The current status of neglected tropical diseases in Japan: A scoping review
by Yuriko Harada, Hanako Iwashita, Taeko Moriyasu, Sachiyo Nagi, Nobuo Saito, Mariko Sugawara-Mikami, Kota Yoshioka, Rie Yotsu, on behalf of Japan NTD Study Group Little attention has been paid to neglected tropical diseases (NTDs) in high-income countries and no literature provides an overview of NTDs in Japan. This scoping review aims to synthesize the latest evidence and information to understand epidemiology of and public health response to NTDs in Japan. Using three academic databases, we retrieved articles that mentioned NTDs in Japan, written in English or Japanese, and published between 2010 and 2020. Websites of ...
Source: PLoS Neglected Tropical Diseases - January 2, 2024 Category: Tropical Medicine Authors: Yuriko Harada Source Type: research

Geographic expansion of Fasciola hepatica (Linnaeus, 1758) due to changes in land use and cover in Brazil
This study analyzed changes in land use and the distribution of F. hepatica in bovine livers in Brazil over 18 years. Data on land use and land cover were collected from the Mapbiomas Project. Data on 414,481,963 slaughtered cattle and condemned livers due to F. hepatica infection were obtained from 4,433 municipalities. Joinpoint analysis was used to study the time series, and the Susceptible-Infected-Recovered (SIR) model was utilized to explore the behavior of F. hepatica infection. In the North, pasture areas significantly increased (P = 0.000001), while forested areas decreased (P = 0.000001). The midwestern and north...
Source: International Journal for Parasitology - December 31, 2023 Category: Parasitology Authors: Thayany Magalh ães de Almeida Irineu Romero Neto Yara de Oliveira Brand ão Marcelo Beltr ão Molento Source Type: research

Geographic expansion of Fasciola hepatica (Linnaeus, 1758) due to changes in land use and cover in Brazil
This study analyzed changes in land use and the distribution of F. hepatica in bovine livers in Brazil over 18 years. Data on land use and land cover were collected from the Mapbiomas Project. Data on 414,481,963 slaughtered cattle and condemned livers due to F. hepatica infection were obtained from 4,433 municipalities. Joinpoint analysis was used to study the time series, and the Susceptible-Infected-Recovered (SIR) model was utilized to explore the behavior of F. hepatica infection. In the North, pasture areas significantly increased (P = 0.000001), while forested areas decreased (P = 0.000001). The midwestern and north...
Source: International Journal for Parasitology - December 31, 2023 Category: Parasitology Authors: Thayany Magalh ães de Almeida Irineu Romero Neto Yara de Oliveira Brand ão Marcelo Beltr ão Molento Source Type: research

Geographic expansion of Fasciola hepatica (Linnaeus, 1758) due to changes in land use and cover in Brazil
This study analyzed changes in land use and the distribution of F. hepatica in bovine livers in Brazil over 18 years. Data on land use and land cover were collected from the Mapbiomas Project. Data on 414,481,963 slaughtered cattle and condemned livers due to F. hepatica infection were obtained from 4,433 municipalities. Joinpoint analysis was used to study the time series, and the Susceptible-Infected-Recovered (SIR) model was utilized to explore the behavior of F. hepatica infection. In the North, pasture areas significantly increased (P = 0.000001), while forested areas decreased (P = 0.000001). The midwestern and north...
Source: International Journal for Parasitology - December 31, 2023 Category: Parasitology Authors: Thayany Magalh ães de Almeida Irineu Romero Neto Yara de Oliveira Brand ão Marcelo Beltr ão Molento Source Type: research

Geographic expansion of Fasciola hepatica (Linnaeus, 1758) due to changes in land use and cover in Brazil
This study analyzed changes in land use and the distribution of F. hepatica in bovine livers in Brazil over 18 years. Data on land use and land cover were collected from the Mapbiomas Project. Data on 414,481,963 slaughtered cattle and condemned livers due to F. hepatica infection were obtained from 4,433 municipalities. Joinpoint analysis was used to study the time series, and the Susceptible-Infected-Recovered (SIR) model was utilized to explore the behavior of F. hepatica infection. In the North, pasture areas significantly increased (P = 0.000001), while forested areas decreased (P = 0.000001). The midwestern and north...
Source: International Journal for Parasitology - December 31, 2023 Category: Parasitology Authors: Thayany Magalh ães de Almeida Irineu Romero Neto Yara de Oliveira Brand ão Marcelo Beltr ão Molento Source Type: research

