The protective effects of Gamma-linolenic acid against indomethacin-induced gastric ulcer in rats
Br J Nutr. 2024 Mar 6:1-28. doi: 10.1017/S0007114524000382. Online ahead of print.ABSTRACTThe primary goal of the investigation was to analyze the anti-inflammatory, and antioxidant properties of Gamma-linolenic acid (GLA) on rats with Indomethacin (IND)-induced gastric ulcers. Thirty rats were divided into five groups: Control, IND (50 mg/kg, p.o.), IND pretreated with GLA 100 mg/kg (p.o. for 14 days), IND pretreated with GLA 150 mg/kg (p.o. for 14 days), and IND pretreated with omeprazole (20 mg/kg, p.o. for 14 days). The stomach tissues were examined to calculate the ulcer index, and pH, and analyze biochemical markers ...
Source: The British Journal of Nutrition - March 5, 2024 Category: Nutrition Authors: Kaveh Rahimi Masoumeh Ezzati Givi Anahita Rezaie Mohammad Hekmatmanesh Ysamin Shaker Ardakani Source Type: research
The protective effects of Gamma-linolenic acid against indomethacin-induced gastric ulcer in rats
Br J Nutr. 2024 Mar 6:1-28. doi: 10.1017/S0007114524000382. Online ahead of print.ABSTRACTThe primary goal of the investigation was to analyze the anti-inflammatory, and antioxidant properties of Gamma-linolenic acid (GLA) on rats with Indomethacin (IND)-induced gastric ulcers. Thirty rats were divided into five groups: Control, IND (50 mg/kg, p.o.), IND pretreated with GLA 100 mg/kg (p.o. for 14 days), IND pretreated with GLA 150 mg/kg (p.o. for 14 days), and IND pretreated with omeprazole (20 mg/kg, p.o. for 14 days). The stomach tissues were examined to calculate the ulcer index, and pH, and analyze biochemical markers ...
Source: The British Journal of Nutrition - March 5, 2024 Category: Nutrition Authors: Kaveh Rahimi Masoumeh Ezzati Givi Anahita Rezaie Mohammad Hekmatmanesh Ysamin Shaker Ardakani Source Type: research
The protective effects of Gamma-linolenic acid against indomethacin-induced gastric ulcer in rats
Br J Nutr. 2024 Mar 6:1-28. doi: 10.1017/S0007114524000382. Online ahead of print.ABSTRACTThe primary goal of the investigation was to analyze the anti-inflammatory, and antioxidant properties of Gamma-linolenic acid (GLA) on rats with Indomethacin (IND)-induced gastric ulcers. Thirty rats were divided into five groups: Control, IND (50 mg/kg, p.o.), IND pretreated with GLA 100 mg/kg (p.o. for 14 days), IND pretreated with GLA 150 mg/kg (p.o. for 14 days), and IND pretreated with omeprazole (20 mg/kg, p.o. for 14 days). The stomach tissues were examined to calculate the ulcer index, and pH, and analyze biochemical markers ...
Source: The British Journal of Nutrition - March 5, 2024 Category: Nutrition Authors: Kaveh Rahimi Masoumeh Ezzati Givi Anahita Rezaie Mohammad Hekmatmanesh Ysamin Shaker Ardakani Source Type: research
The protective effects of Gamma-linolenic acid against indomethacin-induced gastric ulcer in rats
Br J Nutr. 2024 Mar 6:1-28. doi: 10.1017/S0007114524000382. Online ahead of print.ABSTRACTThe primary goal of the investigation was to analyze the anti-inflammatory, and antioxidant properties of Gamma-linolenic acid (GLA) on rats with Indomethacin (IND)-induced gastric ulcers. Thirty rats were divided into five groups: Control, IND (50 mg/kg, p.o.), IND pretreated with GLA 100 mg/kg (p.o. for 14 days), IND pretreated with GLA 150 mg/kg (p.o. for 14 days), and IND pretreated with omeprazole (20 mg/kg, p.o. for 14 days). The stomach tissues were examined to calculate the ulcer index, and pH, and analyze biochemical markers ...
Source: The British Journal of Nutrition - March 5, 2024 Category: Nutrition Authors: Kaveh Rahimi Masoumeh Ezzati Givi Anahita Rezaie Mohammad Hekmatmanesh Ysamin Shaker Ardakani Source Type: research
Synthesis and biological evaluation of triazolones/oxadiazolones as novel urease inhibitors
Bioorg Med Chem. 2024 Feb 25;102:117656. doi: 10.1016/j.bmc.2024.117656. Online ahead of print.ABSTRACTUrease is the main virulence factor of infectious gastritis and gastric ulcers. Urease inhibitors are regarded as the first choice for the treatment of such diseases. Based on the triazolone/oxadiazolone skeleton, a urea-like fragment being able to specifically bind the urease activity pocket and prevent urea from hydrolysis, we designed and synthesized 45 triazolones/oxadiazolones as urease inhibitors. Eight compounds were proved to show excellent inhibitory activity against Helicobacter pylori urease, being more potency...
