Fight Aging! Newsletter, September 4th 2017

In conclusion, KPE delays intrinsic skin aging process by inhibiting cellular senescence and mitochondrial dysfunction. KPE does not only attenuate cellular senescence through inhibition of the p53/p21, p16/pRb, and PI3K/AKT signaling pathways but also improve mitochondrial biogenesis through PGC-1α stimulation. Consequently, KPE prevents wrinkle formation, skin atrophy, and loss of elasticity by increasing collagen and elastic fibers in hairless mice. The Society for the Rescue of our Elders https://www.fightaging.org/archives/2017/08/the-society-for-the-rescue-of-our-elders/ The Society for the Rescue of our Elders initiative arises from the same circle of people who run the Life Extension Foundation and the RAAD festival, and is one of the more promising items I've seen emerge from that group. If they put their minds to it, they should be well able to run useful human trials of senolytic drug candidates and a range of other nascent rejuvenation therapies as these treatments emerge - trying all of the more reliable and useful treatments from mouse studies in human volunteers in order to accelerate progress. My complaint in the past has been that their efforts get corrupted by their supplement business, and other forms of useless nonsense, but so far that isn't visible here. It is certainly possible to argue the utility of some of the proposed trials, my usual complaints about SENS damage repair to reverse aging on the one side versus tinker...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Authors: Charytoniuk T, Małyszko M, Bączek J, Fiedorczyk P, Siedlaczek K, Małyszko J Abstract Nephrectomy, which constitutes a gold-standard procedure for the treatment of renal-cell carcinoma (RCC), has been widely discussed in the past decade as a significant risk factor of the development of chronic kidney disease (CKD). RCC is the third most common genitourinary cancer in the United States, with an estimated more than 65,000 new cases and 14,970 deaths. The aim of this review was to precisely and comprehensively summarize the status of current knowledge in chronic kidney disease risk factors after nephrectom...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Publication date: October 2018Source: Pregnancy Hypertension, Volume 14Author(s): Cheng-Qiu Lu, Jie Lin, Lin Yuan, Jian-Guo Zhou, Kun Liang, Qing-Hua Zhong, Jin-Hua Huang, Li-Ping Xu, Hui Wu, Zhi Zheng, Li-Li Ping, Yi Sun, Zhan-Kui Li, Ling Liu, Qin Lyu, Chao ChenAbstractObjectiveTo identify the effect of pregnancy induced hypertension on neonatal outcomes in early and moderate preterm infants of gestational age less than 34 weeks.Study designProspectively collected data in 773 premature deliveries less than 34 weeks from 10 centers in China between July 2014 and July 2016 were analyzed in this cohort study. Univariate...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
U.S. health officials revised rules for gene therapy experiments
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Authors: Russo Picasso MF, Vicens J, Giuliani C, Jaén ADV, Cabezón C, Figari M, Gómez Saldaño AM, Figar S Abstract Background: Two hypotheses attempt to explain the increase of thyroid cancer (TC) incidence: overdetection by excessive diagnostic scrutiny and a true increase in new cases brought about by environmental factors. Changes in the mechanism of detection and the risk of incidentally diagnosed TC could result in an increase of TC incidence. Methods: Retrospective cohort study. We identified incident cases of TC from the pathological reports of patients in a HMO and review of ...
Source: Journal of Cancer Epidemiology - Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research
Contributors : Ting La ; Xu D ZhangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusTo investigate miRNAs in quiescent cancer cell
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Mus musculus Source Type: research
(MedPage Today) -- Also, breast-conserving surgery or mastectomy?
Source: MedPage Today OB/GYN - Category: OBGYN Source Type: news
(MedPage Today) -- But diabetic individuals did have a higher risk for heart failure
Source: MedPage Today Pediatrics - Category: Pediatrics Source Type: news
U.S. health officials revised rules for gene therapy experiments
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
(Reuters Health) - People with diabetes are more likely to develop certain cancers than those without the condition, and a new analysis suggests that the increased risk is greater for women than for men.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Conclusions: Higher hs-CRP as a marker of low-grade inflammation was detected in prepubertal children exposed to maternal GDM, but no differences were seen in height, weight, BMI, or markers of glucose and lipid metabolism compared to control children. This finding may reflect an ongoing process of metabolic changes in children born after a GDM pregnancy.Horm Res Paediatr
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
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