Metformin reduces autoimmune antibody levels in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
CONCLUSION: Metformin significantly reduces TPOAb level and TgAb level in patients with HT and SH, especially TPOAb. This study is the first to provide a preliminary theoretical basis for the clinical application of metformin in the treatment of HT. PMID: 32741222 [PubMed - as supplied by publisher] (Source: Autoimmunity)
Source: Autoimmunity - August 4, 2020 Category: Allergy & Immunology Tags: Autoimmunity Source Type: research

Influence of dietary habits on oxidative stress markers in hashimoto's thyroiditis.
CONCLUSIONS: The present study suggests a protective effect of low intake of animal foods towards thyroid autoimmunity and a positive influence of such nutritional patterns on redox balance and potentially on oxidative stress-related disorders. PMID: 32729374 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - July 31, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Ovarian Reserve and Serum Concentration of Thyroid Peroxidase Antibodies in Euthyroid Women With Different Polycystic Ovary Syndrome Phenotypes
We examined 141 women with PCOS [phenotype A was diagnosed in 67 (47.5%) women, phenotype B in 30 (21.3%), phenotype C in 28 (19.9%), and phenotype D in 16 (11.3%)] and 88 control subjects of similar age; all women were euthyroid. Serum concentrations of AMH, thyroid-stimulating hormone (TSH), thyroid hormones, and TPOAbs were assessed.Results: We observed positive serum TPOAbs in 21.9% women with PCOS and in 23.9% controls (p = 0.07). We did not find differences in the frequency of detection of positive serum TPOAbs between phenotypes A, B, and C and the control group (p> 0.05). We did not observe a difference in AMH l...
Source: Frontiers in Endocrinology - July 28, 2020 Category: Endocrinology Source Type: research

Does Hashimoto's Thyroiditis Increase the Risk of Cardiovascular Disease in Young Type 1 Diabetic Patients?
Background: Immunological and hormonal disorders have undoubted influence on the development of atherosclerotic process. Autoimmune diseases accompanying type 1 diabetes (T1D) may additionally accelerate atherosclerosis progression and increase the risk of cardiovascular events in the future. The influence of subclinical hypothyroidism on the cardiovascular system, in particular, has recently aroused great interest. The aim of our study was to assess intima-media thickness (cIMT) of common carotid arteries and the occurrence of classical atherosclerosis risk factors together with selected new biomarkers of cardiovascular d...
Source: Frontiers in Endocrinology - July 24, 2020 Category: Endocrinology Source Type: research

Fecal Microbiota Signatures in Celiac Disease Patients With Poly-Autoimmunity
This study provides supportive evidence that specific variations of gut microbial taxa occur in CD patients with poly-autoimmune diseases. These findings open the way to future validation studies on larger cohorts, which might in turn lead to promising diagnostic applications. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - July 23, 2020 Category: Microbiology Source Type: research

Hashimoto's thyroiditis associated with an extra-thyroidal triad of pretibial myxedema, ophthalmopathy, and acropachy.
Authors: Liao C, Hu L, Lan C PMID: 32683842 [PubMed - in process] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - July 21, 2020 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

From Bartter's syndrome to renal tubular acidosis in a patient with Hashimoto's thyroiditis: A case report 
.
We report an HT patient who initially developed hypokalemic metabolic alkalosis and then developed metabolic acidosis within a few years. To our knowledge, this is the first report of two completely opposite acid-base disturbances associated with renal tubular diseases occurring consecutively in the same patient with HT. Our case may provide a valuable clue for exploring the mechanism of renal involvement in autoimmune diseases. PMID: 32691728 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 21, 2020 Category: Urology & Nephrology Authors: Wang S, Dong B, Wang C, Lu J, Shao L Tags: Clin Nephrol Source Type: research

Role of selenium and myo-inositol supplementation on autoimmune thyroiditis progression.
Authors: Pace C, Tumino D, Russo M, Le Moli R, Naselli A, Borzì G, Malandrino P, Frasca F Abstract Previous reports indicate that selenium supplementation may be useful to reduce cell oxidative stress. In particular, selenium may decrease the level of thyroid autoantibodies in patients with Hashimoto's thyroiditis (HT). Recent studies also indicate that myo-inositol may have beneficial effects on thyroid function in patients with HT. Hence, the aim of the present study is to evaluate whether myo-inositol may enhance the protective effect of selenium on HT progression to hypothyroidism. The study was designed...
Source: Endocrine Journal - July 17, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

