Gastrointestinal Stromal Tumor (GIST) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Cancers, Vol. 16, Pages 1707: Utility of Clinical Next Generation Sequencing Tests in KIT/PDGFRA/SDH Wild-Type Gastrointestinal Stromal Tumors
Conclusions: Triple-negative GISTs comprise a diverse cohort with different driver mutations. Compared to KIT/PDGFRA-mutant GIST, limited benefit was observed with imatinib in triple-negative GIST. In depth molecular profiling can be helpful in identifying driver mutations and guiding therapy. (Source: Cancers)
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Ryan A. Denu Cissimol P. Joseph Elizabeth S. Urquiola Precious S. Byrd Richard K. Yang Ravin Ratan Maria Alejandra Zarzour Anthony P. Conley Dejka M. Araujo Vinod Ravi Elise F. Nassif Haddad Michael S. Nakazawa Shreyaskumar Patel Wei-Lien Wang Alexander J Tags: Article Source Type: research

Feasibility and efficacy of minimally invasive limited resection for primary duodenal gastrointestinal stromal tumors: a retrospective cohort study
The primary duodenal gastrointestinal stromal tumor (GIST) is a rare type of gastrointestinal tract tumor. Limited resection (LR) has been increasingly performed for duodenal GIST. However, only a few studies ... (Source: BMC Surgery)
Source: BMC Surgery - April 27, 2024 Category: Surgery Authors: Longhang Wu, Miao Liu, Xianchao Lin, Congfei Wang, Yuanyuan Yang, Haizong Fang, Heguang Huang, Ronggui Lin and Fengchun Lu Tags: Research Source Type: research

Clinical and Biomarker Analysis of a Phase I/II Study of PDR001 plus Imatinib for Advanced Treatment-refractory Gastrointestinal Stromal Tumors
CONCLUSION: In patients with treatment-refractory GIST, PDR001 in combination with imatinib was generally tolerable, but it was not effective.PMID:38662455 | DOI:10.1158/1078-0432.CCR-23-4065 (Source: Cell Research)
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Hyung-Don Kim Min-Hee Ryu Young Soo Park Changhoon Yoo Sung-Joo Kim Yoon-Koo Kang Source Type: research

Clinical and Biomarker Analysis of a Phase I/II Study of PDR001 plus Imatinib for Advanced Treatment-refractory Gastrointestinal Stromal Tumors
CONCLUSION: In patients with treatment-refractory GIST, PDR001 in combination with imatinib was generally tolerable, but it was not effective.PMID:38662455 | DOI:10.1158/1078-0432.CCR-23-4065 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 25, 2024 Category: Cancer & Oncology Authors: Hyung-Don Kim Min-Hee Ryu Young Soo Park Changhoon Yoo Sung-Joo Kim Yoon-Koo Kang Source Type: research

Cancers, Vol. 16, Pages 1668: Germline Genetic Mutations in Adult Patients with Sarcoma: Insight into the Middle East Genetic Landscape
dah Abdel-Razeq Data on germline mutations in soft tissue and bone sarcomas are scarce. We sought to identify the prevalence of germline mutations in adult sarcoma patients treated at a tertiary cancer center. Newly diagnosed patients were offered germline genetic testing via an 84-gene panel. The prevalence of pathogenic germline variants (PGVs) and their association with disease-, and patient- related factors are reported. A total of 87 patients were enrolled, the median age was 48 (19&ndash;78) years, and 47 (54%) were females. Gastrointestinal stromal tumors (n = 12, 13.8%), liposarcoma (n = 10, 11.5%), ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Abu-Hijlih Sharaf Salah Bani Hani Alqaisieh Alzibdeh Ababneh Mahafdah Abdel-Razeq Tags: Article Source Type: research

Hybrid surgical approach excision of gastrointestinal stromal tumor (GIST): A case report of GIST at an unusual location and review of the literature
Key Clinical MessageGastrointestinal stromal tumors are the most common malignant subepithelial lesions involving the gastrointestinal tract. Surgical techniques have been the mainstay of treatment, however, in recent times hybrid surgeries are being introduced yielding better clinical outcomes. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 23, 2024 Category: General Medicine Authors: Islam Khaled, Ahmed Hafez Mousa, Houriah Yasir Nukaly, Mohammed Talha Mohammed Zubair, Mohammad Hassan Alsharif, Jakleen Ziyad Abujamai, Ruqayyah Ali Ahmed, Temaa Alklani, Farah Ennab Tags: CASE REPORT Source Type: research

Efficacy and Safety of Endoscopic Resection for Gastric Gastrointestinal Stromal Tumors Originating from the Muscularis Propria
ConclusionsER is proven to be an effective and reasonably safe approach for gastric GISTs originating from the MP. Notably, larger tumor size and irregular shape are identified as risk factors for piecemeal resection during ER procedures. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research

