Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
This study aimed to investigate the possible alleviating effect of a combined treatment of pantoprazole (PANTO) and adipose tissue-derived mesenchymal stem cells (ADSCs) in comparison with each treatment alone on the healing process of the experimentally induced GU in rats, and to uncover the involved pathways. Rats were divided into five groups: (1) Control, (2) GU, (3) PANTO, (4) ADSCs and (5) ADSCs + PANTO. Markers of oxidative stress, inflammation and apoptosis were assessed. The current data indicated that PANTO-, ADSCs- and ADSCs + PANTO-treated groups showed significant drop (p < 0.05) in serum adva...
Source: Inflammopharmacology - April 23, 2024 Category: Drugs & Pharmacology Source Type: research
Syringic acid guards against indomethacin-induced gastric ulcer by alleviating inflammation, oxidative stress and apoptosis
Biotech Histochem. 2024 Apr 22:1-10. doi: 10.1080/10520295.2024.2344477. Online ahead of print.ABSTRACTThe purpose of this study was to evaluate the effects of syringic acid, an anti-oxidant, on indomethacin induced gastric ulcers in rats. Experimental groups were control, ulcer, ulcer treated with 20 mg/kg esomeprazole (a proton pump inhibitor that reduces acid secretion), and ulcer treated with 100 mg/kg syringic acid. Rats were pretreated with esomeprazole or syringic acid two weeks before ulcer induction. Our histopathological observations showed that either syringic acid or esomeprazole attenuated the severity of gast...
Source: Biotechnic and Histochemistry - April 22, 2024 Category: Research Authors: Irmak Ferah Okkay Ufuk Okkay Betul Cicek Ozhan Karatas Aysegul Yilmaz Fatma Yesilyurt Ahmet Hacimuftuoglu Source Type: research
Syringic acid guards against indomethacin-induced gastric ulcer by alleviating inflammation, oxidative stress and apoptosis
Biotech Histochem. 2024 Apr 22:1-10. doi: 10.1080/10520295.2024.2344477. Online ahead of print.ABSTRACTThe purpose of this study was to evaluate the effects of syringic acid, an anti-oxidant, on indomethacin induced gastric ulcers in rats. Experimental groups were control, ulcer, ulcer treated with 20 mg/kg esomeprazole (a proton pump inhibitor that reduces acid secretion), and ulcer treated with 100 mg/kg syringic acid. Rats were pretreated with esomeprazole or syringic acid two weeks before ulcer induction. Our histopathological observations showed that either syringic acid or esomeprazole attenuated the severity of gast...
Source: Biotechnic and Histochemistry - April 22, 2024 Category: Research Authors: Irmak Ferah Okkay Ufuk Okkay Betul Cicek Ozhan Karatas Aysegul Yilmaz Fatma Yesilyurt Ahmet Hacimuftuoglu Source Type: research
The trends of pediatric duodenal ulcer and predictors of recurrence
CONCLUSIONS: Hp-positive DU seems to wane. Patients with male sex, lower Hb level, or perforation at diagnosis carried a higher risk of recurrence, which may warrant active surveillance and endoscopic follow-up.PMID:38644127 | DOI:10.1016/j.jfma.2024.04.011 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 21, 2024 Category: General Medicine Authors: Pai-Jui Yeh Chien-Chang Chen Hsun-Chin Chao Jin-Yao Lai Yung-Ching Ming Mi-Chi Chen Ming-Wei Lai Source Type: research
Ferulic acid nanoemulsion as a promising anti-ulcer tool: In vitro and in vivo assessment
Conclusion: Findings suggest that the prepared ferulic acid nanoemulsion is an ideal anti-ulcer system, which is worthy of further investigations.PMID:38602337 | DOI:10.1080/03639045.2024.2341786 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 11, 2024 Category: Drugs & Pharmacology Authors: Hend Abd-Allah Gehad A Abdel Jaleel Azza Hassan Mevidette El Madani Maha Nasr Source Type: research
Ferulic acid nanoemulsion as a promising anti-ulcer tool: in vitro and in vivo assessment
CONCLUSION: Findings suggest that the prepared ferulic acid nanoemulsion is an ideal anti-ulcer system, which is worthy of further investigations.PMID:38602337 | DOI:10.1080/03639045.2024.2341786 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 11, 2024 Category: Drugs & Pharmacology Authors: Hend Abd-Allah Gehad A Abdel Jaleel Azza Hassan Mevidette El Madani Maha Nasr Source Type: research
Effects of total saikosaponins on CYP3A4 and CYP1A2 in HepaRG cells
Exp Ther Med. 2024 Mar 21;27(5):217. doi: 10.3892/etm.2024.12505. eCollection 2024 May.ABSTRACTTotal saikosaponins (TSS) form a group of chemically and biologically active components that can be extracted from Bupleurum, with reported antidepressive, anti-inflammatory, antiviral, antiendotoxin, antitumor, anti-pulmonary fibrosis and anti-gastric ulcer effects. Bupleurum or TSS is frequently utilized in clinical practice alongside other medications (such as entecavir, lamivudine, compound paracetamol and amantadine hydrochloride capsules), leading to an increased risk of drug-drug interactions. The cytochrome P450 (CYP) fam...
