GSE254115 Examining the non-coding RNA profiles of macrophages from mice infected with Fasciola hepatica reveals a co-operation between host and parasite to reduce pro-inflammatory responses and promote tissue repair
Contributors : Dayna Sais ; Sheila Donnelley ; Nham TranSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusParasitic worms (helminths) ensure their survival to establish chronic infection within mammalian hosts by strategically regulating their host ’s immune responses. Deciphering the mechanisms behind this immune modulation will inform the development of novel strategies for infection control. It is now understood that the co-ordinated control of gene expression by non-coding RNAs (ncRNA) underpins the activation and regulat...
Source: GEO: Gene Expression Omnibus - April 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Mus musculus Source Type: research
New benzimidazole derivative compounds with in vitro fasciolicidal properties
Control of the zoonotic food-borne parasite Fasciola hepatica remains a major challenge in humans and livestock. It is estimated that annual economic losses due to fasciolosis can reach US$3.2 billion in agricult... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 3, 2024 Category: Microbiology Authors: Elora Valderas-Garc ía, Verónica Castilla-Gómez de Agüero, Laura González del Palacio, Giulio Galli, Nerea Escala, Marta Ruiz-Somacarrera, Marta González-Warleta, Esther del Olmo, Rafael Balaña-Fouce and María Martínez-Valladares Tags: Research Source Type: research
Blood parameters and parasite burden in cattle with chronic fascioliasis
The objective of this work was to gain insight in these aspects. Cattle from Mendoza province, Argentina, were inspected at a farm and at the abattoir determining the presence or absence of Fasciola hepatica. Each animal was sampled for blood and feces and in the slaughterhouse the livers were inspected. Hematology and blood chemistry parameters were determined, feces were examined for F. hepatica eggs by a quantitative sedimentation technique and livers were thoroughly inspected to determine the number of flukes. Infected cattle presented a mild burden of liver flukes per animal, strongly correlated (r=0.72) to the number...
Source: Acta Tropica - March 29, 2024 Category: Infectious Diseases Authors: Gisela Neira Roberto Meray Sierra Franco Cremaschi Noelia Sohaefer Mariana Gonz ález Dayana Godoy Silvana Scarcella Source Type: research
Blood parameters and parasite burden in cattle with chronic fascioliasis
The objective of this work was to gain insight in these aspects. Cattle from Mendoza province, Argentina, were inspected at a farm and at the abattoir determining the presence or absence of Fasciola hepatica. Each animal was sampled for blood and feces and in the slaughterhouse the livers were inspected. Hematology and blood chemistry parameters were determined, feces were examined for F. hepatica eggs by a quantitative sedimentation technique and livers were thoroughly inspected to determine the number of flukes. Infected cattle presented a mild burden of liver flukes per animal, strongly correlated (r=0.72) to the number...
Source: Acta Tropica - March 29, 2024 Category: Infectious Diseases Authors: Gisela Neira Roberto Meray Sierra Franco Cremaschi Noelia Sohaefer Mariana Gonz ález Dayana Godoy Silvana Scarcella Source Type: research
Correction: Fasciola hepatica soluble antigens (FhAg) induce ovine PMN innate immune reactions and NET formation in vitro and in vivo
(Source: Veterinary Research)
Source: Veterinary Research - March 26, 2024 Category: Veterinary Research Source Type: research
Correlation between the Fasciola hepatica infection rate (number of parasites in the liver parenchyma) and the antibody titration, detected by ELISA assay
This study aimed to demonstrate the existence of a possible correlation between the level of liver fluke infection in cattle caused byFasciola hepatica and the titers of anti-parasite antibodies in the blood. 113 blood samples were taken from non-dewormed pasture cattle in the communal slaughterhouse of the Jijel city in order to determine the serological titration of anti-fluke antibodies by the ELISA method. After slaughtering the animals studied, a count of parasites present in the inspected livers was carried out in order to assess the level of parasitic infection. The prevalence of bovine fasciolosis (due toFasciola h...
Source: Journal of Parasitic Diseases - March 11, 2024 Category: Parasitology Source Type: research
Gastropod invasions in anthropogenically impacted impoundments in South Africa: tracing their origins and exploring field evidence of parasite spillback and amplification
Int J Parasitol. 2024 Mar 5:S0020-7519(24)00050-X. doi: 10.1016/j.ijpara.2024.02.004. Online ahead of print.ABSTRACTInvasive snails are associated with ecological problems in freshwater bodies worldwide. However, their impact on the transmission of digenean infections remain underreported. In the present study, 1708 specimens representing four snail species were sampled from four impoundments in the Limpopo River system in South Africa. Gyraulus chinensis (Planorbidae), Physella acuta (Physidae) and Pseudosuccinea columella (Lymnaeidae), which are invasive, were found in all the sampling sites. In contrast, the native lymn...