COVID-19 complicated by Hashimoto's thyroiditis.
PMID: 32668831 [PubMed - as supplied by publisher] (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - July 16, 2020 Category: General Medicine Authors: Tee LY, Hajanto S, Rosario BH Tags: Singapore Med J Source Type: research

Iodized table salt consumption among patients with Hashimoto's thyroiditis.
Authors: Mazokopakis EE PMID: 32632886 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - July 9, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Analysis of Hashimoto's thyroiditis on fine needle aspiration samples by MALDI-Imaging
Publication date: Available online 6 July 2020Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Giulia Capitoli, Isabella Piga, Francesca Clerici, Virginia Brambilla, Allia Mahajneh, Davide Leni, Mattia Garancini, Angela Ida Pincelli, Vincenzo L'Imperio, Stefania Galimberti, Fulvio Magni, Fabio Pagni (Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics)
Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - July 7, 2020 Category: Biochemistry Source Type: research

Unidentified Neuronal Surface IgG Autoantibodies in a Case of Hashimoto's Encephalopathy
We present a case of a young patient with pre-existing Hashimoto's thyroiditis and progressive cognitive complaints, absence-like episodes, and sporadic bilateral epileptiform frontal and frontotemporal activity. No abnormalities were observed during the neurological examination and on MRI. Antibodies to thyroid peroxidase (TPO) were elevated and remained positive while the symptoms were present. Levothyroxine and methylprednisolone did not ameliorate the complaints. Subsequent treatment with high-dose intravenous immunoglobulins (IVIG) led to improved cognitive functions and to the disappearance of the absence-like-episod...
Source: Frontiers in Immunology - July 7, 2020 Category: Allergy & Immunology Source Type: research

Hypothyroidism.
Abstract Hypothyroidism is a common condition in which the thyroid gland provides insufficient amounts of thyroid hormone for the needs of peripheral tissues. The most common cause in adults is chronic lymphocytic thyroiditis (Hashimoto thyroiditis), but there are many other causes. Because most of the clinical features of hypothyroidism are nonspecific, the diagnosis requires laboratory testing. Serum thyroid-stimulating hormone (TSH) measurement is the best diagnostic test; an elevated TSH level almost always signals primary hypothyroidism. Serum free thyroxine levels may be below the reference range (overt hypo...
Source: Annals of Internal Medicine - July 7, 2020 Category: Internal Medicine Authors: McDermott MT Tags: Ann Intern Med Source Type: research

IL-2 enhanced MHC class I expression in papillary thyroid cancer with Hashimoto's thyroiditis overcomes immune escape in vitro
In conclusion, IL-2 up-regulated HLA-class I expression and enhanced anti-tumor T cell immunity during the development of PTC and HT. IL-2 may be a promising immunotherapy for PTC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jia-Qian Hu, Bo-Wen Lei, Duo Wen, Ben Ma, Ting-Ting Zhang, Zhong-Wu Lu, Wen-Jun Wei, Yu-Long Wang, Yu Wang, Duan-Shu Li, Qing-Hai Ji, Tian Liao Tags: Research Paper Source Type: research

Associations of Yersinia enterocolitica infection with autoimmune thyroid diseases: a systematic review and meta-analysis.
CONCLUSIONS: The current studies suggest that Y. enterocolitica may be associated with the development of AITD. Further study is needed to explore the underlying mechanisms. PMID: 32564766 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - June 21, 2020 Category: Endocrinology Authors: Zangiabadian M, Mirsaeidi M, Pooyafar MH, Goudarzi M, Nasiri MJ Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

The importance of nutritional factors and dietary management of Hashimoto's thyroiditis.
Abstract Hashimoto (HT) is an autoimmune disease in which destruction of the thyroid occurs as a result of lymphocyte infiltration. It is caused by an increased level of titers of antibody against thyroid peroxidase (TPO) and thyroglobulin (TG). Because of that,in HT patients, changes are observed in the level and metabolism of thyroid hormones, which leads to unspecified physical and psychological symptoms. A high level of antibodies attacking thyroid antigens has been positively correlated with the symptoms. From the etiological point of view, the most important are genetic factors; however, environmental factor...
Source: Annals of Agricultural and Environmental Medicine : AAEM - June 19, 2020 Category: Environmental Health Authors: Ihnatowicz P, Drywień M, Wątor P, Wojsiat J Tags: Ann Agric Environ Med Source Type: research

