Metformin Found to Reduce Liver Inflammation
Metformin produces a modest and unreliable extension of life in animal models, and human data shows a small increase in life span in diabetic patients. This is thought to work as a calorie restriction mimetic drug, triggering one slice of the beneficial response to a reduced nutrient intake. Researchers here dig further in the biochemistry of the drug, and find that it reduces liver inflammation in addition to other, known effects. This is interesting, and suggestive that any benefits it produces are going to be much smaller in healthier older adults with lower levels of chronic inflammation. It doesn't change the fact tha...
Source: Fight Aging! - September 17, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit.
Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Public Cannot Distinguish Between Scientific versus Unscientific, Likely Good versus Likely Bad Approaches to Longevity
One of the challenges inherent in patient advocacy for greater human longevity, for more research into aging and rejuvenation, is that journalists and the public at large either cannot or will not put in the effort needed to distinguish between: (a) scientific, plausible, and likely useful projects, those with a good expectation of addressing aging to a meaningful degree; (b) scientific, plausible, and likely unhelpful projects, those that will do little to move the needle on life expectancy, and (c) products and programs that consist of marketing, lies, and little else. This last category is depressingly large, and the fi...
Source: Fight Aging! - August 20, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What is ME – Myalgic Encephalomyelitis?
Myalgic Encephalomyelitis, also known as Chronic Fatigue Syndrome, is a little-understood, female-biased [1] illness. It is estimated that up to 90% of people with the condition go diagnosed [2] and about 25% of sufferers are severely ill [3]. In recognition of the profound physical and psychological impact this disease has on its victims, August 8th has been designated as a Severe ME Awareness Day.
What is Myalgic Encephalomyelitis (ME)?
The disease is best known for a state of extreme and unremitting fatigue. A range of additional symptoms may suggest the presence of an infectious disease: myalgia, nausea, cogniti...
Source: GIDEON blog - August 8, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Identify News Source Type: blogs
Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons.
Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Efforts Continue to Use COVID-19 as a Learning Moment Regarding the Costs of Aging
Near everyone who dies from the SARS-Cov-2 virus responsible for the COVID-19 pandemic is old. The old are vulnerable firstly because their immune systems are much diminished in effectiveness, and secondly because the state of chronic inflammation characteristic of old age makes the cytokine storm that causes much of the SARS-Cov-2 mortality more likely and more severe.
Members of the medical research community focused on intervention in the aging process - a way to treat all age-related conditions by addressing their underlying causes - are attempting to use the attention given to COVID-19 to educate the public and...
Source: Fight Aging! - July 17, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 6th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - July 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Autophagy in Cardiovascular Aging is a Complicated Matter
Cell and tissue biology always turns out to be more complicated than we would all prefer. Present understanding is rarely complete to the point at which all obstacles are known. It is one of the reasons why the development of new classes of medical therapy is a challenging business. Consider the topic of autophagy in aging, for example. Autophagy is the name given to a collection of processes responsible for recycling unwanted and damaged molecules and structures in the cell. Material is conveyed, in one way or another depending on the type of autophagy, to a lysosome and engulfed. Lysosomes are membrane-bound packages of ...
Source: Fight Aging! - July 2, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 6th 2020
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted.
Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - April 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Longevity 2020 Online Conference, to be Held April 27th to May 1st 2020
All of the longevity industry and gerontology conferences in coming months have been cancelled or rescheduled as a result of the present mix of COVID-19 pandemic and hysteria. An equal mix of both, perhaps. The best data to date puts the mortality rate at 0.66% or so, meaning about six yearly flu seasons worth of risk, and even that number is most likely still overstating the risk, as it misses the presently unknown count of infections that result in only minor symptoms. An article from earlier in the month on the uncertainties in all published numbers remains one of the more sane pieces written on the topic.
Still,...
Source: Fight Aging! - April 2, 2020 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Age-Slowing Interventions in the Context of Lung Aging
Researchers here consider a very conservative set of interventions known to modestly slow the progression of aging in laboratory species, largely by altering metabolism to upregulate beneficial cellular stress responses. The researchers look through the lens of lung aging, specifically, reviewing the evidence for these therapies to slow the deterioration in lung function and onset of lung disease in older individuals, or to be the basis for treating established lung disease.
To date, the most reliable, best-researched way to extend life span is through the practice of calorie restriction (CR), which involves reduc...
Source: Fight Aging! - April 1, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Ovulation Testing After Tubal Reversal: A Fertility Surgeon ’s Advice
Ovulation testing can increase your chances of pregnancy. Dr Monteith offers easy to understand advice for a seemingly complicated fertility test.
The post Ovulation Testing After Tubal Reversal: A Fertility Surgeon’s Advice appeared first on A Personal Choice. (Source: Tubal Reversal Blog)
Source: Tubal Reversal Blog - March 27, 2020 Category: Reproduction Medicine Authors: Dr. Monteith Tags: basal body temperature clomid Femera lh testing menstruation metformin ovulation ovulation testing period pregnancy Source Type: blogs
My Infertility Journey as a Woman in Medicine
Editor’s Note: For more on the challenges as well as strategies to address physician infertility, please read this Academic Medicine Invited Commentary, cowritten by the author of this blog post.
Most of us in medicine pride ourselves on being organized, detail-oriented, conscientious and able to achieve excellent results with enough hard work—and are not used to failure and loss of control. My experience with infertility has been the first time that I truly experienced failure and complete loss of control, realizing that fertility is not a merit-based system. No matter how hard I try, how many doctors I cons...
Source: Academic Medicine Blog - March 11, 2020 Category: Universities & Medical Training Authors: Guest Author Tags: Featured Guest Perspective infertility physician well-being women in academic medicine Source Type: blogs
You think insurance is confusing? Try being a patient.
My husband is a type 2 diabetic with mild chronic kidney disease, which has been well controlled on 500 mg metformin BID plus saxagliptin (AstraZeneca’s Onglyza). At the end of last year, he got a letter from his Medicare Advantage PPO, UnitedHealthcare (UHC), advising him that the Onglyza (UHC only uses brand names) would no […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 4, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/lynne-peterson" rel="tag" > Lynne Peterson < /a > < /span > Tags: Patient Diabetes Medications Source Type: blogs
Fight Aging! Newsletter, February 3rd 2020
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - February 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
