The one thing you need to do before IVF
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 21, 2019 Category: Reproduction Medicine Source Type: blogs

Kya aap apne IVF clinic mein ek number ke roop mein treat kare jaane se ...
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 20, 2019 Category: Reproduction Medicine Source Type: blogs

The story of an embryo !
We retrieved 4 oocyte cumlus complexes from 4 follicles for this older woman with a very low AMH levelAll the 4 eggs were mature ( M2) and we did ICSI for all of themHowever, only 1 fertilisedThis divided well until Day 4, by which point it had formed a moruleHowever, the blastocyst on Day 5 was of poor qualityThis photo-essay emphasises how much biological variability there is in egg and embryo quality, which is why it is so hard for us to predict the outcome of any IVF cycle  (Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 18, 2019 Category: Reproduction Medicine Source Type: blogs

How an IVF embryologist is like a chef !
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 17, 2019 Category: Reproduction Medicine Source Type: blogs

Hindi IVF video. Kya aapke clinic mein koi privacy nahin hai?
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 16, 2019 Category: Reproduction Medicine Source Type: blogs

Why biology is no longer destiny for Indian women?
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 15, 2019 Category: Reproduction Medicine Source Type: blogs

What IVF patients need to achieve success !
When we transfer a top-quality blastocyst, patients are obviously very hopeful that they're going to get pregnant. So are doctors, because we're human beings. We want all our patients to get pregnant so that they can refer other patients to us as well.However, when the blastocyst does not implant, this causes a lot of heartache and heartburn. Patients are naturally upset, and they can't understand why the cycle failed. But the reality is doctor can't understand why the cycle failed, either, because we cannot control the process of implantation. This is something we need to come to terms with.Patients would love scient...
Source: Dr.Malpani's Blog - May 13, 2019 Category: Reproduction Medicine Source Type: blogs

Should you use donor eggs to have a baby ?
IVF patients need to be very careful when making decisions , because some of these can be life changing.If you are older and have poor ovarian reserve, should you use donor eggs or try with your own? You need to take your time before you finalize what you want to do.You need to listen to your head; your heart; your gut; and get second opinions before pulling the trigger. You have to explore all your options , and do a lot of soul searching, so you have peace of mind you made the right decision.The most important thing is you need to make your own decision for yourself.You just can't let a doctor make this for you...
Source: Dr.Malpani's Blog - May 12, 2019 Category: Reproduction Medicine Source Type: blogs

The importance of embryo grading in the IVF lab
When a top quality embryo and poor quality embryo look similar fromDr Aniruddha Malpani (Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 11, 2019 Category: Reproduction Medicine Source Type: blogs

The dirty little secret about modern IVF tests.
Most patients expect that IVF doctors will do lots of tests for them , in order to tailor their treatment so that they can maximize their chances of getting pregnant.The problem is that a lot of the new IVF tests which are available, such as theERA test and thePGS test do not provide the doctor with any clinically actionable information for that individual patient.These tests are still unproven, which is why they are not done in the world's best IVF centers .There's a lot of overlap in the results between fertile patients and infertile patients, which means you will get abnormal results in fertile patients as well.And they...
Source: Dr.Malpani's Blog - May 11, 2019 Category: Reproduction Medicine Source Type: blogs

What we still do not know about IVF
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 10, 2019 Category: Reproduction Medicine Source Type: blogs

What IVF patients need to do to make the right choices for themselves
IVF patients need to be very careful when making decisions , because some of these can be life changing.If you are older and have poor ovarian reserve, should you use donor eggs or try with your own? You need to take your time before you finalize what you want to do.You need to listen to your head; your heart; your gut; and get second opinions before pulling the trigger. You have to explore all your options , and do a lot of soul searching, so you have peace of mind you made the right decision.The most important thing is you need to make your own decision for yourself.You just can't let a doctor make this for you...
Source: Dr.Malpani's Blog - May 10, 2019 Category: Reproduction Medicine Source Type: blogs

Why IVF patients should make their own choices
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 9, 2019 Category: Reproduction Medicine Source Type: blogs