Source: International Journal for Parasitology - March 7, 2024 Category: Parasitology Authors: James Omondi Outa Parthi Bhika Annemari è Avenant-Oldewage Source Type: research
Gastropod invasions in anthropogenically impacted impoundments in South Africa: tracing their origins and exploring field evidence of parasite spillback and amplification
Int J Parasitol. 2024 Mar 5:S0020-7519(24)00050-X. doi: 10.1016/j.ijpara.2024.02.004. Online ahead of print.ABSTRACTInvasive snails are associated with ecological problems in freshwater bodies worldwide. However, their impact on the transmission of digenean infections remain underreported. In the present study, 1708 specimens representing four snail species were sampled from four impoundments in the Limpopo River system in South Africa. Gyraulus chinensis (Planorbidae), Physella acuta (Physidae) and Pseudosuccinea columella (Lymnaeidae), which are invasive, were found in all the sampling sites. In contrast, the native lymn...
Source: International Journal for Parasitology - March 7, 2024 Category: Parasitology Authors: James Omondi Outa Parthi Bhika Annemari è Avenant-Oldewage Source Type: research
Letter to the Editor: A Case Report of Biliary Obstruction Caused by Live Fasciola hepatica
Surgical Infections, Ahead of Print. (Source: Surgical Infections)
Source: Surgical Infections - March 6, 2024 Category: Surgery Authors: Hui Wei Jianhao Huang Xiaoli Yang Kai He Source Type: research
Laboratory Assessment of Molluscicidal Activities of Cannabis sativa, Acacia nilotica, and Tinospora cordifolia Against Snail Host of Fasciola spp.
Vector-Borne and Zoonotic Diseases, Ahead of Print. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - February 16, 2024 Category: Infectious Diseases Authors: Nilay Vishal Singh Arundhati Singh Vinay Kumar Singh Source Type: research
Fasciola nyanzae
Trends Parasitol. 2024 Feb 13:S1471-4922(24)00007-2. doi: 10.1016/j.pt.2024.01.007. Online ahead of print.NO ABSTRACTPMID:38355314 | DOI:10.1016/j.pt.2024.01.007 (Source: Trends in Parasitology)
Source: Trends in Parasitology - February 14, 2024 Category: Parasitology Authors: Ruben Schols Tine Huyse Source Type: research
Fasciola nyanzae
Trends Parasitol. 2024 Feb 13:S1471-4922(24)00007-2. doi: 10.1016/j.pt.2024.01.007. Online ahead of print.NO ABSTRACTPMID:38355314 | DOI:10.1016/j.pt.2024.01.007 (Source: Trends in Parasitology)
Source: Trends in Parasitology - February 14, 2024 Category: Parasitology Authors: Ruben Schols Tine Huyse Source Type: research
Fasciola nyanzae
Trends Parasitol. 2024 Feb 13:S1471-4922(24)00007-2. doi: 10.1016/j.pt.2024.01.007. Online ahead of print.NO ABSTRACTPMID:38355314 | DOI:10.1016/j.pt.2024.01.007 (Source: Trends in Parasitology)
Source: Trends in Parasitology - February 14, 2024 Category: Parasitology Authors: Ruben Schols Tine Huyse Source Type: research
Fumarate respiration of Fasciola flukes as a potential drug target
This study aimed to evaluate the occurrence of fumarate respiration in Fasciola flukes. We analyzed the properties of the respiratory chain of Fasciola flukes in both adults and newly excysted juveniles (NEJs). Fasciola flukes travel and mature through the stomach, bowel, and abdominal cavity to the liver, where oxygen levels gradually decline. High fumarate reductase activity was observed in the mitochondrial fraction of adult Fasciola flukes. Furthermore, rhodoquinone-10 (RQ10 Em’= −63 mV), a low-potential electron mediator used in fumarate respiration was found to be predominant in adults. In contrast, the activity ...
Source: Frontiers in cellular and infection microbiology - January 25, 2024 Category: Microbiology Source Type: research
Histopathological changes and oxidative stress associated with Fascioliasis in bovines
In this study, our objective was to gain insight into the pathophysiological consequences of Fascioliasis in cattle through the evaluation of metabolic, oxidative stress, and histological parameters. A thorough investigation was carried out on the liver of 197 bovines after their slaughter, which unveiled the occurrence of Fascioliasis, with a prevalence rate of 13.2% observed. The bovine that were infected exhibited notable increase in serum transaminases (ALT, AST, and ALP) and malondialdehyde (MDA) and catalase (CAT) while the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels. The lipid profile analysi...
Source: Tropical Animal Health and Production - January 18, 2024 Category: Veterinary Research Source Type: research
