Cervical Aggressive Fibromatosis Causing Airway Obstruction
We report the case of a 26-year-old Tunisian female who presented with acute obstructive dyspnea and a 3-week history of cervical swelling. The swelling was initially only located in the left submandibular area, it then gradually extended to all the anterior cervical supra- and infrahyoid regions causing a clinical presentation resembling that of obstructive dyspnea, the patient was admitted, and an emergency tracheotomy was performed. Tissue samples were taken, pathological analysis revealed an aggressive case of fibromatosis. The patient was treated with corticosteroids and antihormonal therapy, the fibrous mass shrunk c...
Source: Ear, Nose and Throat Journal - November 10, 2023 Category: ENT & OMF Authors: Azer Chebil Mehdi Hasnaoui Mohamed Masmoudi Abedrraouf Ben Fatma Saida Jerbi Khelifa Mighri Source Type: research
Cervical Aggressive Fibromatosis Causing Airway Obstruction
We report the case of a 26-year-old Tunisian female who presented with acute obstructive dyspnea and a 3-week history of cervical swelling. The swelling was initially only located in the left submandibular area, it then gradually extended to all the anterior cervical supra- and infrahyoid regions causing a clinical presentation resembling that of obstructive dyspnea, the patient was admitted, and an emergency tracheotomy was performed. Tissue samples were taken, pathological analysis revealed an aggressive case of fibromatosis. The patient was treated with corticosteroids and antihormonal therapy, the fibrous mass shrunk c...
Source: Ear, Nose and Throat Journal - November 10, 2023 Category: ENT & OMF Authors: Azer Chebil Mehdi Hasnaoui Mohamed Masmoudi Abedrraouf Ben Fatma Saida Jerbi Khelifa Mighri Source Type: research
Cervical Aggressive Fibromatosis Causing Airway Obstruction
We report the case of a 26-year-old Tunisian female who presented with acute obstructive dyspnea and a 3-week history of cervical swelling. The swelling was initially only located in the left submandibular area, it then gradually extended to all the anterior cervical supra- and infrahyoid regions causing a clinical presentation resembling that of obstructive dyspnea, the patient was admitted, and an emergency tracheotomy was performed. Tissue samples were taken, pathological analysis revealed an aggressive case of fibromatosis. The patient was treated with corticosteroids and antihormonal therapy, the fibrous mass shrunk c...
Source: Ear, Nose and Throat Journal - November 10, 2023 Category: ENT & OMF Authors: Azer Chebil Mehdi Hasnaoui Mohamed Masmoudi Abedrraouf Ben Fatma Saida Jerbi Khelifa Mighri Source Type: research
Cervical Aggressive Fibromatosis Causing Airway Obstruction
We report the case of a 26-year-old Tunisian female who presented with acute obstructive dyspnea and a 3-week history of cervical swelling. The swelling was initially only located in the left submandibular area, it then gradually extended to all the anterior cervical supra- and infrahyoid regions causing a clinical presentation resembling that of obstructive dyspnea, the patient was admitted, and an emergency tracheotomy was performed. Tissue samples were taken, pathological analysis revealed an aggressive case of fibromatosis. The patient was treated with corticosteroids and antihormonal therapy, the fibrous mass shrunk c...
Source: Ear, Nose and Throat Journal - November 10, 2023 Category: ENT & OMF Authors: Azer Chebil Mehdi Hasnaoui Mohamed Masmoudi Abedrraouf Ben Fatma Saida Jerbi Khelifa Mighri Source Type: research
PDGFR β signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis
CONCLUSIONS: The β-catenin transcriptional target ABL1 is necessary for proliferation and maintenance of HIF1α in desmoid cells. Regulation of c-Abl activity by PDGF signaling and targeted therapies modulates desmoid cell proliferation, thereby suggesting a reason for variable biologic behavior between tumors, a mechanism for sorafenib activity in desmoids, and markers predictive of outcome in patients.PMID:37943631 | DOI:10.1158/1078-0432.CCR-23-2313 (Source: Cell Research)
Source: Cell Research - November 9, 2023 Category: Cytology Authors: Jia Hu Meera R Hameed Narasimhan P Agaram Karissa A Whiting Li-Xuan Qin Anthony M Villano Rachael B O'Connor Julian M Rozenberg Sonia Cohen Katherine Prendergast Sara Kryeziu Richard L White Mitchell C Posner Nicholas D Socci Mrinal M Gounder Samuel Singe Source Type: research
PDGFR β signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis
CONCLUSIONS: The β-catenin transcriptional target ABL1 is necessary for proliferation and maintenance of HIF1α in desmoid cells. Regulation of c-Abl activity by PDGF signaling and targeted therapies modulates desmoid cell proliferation, thereby suggesting a reason for variable biologic behavior between tumors, a mechanism for sorafenib activity in desmoids, and markers predictive of outcome in patients.PMID:37943631 | DOI:10.1158/1078-0432.CCR-23-2313 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 9, 2023 Category: Cancer & Oncology Authors: Jia Hu Meera R Hameed Narasimhan P Agaram Karissa A Whiting Li-Xuan Qin Anthony M Villano Rachael B O'Connor Julian M Rozenberg Sonia Cohen Katherine Prendergast Sara Kryeziu Richard L White Mitchell C Posner Nicholas D Socci Mrinal M Gounder Samuel Singe Source Type: research
PDGFR β signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis
CONCLUSIONS: The β-catenin transcriptional target ABL1 is necessary for proliferation and maintenance of HIF1α in desmoid cells. Regulation of c-Abl activity by PDGF signaling and targeted therapies modulates desmoid cell proliferation, thereby suggesting a reason for variable biologic behavior between tumors, a mechanism for sorafenib activity in desmoids, and markers predictive of outcome in patients.PMID:37943631 | DOI:10.1158/1078-0432.CCR-23-2313 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 9, 2023 Category: Cancer & Oncology Authors: Jia Hu Meera R Hameed Narasimhan P Agaram Karissa A Whiting Li-Xuan Qin Anthony M Villano Rachael B O'Connor Julian M Rozenberg Sonia Cohen Katherine Prendergast Sara Kryeziu Richard L White Mitchell C Posner Nicholas D Socci Mrinal M Gounder Samuel Singe Source Type: research
PDGFR β signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis
CONCLUSIONS: The β-catenin transcriptional target ABL1 is necessary for proliferation and maintenance of HIF1α in desmoid cells. Regulation of c-Abl activity by PDGF signaling and targeted therapies modulates desmoid cell proliferation, thereby suggesting a reason for variable biologic behavior between tumors, a mechanism for sorafenib activity in desmoids, and markers predictive of outcome in patients.PMID:37943631 | DOI:10.1158/1078-0432.CCR-23-2313 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 9, 2023 Category: Cancer & Oncology Authors: Jia Hu Meera R Hameed Narasimhan P Agaram Karissa A Whiting Li-Xuan Qin Anthony M Villano Rachael B O'Connor Julian M Rozenberg Sonia Cohen Katherine Prendergast Sara Kryeziu Richard L White Mitchell C Posner Nicholas D Socci Mrinal M Gounder Samuel Singe Source Type: research
PDGFR β signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis
CONCLUSIONS: The β-catenin transcriptional target ABL1 is necessary for proliferation and maintenance of HIF1α in desmoid cells. Regulation of c-Abl activity by PDGF signaling and targeted therapies modulates desmoid cell proliferation, thereby suggesting a reason for variable biologic behavior between tumors, a mechanism for sorafenib activity in desmoids, and markers predictive of outcome in patients.PMID:37943631 | DOI:10.1158/1078-0432.CCR-23-2313 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 9, 2023 Category: Cancer & Oncology Authors: Jia Hu Meera R Hameed Narasimhan P Agaram Karissa A Whiting Li-Xuan Qin Anthony M Villano Rachael B O'Connor Julian M Rozenberg Sonia Cohen Katherine Prendergast Sara Kryeziu Richard L White Mitchell C Posner Nicholas D Socci Mrinal M Gounder Samuel Singe Source Type: research
Historical Notes on Ossifying Fibroma of the Mandible
(Source: Head and Neck Pathology)
Source: Head and Neck Pathology - November 9, 2023 Category: Pathology Source Type: research
GSE244160 PDGFR β signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis [ChIP-seq]
Conclusions: The β-catenin transcriptional target ABL1 is necessary for proliferation and maintenance of HIF1α protein expression in desmoid cells. Regulation of c-Abl activity by PDGF signaling and targeted therapies modulates desmoid cell proliferation, thereby suggesting a reason for variable biologic behavior between tumors, a mechanism for sorafenib activity in desmoids, and markers predictive of outcome in pat ients. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - November 1, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE239409 PDGFR β signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis
Series Type : Expression profiling by array ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - November 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE239407 PDGFR β signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis [RNA-seq II]
Contributors : Jia Hu ; Aimee M CragoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe mechanisms underlying oncogenesis in desmoid-type fibromatosis are poorly understood. This project sought to understand how β-catenin may function to promote desmoid formation and how external signaling by PDGFRβ modulates this activity. To examine this question, RNA-seq was performed on CTNNB1 knock-downs. Gene set enrichment analysis suggested that the oncogene controlled HIF1 and angiogenesis pathways; expression of related genes accurately differentiated desmoids analyzed by U133A array ...
Source: GEO: Gene Expression Omnibus - November 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE239406 PDGFR β signaling cooperates with β-catenin to modulate c-Abl and biologic behavior of desmoid-type fibromatosis [RNA-seq I]
Contributors : Jia Hu ; Aimee M CragoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe mechanisms underlying oncogenesis in desmoid-type fibromatosis are poorly understood. This project sought to understand how β-catenin may function to promote desmoid formation and how external signaling by PDGFRβ modulates this activity. To examine this question, RNA-seq was performed on CTNNB1 knock-downs. Gene set enrichment analysis suggested that the oncogene controlled HIF1 and angiogenesis pathways; expression of related genes accurately differentiated desmoids analyzed by U133A array ...
Source: GEO: Gene Expression Omnibus - November 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Bilateral ovarian fibromas as the sole manifestation of Gorlin syndrome in a 22-year-old woman: a case report and literature review
Nevoid basal cell carcinoma syndrome (NBCCS, Gorlin syndrome) is a rare autosomal dominantly inherited disorder that is characterized by multisystem disorder such as basal cell carcinomas, keratocystic odontog... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - October 31, 2023 Category: Pathology Authors: Menghan Zhu, Jun Li, Jie Duan, Jing Yang, Weiyong Gu and Wei Jiang Tags: Case Report Source Type: research