Why do so many IVF cycles fail?
    Most patients who do IVF expect that the cycle is going to work. After all, isn't the technology great? Shouldn't they get results after spending so much money? Aren't they going to a doctor who's promising them that they have a very good chance of getting pregnant?And surely God will be kind this time around ! After all, haven't they done everything humanly possible to have a baby ?It's especially when the doctor shows them their top-quality blastocysts, they think that they are pregnant when these are transferred to their uterus.But the reality is that an embryo is not a baby. Human reproduct...
Source: Dr.Malpani's Blog - May 9, 2019 Category: Reproduction Medicine Source Type: blogs

Failed Implantation is the rule in human reproduction !
One of the most frustrating problems in IVF today is recurrent implantation failure. This is the medical terms used to describe the distressingly common scenario when top quality embryos don't become babies , cycle after cycle.This upsets patients as well as doctors !Doctors are very hopeful and optimistic ( as are patients) when we transfer a top quality blastocyst into a receptive endometrium, because everything seems medically perfect.However, then the embryos stubbornly refuse to implant, the patient naturally gets upset , and starts wondering whether the doctor did something wrong - or pressurise the doctor to do some...
Source: Dr.Malpani's Blog - May 8, 2019 Category: Reproduction Medicine Source Type: blogs

My interview with ETHealthworld
Shahid Akhter, the editor, ETHealthworld, spoke to Dr Aniruddha Malpani, Medical Director at Malpani IVF Clinic, Mumbai to know about IVFchallenges that still dominate and the way forward.https://health.economictimes.indiatimes.com/news/industry/family-planning-also-means-helping-infertile-couples-to-have-babies-dr-aniruddha-malpani/69210098 (Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 7, 2019 Category: Reproduction Medicine Source Type: blogs

What we still do not know about IVF treatment
IVF success rates have improved dramatically in the past few years, because the technology has become progressively better.However, one thing IVF teaches doctors very quickly is a lot of humility. This is because we still have no way of being able to predict what is going to happen to an individual egg; an individual embryo; and an individual patient.While we know that about 40% of eggs will become blastocysts in a young woman, we cannot predict which egg will develop into a blast, and which will arrest, even though they look identical at the time of retrieval.Similarly, we cannot predict which will blastocyst will im...
Source: Dr.Malpani's Blog - May 7, 2019 Category: Reproduction Medicine Source Type: blogs

Why aren't young Indian professional women freezing their eggs?
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 7, 2019 Category: Reproduction Medicine Source Type: blogs

Poor ovarian responders in IVF. Hindi video
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 6, 2019 Category: Reproduction Medicine Source Type: blogs

Why IVF patients should make their own choices
Not all of medicine is black or white , and there are lots of gray zone areas, especially in IVF.This is why it's so important for patients to express their preferences, and for doctors to respect these.Thus, many IVF patients have fibroids, which are a very common finding in young fertile women as well. Now most fibroids are in the wall of the uterus, and because they don't affect fertility, good doctors are happy to leave them alone. On the other hand, there are also aggressive doctors , who want patients to have these fibroids removed, and this means patients are often confused as to what to do !This is why they often c...
Source: Dr.Malpani's Blog - May 3, 2019 Category: Reproduction Medicine Source Type: blogs

Being infertile does not mean that you are a failure!
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 3, 2019 Category: Reproduction Medicine Source Type: blogs

The patient IVF patient !
Patience, persistence, and perseverance are extremely important for IVF patients.Part of the problem is that everyone wants instant gratification in this day and age !They have very unrealistic expectations of IVF success rates, partly because of all the tall claims made in misleading ads and clinic websites, which claim pregnancy rates of 60% and 70% ! These are a complete lie, but these inflated false expectations, coupled with unrealistic time frames, usually means that patients end up killing their own dreams. They go to pieces when their first IVF cycle fails, and they forget that they need to factor in the fact that ...
Source: Dr.Malpani's Blog - May 2, 2019 Category: Reproduction Medicine Source Type: blogs

Why transferring one embryo at a time is the best option for IVF patients?
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 2, 2019 Category: Reproduction Medicine Source Type: blogs

Why IVF babies are at increased risk as compared to normal pregnancies?
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - May 1, 2019 Category: Reproduction Medicine Source Type: blogs

Repeated IVF failure versus recurrent implantation failure
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 30, 2019 Category: Reproduction Medicine Source Type: blogs