Circulating microRNA Expression Profiling Identifies miR-125a-5p Promoting T Helper 1 Cells Response in the Pathogenesis of Hashimoto's Thyroiditis
MicroRNAs (miRNAs) have emerged as key regulators of cellular processes by suppressing target mRNAs at the posttranscriptional level. However, little is known regarding the expression of miRNAs in peripheral blood mononuclear cells (PBMCs) from Hashimoto's thyroiditis (HT) patients. Therefore, 38 HT patients and 36 healthy volunteers were enrolled in this study to identify HT-mediated changes in miRNA expression. Over 1,000 dysregulated miRNAs and their biological functions in the HT patients were identified. Among them, miR-125a-5p expression was upregulated and inversely correlated with low levels of MAF, a transcription...
Source: Frontiers in Immunology - June 11, 2020 Category: Allergy & Immunology Source Type: research

The Effects of Alternate-Day Corticosteroids in Autoimmune Disease Patients.
Conclusions: Treatment with alternate-day corticosteroids achieved a statistically significant decrease in serum autoantibody levels in patients with systemic lupus erythematosus and Hashimoto's thyroiditis. PMID: 32509344 [PubMed] (Source: Autoimmune Diseases)
Source: Autoimmune Diseases - June 10, 2020 Category: Allergy & Immunology Tags: Autoimmune Dis Source Type: research

RET, NTRK, ALK, BRAF and MET fusions in a large cohort of pediatric papillary thyroid carcinomas.
CONCLUSIONS: Fusion genes were the most common genetic cause of pediatric PTCs. Fusion gene positive PTCs showed more aggressive behavior than fusion gene negative PTCs. Several novel rearrangements were identified. Fusion genes seem to be a molecular marker number one in pediatric PTC patients. PMID: 32495721 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - June 6, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Increased risk of endocrine autoimmunity in first-degree relatives of patients with autoimmune Addison's disease.
Abstract Objective: Autoimmune conditions tend to cluster in subjects with Addison's disease (AD) and probably also among their relatives. The aim of the study was to estimate the frequency of the endocrine gland-specific autoantibodies in first-degree relatives of patients with AD. Methods: Autoantibodies were investigated in 113 family members using RIA and ELISA assays. The control group comprised 143 age-matched volunteers. Results: Autoimmune diseases were diagnosed in 38.1% relatives. Hashimoto's thyroiditis was found in 20.3%, Graves' disease in 8.0%, vitiligo and type 1 diabetes in 3.5%, whereas ...
Source: European Journal of Endocrinology - June 5, 2020 Category: Endocrinology Authors: Fichna M, Małecki PP, Młodzikowska M, Gębarski B, Ruchała M, Fichna P Tags: Eur J Endocrinol Source Type: research

Polymorphisms of IRAK1 gene on X chromosome is associated with Hashimoto's thyroiditis in Korean Children.
In this study, we observed that SNPs of IRAK1 including rs3027898, rs1059703 and rs1059702 in 115 Korean AITD pediatric patients (Grave's disease [GD]=74 (Female (F)=52/Male (M)=22); Hashimoto's disease [HD]=41 (F=38/M=3); thyroid-associated ophthalmopathy [TAO]=40 (F=27/M=13); without (w/o)-TAO=75 (F=63/M=12); Total M=25, Total F=90; mean age=11.9years) and 204 healthy Korean individuals (male=104, female=100). The data from cases and controls were analyzed from separate sex-stratified or all combined by Chi square test for categorical variables and Student's t-test for numerical variables. Our study revealed that SNPs of...
Source: Endocrinology - June 4, 2020 Category: Endocrinology Authors: Shin HR, Cho WK, Baek IC, Lee NY, Lee YJ, Kim SK, Ahn MB, Suh BK, Kim TG Tags: Endocrinology Source Type: research

First proof of association between autoimmune polyglandular syndrome and multiple endocrine neoplasia in humans.
We describe a unique, complex case of a man resulted affected by both APS-2 and MEN-2a. The patient developed Hashimoto's thyroiditis, diabetes mellitus type 1 and AAD, despite testing negative for adrenal cortex autoantibodies (ACA) and steroid 21-hydroxylase autoantibodies (21-OHAb). Moreover, he had also a family history for MEN-2a and he first developed medullay thyroid cancer, then bilateral pheochromocytoma on the adrenal substrate of an AAD. On adrenal histology we found complete bilateral cortical atrophy in the presence of a lymphocytic infiltration and fibrosis, confirming an ACA and 21-OHAb-negative AAD. This da...
Source: Endocrine Journal - June 3, 2020 Category: Endocrinology Tags: Endocr J Source Type: research

