Fight Aging! Newsletter, April 8th 2019
This study did not confirm the hypothesis that ELL individuals have lower polygenic risk scores for cardiovascular-related phenotypes. Only the HDL cholesterol and triglyceride PRS were nominally significantly associated with ELL participants. In contrast and as expected, ELL individuals had higher polygenic risk scores for exceptional longevity (EL). In regards to the associations of the various cardiovascular PRS with EL, no findings survived correction for multiple testing. This is despite validating the utility of the lipid PRS by confirming positive associations with measured lipid levels in our sample. Interestingly,...
Source: Fight Aging! - April 7, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Ion Channels in the Mitochondrial Dysfunction that Occurs with Aging
Mitochondria are the power plants of the cell, present by the hundred in near every cell type in the body. They are important in many fundamental cellular processes, but their primary task is to package chemical energy stores in the form of adenosine triphosphate (ATP). Mitochondrial function declines with age in all tissues, and this is particularly problematic in energy-hungry tissues such as the brain and muscles. The cause of this decline may be failure of the quality control mechanisms of mitophagy, responsible for dismantling damaged mitochondria, or it may have deeper roots, such as loss of capacity for mitochondria...
Source: Fight Aging! - April 4, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Kunjin Virus Infection
The following background information on Kunjin virus infection is abstracted from Gideon www.GideonOnline.com and the Gideon e-book series [1] Primary references are available on request.
Kunjin virus (KUN), a subtype of West Nile virus, was first isolated in Australia in 1960, from mosquitoes (Culex annulirostris). The virus is named for an Aboriginal clan living on the Mitchell River in Kowanyama, northern Queensland
Most cases of human infection are reported in Australia, with sporadic reports from Nepal. Serosurveys suggest the presence of human infection in Malaysia, Indonesia and Papua New Guinea.
In Australia...
Source: GIDEON blog - April 3, 2019 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: Ebooks Epidemiology ProMED Source Type: blogs
Fight Aging! Newsletter, March 18th 2019
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases.
There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - March 17, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Burden of Age-Related Disease Varies Broadly Between Regions of the World
Researchers here present an interesting view of the variance in the burden of age-related disease exhibited by populations around the world. Unsurprisingly, the impact of age falls most heavily on those living in the poorest and least developed regions. Modern medicine and the other comforts of technology, for all that they do not directly target the causes of aging, do manage to have a sizable influence on the pace at which aging and age-related disease progresses over a lifetime. The largest gaps are mostly likely due to a combination of sanitation, particulate exposure from fires, and control of pathogens - akin to the ...
Source: Fight Aging! - March 15, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
When IVF is bad for you !
While IVF can be a very effective treatment option for infertile couples, the sad truth is that it sometimes causes more harm than good.Thus, many IVF doctors push unproven and untested tests and treatments on their patients. These are disguised in the garb of being the "latest technological advance", but actually serve only to improve the clinic's profits, and not the patient's pregnancy rates. However, patients are desperate, and unethical doctors are happy to take advantage of the patient's vulnerability.Over the last 30 years, we have seen many of these "advances" come and go. They were introduced with a lo...
Source: Dr.Malpani's Blog - March 12, 2019 Category: Reproduction Medicine Source Type: blogs
Senate GOP Bill Doesn ’t Extend TPS. It Guts It
President Trumpannounced on Saturday that he had a new plan to open government that includes “a three-year extension of temporary protected status or TPS.” But as in the case of DACA—for reasons I explainedhere—theactual legislation that Senate Majority Leader Mitch McConnell introduced to implement his proposal does not extend TPS. Rather, it ends it as it exists now, and replaces with an entirely different program with much more restrictive criteria.Temporary protective status, or TPS, is granted to nationals of country where the government feels it could not, at one time or another, send people back to due to a ...