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Yunyan Tang Hongfang Li Jianhua Tang Lei Hu Feifei Ma Yanmiao Liu Fushan Tang Source Type: research
Effects of total saikosaponins on CYP3A4 and CYP1A2 in HepaRG cells
Exp Ther Med. 2024 Mar 21;27(5):217. doi: 10.3892/etm.2024.12505. eCollection 2024 May.ABSTRACTTotal saikosaponins (TSS) form a group of chemically and biologically active components that can be extracted from Bupleurum, with reported antidepressive, anti-inflammatory, antiviral, antiendotoxin, antitumor, anti-pulmonary fibrosis and anti-gastric ulcer effects. Bupleurum or TSS is frequently utilized in clinical practice alongside other medications (such as entecavir, lamivudine, compound paracetamol and amantadine hydrochloride capsules), leading to an increased risk of drug-drug interactions. The cytochrome P450 (CYP) fam...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yunyan Tang Hongfang Li Jianhua Tang Lei Hu Feifei Ma Yanmiao Liu Fushan Tang Source Type: research
Retraction Note: The gastro protective effects of Cibotium barometz hair on ethanol-induced gastric ulcer in sprague-dawley rats
(Source: BMC Veterinary Research)
Source: BMC Veterinary Research - April 6, 2024 Category: Veterinary Research Authors: Nahla Saeed AL-Wajeeh, Maryam Hajerezaie, Suzita Mohd Noor, Mohammed Farouq Halabi, Nawal Al-Henhena, Ainnul Hamidah Syahadah Azizan, Sareh Kamran, Pouya Hassandarvish, Abdrabuh N. Shwter, Hamed karimian, Hapipah Mohd Ali and Mahmood Ameen Abdulla Tags: Retraction Note Source Type: research
Using a novel hemostatic peptide solution to prevent bleeding after endoscopic submucosal dissection of a gastric tumor
CONCLUSION: PuraStat application is not associated with post-ESD bleeding. However, the study suggests that gravitational forces may affect the effectiveness of applied PuraStat.PMID:38577651 | PMC:PMC10989251 | DOI:10.4253/wjge.v16.i3.168 (Source: Cancer Control)
Source: Cancer Control - April 5, 2024 Category: Cancer & Oncology Authors: Kuniyo Gomi Yorimasa Yamamoto Erika Yoshida Misako Tohata Masatsugu Nagahama Source Type: research
Potential for expanded application of endoscopic hand suturing: A pilot study of 15 cases
In conclusion, EHS appears feasible and safe in situations. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - April 5, 2024 Category: Gastroenterology Authors: Higuchi, Kazutoshi Goto, Osamu Koizumi, Eriko Nakagome, Shun Habu, Tsugumi Ishikawa, Yumiko Kirita, Kumiko Noda, Hiroto Onda, Takeshi Omori, Jun Akimoto, Naohiko Iwakiri, Katsuhiko Tags: Innovation forum Source Type: research
Gastroprotective Effect of 2,3-Dimethylquinoxaline Against Indomethacin-Induced Gastric Ulcer in Rat
CONCLUSION: DMQ demonstrated promising gastroprotective effects against IND-induced gastric ulcers, as evidenced by alterations in histopathological data and upregulation of gene expression.PMID:38566982 | PMC:PMC10986627 | DOI:10.2147/JIR.S453425 (Source: Cancer Control)
Source: Cancer Control - April 3, 2024 Category: Cancer & Oncology Authors: Abdelbagi Alfadil Source Type: research
Overexpression of HSP27 accelerates stress-induced gastric ulcer healing via the CXCL12/CXCR4 axis
Clin Exp Pharmacol Physiol. 2024 May;51(5):e13857. doi: 10.1111/1440-1681.13857.ABSTRACTChronic stress often triggers gastrointestinal complications, including gastric injury and ulcers. Understanding the role of heat shock protein 27 (HSP27) in stress-induced gastric ulcers could unveil novel therapeutic targets. Here, we established a stress-induced gastric ulcer rat model using water immersion restraint stress and administered adenovirus-packaged HSP27 overexpression vector. Gastric ulcer severity was scored, and mucosal changes were assessed. Gastric epithelial and endothelial cells were treated with lipopolysaccharide...
Source: Clinical and Experimental Pharmacology and Physiology - April 3, 2024 Category: Drugs & Pharmacology Authors: Qiaoyan Lu Hua Tang Source Type: research
Overexpression of HSP27 accelerates stress-induced gastric ulcer healing via the CXCL12/CXCR4 axis
Clin Exp Pharmacol Physiol. 2024 May;51(5):e13857. doi: 10.1111/1440-1681.13857.ABSTRACTChronic stress often triggers gastrointestinal complications, including gastric injury and ulcers. Understanding the role of heat shock protein 27 (HSP27) in stress-induced gastric ulcers could unveil novel therapeutic targets. Here, we established a stress-induced gastric ulcer rat model using water immersion restraint stress and administered adenovirus-packaged HSP27 overexpression vector. Gastric ulcer severity was scored, and mucosal changes were assessed. Gastric epithelial and endothelial cells were treated with lipopolysaccharide...
Source: Clinical and Experimental Pharmacology and Physiology - April 3, 2024 Category: Drugs & Pharmacology Authors: Qiaoyan Lu Hua Tang Source Type: research