Programmed Death-Ligand 1 (PD-L1) Is a Potential Biomarker of Disease-Free Survival in Papillary Thyroid Carcinoma: a Systematic Review and Meta-Analysis of PD-L1 Immunoexpression in Follicular Epithelial Derived Thyroid Carcinoma
AbstractThe expression of programmed death-ligand 1 (PD-L1) is an established prerequisite for the administration of checkpoint inhibitor therapy and is of prognostic value in several cancer types. Data concerning the potential effect of PD-L1 on the prognosis of thyroid carcinoma are limited. Therefore, this study aimed to provide a systematic review of the published data on this topic. The literature was reviewed to gather and quantify evidence on the prognostic role of PD-L1 in follicular epithelial derived thyroid carcinomas and determine its association with clinicopathological parameters. A meta-analysis was performe...
Source: Endocrine Pathology - May 29, 2020 Category: Pathology Source Type: research

Tissue level implants in healthy versus medically compromised patients. A cohort comparative study.
CONCLUSIONS: In terms of Success, Failure and Survival rates, tissue level implants placed in Healthy and in Medically compromised individuals showed no short-term (1 year) differences. PMID: 32407061 [PubMed - as supplied by publisher] (Source: Minerva Stomatologica)
Source: Minerva Stomatologica - May 16, 2020 Category: Dentistry Tags: Minerva Stomatol Source Type: research

Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
Purpose: To explore the risk factors that may predict the lymph node metastasis potential of these lesions and new prevention strategies in papillary thyroid carcinoma patients.Materials and Methods: In total, 9,369 papillary thyroid carcinoma patients with 37.17% lymph node metastasis were analyzed (Revman 5.3 software) in this study. The PubMed and Embase databases were used for searching works systematically that were published through to January 22, 2020.Results: Several factors were related to the increased risk of lymph node metastasis in patients with papillary thyroid carcinoma: age
Source: Frontiers in Endocrinology - May 15, 2020 Category: Endocrinology Source Type: research

Gut microbiota and metabolites in the pathogenesis of endocrine disease.
Abstract Type 1 diabetes (T1D) and Hashimoto's thyroiditis (HT) are the two most common autoimmune endocrine diseases that have rising global incidence. These diseases are caused by the immune-mediated destruction of hormone-producing endocrine cells, pancreatic beta cells and thyroid follicular cells, respectively. Both genetic predisposition and environmental factors govern the onset of T1D and HT. Recent evidence strongly suggests that the intestinal microbiota plays a role in accelerating or preventing disease progression depending on the compositional and functional profile of the gut bacterial communities. A...
Source: Biochemical Society Transactions - May 15, 2020 Category: Biochemistry Authors: Fenneman AC, Rampanelli E, Yin YS, Ames J, Blaser MJ, Fliers E, Nieuwdorp M Tags: Biochem Soc Trans Source Type: research

Incidence of thyroid disorders in the second decade of adequate iodine supply in Slovenia.
CONCLUSION: In the second decade of adequate iodine supply in Slovenia, we established a similar or even a lower incidence of most thyroid diseases in the observed 4 years with the exception of Hashimoto's thyroiditis. PMID: 32377868 [PubMed - as supplied by publisher] (Source: Wiener Klinische Wochenschrift)
Source: Wiener Klinische Wochenschrift - May 6, 2020 Category: General Medicine Authors: Gaberšček S, Gaberšček B, Zaletel K Tags: Wien Klin Wochenschr Source Type: research

Phospholipase A2 Receptor Autoantibodies as a Novel Serological Biomarker for Autoimmune Thyroid Disease Associated Nephropathy
Conclusions: PLA2R is a potential pathogenic target antigen for HT, and the production of PLA2R antibodies may cause autoimmune thyroid disease-associated nephropathy. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - April 30, 2020 Category: Allergy & Immunology Source Type: research

Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection.
Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection. Gen Comp Endocrinol. 2020 Apr 30;:113495 Authors: Weber A, Pawar HN, Klein JR Abstract Thyroid stimulating hormone (TSH), a hormone produced in the anterior pituitary, is used to regulate thyroid hormone secretion. It has been known for over three decades that TSH is made by the cells of the immune system; however, the functional role of immune system TSH is unclear. We previously demonstrated th...
Source: General and Comparative Endocrinology - April 30, 2020 Category: Endocrinology Authors: Weber A, Pawar HN, Klein JR Tags: Gen Comp Endocrinol Source Type: research

Simultaneous measurement of twenty-nine circulating cytokines and growth factors in female patients with overt autoimmune thyroid diseases.
In conclusion, BAFF is the best circulating indicator to identify GD and HT among all chosen 29 biomarkers, and it could be used to predict the disease severity in HT and active GD. Meanwhile, IFN-α could be another reliable parameter for recognising HT. PMID: 32338082 [PubMed - as supplied by publisher] (Source: Autoimmunity)
Source: Autoimmunity - April 29, 2020 Category: Allergy & Immunology Tags: Autoimmunity Source Type: research

IL-10 restores MHC class Ⅰ expression and interferes immunity in papillary thyroid cancer with Hashimoto's thyroiditis.
Abstract The incidence of papillary thyroid cancer (PTC) with concomitant Hashimoto's thyroiditis (HT) is increasing. Interleukin-10 (IL-10) is a cytokine previously reported to be elevated in this condition. Evidence from multiple human malignancies showed IL-10 participated in tumor immunity and exhibited therapeutic potential. The aim of this study is to investigate whether IL-10 interferes tumor immunity in PTC with concomitant HT. Expression of IL-10 and major histocompatibility complex (MHC) class Ⅰ were compared on PTC tissues with or without concomitant HT. PTC cell lines K1 and TPC-1 were stimulated wit...
Source: Endocrinology - April 29, 2020 Category: Endocrinology Authors: Lu ZW, Hu JQ, Liu WL, Wen D, Wei WJ, Wang YL, Wang Y, Liao T, Ji QH Tags: Endocrinology Source Type: research

Elevated MicroRNA-326 Levels Regulate the IL-23/IL-23R/Th17 Cell Axis in Hashimoto's Thyroiditis by Targeting a Disintegrin and Metalloprotease 17
Thyroid, Ahead of Print. (Source: Thyroid)
Source: Thyroid - April 24, 2020 Category: Endocrinology Authors: Yongping Liu Xuejiao Cui Shuo Wang Jing Liu Na Zhao Mingshi Huang Jing Qin Yushu Li Zhongyan Shan Weiping Teng Source Type: research

Deborah Doniach: Discovering Thyroid Autoimunity; the end of horror autotoxicus.
Authors: Bahn RS, Doniach T, McLachlan S Abstract Deborah Doniach MD, FRCP was born in Geneva, Switzerland in 1912. She attended high school at the Lycée Molière and medical school at the Sorbonne in Paris. Deborah married Israel (Sonny) Doniach in 1933. Following the births of their two children, she resumed her studies at the Royal Free Hospital Medical School in London, graduating in 1945. After additional training in Immunopathology and Endocrinology, Dr. Doniach joined the faculty in the Department of Immunology at the Middlesex Hospital and rose to become Honorary Consultant Immunopathologist an...
Source: Thyroid : official journal of the American Thyroid Association - April 20, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples.
Abstract Our previous investigation showed significantly increased arsenic (As) content in thyroid tissue samples of patients with Hashimoto's thyroiditis (HT). This research aimed to extend previous findings and provide reliable insight into the close relationship between As and other trace elements with HT by considering a greater number of thyroid tissue samples, accompanied by blood and urine samples. The essential trace elements for thyroid homeostasis (Mn, Cu, Zn, Se) and the main threatening toxic trace elements (Ni, As, Pb, Cd, U) was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Relev...
Source: Environmental Research - April 18, 2020 Category: Environmental Health Authors: Stojsavljević A, Rovčanin B, Jagodić J, Radojković DD, Paunović I, Gavrović-Jankulović M, Manojlović D Tags: Environ Res Source Type: research

Comment on “Prevalence of undifferentiated inflammatory arthropathy in patients with Hashimoto's thyroiditis in an endocrinology clinic” by Luis M. Valderrama‐Hinds and co‐workers. Int J Rheum Dis 2019; 22: 1985‐1989
International Journal of Rheumatic Diseases, Volume 23, Issue 4, Page 597-598, April 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Giuseppe Giuffrida, Alfredo Campenn ì, Francesco Trimarchi, Rosaria Maddalena Ruggeri Tags: CORRESPONDENCE Source Type: research