Source: Cato-at-liberty - January 22, 2019 Category: American Health Authors: David Bier Source Type: blogs
Why IVF Genetic Screening of embryos should not be used in clinical practice
Sadly, many IVF doctors are selling PGT/ PGS to their IVF patients, claiming that this will improve their IVF success rates. They charge a lot more money for doing this unproven experimental procedure.Don't let your doctor use you as a guinea paig ! (Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - December 28, 2018 Category: Reproduction Medicine Source Type: blogs
The Ovarian Rejuvenation Scam
Patients with ovarian failure can be very depressed and disheartened when they learn that they can't have a baby with their own eggs .Lots of them are not prepared to accept this harsh truth, and are not willing to use donor eggs , even though this has a very high success rate, either for psychological or religious reasons. As a result of their desperation, they are emotionally very vulnerable , and are happy to clutch at straws. Because they're willing to do anything in order to have a baby, it ’s easy for crooked doctors to cheat them . In the past , doctors would take them for a ride, by “treating” them with hormo...
Source: Dr.Malpani's Blog - December 12, 2018 Category: Reproduction Medicine Source Type: blogs
Innovative Ultrasound Trial Goes off Without a Hitch and Successfully Treats Early Stage Alzheimer ’s
At West Virginia University ’s Rockefeller Neuroscience Institute, a group of researchers led by neurosurgeon Ali R. Rezai, MD, are successfully using ultrasound waves to treat early stage Alzheimer ’s.The groundbreaking procedure uses microscopic bubbles and a specialized helmet with over 1,000 probes to emit ultrasound waves focused on an exact spot in the brain. In turn, the blood-brain barrier is disrupted, a region in between the brain ’s blood vessels and cells that’s considered practically impenetrable. “It’s protected on one end for us to function but also prevents larger molecules or chemotherapy or m...
Source: radRounds - December 8, 2018 Category: Radiology Authors: Julie Morse Source Type: blogs
Optically Pumped Magnetometer to Measure Electric Activity of Fetal Hearts
Assessing the electrical activity of a fetal heart is extremely difficult, since ECG is not an option. Ultrasound is not a substitute for electrical conduction study like ECG, so there’s always a search for a better alternative. Researchers at the University of Copenhagen believe that a new technology they’re working will give clinicians an unprecedented diagnostic tool for fetal cardiac assessment.
Published in journal Nature Scientific Reports, the technology relies on a cloud of cesium atoms that is very sensitive to magnetic fields, and therefore able to discern faint electromagnetic signals coming from th...
Source: Medgadget - November 5, 2018 Category: Medical Devices Authors: Editors Tags: Cardiology Materials Medicine Pediatrics Source Type: blogs
Brain stimulation during sleep does not enhance memory for learned material
“Learn while you sleep” has been the claim of snake oil salesmen since the 1950s. The old pseudoscience methods involved listening to tapes and records. From a 1958 article byLester David:Max Sherover, president of the Linguaphone Institute of New York ... coined the word “dormiphonics, ” defining it as a “new scientific method that makes quick relaxed learning possible, awake or asleep.” Dormiphonics, declares Mr. Sherover, works by “repeated concentrated impact of selected material on the conscious and subconscious mind.”An “experiment” was conducted at the Tulare County Prison, where 100 convicts “...
Source: The Neurocritic - September 10, 2018 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
Fractional Reserve Banking and " Austrian " Business Cycles, Part III
Inthe first of this series of posts, I explained that the mere presence of fractional-reserve banks itself has little bearing on an economy ’s rate of money growth, which mainly depends on the growth rate of its stock of basic (commodity or fiat) money. The one exception to this rule, I said, consists of episodes in which growth in an economy’s money stock, defined broadly to include the public’s holdings of readily-redeemable ban k IOUs as well as its holdings of basic money, is due in whole or in part to a decline in bank reserve ratiosIn asecond post, I pointed out that, while falling bank reserve ratios might in ...
Source: Cato-at-liberty - August 28, 2018 Category: American Health Authors: George Selgin Source Type: blogs
Fight Aging! Newsletter, August 13th 2018
We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response.
In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - August 12, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Papers Drawn from the Ongoing Investigation of Naked Mole-Rat Biochemistry
A sizable amount of effort is devoted to the comparative biology of aging, and in particular mapping the noteworthy differences between naked mole-rats and other similar-sized rodent species. Naked mole-rats live nearly ten times longer than mice and are near immune to cancer. It is possible that a sufficiently comprehensive understanding of why this is the case could result in therapies for humans, though I believe the odds of this coming to pass in the near future of the next couple of decades are much larger for cancer than aging. Research into calorie restriction mimetic drugs has demonstrated that safely inducing even...
Source: Fight Aging! - August 7, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
