Gastrointestinal Stromal Tumor (GIST) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST
Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in gastrointestinal tract and derived from the interstitial cell of Cajal (ICC) lineage. Both ICC and GIST cells highly rely on KIT sign... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 27, 2024 Category: Molecular Biology Authors: Shishan Zhou, Omar Abdihamid, Fengbo Tan, Haiyan Zhou, Heli Liu, Zhi Li, Sheng Xiao and Bin Li Tags: Review Source Type: research

Cancers, Vol. 16, Pages 947: Advancing Precision Oncology in Hereditary Paraganglioma-Pheochromocytoma Syndromes: Integrated Interpretation and Data Sharing of the Germline and Tumor Genomes
INT²GRATE Oncology Consortium Standard methods of variant assessment in hereditary cancer susceptibility genes are limited by the lack of availability of key supporting evidence. In cancer, information derived from tumors can serve as a useful source in delineating the tumor behavior and the role of germline variants in tumor progression. We have previously demonstrated the value of integrating tumor and germline findings to comprehensively assess germline variants in hereditary cancer syndromes. Building on this work, herein, we present the development and application of the INT&sup2;GRATE|HPPGL platform. IN...
Source: Cancers - February 26, 2024 Category: Cancer & Oncology Authors: Rana Koeller Walker Unal Levine Chittenden Isidro Hayes Manam Buehler Manning Barletta Hornick Garber Ghazani INT ²GRATE Oncology Consortium Tags: Article Source Type: research

Advanced gastrointestinal stromal tumor: reliable classification of imatinib plasma trough concentration via machine learning
Patients with advanced gastrointestinal stromal tumors (GISTs) exhibiting an imatinib plasma trough concentration (IM Cmin) under 1100 ng/ml may show a reduced drug response rate, leading to the suggestion of mon... (Source: BMC Cancer)
Source: BMC Cancer - February 24, 2024 Category: Cancer & Oncology Authors: Pan Ran, Tao Tan, Jinjin Li, Hao Yang, Juan Li and Jun Zhang Tags: Research Source Type: research

Exploring Perforated Jejunal GIST: A Rare Case Report and Review of Molecular and Clinical Literature
Curr Issues Mol Biol. 2024 Feb 1;46(2):1192-1207. doi: 10.3390/cimb46020076.ABSTRACTThis case report details a rare instance of a perforated jejunal gastrointestinal stromal tumor (GIST) in a 76-year-old female patient. The patient presented with acute abdominal pain and distension without any changes in bowel habits or episodes of nausea and vomiting. Initial diagnostics, including abdominal plain radiography and ultrasonography, were inconclusive; however, a computed tomography (CT) scan revealed pneumoperitoneum and an irregular fluid collection suggestive of small intestine perforations. Surgical intervention uncovered...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Milos Mirovic Milica Dimitrijevic Stojanovic Marina Jovanovic Vesna Stankovic Danijela Milosev Natasa Zdravkovic Bojan Milosevic Aleksandar Cvetkovic Marko Spasic Berislav Vekic Ivan Jovanovic Bojana S Stojanovic Marko Petrovic Ana Bogut Miodrag Peulic Bo Source Type: research