Idiopathic gingival fibromatosis and primary analysis of dominant bacteria in subgingival biofilm: a case report

J Int Med Res. 2024 Apr;52(4):3000605241245302. doi: 10.1177/03000605241245302.ABSTRACTIdiopathic gingival fibromatosis (IGF), a rare fibroproliferative disease of unknown etiology, affects gingival tissue and has substantial adverse effects on patients. Therefore, the pathogenesis of IGF requires more extensive and in-depth research. In this case, a patient with confirmed IGF underwent initial nonsurgical periodontal therapy and gingivectomy, and the prognosis was good. The patient had no loss of periodontal attachment but had a history of swelling and bleeding of the gingiva prior to fibrous enlargement, which prompted further investigation. We explored the patient's subgingival microbiome and found a high abundance of periodontal pathogens. Gingival tissue biopsy revealed abundant fibrous tissue containing multiple inflammatory cell infiltrates. These results suggest that gingival inflammation secondary to periodontal pathogens can contribute to IGF onset.PMID:38663906 | DOI:10.1177/03000605241245302

Source: Cell Research - April 25, 2024 Category: Cytology Authors: Jingli Zhu Xinyue Fan Lili Ding Tianzhu Song Source Type: research