we evaluated the association between thyroid echogenicity on ultrasonography (US) and thyroid function in pediatric and adolescent Hashimoto's thyroiditis (HT) patients. In 86 pediatric and adolescent HT patients, the association between echogenicity and thyroid function and microsomal autoantibody status was evaluated. Among patients with overt hypothyroidism, 89.2% (33/37) showed a US grade of 3 or 4. All of the patients at grade 4 presented with overt hypothyroidism. In contrast, 97.8% (44/49) of the patients with subclinical hypothyroidism or euthyroidism showed grades 1 or 2. Patients with increased th...
Source: Medicine - April 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Acute exacerbation of Hashimoto's thyroiditis in a patient treated with dimethyl fumarate for multiple sclerosis: A case report
Conclusion: The association of MS with autoimmune thyroid diseases supports a common immune-mediated pathogenic mechanism. We assume that the acute exacerbation of HT in our MS patient is associated not with the immunomodulatory effect of DMF but rather with its antioxidative mechanism. Constant monitoring of thyroid hormone levels should be recommended especially if the MS patients in treatment with DMF are affected by concomitant autoimmune thyroid diseases. (Source: Medicine)
Source: Medicine - April 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Higher levels of serum TLR2 and TLR4 in patients with Hashimoto's Thyroiditis.
CONCLUSION: These findings suggest that TLR-2 and TLR-4 play important role in the immunopathologic mechanism of disease by causing an increase in proinflammatory response. PMID: 30924423 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 28, 2019 Category: Endocrinology Authors: Aktaş T, Celik SK, Genc GC, Arpaci D, Can M, Dursun A Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

[Hashimoto thyroiditis, therapeutic options and extrathyroidal options - an up-to-date overview].
Abstract Hashimoto's thyroiditis is one of the most common organspecific autoimune diseases and the most frequent cause of hypothyroidism in areas with sufficient iodine supply. Excessively stimulated T cells CD4+ and their differentiated cells are known to play a key role in the pathogenesis. It is currently accepted that on the one hand genetic susceptibility, environmental factors, existential factors (gender difference) play an important role, on the other hand gut and intestinal microbiota seem to contribute to its development too. Diagnosis requires a detailed medical history, sonography, and ...
Source: Nuklearmedizin - March 27, 2019 Category: Radiology Authors: Petnehazy E, Buchinger W Tags: Wien Med Wochenschr Source Type: research

Successful treatment of myxedema coma with a combination of levothyroxine and liothyronine.
Authors: Ueda K, Kiyota A, Tsuchida M, Okazaki M, Ozaki N Abstract Myxedema coma is a rare endocrine emergency resulting from the decompensation of severe hypothyroidism, which is associated with a high mortality rate. It is characterized by the deterioration of mental status, hypothermia, hypotension, hyponatremia, and hypoventilation. Early disease diagnosis and advancements in intensive supportive care have reduced the mortality rate. Besides intensive supportive care, appropriate management of the underlying thyroid hormone deficiency is essential. However, as the disease is rare and unrecognized, evidence-base...
Source: Endocrine Journal - March 13, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Serum autotaxin levels are associated with Graves' disease.
In conclusion, the serum ATX levels were higher in subjects with Graves' disease, possibly because of a mechanism that does not involve hyperthyroidism. These results suggest the possible involvement of the ATX/LPA axis in the pathogenesis of Graves' disease. PMID: 30814442 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - March 5, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Upregulated tissue expression of T helper (Th) 17 pathogenic interleukin (IL)-23 and IL-1 β in Hashimoto's thyroiditis but not in Graves' disease.
Upregulated tissue expression of T helper (Th) 17 pathogenic interleukin (IL)-23 and IL-1β in Hashimoto's thyroiditis but not in Graves' disease. Endocr J. 2019 Feb 27;: Authors: Zake T, Skuja S, Kalere I, Konrade I, Groma V Abstract T helper (Th) 17 cells and interleukin (IL)-17 play a significant role in the pathogenesis of autoimmune thyroid disease (AITD). However, it has recently become clear that Th17 cells are more heterogeneous and exhibit two different phenotypes, whereas IL-23 and IL-1β are crucial for the generation of pathogenic Th17 lymphocytes. We aimed to investigate the associ...
Source: Endocrine Journal - March 5, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Dysregulated Interleukin -33/ST2 Pathway Perpetuate Chronic Inflammation in Hashimoto's Thyroiditis.
CONCLUSION: IL-33/ST2 pathway participates in HT via affecting production of inflammatory cytokines. PMID: 30819087 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 4, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves' Ophthalmopathy.
The objective of this study was to investigate whether IRF7 polymorphisms are associated with autoimmune thyroid diseases (AITDs). We selected three single nucleotide polymorphisms (SNPs) of IRF7, namely, rs1061501, rs1131665, and rs1061502 for genotyping using PCR-based ligase detection reaction (LDR) method in a total of 1659 participants (592 with Graves' disease, 297 with Hashimoto's thyroiditis, and 770 healthy controls). Gene-disease and genotype-clinical phenotype associations were evaluated for the three SNPs. Our results showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in AIT...
Source: International Journal of Endocrinology - February 19, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Juvenile polyautoimmunity in a rheumatology setting
Publication date: Available online 14 February 2019Source: Autoimmunity ReviewsAuthor(s): Clara Malagón, Maria del Pilar Gomez, Catalina Mosquera, Camilo Vargas, Tatiana Gonzalez, Cristine Arango, Lorena Martin, Pilar Perez, Laura Amaya-Uribe, Nicolas Molano-Gonzalez, Juan-Manuel AnayaAbstractOvert polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, famili...
Source: Autoimmunity Reviews - February 15, 2019 Category: Allergy & Immunology Source Type: research