Tissue Infiltrating LTi —Like Group 3 Innate Lymphoid Cells and T Follicular Helper Cells in Graves' and Hashimoto's Thyroiditis
Conclusion: Tissue infiltrating Lymphoid Tissue inducer—like group 3 Innate Lymphoid cells and T follicular helper cells are increased in most thyroid autoimmune disease. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - April 9, 2020 Category: Allergy & Immunology Source Type: research

Co-aggregation and heritability of organ-specific autoimmunity: a population-based twin study.
Conclusions: Overall, co-aggregation was more pronounced in monozygotic than in dizygotic twins, suggesting that disease overlap is largely attributable to genetic factors. Co-aggregation was common, and twins faced up to a ten-fold risk of developing diseases not present in their co-twin. Our results validate and refine previous heritability estimates based on smaller twin cohorts. PMID: 32229696 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 3, 2020 Category: Endocrinology Authors: Skov J, Eriksson D, Kuja-Halkola R, Höijer J, Gudbjörnsdottir S, Svensson AM, Magnusson PKE, Ludvigsson JF, Kämpe O, Bensing S Tags: Eur J Endocrinol Source Type: research

A novel mouse model of autoimmune thyroiditis induced by immunization with adenovirus containing full-length thyroglobulin cDNA: Implications to genetic studies of thyroid autoimmunity.
CONCLUSIONS: Our data describe a novel murine model of autoimmune thyroiditis which does not require the use of adjuvants to break down tolerance and that will allow investigators to test the effects of hTG variants in the pathoetiology of Hashimoto's thyroiditis (HT). PMID: 32228171 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 3, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Clinical and Ultrasonic Risk Factors for Lateral Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-Analysis
Background: Clinical and ultrasonic risk factors for lateral lymph node metastasis (LLNM) in papillary thyroid microcarcinoma (PTMC) are not well-defined. Herein, a systematic review and meta-analysis was conducted to investigate clinicopathologic and ultrasonic risk features for LLNM in PTMC.Methods: A systematic search of electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) for studies published until April 2019 was performed. Case–control studies and randomized controlled trials that studied clinical and ultrasonic risk factors of LLNM in PTMC were included.Results: Fourteen studies (all ret...
Source: Frontiers in Oncology - April 3, 2020 Category: Cancer & Oncology Source Type: research

Elevated microRNA-326 levels regulate the IL-23/IL-23R/Th17 cell axis in Hashimoto's thyroiditis by targeting a disintegrin and metalloprotease 17.
CONCLUSIONS: Our findings suggest that the effect of miR-326 on the IL-23/IL-23R/Th17 cell axis in HT patients might be partially due to the targeting of ADAM17. PMID: 32204685 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 26, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

CORRIGENDUM FOR "A Case of Hashimoto's Thyroiditis with Multiple Drug Resistance and High Expression of Efflux Transporters".
CORRIGENDUM FOR "A Case of Hashimoto's Thyroiditis with Multiple Drug Resistance and High Expression of Efflux Transporters". J Clin Endocrinol Metab. 2020 Apr 01;105(4): Authors: PMID: 32170861 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2020 Category: Endocrinology Tags: J Clin Endocrinol Metab Source Type: research

Study of Epstein–Barr virus serological profile in Egyptian patients with Hashimoto's thyroiditis: A case-control study
Publication date: Available online 12 March 2020Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Samir Naeim Assaad, Marwa Ahmed Meheissen, Eman Tayae Elsayed, Saher N. Alnakhal, Tarek M. Salem (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - March 14, 2020 Category: Endocrinology Source Type: research

Association of CTLA4 (rs4553808) and PTPN22 (rs2476601) gene polymorphisms with Hashimoto's thyroiditis disease: A case-control study and an In-silico analysis
Publication date: Available online 10 March 2020Source: Meta GeneAuthor(s): MahmoudAli Kaykhaei, Hosein Moghadam, Soroosh Dabiri, Saeedeh Salimi, Danial Jahantigh, Dor Mohammad Kordi Tamandani, Ava Rasouli, Mehrnaz Narooie-Nejad (Source: Meta Gene)
Source: Meta Gene - March 11, 2020 Category: Genetics & Stem Cells Source Type: research

