Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Evidence that Metformin Does Not Interfere in the Beneficial Response to Exercise
There have been suggested that metformin, a at best weak calorie restriction mimetic, can suppress some of the beneficial metabolic response to exercise. Metformin is in general a poor choice in comparison to mTOR inhibitors when it comes to animal evidence for an ability to modestly slow the progression of aging. The primary human evidence for metformin to be useful, and why it attracted interest in the first place, comes from a large study of diabetic patients, and the gain in life expectancy was not large. Researchers here provide evidence against any suppression by metformin of beneficial mechanisms resulting from exer...
Source: Fight Aging! - November 26, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Present Calorie Restriction Mimetics are a Poor Substitute for the Practice of Calorie Restriction
The portion of the medical research and development community that is focused on aging spends most of its time and funding on classes of treatment that cannot outperform good lifestyle choices when it comes to improving health and slowing degenerative aging. Why is this? If billions and decades are to be expended on building a pipeline from fundamental research through to clinical trials, why is the goal only an incremental benefit to health, smaller than that produced by regular exercise, intermittent fasting, or the practice of calorie restriction? Why such a lack of ambition, given the many possible projects that could ...
Source: Fight Aging! - November 24, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 15th 2021
This article will review the relationship between diabetes mellitus and AD as it relates to tau pathology. More understanding of the link between diabetes mellitus and AD could change the approach researchers and clinicians take toward both diseases, potentially leading to new treatments and preventative strategies in the future.
Signaling from White Fat Tissue Contributes to Age-Related Hair Follicle Dysfunction
https://www.fightaging.org/archives/2021/11/signaling-from-white-fat-tissue-contributes-to-age-related-hair-follicle-dysfunction/
Changes in fat tissue behavior in the skin take place with age,...
Source: Fight Aging! - November 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Literature on Prevention of Cellular Senescence in Stem Cells
In today's open access paper, the authors report on a literature search for efforts to reduce cellular senescence in stem cell populations. The majority of the work they list, involving the assessment of pharmacological agents that can influence the onset of cellular senescence, has taken place in cell cultures, an environment that has very little relevance to what happens in stem cell niches in a living organism. Stem cells in a petri dish undergo very different rates of replication, have different stresses and signals, are not subject to interactions with supporting cells of the niche, and so forth.
Thus I'd be in...
Source: Fight Aging! - November 9, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 1st 2021
In conclusion, mitophagy pathways play an important role in maintaining physiological homeostasis, are involved in the mechanisms of aging and neurodegenerative disorders, and represent promising targets for the development of potential therapeutic agents aimed at regulating mitochondria quality control in neurons and glial cells. A significant number of molecules that induce or inhibit mitophagy are currently under consideration, which may be useful for testing hypotheses or developing drugs for the treatment of neurodegenerative diseases. The validation of promising drugs in animal and cell models, including neurons and ...
Source: Fight Aging! - October 31, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence Promotes Metabolic Dysfunction, in Turn Promoting Cellular Senescence
Aging is built on feedback loops, interactions between damage and dysfunction in which both sides accelerate the other. This is a feature of all complex systems, not just biological ones. The existence of feedback loops in which damage accumulation causes dysfunction that accelerates damage accumulation is the fundamental reason as to why aging is an accelerating process. It starts slowly, and moves ever more rapidly with time. Aging in one's 30s is a very different beast to aging in one's 70s, and the downhill slide is much faster in later life.
The way to break this cycle is to repair the damage. This is true whet...
Source: Fight Aging! - October 27, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The dream patient that makes a doctor very happy
Mr. Williams is a 52-year old male who has been following me for some time. He has just been started on metformin for newly diagnosed diabetes. Lisinopril is his only other medication for high blood pressure. When he had his yearly physical, he was also found to have a high LDL“bad” cholesterol of 150.Read more …The dream patient that makes a doctor very happy originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 26, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/suneel-dhand" rel="tag" > Suneel Dhand, MD < /a > < /span > Tags: Conditions Cardiology Source Type: blogs
Fight Aging! Newsletter, September 27th 2021
This study provides causal evidence of a lipoprotein-Aß /capillary axis for onset and progression of a neurodegenerative process.