Autoimmune Diseases in Patients with Cushing's Syndrome after Resolution of Hypercortisolism: Case Reports and Literature Review.
Conclusions: Our results demonstrate that patients successfully treated for CS could develop autoimmune diseases. Therefore, after treatment, CS patients need to be strictly monitored in order to evaluate the possible onset of autoimmune diseases. PMID: 30662460 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - January 23, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Thyroid Carcinoma Coexisting with Hashimoto's Thyreoiditis: Clinicopathological and Molecular Characteristics Clue up Pathogenesis.
Nagy E, Méhes G Abstract Thyroid cancer (TC) coexisting with Hashimoto's thyroiditis (HT) presents with several characteristic features including multifocality and lower clinical stages compared to de novo carcinomas but its exact biology is still not understood. We reexamined clinico-pathological and molecular correlations between Hashimoto's thyroditis and papillary thyroid cancer. A total of 262 patients with TC was evaluated who underwent thyroidectomy at the Surgical Department of the University of Debrecen. Clinical data, histology and molecular data were evaluated. Our cohort included 43 patients (1...
Source: Pathology Oncology Research - January 21, 2019 Category: Pathology Authors: Molnár C, Molnár S, Bedekovics J, Mokánszki A, Győry F, Nagy E, Méhes G Tags: Pathol Oncol Res Source Type: research

Radiation-induced morphea: autoimmunity as a risk factor.
We report the case of a woman with a history of vitiligo and Hashimoto's thyroiditis, who developed RIM following radiotherapy for breast carcinoma. We suggest that a history of autoimmune disease is a possible risk factor for the development of RIM. PMID: 30774102 [PubMed - in process] (Source: The Netherlands Journal of Medicine)
Source: The Netherlands Journal of Medicine - January 1, 2019 Category: General Medicine Authors: Machan A, Oumakhir S, Khalidi M, Hjira N, Boui M Tags: Neth J Med Source Type: research

The Association between Burning Mouth Syndrome and Level of Thyroid Hormones in Hashimotos Thyroiditis in Public Hospitals in Shiraz, 2016
Conclusion:The level of TSH, Anti-TPO, and Anti-TG, Free T3, and TSH indices of Hashimoto ’s patients were associated with the presence and severity of BSM. However, Free T4 level was only associated with the presence of BMS and not the intensity. (Source: Journal of Dentistry, Shiraz University of Medical Sciences)
Source: Journal of Dentistry, Shiraz University of Medical Sciences - December 19, 2018 Category: Dentistry Source Type: research

Autoimmune diseases in autoimmune atrophic gastritis.
Abstract Autoimmune diseases, characterized by an alteration of the immune system which results in a loss of tolerance to self antigens often coexist in the same patient. Autoimmune atrophic gastritis, characterized by the development of antibodies agains parietal cells and against intrinsic factor, leads to mucosal destruction that affects primarily the corpus and fundus of the stomach. Autoimmune atrophic gastritis is frequently found in association with thyroid disease, including Hashimoto's thyroiditis, and with type 1 diabetes mellitus, Other autoimmune conditions that have been described in association with ...
Source: Acta Bio-Medica : Atenei Parmensis - December 17, 2018 Category: General Medicine Authors: Rodriguez-Castro KI, Franceschi M, Miraglia C, Russo M, Nouvenne A, Leandro G, Meschi T, De' Angelis GL, Di Mario F Tags: Acta Biomed Source Type: research