What should we change in the next IVF cycle ?
A patient sent me this emailDear Doctor, As you know, my first cycle failed, even though everything was perfect, and I am heartbroken !You have suggested that we stick to the same medical protocol , but I have a bunch of questions which I would like you to  answer .1. Should we opt for PGS or test the endometrium health to assess the exact issue?PGS reduces pregnancy rates in my opinion. Read more athttp://blog.drmalpani.com/2015/05/how-pgs-overpromises-and-underperforms.htmlThe ERA test is also a waste of money ( but very profitable for doctors to do !)Read more athttps://www.drmalpani.com/knowledge-center/artic...
Source: Dr.Malpani's Blog - April 27, 2019 Category: Reproduction Medicine Source Type: blogs

Why biology is no longer destiny for Indian women.
Once upon a time, career women who were ambitious had to make a hard choice when they were 30 . They knew that their fertility was maximal when they were young, and that the best time to have a baby was when they were about 25. On the other hand, this was the time when they were growing rapidly in their career, and if they wanted to get promoted, they couldn't afford to take a break in order to have a baby. This was a major dilemma, and they were unsure what to do.Today, fortunately, young Indian professionals have a choice , which allows them to eat their cake and have it too ! They can freeze their eggs when they are 30 ...
Source: Dr.Malpani's Blog - April 26, 2019 Category: Reproduction Medicine Source Type: blogs

Why professional women should consider freezing their eggs routinely when they are 30
Everyone knows that egg quality declines as women get older, and their chances of getting pregnant drop. This is why women who want to pursue a career are in a quandary. Should they defer child bearing, because they want to become the CEO? Or should they get pregnant, put their career on hold, and then maybe pursue a career later on after their children have grown up? Many Indian women are aware of the fact that egg freezing allows them to have their cake and eat it too, because they can freeze their eggs when they're young , without taking a break in their career, and use these frozen eggs to have a healthy baby...
Source: Dr.Malpani's Blog - April 25, 2019 Category: Reproduction Medicine Source Type: blogs

Why aren't young Indian professional women freezing their eggs?
We often see women who are now 40 and want to do IVF to get pregnant. They postponed having a baby because they were busy pursuing their career, and are dismayed to find out that the chances of having a baby with IVF at their ager are low, because their egg quality has dropped dramatically as they have aged.They wish they had got pregnant when they were younger, but the tragedy is that we can't reverse the clock.When I tell them that they could have frozen their eggs when they were 30, they are very upset that their gynecologist did not discuss this option with them at that time. They missed the chance to have their c...
Source: Dr.Malpani's Blog - April 24, 2019 Category: Reproduction Medicine Source Type: blogs

IVF as a safety net
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 23, 2019 Category: Reproduction Medicine Source Type: blogs

Why are you better than other IVF clinics?
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 16, 2019 Category: Reproduction Medicine Source Type: blogs

Information Therapy for IVF patients
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 15, 2019 Category: Reproduction Medicine Source Type: blogs

Have you failed a donor egg IVF cycle?
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 14, 2019 Category: Reproduction Medicine Source Type: blogs

Why are pregnancy rates with donor egg IVF so low in India?
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 13, 2019 Category: Reproduction Medicine Source Type: blogs

The donor egg scam
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 11, 2019 Category: Reproduction Medicine Source Type: blogs

When you should worry about the quality of your IVF clinic !
If the embryologist doesn't even bother to spell "single" correctly, you should worry a lot about his competence and ability ! (Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 10, 2019 Category: Reproduction Medicine Source Type: blogs

Doing IVF for social reasons
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 9, 2019 Category: Reproduction Medicine Source Type: blogs

Allowing IVF patients to decide
 As an IVF doctor, I'm very respectful of patients' preferences. After all, infertility is not a medical problem, it's a social construct. Lots of people are quite happy not having a baby, so if they choose not to have one, that's their choice too ! We treat them as intelligent adults and explain all their options to them, including adoption or third-party reproduction, so they can make a well-informed choice.I try not to be dictatorial, which means if they have personal, we encourage patients to express them, and try to work with them.On the other hand, I'm still the doctor in the room , and as a medical professional...
Source: Dr.Malpani's Blog - April 8, 2019 Category: Reproduction Medicine Source Type: blogs

Being Infertile does not mean that you are a failure !
One of the problems of being infertile is that patients start thinking of themselves as failures, since they can't even do such a simple thing like making a baby in their bedroom - something which millions of women do routinely all the time.This can be very hard to come to terms with, especially for a lot of young, successful, professional career women , who are so used to getting everything they want in life.They are academically smart, accomplished , do well in exams, get the job which they want, and the husband they want.When they find that they can't get a baby, their self-esteem takes a big hit, and they start wonderi...
Source: Dr.Malpani's Blog - April 6, 2019 Category: Reproduction Medicine Source Type: blogs

