A desmoplastic fibroblastoma that developed in the anterior mediastinum: a case report
ConclusionsDesmoplastic fibroblastoma of the mediastinum is an extremely rare disease. Preoperative diagnosis is difficult. Early surgical resection is suitable for diagnosis and treatment planning. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - October 18, 2021 Category: General Medicine Source Type: research

First presentation of a frameshift mutation in the SETD2 gene of a juvenile psammomatoid ossifying fibroma (JPOF) associated with an aneurysmal bone cyst
The rarity of juvenile psammomatoid ossifying fibroma (JPOF) and lack of cytogenetic studies prompted us to report a novel SETD2 gene mutation in a benign odontogenic tumour. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - October 17, 2021 Category: Pathology Authors: A. Toferer, A. Truschnegg, K. Kashofer, C. Beham-Schmid and A. Beham Tags: Case Report Source Type: research

Clinico ‐pathological profiling of peripheral ossifying fibroma of the oral cavity
Peripheral ossifying fibroma represents a separate entity with diverse histological presentation. Considerable overlapping of clinical and histological features is present among different reactive gingival lesions, which warrant a meticulous review for the diagnosis of POF. AbstractPOF represents a separate entity with diverse histological presentation. Considerable overlapping of clinical and histological features are present among different reactive gingival lesions, which warrant a meticulous review for the diagnosis of POF. (Source: Clinical Case Reports)
Source: Clinical Case Reports - October 14, 2021 Category: General Medicine Authors: Ashish Shrestha, Shashi Keshwar, Neetu Jain, Toniya Raut, Mehul Rajesh Jaisani, Shiva Lal Sharma Tags: CASE REPORT Source Type: research

Skin anomalies in acromegalic patients (Review of the practical aspects)
Exp Ther Med. 2021 Nov;22(5):1330. doi: 10.3892/etm.2021.10765. Epub 2021 Sep 20.ABSTRACTAcromegaly is a hormonal disorder which occurs as the result of growth hormone (GH) and insulin growth factor 1 (IGF-1) over-secretion; both hormones are related to skin anomalies. The skin acts as a large endocrine organ, hosting GH receptors in every cell while IGF-1 receptors are expressed only in keratinocytes. This review is a literature review of skin anomalies found in acromegaly, either related to the disease itself or associated with related complications such as secondary diabetes mellitus, or involving associated conditions ...
Source: Experimental and Therapeutic Medicine - October 11, 2021 Category: General Medicine Authors: Florica Sandru Adelina Popa Dan Nicolae Paduraru Alexandru Filipescu Mara Carsote Adina Ghemigian Source Type: research

Hyaline fibromatosis syndrome: a case presenting with gingival enlargement as the only clinical manifestation and a report of two new mutations in the ANTXR2 gene
Hyaline fibromatosis syndrome (HFS) is a rare autosomal recessive disorder caused by mutations in the gene for anthrax toxin receptor-2 (ANTXR2). The clinical features of HFS include skin thickening with nodules,... (Source: BMC Oral Health)
Source: BMC Oral Health - October 9, 2021 Category: Dentistry Authors: Yiying Liu, Xin Zeng, Yi Ding, Yi Xu and Dingyu Duan Tags: Case report Source Type: research

Reconstruction for diverse fronto-orbital defects with computer-assisted designed and computer-assisted manufactured PEEK implants in one-stage operation: Case reports
In this study, we report 2 cases with fronto-orbital defects of different etiologies in one-stage surgical reconstruction with polyetheretherketone (PEEK) prosthesis using computer-assisted design and computer-assisted manufactured (CAD–CAM) techniques. Patient concerns: One patient was a 49-year-old man, who admitted with a depressed and comminuted fracture in the left fronto-orbital region as a result of a motor vehicle collision. The other patient was a 45-year-old woman who was hospitalized with an unexpected diagnosis of a fronto-orbital bone tumor during a head CT examination in a minor traumatic brain i...
Source: Medicine - October 8, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Giant Cell-Rich Tumors of Bone
The term giant cell-rich tumors of bone refers to a shared morphologic pattern in a group of different osseous lesions, that is, the abundance of osteoclastlike giant cells. Fitting with a broad spectrum of clinical presentations and biological behavior, the recent detection of characteristic molecular alterations in giant cell tumor of bone (H3-3), nonossifying fibroma (KRAS, FGFR1), giant cell granuloma of the jaws (KRAS, FGFR1, TRPV4), and aneurysmal bone cyst (USP6) have contributed significantly to the biological understanding of these morphologically related but clinically distinct lesions and their systematic classi...
Source: Surgical Pathology Clinics - October 7, 2021 Category: Pathology Authors: Wolfgang Hartmann, Dorothee Harder, Daniel Baumhoer Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Lateral canthal fibroma in a dog
Can Vet J. 2021 Oct;62(10):1064-1066.ABSTRACTA 9-year-old castrated male pitbull dog was presented for evaluation of a subconjunctival swelling of 10 days duration. On ophthalmic examination, a subcutaneous mass was identified at the right lateral canthus. An excisional biopsy was performed, and histopathological analysis confirmed a diagnosis of a subcutaneous fibroma. Eleven months after surgical excision, the dog had no evidence of recurrence. Fibroma should be included in the differential diagnosis of rapidly enlarging eyelid masses.PMID:34602632 | PMC:PMC8439337 (Source: The Canadian Veterinary Journal)
Source: The Canadian Veterinary Journal - October 4, 2021 Category: Veterinary Research Authors: Marie-Pier Boutin Franck J Ollivier Source Type: research