The Staggering Ongoing Cost of Failing to Aggressively Pursue the Development of Rejuvenation Therapies
https://www.fightaging.org/archives/2021/09/the-staggering-ongoing-cost-of-failing-to-aggressively-pursue-the-development-of-rejuvenation-therapies/
No feasible amount of funding that could be devoted to the research and development of rejuvenation therapies would be too much. If near all other projects were dropped, and institutions radically retooled on a short term basi...
Source: Fight Aging! - September 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Staggering Ongoing Cost of Failing to Aggressively Pursue the Development of Rejuvenation Therapies
No feasible amount of funding that could be devoted to the research and development of rejuvenation therapies would be too much. If near all other projects were dropped, and institutions radically retooled on a short term basis, then the world might be able to devote $300 billion per year into medical research and development aimed at aging. That is an unachievable upper bound, of course. Given a few decades in which to train new researchers while rapidly and radically expanding existing institutions, then humanity might start to approach that scale of expenditure. Realistically it will take 20-30 years following the first...
Source: Fight Aging! - September 24, 2021 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Fight Aging! Newsletter, September 20th 2021
In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients.
NANOG Expression versus Cellular Senescence
https://www.fightaging.org/archives/2021/09/nanog-expression-versus-cellular-senescence/
Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living a...
Source: Fight Aging! - September 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Restoration of Autophagy as a Goal in the Treatment of Aging
The processes of autophagy act to remove damaged molecular machinery and structures in the cell. Autophagy becomes dysfunctional with age, however. This is likely downstream of underlying causes of aging that cause changes in gene expression that degrade the function of autophagic processes in one way or another. For example mitophagy, the clearance of damaged mitochondria by autophagy, is indirectly negatively impacted by changes in mitochondrial dynamics resulting from altered gene expression. Equally, age-related changes in gene expression produce defects in the formation of autophagosomes, and this affects all aspects ...
Source: Fight Aging! - September 16, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Notes from the Aging Research and Drug Discovery 2021 Conference
The Longevity.technology team has been publishing notes on the recent Aging Research and Drug Discovery (ARDD) conference, one of the few events at the end of this year to be held in person again after the long pandemic hiatus. It was a challenge for conference organizers to look into the crystal ball six to twelve months in advance and commit to a late 2021 event, but some did. The 2022 conference season will no doubt be interesting, as restrictions relax sufficiently for reliable travel and advance scheduling, and a few years of the suppressed urge to network is finally unleashed. The ARDD conferences are more focused on...
Source: Fight Aging! - September 14, 2021 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, September 6th 2021
In conclusion, patients over 90 years of age had an overall low prevalence of fractures and relative preservation of bone health, suggesting a preserved bone molecular profile in these individuals. Epigenetic factors and activity levels might also have favorably affected bone health. The low percentage of osteoporosis and fractures likely reduced the morbidity and mortality in this population, potentially contributing to their overall longevity.
Building a Therapy for Aging Based on SIRT6 Upregulation
https://www.fightaging.org/archives/2021/08/building-a-therapy-for-aging-based-on-sirt6-upregulation/
G...
Source: Fight Aging! - September 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Metformin Remains a Poor Choice in the Treatment of Aging
Now that we find ourselves in an era in which there is growing support and funding for the treatment of aging as a medical condition, the battle ceases to be one of persuading people to take the idea seriously, and more a matter of convincing research and development concerns to focus on projects that are more likely rather than less likely to produce meaningful gains. Rejuvenation and many added years is the desired goal, not merely a gentle slowing of aging that is little better than the results of optimal exercise and diet. Unfortunately, most of the research and development community is indeed working on projects that ...
Source: Fight Aging! - September 2, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