Duodenal gastrointestinal stromal tumor presenting with life ‐threatening upper GI bleeding in a young patient: A case report and literature review
We present a case of a 31-year-old male patient presented with massive active hemateme sis and melena with hemorrhagic shock. The patient presented with massive hematemesis and melena of 1 h duration. Endoscopy showed pulsating active bleeding from the third part of the duodenum which was difficult to manage via endoscopy. Histopathologic evaluation showed spindle cell type GIST. In traoperatively, there was a nodular mass with active bleeding on the third part of the duodenum. Duodenectomy with end-to-end anastomosis was done. Discharged with no postoperative complication and was put on imatinib. There are considerable ...
Source: Clinical Case Reports - April 18, 2024 Category: General Medicine Authors: Samuel Addisu Abera, Amanuel Kassa Tadesse, Kirubel Addisu Abera, Kassa Berie Zegeye, Mohammed Alemu Ibrahim, Ashenafi Amsalu Feleke, Cheru lilay Gebrehiwet, Segenet Bizuneh Mengistu, Hirut Tesfahun Alemu, Yohannis Derbew Molla Tags: CASE REPORT Source Type: research

Adjuvant therapy for rare rectal gastrointestinal stromal tumors: A case report
Key Clinical MessageAnorectal gastrointestinal stromal tumors are extremely rare, constituting less than 0.1% of rectal tumors. Surgical resection using a transanal wide excision followed by adjuvant therapy with tyrosine kinase inhibitors can be a successful treatment combination to remove the mass and prevent recurrence while preserving the integrity of the anal sphincter.AbstractGastrointestinal stromal tumors (GISTs) are a rare subset of neoplasms, accounting for about 1% –2% of primary gastrointestinal malignancies. The stomach is the most common site for GISTs, with anorectal GISTs being exceptionally rare, represe...
Source: Clinical Case Reports - April 17, 2024 Category: General Medicine Authors: Ting ‐Yi Chu, Ta‐Wei Pu, Chao‐Yang Chen Tags: CASE REPORT Source Type: research

A rare case of extragastrointestinal stromal tumor of vocal cord - case report
We present a second case report of Extra-gastrointestinal stromal tumor of larynx a 47-year-old male reported to ENT Department Command Hospital Central Command Lucknow with complaints of Hoarseness. On examination found to have right vocal cord growth for which he underwent excision of right vocal cord growth. Histopathological examination showed typical of a spindle-cell GIST, showing strong immunoreactivity for CD 117, DOG1, Vimentin and CD 99. 6 months follow up post surgery with no recurrence. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 16, 2024 Category: ENT & OMF Source Type: research

The advent of the first electric driven EUS-guided 17 gauge core needle biopsy - A pilot study on subepithelial lesions
CONCLUSIONS: By using an electric driven 17-G biopsy device, a true cylinder of core tissue can be obtained in one single puncture from the area of interest reducing the need for a second sampling. The absolute benefit of EUS-guided CNB is that the sample can be handled and histologically prepared in the same manner as standard percutaneous core needle sample, e.g., breast and prostate cancer.PMID:38618997 | DOI:10.1080/00365521.2024.2336611 (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Fredrik Swahn Robert Glavas Lucin Hultin Malin Wickbom Source Type: research

English version of Japanese Clinical Practice Guidelines 2022 for gastrointestinal stromal tumor (GIST) issued by the Japan Society of Clinical Oncology
AbstractThe Japan Society of Clinical Oncology Clinical Practice Guidelines 2022 for gastrointestinal stromal tumor (GIST) have been published in accordance with the Minds Manual for Guideline Development 2014 and 2017. A specialized team independent of the working group for the revision performed a systematic review. Since GIST is a rare type of tumor, clinical evidence is not sufficient to answer several clinical and background questions. Thus, in these guidelines, we considered that consensus among the experts who manage GIST, the balance between benefits and harms, patients ’ wishes, medical economic perspective, etc...
Source: International Journal of Clinical Oncology - April 13, 2024 Category: Cancer & Oncology Source Type: research

Financial difficulties experienced by patients with gastrointestinal stromal tumours (GIST) in the Netherlands: data from a cross-sectional multicentre study
ConclusionEven in a country where the costs of TKIs and follow-up care are covered by health insurance, financial difficulties can be present in GIST patients, especially in patients on TKI treatment, and may negatively influence the quality of life. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 10, 2024 Category: Cancer & Oncology Source Type: research

Clinically Undiagnosed Diseases in Autopsies: Frequency and Risk Factors
CONCLUSIONS.—: Autopsy is a useful investigation for the detection of clinically undiagnosed entities. In our cohort, cardiac amyloidosis showed the highest number of underlying risk factors, but was clinically underdiagnosed. Our findings underline the necessity of improved clinical detection of cardiac amyloidosis, especially in light of emerging therapeutic options. Moreover, we characterize the most common entities prone to clinical underdiagnosis.PMID:38576236 | DOI:10.5858/arpa.2023-0429-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 5, 2024 Category: Laboratory Medicine Authors: Umberto Maccio Christoph Andreas Meier Michael Reinehr Frank Ruschitzka Reto Sch üpbach Holger Moch Zsuzsanna Varga Source Type: research