Source: Bioorganic and Medicinal Chemistry - February 29, 2024 Category: Chemistry Authors: Yi-Ning Wang Su-Ya Li Liang-Chao Yuan Shu-Fang Bu Yao Zeng Zhu-Ping Xiao Hai-Liang Zhu Source Type: research
Synthesis and biological evaluation of triazolones/oxadiazolones as novel urease inhibitors
Bioorg Med Chem. 2024 Feb 25;102:117656. doi: 10.1016/j.bmc.2024.117656. Online ahead of print.ABSTRACTUrease is the main virulence factor of infectious gastritis and gastric ulcers. Urease inhibitors are regarded as the first choice for the treatment of such diseases. Based on the triazolone/oxadiazolone skeleton, a urea-like fragment being able to specifically bind the urease activity pocket and prevent urea from hydrolysis, we designed and synthesized 45 triazolones/oxadiazolones as urease inhibitors. Eight compounds were proved to show excellent inhibitory activity against Helicobacter pylori urease, being more potency...
Source: Bioorganic and Medicinal Chemistry - February 29, 2024 Category: Chemistry Authors: Yi-Ning Wang Su-Ya Li Liang-Chao Yuan Shu-Fang Bu Yao Zeng Zhu-Ping Xiao Hai-Liang Zhu Source Type: research
Real-world evidence of Pressure-Enabled Drug Delivery for trans-arterial chemoembolization and radioembolization among patients with hepatocellular carcinoma and liver metastases
Conclusion: Despite higher baseline disease burden and complexity, post-procedure HRU and clinical complications for PEDD patients were similar to non-PEDD patients. The complex baseline clinical profile may reflect selection of challenging cases for PEDD use. Future studies should validate the benefits observed with PEDD embolization in larger samples with greater statistical power.PMID:38414420 | DOI:10.1080/03007995.2024.2322057 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 28, 2024 Category: Research Authors: Keziah Cook Deepshekhar Gupta Yunjuan Liu Chris Miller-Rosales Fangzhou Wei Edward Tuttle Steven C Katz Richard Marshak Alexander Y Kim Source Type: research
Molecules, Vol. 29, Pages 941: Research Progress in Traditional Applications, Phytochemistry, Pharmacology, and Safety Evaluation of Cynomorium songaricum
This article summarizes and categorizes research on the uses, phytochemical characteristics, pharmacological activities, and toxicity of ethnic medicine, with the aim of establishing a solid foundation and proposing new avenues for exploring and developing potential applications of CSR. So far, a total of 98 compounds have been isolated and identified from CSR, including flavonoids, terpenes, steroids, and other compounds. It is worth noting that flavonoids and polysaccharides have significant antioxidant and anti-inflammatory properties. In addition, these compounds also show good application prospects in anti-tumor, anti...
Source: Molecules - February 21, 2024 Category: Chemistry Authors: Jin Zhang Xingyi Chen Lu Han Biao Ma Mengting Tian Changcai Bai Ye Zhang Tags: Review Source Type: research
Molecules, Vol. 29, Pages 880: Dendrobium officinale Polysaccharides as a Natural Functional Component for Acetic-Acid-Induced Gastric Ulcers in Rats
In this study, DOP was extracted and characterized for its structural properties. The potential of DOP to ameliorate gastric ulcers (GUs) was investigated using an acetic-acid-induced GU model in rats. The results demonstrated that DOP exerted a multifaceted protective effect against GU, mitigating the deleterious impact on food intake and body weight in rats. DOP exhibited its protective action by attenuating cellular damage attributed to oxidative stress and inflammatory reactions mediated by enhanced activities of SOD, GSH, and GSH-PX, coupled with a downregulation in the expression of pro-inflammatory cytokines, includ...
