Hospital Admission Factors Independently Affecting the Risk of Mortality of COVID-19 Patients
CONCLUSIONS: We found that low oxygen saturation, old age, and the coexistence of cancer, gastric ulcers, and dementia syndrome were variables that independently increased mortality during hospitalization due to COVID-19. Moreover, we found that decreased platelet count and bilirubin concentration and increased levels of LDH and NT-proBNP were laboratory test results that independently indicated a higher risk of mortality. We also confirmed the usefulness of the SOFA scale in predicting treatment results. The ability to identify mortality risk factors on admission to hospital will facilitate both adjusting the intensity of...
Source: Clinical Lung Cancer - October 14, 2023 Category: Cancer & Oncology Authors: Marcin Paciorek Carlo Bie ńkowski Justyna Dominika Kowalska Agata Skrzat-Klapaczy ńska Agnieszka Bednarska Dominika Krogulec Gra żyna Cholewińska Jacek Kowalski Regina Podlasin Katarzyna Ropelewska- Łącka Piotr Wasilewski Piotr W Boros Magdalena M M Source Type: research
Hospital Admission Factors Independently Affecting the Risk of Mortality of COVID-19 Patients
CONCLUSIONS: We found that low oxygen saturation, old age, and the coexistence of cancer, gastric ulcers, and dementia syndrome were variables that independently increased mortality during hospitalization due to COVID-19. Moreover, we found that decreased platelet count and bilirubin concentration and increased levels of LDH and NT-proBNP were laboratory test results that independently indicated a higher risk of mortality. We also confirmed the usefulness of the SOFA scale in predicting treatment results. The ability to identify mortality risk factors on admission to hospital will facilitate both adjusting the intensity of...
Source: Clinical Lung Cancer - October 14, 2023 Category: Cancer & Oncology Authors: Marcin Paciorek Carlo Bie ńkowski Justyna Dominika Kowalska Agata Skrzat-Klapaczy ńska Agnieszka Bednarska Dominika Krogulec Gra żyna Cholewińska Jacek Kowalski Regina Podlasin Katarzyna Ropelewska- Łącka Piotr Wasilewski Piotr W Boros Magdalena M M Source Type: research
pH-Responsive Polymeric Micelle Dynamic Complexes for Selective Killing of < em > Helicobacter pylori < /em >
This study provides insight into the influence of both polymer architecture and dynamic assembly on the bioactivities of antimicrobial polymers, where the disassembly of coacervates into narrowly dispersed micelles at pH 3 make them potent antimicrobials aided by the protonated carboxylic acid block.PMID:37828909 | DOI:10.1021/acs.biomac.2c01374 (Source: Biomacromolecules)
Source: Biomacromolecules - October 13, 2023 Category: Biochemistry Authors: Jason Tan Yunhui Fang Chuan Yang Joyce Tay Nathanael Tan Nithiyaa D/O Bala Krishnan Boon Lin Chua Yanli Zhao Yunbo Chen James L Hedrick Yi Yan Yang Source Type: research
pH-Responsive Polymeric Micelle Dynamic Complexes for Selective Killing of < em > Helicobacter pylori < /em >
This study provides insight into the influence of both polymer architecture and dynamic assembly on the bioactivities of antimicrobial polymers, where the disassembly of coacervates into narrowly dispersed micelles at pH 3 make them potent antimicrobials aided by the protonated carboxylic acid block.PMID:37828909 | DOI:10.1021/acs.biomac.2c01374 (Source: Biomacromolecules)
Source: Biomacromolecules - October 13, 2023 Category: Biochemistry Authors: Jason Tan Yunhui Fang Chuan Yang Joyce Tay Nathanael Tan Nithiyaa D/O Bala Krishnan Boon Lin Chua Yanli Zhao Yunbo Chen James L Hedrick Yi Yan Yang Source Type: research
pH-Responsive Polymeric Micelle Dynamic Complexes for Selective Killing of < em > Helicobacter pylori < /em >
This study provides insight into the influence of both polymer architecture and dynamic assembly on the bioactivities of antimicrobial polymers, where the disassembly of coacervates into narrowly dispersed micelles at pH 3 make them potent antimicrobials aided by the protonated carboxylic acid block.PMID:37828909 | DOI:10.1021/acs.biomac.2c01374 (Source: Biomacromolecules)
Source: Biomacromolecules - October 13, 2023 Category: Biochemistry Authors: Jason Tan Yunhui Fang Chuan Yang Joyce Tay Nathanael Tan Nithiyaa D/O Bala Krishnan Boon Lin Chua Yanli Zhao Yunbo Chen James L Hedrick Yi Yan Yang Source Type: research
STITCH enabled molecular interaction of glycrhizzin with peri-implant microbiota
Bioinformation. 2023 Apr 30;19(4):499-501. doi: 10.6026/97320630019499. eCollection 2023.ABSTRACTGlycyrrhizin is present in the root extract of the licorice plant used for various conditions, including gastric ulcers. Therefore, it is of interest to document the STITCH enabled molecular interaction of glycrhizzin with peri-implant microbiota. The peri implant pathogens includes Aggregatibacter actinomycetemcomitans (D7S-1), Centipeda periodontii, Campylobacter gracilisi, Fusobacterium nucleatumi, Slackia exigua, Prevotella intermedia, Tannerella forsythia, Staphylococcus aureus, Bacteroides fragilis, and Bacteroides fragil...