How much does an IVF cycle cost ?
IVF can be an expensive treatment, and cost is a major constraint for lots of patients, who need to be careful about how they spend their money.The problem is that lots of IVF clinics provide very misleading information about how much they charge for an IVF cycle. Many take out full-page ads , saying they charge only Rs 25000 for an IVF cycle, which seems like a very attractive bargain for infertile couples.However, it's only when the patient starts the cycle, that she realizes that there're all kinds of additional costs she has to pay for , which were hidden from her. However, once she's started the treatment, she forced ...
Source: Dr.Malpani's Blog - April 5, 2019 Category: Reproduction Medicine Source Type: blogs

If you only have one embryo, should you do a Day 3 or a Day 5 transfer ?
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 5, 2019 Category: Reproduction Medicine Source Type: blogs

Systematic investment plan (sip) strategy in ivf
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 4, 2019 Category: Reproduction Medicine Source Type: blogs

Why transferring one embryo at a time is the best option for IVF patients !
Patients are often confused as to how many embryos to transfer, especially when they have three or four top quality blastocysts. Many of them want the doctor to put back more embryos, in order to maximize their chance of getting pregnant in the first cycle itself.This may be tempting, and while it is true that putting two embryos back will increase the chances as compared to transferring just one in that single cycle, this comparison can be very misleading.Thus , putting back more than two embryos, especially when these are top-quality blastocysts, is a bad idea because of the risk of high-order multiples or triplets, whic...
Source: Dr.Malpani's Blog - April 4, 2019 Category: Reproduction Medicine Source Type: blogs

The IVF doctor's dilemma
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 4, 2019 Category: Reproduction Medicine Source Type: blogs

Why the IVF lab is a lot like a kitchen
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 3, 2019 Category: Reproduction Medicine Source Type: blogs

Allowing IVF patients to make their own decisions
As an IVF doctor, I'm very respectful of patients' preferences. After all, infertility is not a medical problem, it's a social construct. Lots of people are quite happy not having a baby, so if they choose not to have one, that's their choice too ! We treat them as intelligent adults and explain all their options to them, including adoption or third-party reproduction, so they can make a well-informed choice.I try not to be dictatorial, which means if they have personal, we encourage patients to express them, and try to work with them.On the other hand, I'm still the doctor in the room , and as a medical professional, I wi...
Source: Dr.Malpani's Blog - April 3, 2019 Category: Reproduction Medicine Source Type: blogs

Busy IVF clinics vs efficient IVF clinics!
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - April 3, 2019 Category: Reproduction Medicine Source Type: blogs

How many IVF cycles should I try?
Patients know that the pregnancy rate in a single IVF cycle is not 100% , and that they need to be patient until they get pregnant.A key question is - How many cycles should I try?After all, they need to know how much time and energy they need to devote to IVF, and how much this is going to cost them.This is always a tricky question, and the answer is - It depends !There are many variables at play here !What are your goals ? To experience pregnancy, or to have a baby ?What are your personal preferences ? Will you consider using donor gametes ?How old are you ?How much money can you afford to spend ? How important is this f...
Source: Dr.Malpani's Blog - April 1, 2019 Category: Reproduction Medicine Source Type: blogs

The biochemical pregnancy scam.
Lots of IVF clinics claim to have very high pregnancy rates, and it often appears that practically anyone who does an IVF cycle in these clinics gets pregnant !Sadly, most of them don't end up with babies !This is because of the clever scam which these clinics run, where they give HCG injections routinely to all their patients after the embryo transfer.The beauty about giving an HCG injection is that this injected HCG enters the blood stream and gets excreted in the urine . If patients do a urine pregnancy test or a blood test after this injection, it'll come back as positive, and they'll be delighted that the IVF cycle wa...
Source: Dr.Malpani's Blog - March 31, 2019 Category: Reproduction Medicine Source Type: blogs

Is LH the villain in IVF protocols ?
(Source: Dr.Malpani's Blog)
Source: Dr.Malpani's Blog - March 30, 2019 Category: Reproduction Medicine Source Type: blogs