Immunohistochemical Characterization of Bcl-2 in Oral Potentially Malignant Disorders
Bcl-2 is a group of apoptotic proteins that play a key role in cellular homeostasis. Overexpression of Bcl-2 has been associated with the poor prognosis of oral squamous cell carcinoma (OSCC). The aim of this study is to analyze the immunohistochemical expression of Bcl-2 in healthy oral mucosa, different oral potentially malignant disorders and OSCC, and to determine its diagnostic value. A retrospective observational study was carried out in the Oral Medicine Unit of the University of Santiago de Compostela. All the clinicopathologic data were collected and paraffin-embedded blocks were available to perform the immunohis...
Source: Applied Immunohistochemistry and Molecular Morphology - October 1, 2021 Category: Chemistry Tags: Research Articles Source Type: research

Malignant Transformation of Ossifying Fibroma to Juvenile Aggressive Ossifying Fibroma to Fibroblastic Osteosarcoma: A Case Report
The researchers present a case of mandibular juvenile ossifying fibroma (JOF) undergoing malignant transformation to fibroblastic osteosarcoma (FOS) and propose to use this unique case report. In contrast to extragnathic OS (osteosarcoma), comprehensive genomic studies of gnathic OS are lacking and, hence, there are no validated diagnostic and therapeutic molecular targets for gnathic OS. Distinguishing fibroblastic OS of the jaws from its close mimics, such as ossifying fibroma (OF) and fibromatosis of the jaws, poses major challenge for pathologists. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - October 1, 2021 Category: ENT & OMF Authors: V.A. Ma ñón, C. Chow, N. Vigneswaran, J.C. Melville Source Type: research

Activity of the Gamma Secretase Inhibitor AL101 in Desmoid Tumors: A Case Report of 2 Adult Cases
Curr Oncol. 2021 Sep 21;28(5):3659-3667. doi: 10.3390/curroncol28050312.ABSTRACTDesmoid tumors (aggressive fibromatosis) are soft tissue mesenchymal tumors that can be locally invasive and life-threatening. Depending on the location, these tumors are often unresectable or tend to recur after surgery. To date, there are no approved systemic therapies for desmoid tumors. These tumors typically harbor mutations in the β-catenin oncogene CTNNB1 or the tumor suppressor gene adenomatous polyposis coli, resulting in constitutive activation of the WNT pathway. The Notch pathway is part of the underlying cause for desmoid tumo...
Source: Current Oncology - September 30, 2021 Category: Cancer & Oncology Authors: David Chan Jason Kaplan Gary Gordon Jayesh Desai Source Type: research

Activity of the Gamma Secretase Inhibitor AL101 in Desmoid Tumors: A Case Report of 2 Adult Cases
Curr Oncol. 2021 Sep 21;28(5):3659-3667. doi: 10.3390/curroncol28050312.ABSTRACTDesmoid tumors (aggressive fibromatosis) are soft tissue mesenchymal tumors that can be locally invasive and life-threatening. Depending on the location, these tumors are often unresectable or tend to recur after surgery. To date, there are no approved systemic therapies for desmoid tumors. These tumors typically harbor mutations in the β-catenin oncogene CTNNB1 or the tumor suppressor gene adenomatous polyposis coli, resulting in constitutive activation of the WNT pathway. The Notch pathway is part of the underlying cause for desmoid tumo...
Source: Current Oncology - September 30, 2021 Category: Cancer & Oncology Authors: David Chan Jason Kaplan Gary Gordon Jayesh Desai Source Type: research

A rare mandibular neoplasm: case report of a Central Giant Cell Granuloma
Ann Ital Chir. 2021 Sep 10;92:S2239253X21035064.ABSTRACTMandible can be affected by a great variety of neoformations, like aneurysmal bone cyst, odontogenic myxoma, CGCG (Central Giant Cell Granuloma), GCT (giant cell tumor), sarcoma, ameloblastoma, lymphoma, ossifyng fibroma, odontogenic mixoma, granuloma, arteriovenous malformations and Schwannoma. Occasionally is not possible to find clinical or radiological distinctive findings so is usefull to perform additional exams, think about rare disease and perform an explorative surgical treatment which can be adapted to the intraoperatory findings. This attitude may help to r...
Source: Annali Italiani di Chirurgia - September 27, 2021 Category: Surgery Authors: Guido Gabriele Fabrizio Funaioli Flavia Cascino Simone Grandini Vittoria Fantozzi Paolo Gennaro Source Type: research

Peripheral ossifying fibroma: A case report
Stomatologija. 2021;23(2):56-60.ABSTRACTPeripheral ossifying fibroma (POF) is a reactive lesion that originates in the gingiva. Morphological similarity to other epulides and similar nomenclature to neoplastic tumors give rise to obvious problems both at the stage of diagnosis and treatment of POF. Although POF is one of the less common gingival lesions, it accounts for up to 2% of all oral lesions, which means that most general dentists will encounter POF in their practice. This paper aims to present the case of a 56-year-old woman diagnosed with POF. In the described case, POF most likely resulted from chronic periodonta...
Source: Stomatologija - September 16, 2021 Category: Dentistry Authors: Jakub Mokrysz Zuzanna Nowak Maciej Ch ęciński Source Type: research