Fight Aging! Newsletter, September 4th 2017
In conclusion, KPE delays intrinsic skin aging process by inhibiting cellular senescence and mitochondrial dysfunction. KPE does not only attenuate cellular senescence through inhibition of the p53/p21, p16/pRb, and PI3K/AKT signaling pathways but also improve mitochondrial biogenesis through PGC-1α stimulation. Consequently, KPE prevents wrinkle formation, skin atrophy, and loss of elasticity by increasing collagen and elastic fibers in hairless mice.
The Society for the Rescue of our Elders
https://www.fightaging.org/archives/2017/08/the-society-for-the-rescue-of-our-elders/
The Society for the Res...
Source: Fight Aging! - September 3, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MKSAP: 38-year-old woman with a HbA1c value of 9.1%
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 38-year-old woman is evaluated after laboratory study results show an HbA1c value of 9.1%. Her HbA1c goal is less than 7% because she has high function, long life expectancy, few comorbidities, good support, health literacy, and access to care. Medical history is significant for morbid obesity, obstructive sleep apnea, hypertension, and hyperlipidemia. Family history is notable for her mother, sister, and brother with type 2 diabetes, obesity, hypertension, and hyperlipidemia. Medications are insulin glargine ...
Source: Kevin, M.D. - Medical Weblog - September 2, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Diabetes Endocrinology Primary Care Source Type: blogs
A Popular Science Article on Calorie Restriction Mimetic Development
This popular science piece covers some of the major themes of recent years in the development of calorie restriction mimetic drugs, pharmaceuticals intended to recreate at least a little of the beneficial metabolic response to lowered calorie intake. The article is a cut above the average in terms of quality, but I remain bothered that this line of work receives so much attention in comparison to far better approaches to the treatment of aging, such as the SENS portfolio of therapies based on repair of the molecular damage that causes aging.
Calorie restriction mimetics cannot produce rejuvenation, and cannot do mor...
Source: Fight Aging! - August 28, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 21st 2017
This study didn't measure whether receiving the cardiosphere-derived cells extended lifespans, so we have a lot more work to do. We have much to study, including whether CDCs need to come from a young donor to have the same rejuvenating effects and whether the extracellular vesicles are able to reproduce all the rejuvenating effects we detect with CDCs."
Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats
Cardiosphere-derived cell (CDC) therapy has exhibited several favourable effects on heart structure and function in humans and in preclinical models; however, the ...
Source: Fight Aging! - August 20, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Incentive-Based Systems to Improve Patient Compliance: Interview with Matt Loper, CEO of Wellth
Wellth, a digital health company based in New York, has developed a system that provides patients with daily financial incentives to improve their compliance with drug regimens. Low patient compliance results in significant issues in terms of patient health and increased financial costs. The company is particularly interested in targeting type 2 diabetes, congestive heart failure, post heart attack recovery, COPD, and asthma.
The Wellth system is geared towards high-risk, high-cost patients, and works by providing patients with daily incentives and reminders to take their medication. The patient sends a photo of their medi...
Source: Medgadget - August 14, 2017 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Geriatrics Medicine Public Health Source Type: blogs
Is the Mitochondrial Permeability Transition Pore at the Center of Mitochondrial Contributions to Aging?
Researchers here outline a model of mitochondrial dysfunction as a contributing cause of aging that centers around mitochondrial permeability transition pores, molecular structures that govern the permeability of the inner mitochondrial membrane. These pores are known to be associated with the mitochondrial stress and functional failure that is observed in the biochemistry of numerous age-related diseases, but the degree to which this is a consequence versus a cause of damage is one of many open questions in the cellular biology of aging. The more usual focus of the mitochondrial contribution to aging is damage to mitochon...
Source: Fight Aging! - August 14, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 14th 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - August 13, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Why and How are We Living Longer?
Both healthy and overall life expectancy has gently trended upwards over the last few centuries. In recent decades the pace has been two years per decade for life expectancy at birth, and perhaps one year every decade for life expectancy at 65. If we understand aging to be an accumulation of cell and tissue damage, and we understand that no past therapies have deliberately addressed this damage, then it is probably a fair question to ask why this trend in human life span exists. Is it an inadvertent slowing of damage accumulation, the result of somewhat papering over the consequences of that damage, or some other effect? T...