Relationship between Hashimoto's thyroiditis and papillary thyroid carcinoma in children and adolescents.
CONCLUSIONS: HT is associated with an increased occurrence of PTC in children and adolescents. PMID: 30536322 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - December 13, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Sonographic Characteristics of Papillary Thyroid Carcinoma with Coexistent Hashimoto's Thyroiditis: Conventional Ultrasound, Acoustic Radiation Force Impulse Imaging and Contrast-Enhanced Ultrasound
Our objective was to provide the various sonographic characteristics of papillary thyroid carcinomas for Hashimoto's thyroiditis (HT) patients, including conventional ultrasound (US), acoustic radiation force impulse Virtual Touch imaging and quantification (ARFI-VTIQ) and contrast-enhanced ultrasound (CEUS). Sixty-nine HT patients with 85 thyroid nodules (TNs) (49 malignant and 36 benign) were enrolled in this study. We evaluated the size, shape, margin, echogenicity, presence of halo, calcification, vascularity and ARFI-VTIQ and CEUS parameters for each nodule and compared the findings with the reference standards of his...
Source: Ultrasound in Medicine and Biology - December 8, 2018 Category: Radiology Authors: Qinghai Peng, Chengcheng Niu, Meixiang Zhang, Qiang Peng, Sijie Chen Tags: Original Contribution Source Type: research

Gender Alters the MHC Class I HLA-A Association with Polyglandular Autoimmunity.
GJ Abstract Context: The Major Histocompatibility Complex (MHC) strongly contributes to the development of polyglandular autoimmunity (PGA). Objective: To evaluate the impact of gender on human leukocyte antigen (HLA) association with PGA for the first time. Design: Cross-sectional immunogenetic study. Setting: Academic, tertiary referral, orphan disease center for PGA (ORPHA 282196) and immunogenetics laboratory. Subjects: 158 patients with coexistent type 1 diabetes and autoimmune thyroid disease (adult type three PGA, ORPHA 227982) and 479 unrelated healthy controls. Methods: All 637 C...
Source: The Journal of Clinical Endocrinology and Metabolism - December 5, 2018 Category: Endocrinology Authors: Flesch BK, König J, Frommer L, Hansen MP, Kahaly GJ Tags: J Clin Endocrinol Metab Source Type: research

The protective effect of myo-inositol on human thyrocytes.
Abstract Patients affected by autoimmune thyroiditis reached positive effects on indices of thyroid autoimmunity and/or thyroidal function, after following a treatment with selenomethionine (Se) alone, or Se in combination with Myo-inositol (Myo-Ins). Our purpose was to investigate if Myo-Ins alone, or a combination of Se + Myo-Ins, is effective in protecting thyroid cells from the effects given by cytokines, or hydrogen peroxide (H2O2). We assessed the interferon (IFN)-γ-inducible protein 10 (IP-10/CXCL10) secretion by stimulating primary thyrocytes (obtained from Hashimoto's thyroiditis or fr...
Source: ENDOCR REV - December 4, 2018 Category: Endocrinology Authors: Ferrari SM, Elia G, Ragusa F, Paparo SR, Caruso C, Benvenga S, Fallahi P, Antonelli A Tags: Rev Endocr Metab Disord Source Type: research

The thyroid in ischemic heart disease: An autopsy study.
In this report, we studied the cases with pathologically evident ischemic heart disease (IHD) at autopsy and correlated with the absence or presence of thyroid disease. In a 5-year retrospective autopsy-based study, cases with IHD in whom the thyroid gland was dissected at autopsy were analyzed. The thyroid gland was available for assessment in 181 of the 255 autopsied cases with IHD. The majority were males with a mean age of 59.9 years. Thyroid pathology was noted in 58 patients (32.0%) in the form of uninodular or multinodular goiter (56.9%), lymphocytic thyroiditis (37.9%), and Hashimoto's thyroiditis (5.2%). Based on ...
Source: Indian Heart J - December 1, 2018 Category: Cardiology Authors: Vaideeswar P, Singaravel S, Gupte P Tags: Indian Heart J Source Type: research

The increasing prevalence of chronic lymphocytic thyroiditis in papillary microcarcinoma
AbstractAlthough the incidence of some malignancy has decreased over the recent years, this is not the case of papillary thyroid microcarcinoma (PTMC), whose incidence has increased worldwide. Most PTMC are found incidentally after histological examination of specimens from surgery for benign thyroid disease. Hashimoto ’s thyroiditis, whose incidence has also increased, coexists in about one in three PTMC patients. Three different mechanisms have been proposed to clarify the association between chronic lymphocytic thyroiditis and PTMC, namely tumor development/growth by: (i) TSH stimulation, (ii) expression of c erta...
Source: Reviews in Endocrine and Metabolic Disorders - November 20, 2018 Category: Endocrinology Source Type: research