Do Statins Raise Odds for Type 2 Diabetes? Maybe, but heart benefits likely outweigh any potential risk from the drugs, experts say
The following is an article recently published on WebMD. Many patients have mentioned to me the reports about statins increasing the risk of developing Type 2 Diabetes. I definitely agree with Drs Crandall and Donovan (see statements in orange below). The benefits of statins in terms of prevention of cardiovascular events outweigh the slight increase risk in HgbA1C/DM.By Serena GordonHealthDay ReporterTUESDAY, Oct. 24, 2017 (HealthDay News) -- Cholesterol-lowering medications known as statins may lower your risk of heart disease, but also might boost the odds you ' ll develop type 2 diabe...
Source: Dr Portnay - November 13, 2017 Category: Cardiology Authors: Dr Portnay Source Type: blogs
Fight Aging! Newsletter, October 30th 2017
In this study, the researchers showed a causal link between dynamic changes in the shapes of mitochondrial networks and longevity.
The scientists used C. elegans (nematode worms), which live just two weeks and thus enable the study of aging in real time in the lab. Mitochondrial networks inside cells typically toggle between fused and fragmented states. The researchers found that restricting the worms' diet, or mimicking dietary restriction through genetic manipulation of an energy-sensing protein called AMP-activated protein kinase (AMPK), maintained the mitochondrial networks in a fused or "youthful" state. In add...
Source: Fight Aging! - October 29, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Interview with Yuri Deigin of Youthereum Genetics: the Merging of an Initial Coin Offering and Pluripotency Factors
Initial coin offerings (ICOs) are driving most of the light and heat in the blockchain world these days. People are raising enormous sums in cryptocurrencies for ventures with somewhere between little plausibility and ordinary levels of startup plausibility. In many ways it looks a lot like the last years of the internet bubble way back when; there are a lot of parallels. The flows of funding may be driven by some combination of people bypassing Chinese currency controls, early holders of Bitcoins and Ether diversifying their holdings within the blockchain ecosystem, and various large investment concerns whose owners have ...
Source: Fight Aging! - October 27, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Test almost all of your most important ECG rhythm interpretation skills with this case.
Sent by Anonymous, written by Meyers, edits by Smith:A female in her 70s with history of HTN woke up around 2am with severe shortness of breath. EMS found the patient in moderate respiratory distress, hypoxemic on room air, with diffuse rales. CPAP was initiated. The prehospital ECG is unavailable but reportedly showed a wide complex regular tachycardia at around 150 bpm. 150mg amiodarone was given for presumed VT with no obvious effect.She arrived at the ED at 2:52 AM. She had normal mental status, and was in moderate respiratory distress with diffuse rales, with respiratory rate 30/min, and initial blood pressure 129/60....
Source: Dr. Smith's ECG Blog - October 26, 2017 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, October 16th 2017
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - October 15, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Genre of Popular Science Articles on Treating Aging that Fail to Mention SENS Rejuvenation Research Programs
This popular science article on efforts to treat aging as a medical condition is a particularly good example of the type that fail to mention SENS rejuvenation research and any related efforts that involve repair of the cell and tissue damage that causes aging. This one even omits any mention of senolytics, the rapidly broadening efforts to clear senescent cells that are supported by increasingly robust evidence, which has to be a deliberate omission in any overview of the current state of the field. The rise of senolytics and the current enthusiasm for study of senescent cells is very hard to miss. Why do authors do this?...
Source: Fight Aging! - October 10, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 9th 2017
In this study, we investigated the Hippo pathway, which is known from my lab's previous studies to prevent adult heart muscle cell proliferation and regeneration. When patients are in heart failure there is an increase in the activity of the Hippo pathway. This led us to think that if we could turn Hippo off, then we might be able to induce improvement in heart function."
"We designed a mouse model to mimic the human condition of advanced heart failure. Once we reproduced a severe stage of injury in the mouse heart, we inhibited the Hippo pathway. After six weeks we observed that the injured hearts had recovered the...