Source: Fight Aging! - August 7, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MKSAP: 67-year-old woman who takes diclofenac
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 67-year-old woman is evaluated during a routine examination. She has a history of hip and knee pain related to degenerative joint disease. The joint pain is now well controlled with diclofenac, which was started 3 months ago. A previous trial of high-dose acetaminophen was not effective. She does not have any gastrointestinal symptoms, and she takes the diclofenac with food most of the time. Her medical history is otherwise notable for type 2 diabetes mellitus, hyperlipidemia, and hypertension. Her parents bot...
Source: Kevin, M.D. - Medical Weblog - August 5, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions GI Medications Orthopedics Source Type: blogs
The Geroscience Perspective
The authors of this article express a representative version of the geroscience perspective on aging research and its application in medicine. It is similar to that of the Longevity Dividend initiative of the past decade, which is to say that if a large amount of time and funding is invested, perhaps calorie restriction mimetic and similar marginally effective drugs can be brought to the clinic in order to modestly slow the progression of aging and add a few years of healthy life expectancy sometime prior to 2030. I believe I'm not the only one to be entirely underwhelmed by this strategy. This is not the future of aging r...
Source: Fight Aging! - July 25, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 3rd 2017
In conclusion, the analyses do not permit us to predict the trajectory that maximum lifespans will follow in the future, and hence provide no support for their central claim that the maximum lifespan of humans is "fixed and subject to natural constraints". This is largely a product of the limited data available for analysis, owing to the challenges inherent in collecting and verifying the lifespans of extremely long-lived individuals.
A reply from Jan Vijg's research group
The authors of the accompanying comment disagree with our finding of a limit to human lifespan. Although we thank them for alerting us...
Source: Fight Aging! - July 2, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Review of the Intersection Between Aging Research and Calorie Restriction Research
Below, find linked a very readable review of the intersection between aging research and calorie restriction research. While less so now than a decade ago, it nonetheless remains the case that much of the ongoing research into aging is in fact not concerned with treating aging as a medical condition. It is observational only, an field of programs of investigation and mapping that are quite disconnected from any impetus to improve medical technology. In the other portion of the aging research community, however, the part of more interest to us, in which scientists are aiming at interventions that target the causes of aging,...
Source: Fight Aging! - June 30, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Enthusiasm for Rapamycin and Polypills in the Search for Ways to Slow Aging
The author of this paper is one of the more outspoken advocates in the research community when it comes to mTOR and rapamycin as a path to slowing the progression of aging. He keeps up quite the output of position papers, such as this one, which calls for immediate human trials of polypills made up of rapamycin and a brace of other drugs broadly used in treatment of age-related conditions, such as statins and metformin. I have to think that the evidence to date suggests this will be less effective than hoped, while still very plausibly being better than doing nothing, even considering the side-effects of the drugs involved...
Source: Fight Aging! - June 21, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MKSAP: 56-year-old woman with type 2 diabetes mellitus
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 56-year-old woman presents to the office to discuss management of her type 2 diabetes mellitus. She is unhappy with her recent HbA1c value. She adheres to the maximum dose metformin monotherapy, which she has been taking for 1 year. Additionally, she has been working toward weight reduction without success; however, weight loss remains a top priority for this patient. Medical history is significant for hypertension, dyslipidemia, and recurrent vulvovaginal candidiasis. Family history includes type 2 diabetes i...
Source: Kevin, M.D. - Medical Weblog - June 17, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Diabetes Source Type: blogs
A Report from the 2nd Scripps Symposium on the Biology of Aging
This open access paper reports on the proceedings at the 2nd Scripps Symposium on the Biology of Aging held earlier this year. Like much of the field now, the focus in unabashedly on intervening in the aging process, which is good to see. Also like much of the field there is still considerable reluctance to talk in public about the potential for rejuvenation and radical life extension, however, rather than aiming at more modest gains. Still, the core message that we should treat aging as a medical condition has now spread far beyond the small groups that started this advocacy. One of the seven SENS rejuvenation research pr...
Source: Fight Aging! - June 9, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