Source: Bioinformation - October 12, 2023 Category: Bioinformatics Authors: Karthickraj Selladurai Sahana Selvaganesh Vishnu Priya Veeraraghavan Thiyaneswaran Nesappan Rajalakshmanan Eswaramoorthy Source Type: research
STITCH enabled molecular interaction of glycrhizzin with peri-implant microbiota
Bioinformation. 2023 Apr 30;19(4):499-501. doi: 10.6026/97320630019499. eCollection 2023.ABSTRACTGlycyrrhizin is present in the root extract of the licorice plant used for various conditions, including gastric ulcers. Therefore, it is of interest to document the STITCH enabled molecular interaction of glycrhizzin with peri-implant microbiota. The peri implant pathogens includes Aggregatibacter actinomycetemcomitans (D7S-1), Centipeda periodontii, Campylobacter gracilisi, Fusobacterium nucleatumi, Slackia exigua, Prevotella intermedia, Tannerella forsythia, Staphylococcus aureus, Bacteroides fragilis, and Bacteroides fragil...
Source: Bioinformation - October 12, 2023 Category: Bioinformatics Authors: Karthickraj Selladurai Sahana Selvaganesh Vishnu Priya Veeraraghavan Thiyaneswaran Nesappan Rajalakshmanan Eswaramoorthy Source Type: research
Idiopathic Gastric Antral Ulcers
Intern Med. 2023 Oct 6. doi: 10.2169/internalmedicine.2554-23. Online ahead of print.ABSTRACTA Japanese woman presented with gastric antral ulcers accompanied by erosion and edema, demonstrating a chronic pattern of improvement and recurrence for more than six years. The patient had no relevant treatment history, and Helicobacter pylori infection was ruled out. Other potential etiologies contributing to gastric ulcers were eliminated on the basis of endoscopic biopsy and blood laboratory findings. Consequently, the patient was diagnosed with idiopathic gastric antral ulcer. This disease is often overlooked, and the chronol...
Source: Internal Medicine - October 9, 2023 Category: Internal Medicine Authors: Masaya Iwamuro Takehiro Tanaka Seiji Kawano Yoshiro Kawahara Motoyuki Otsuka Source Type: research
1,4-Diaryl-1,2,3-triazole neolignan –celecoxib hybrids inhibit experimental arthritis induced by zymosan
AbstractRheumatoid arthritis (RA) is a chronic autoimmune disease that causes cartilage damage. Anti-inflammatories are widely used in the management of RA, but they can have side effects such as gastrointestinal and/or cardiovascular disorders. Studies published by our group showed that the synthesis of hybrid triazole analogs neolignan –celecoxib containing the substituent groups sulfonamide (L15) or carboxylic acid (L18) exhibited anti-inflammatory activity in an acute model of inflammation, inhibited expression of P-selectin related to platelet activation and did not induce gastric ulcer, minimizing the related side ...
Source: Inflammopharmacology - October 8, 2023 Category: Drugs & Pharmacology Source Type: research
Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases
ConclusionIn this study, the pathogenic bacterial genera in the gut microbiota that promote the occurrence of PUDs were found to be causally related. There are multiple correlations between intestinal flora and PUDs, overlapping PUDs have overlapping associated genera. The variance in ulcer-related bacterial genera across different locations underscores the potential influence of anatomical locations and physiological functions. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - October 5, 2023 Category: Allergy & Immunology Source Type: research
Use of immunoinformatics and the simulation approach to identify Helicobacter pylori epitopes to design a multi-epitope subunit vaccine for B- and T-cells
Helicobacter pylori cause a variety of gastric malignancies, gastric ulcers, and cause erosive diseases. The extreme nature of the bacterium and the implantation of this bacterium protects it against designing a ... (Source: BMC Biotechnology)
Source: BMC Biotechnology - September 27, 2023 Category: Biotechnology Authors: Zahra Ahmadzadeh Chaleshtori, Ali Asghar Rastegari, Hashem Nayeri and Abbas Doosti Tags: Research Source Type: research