Source: Fight Aging! - October 8, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards the Recognition of Aging as a Treatable Medical Condition
In recent years numerous groups have made a start on the long road of changing the public view of aging, from considering it a normal state to considering it a pathological state. To have it recognized as a harmful medical condition that can in principle be treated - that medical technologies can be developed for this purpose soon enough to matter. This is a process of unofficial advocacy and persuasion on the one hand, to change minds and educate people, but on the other there is also a strong component of formalism, of working with regulatory definitions. Medical research and development is, sadly, heavily regulated. The...
Source: Fight Aging! - October 6, 2017 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Fight Aging! Newsletter, October 2nd 2017
This study featured two independent experiments. The first established the safety of administering a therapeutic gene delivery vector, BNP116, created from an inactivated virus over three months, into 48 pigs without heart failure through the coronary arteries via catheterization using echocardiography. The second experiment examined the efficacy of the treatment in 13 pigs with severe heart failure induced by mitral regurgitation. Six pigs received the gene and 7 received a saline solution.
The researchers determined that the gene therapy was safe and significantly reversed heart failure by 25 percent in the left v...
Source: Fight Aging! - October 1, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing Juvenescence: Investing in the Age of Longevity
Jim Mellon and Al Chalabi's new book Juvenescence: Investing in the Age of Longevity is, I think, an important milestone, and the Juvenescence team were kind enough to send me a review copy a few days ago, prior to today's launch. Why important? It is the first time that a group of financially influential individuals have come out and, at length and in detail, outlined why exactly they support the cause of rejuvenation research and why they think it has a good chance of success in the near future. Of course people such as Peter Thiel and Michael Greve have declared much the same degree of support in the past, and their mat...
Source: Fight Aging! - September 27, 2017 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Fight Aging! Newsletter, September 25th 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - September 24, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wolf has been Cried So Very Many Times When it Comes to Anti-Aging Therapies
If you look at the media coverage of work on senolytic therapies, treatments that can clear out senescent cells and thus remove the contribution of these cells to the aging process, it is usually the case that there isn't much to distinguish it from the coverage of any random claim of progress towards anti-aging effects from either within or outside the scientific community: supplements, vitamins, diets, pharmaceuticals, and so forth. None of these other items work in the sense of repairing some of the cell and tissue damage that causes aging. The few that do slow aging do so marginally and in many cases unreliably. The ou...
Source: Fight Aging! - September 22, 2017 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
My Husband Outlived His Brain Tumor Prognosis by 12 Years: How His Experience Could Help John McCain and Others
In conclusion, I would never advise John McCain and his family, or any other GBM patient, as to which of these treatments—or which combination of treatments—they should use. I hope they will learn about all of them, and decide on their own which one or ones they would like to try. I would also encourage them to do their own research, or to hire a researcher with experience in finding sensible, science-based, cutting-edge treatments.
I am very worried that they will not know about these treatments, and others like them, and will just use the standard of care. That would be a shame. It might also be a death sentence. (S...
Source: HONEST MEDICINE: My Dream for the Future - September 22, 2017 Category: Consumer Health News Authors: JuliaS1573 at aol.com (Julia Schopick) Source Type: blogs
Fight Aging! Newsletter, September 11th 2017
This study developed the first procedure for the removal of epithelium from the lung airway with the full preservation of vascular epithelium, which could be applied in vivo to treat diseases of lung epithelium. Whole lung scaffolds with an intact vascular network may also allow for recellularization using patient-specific cells and bioengineering of chimeric lungs for transplantation. In addition to the clinical potential, lung scaffolds lacking an intact epithelial layer but with functional vascular and interstitial compartments may also serve as a valuable physiological model for investigating (i) lung development, (ii)...
Source: Fight Aging! - September 10, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Link Between Mechanisms of Calorie Restriction and Ketogenesis
Calorie restriction slows aging in most species and lineages tested to date, though the size of the effect on life span diminishes as species life span increases. Calorie restriction produces very similar short-term health benefits in humans and mice, but mice live as much as 40% longer as a result. We certainly do not. The necessary human studies have yet to run, but the consensus in the research community is that five years of additional life expectancy for calorie restricted humans is about as much as could be expected. The beneficial response to calorie restriction isn't just one mechanism under the hood, though increa...
Source: Fight Aging! - September 7, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