Upregulation of HLA Class I and Antiviral Tissue Responses in Hashimoto's Thyroiditis
Thyroid,Volume 30, Issue 3, Page 432-442, March 2020. (Source: Thyroid)
Source: Thyroid - March 11, 2020 Category: Endocrinology Authors: Therese Weider Sarah J. Richardson Noel G. Morgan Trond H. Paulsen Knut Dahl-J ørgensen Sara Salehi Hammerstad Source Type: research

Simultaneous papillary carcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma of the thyroid; a case report
Primary lymphoma of the thyroid is an uncommon malignancy, whereas papillary thyroid carcinoma is the most common thyroid malignancy. Both have an association with Hashimoto's thyroiditis. We discuss a case of an 83 year old male who presented with a large neck swelling, which subsequently proved to be a primary thyroid lymphoma (extra-nodal marginal zone) with concurrent papillary thyroid carcinoma. These tumours manifested on a background of Hashimoto's thyroiditis. To date there have only been 13 other cases of joint papillary thyroid carcinoma and thyroid lymphoma within the literature. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 9, 2020 Category: Pathology Authors: Laura LE. Whitehouse, Preetha Chengot Tags: Short case Source Type: research

Comment on “Prevalence of undifferentiated inflammatory arthropathy in patients with Hashimoto's thyroiditis in an endocrinology clinic” by Luis M. Valderrama‐Hinds and co‐workers. Int J Rheum Dis 2019; 22: 1985‐1989
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 5, 2020 Category: Rheumatology Authors: Giuseppe Giuffrida, Alfredo Campenn ì, Francesco Trimarchi, Rosaria Maddalena Ruggeri Tags: CORRESPONDENCE Source Type: research

Can Hashimoto's thyroiditis cause vertigo? [Czy choroba Hashimoto mo że być przyczyną zawrotów głowy?].
Can Hashimoto's thyroiditis cause vertigo? [Czy choroba Hashimoto może być przyczyną zawrotów głowy?]. Endokrynol Pol. 2020;70(1):76-86 Authors: Miśkiewicz-Orczyk KA, Lisowska G, Kajdaniuk D, Wojtulek M Abstract Vertigo and balance disorders are common symptoms reported by approximately 15-20% of the adult population worldwide. For many years thyroid diseases have been suspected as the cause of vertigo by ENT physicians. Almost every patient hospitalised due to severe vertigo is investigated for thyroid disease as a suspected cause of acute vestibulopathy. The issue presented in this paper...
Source: Endokrynologia Polska - March 5, 2020 Category: Endocrinology Authors: Miśkiewicz-Orczyk KA, Lisowska G, Kajdaniuk D, Wojtulek M Tags: Endokrynol Pol Source Type: research

[Thyroiditis: What's new in 2019?]
Authors: Rouland A, Buffier P, Petit JM, Vergès B, Bouillet B Abstract Thyroiditis is a frequent and mostly benign disease that can sometimes disrupt the thyroid balance. Their diagnosis, as well as their aetiology, is a necessary step in the management of the patients. Painful thyroiditis includes acute thyroiditis of infectious origin and subacute thyroiditis. The first one can be treated by antibiotics or antifungals depending on the germ found. The second one will be treated with non-steroidal anti-inflammatory drugs or corticosteroids. In cases of Hashimoto's thyroiditis with overt hypothyroidism, repla...
Source: Revue de Medecine Interne - March 1, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Clinical case report: A case of Turner syndrome with Graves’ disease
Conclusion: TS generally presents as hypergonadotropic hypogonadism. However, hypogonadotropic hypogonadism cannot completely exclude TS. The diagnosis of this disease depends on chromosomal examination. The disease should be detected and treated as early as possible to improve life quality of the patient. (Source: Medicine)
Source: Medicine - March 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Pituitary macroadenoma secondary to Hashimoto's thyroiditis: inadvertent diagnosis in a pre-pubertal girl.
We report a prepubertal girl with Hashimoto's thyroiditis who was inadvertently diagnosed to have a pituitary macroadenoma based on neuroimaging. PMID: 32106779 [PubMed - as supplied by publisher] (Source: Tropical Doctor)
Source: Tropical Doctor - February 27, 2020 Category: Tropical Medicine Authors: Bhattacharya D, Kumar R, Yadav J Tags: Trop Doct Source Type: research