Source: Molecules - February 16, 2024 Category: Chemistry Authors: Miao Zhang Liba Xu Long Chen Huan Wu Li Jia Hua Zhu Tags: Article Source Type: research
Antiulcer activity of Mauritia flexuosa L.f. (Arecaceae) pulp oil: An edible Amazonian species with functional properties
This study aimed to evaluate the gastroprotective and antiulcer effects of buriti oil and its possible mechanisms of action. Buriti oil reduced the ulcerative area and lipid peroxidation induced by ethanol. The gastroprotective activity of buriti oil partially depends on nitric oxide and sulfhydryl compounds. In acetic acid-induced gastric ulcers, buriti oil accelerated healing and stimulated the formation of new gastric glands. These results demonstrated the potential of buriti oil as a functional ingredient to promote health benefits in the gastrointestinal tract.PMID:38354821 | DOI:10.1016/j.fitote.2024.105857 (Source: Fitoterapia)
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Maria de F átima Rodrigues Jos é Wellinton da Silva Jucielma Silva de Lima B árbara de Azevedo Ramos Silvania Tavares Paz Diego Lomonaco Davila Zampieri Rafael Matos Ximenes Source Type: research
Antiulcer activity of Mauritia flexuosa L.f. (Arecaceae) pulp oil: An edible Amazonian species with functional properties
This study aimed to evaluate the gastroprotective and antiulcer effects of buriti oil and its possible mechanisms of action. Buriti oil reduced the ulcerative area and lipid peroxidation induced by ethanol. The gastroprotective activity of buriti oil partially depends on nitric oxide and sulfhydryl compounds. In acetic acid-induced gastric ulcers, buriti oil accelerated healing and stimulated the formation of new gastric glands. These results demonstrated the potential of buriti oil as a functional ingredient to promote health benefits in the gastrointestinal tract.PMID:38354821 | DOI:10.1016/j.fitote.2024.105857 (Source: Fitoterapia)
Source: Fitoterapia - February 14, 2024 Category: Biochemistry Authors: Maria de F átima Rodrigues Jos é Wellinton da Silva Jucielma Silva de Lima B árbara de Azevedo Ramos Silvania Tavares Paz Diego Lomonaco Davila Zampieri Rafael Matos Ximenes Source Type: research
Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK- κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations
Gastric ulcers represent a worldwide health problem, characterized by erosions that affect the mucous membrane of the stomach and may even reach the muscular layer, leading to serious complications. Numerous n... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - February 14, 2024 Category: Complementary Medicine Authors: Dalia H. Abu-Baih, Alshymaa Abdel-Rahman Gomaa, Nada Mohamed Abdel-Wahab, Enas Reda Abdelaleem, Azza M. Abdel Zaher, Noha F. Hassan, Gerhard Bringmann, Usama Ramadan Abdelmohsen, Faisal H. Altemani, Naseh A. Algehainy, Fatma Alzahraa Mokhtar and Miada F. Tags: Research Source Type: research
Effects of fish oil on ethanol-induced gastric ulcer in rats: inflammatory responses and oxidative stress
CONCLUSION: The observed effects may be due to the role of FO in regulating gastric secretions, changes in the expression of NF-κB, and changes in the levels of oxidative stress factors.PMID:38333309 | PMC:PMC10849447 | DOI:10.1097/MS9.0000000000001550 (Source: Annals of Medicine)
Source: Annals of Medicine - February 9, 2024 Category: Internal Medicine Authors: Mahtab Taheri Mirghaed Seyedeh Ommolbanin Ghasemian Seyyed Fazlollah Mousavi Nasab Kaveh Rahimi Source Type: research
Type V gastric ulcer: An unusual etiology of gastrosplenic fistula associated with upper gastrointestinal bleeding
Key Clinical MessageType V gastric ulcer is an unusual etiology of gastrosplenic fistula (GSF). Prompt diagnosis and early embolization of splenic vessels prior to esophagogastroduodenoscopy and surgical resection is crucial. (Source: Clinical Case Reports)
Source: Clinical Case Reports - February 9, 2024 Category: General Medicine Authors: Muhammad Nadeem Yousaf,
Riyasha Dahal,
Subeena Phull,
Vinayak Aryal,
Karun Neupane,
Hamza Ertugrul,
Ebubekir Daglilar Tags: CASE REPORT Source Type: research
A Case of Primary Gastric Lymphoma with Spontaneous Perforation
Gan To Kagaku Ryoho. 2023 Dec;50(13):1468-1470.ABSTRACTAn 85-year-old female patient presented to the emergency department with the chief complaint of sudden upper abdominal pain. The patient suffered from anorexia and epigastric pain for a month, and a local physician suspected a diagnosis of gastric ulcer. An abdominal computed tomography(CT)scan showed intraperitoneal free air as well as irregular thickening and thinning of the gastric wall. Gastric ulcer perforation was suspected, and an emergency operation was performed. Surgical findings showed thickening of the gastric wall in the pylorus and gastric corpus but part...
Source: Pain Physician - February 2, 2024 Category: Anesthesiology Authors: Susumu Suzuki Karin Nakajima Hikaru Terao Shota Ishii Motoharu Hirai Tomohiro Maruyama Kazuhiro Kaneko Tomoi Sato Takayuki Okada Takashi Aono Masaki Hasegawa Source Type: research