Geographic expansion of Fasciola hepatica (Linnaeus, 1758) due to changes in land use and cover in Brazil
This study analyzed changes in land use and the distribution of F. hepatica in bovine livers in Brazil over 18 years. Data on land use and land cover were collected from the Mapbiomas Project. Data on 414,481,963 slaughtered cattle and condemned livers due to F. hepatica infection were obtained from 4,433 municipalities. Joinpoint analysis was used to study the time series, and the Susceptible-Infected-Recovered (SIR) model was utilized to explore the behavior of F. hepatica infection. In the North, pasture areas significantly increased (P = 0.000001), while forested areas decreased (P = 0.000001). The midwestern and north...
Source: International Journal for Parasitology - December 31, 2023 Category: Parasitology Authors: Thayany Magalh ães de Almeida Irineu Romero Neto Yara de Oliveira Brand ão Marcelo Beltr ão Molento Source Type: research

Evaluation of the ovicidal activity and fasciolicidal activity of the extract of ethyl acetate from Artemisia ludoviciana Nutt. spp. mexicana and of artemisinin against adult parasites of Fasciola hepatica
The objective of this work was to evaluate the effect of the ethyl acetate extract from A. ludoviciana (EALM) and artemisinin against adult parasites and eggs of F. hepatica. For the ovicidal assay, cell culture plates with 24 wells were used, and 90 to 110 F. hepatica eggs were placed in each well. The eggs were exposed to concentrations of 100, 200, 300, 400, and 500 mg/L EALM and incubated for 16 days. Additionally, triclabendazole (TCBZ) was used as a reference drug at concentrations of 10 and 50 mg, and the response of artemisinin at concentrations of 10 and 20 mg was simultaneously assessed. Adult flukes were exposed...
Source: Cell Research - December 26, 2023 Category: Cytology Authors: Alonso Ezeta-Miranda Jos é G Avila-Acevedo Yolanda Vera-Montenegro Gerardo Francisco-Marquez Source Type: research

Evaluation of the ovicidal activity and fasciolicidal activity of the extract of ethyl acetate from Artemisia ludoviciana Nutt. spp. mexicana and of artemisinin against adult parasites of Fasciola hepatica
The objective of this work was to evaluate the effect of the ethyl acetate extract from A. ludoviciana (EALM) and artemisinin against adult parasites and eggs of F. hepatica. For the ovicidal assay, cell culture plates with 24 wells were used, and 90 to 110 F. hepatica eggs were placed in each well. The eggs were exposed to concentrations of 100, 200, 300, 400, and 500 mg/L EALM and incubated for 16 days. Additionally, triclabendazole (TCBZ) was used as a reference drug at concentrations of 10 and 50 mg, and the response of artemisinin at concentrations of 10 and 20 mg was simultaneously assessed. Adult flukes were exposed...
Source: Cell Research - December 26, 2023 Category: Cytology Authors: Alonso Ezeta-Miranda Jos é G Avila-Acevedo Yolanda Vera-Montenegro Gerardo Francisco-Marquez Source Type: research

Random forest classification as a tool in epidemiological modelling: Identification of farm-specific characteristics relevant for the occurrence of < i > Fasciola hepatica < /i > on German dairy farms
by Andreas W. Oehm, Yury Zablotski, Amely Campe, Martina Hoedemaker, Christina Strube, Andrea Springer, Daniela Jordan, Gabriela Knubben-SchweizerFasciola hepatica is an internal parasite of both human and veterinary relevance. In order to control fasciolosis, a multitude of attempts to predict the risk of infection such as risk maps or forecasting models have been developed. These attempts mainly focused on the influence of geo-climatic and meteorological features. Predicting bovine fasciolosis on farm level taking into account farm-specific settings yet remains challenging. In the present study, a new methodology for thi...
Source: PLoS One - December 21, 2023 Category: Biomedical Science Authors: Andreas W. Oehm Source Type: research

Immune modulation of goat monocytes by Fasciola gigantica Legumain-1 protein (Fg-LGMN-1)
Exp Parasitol. 2023 Dec 9:108671. doi: 10.1016/j.exppara.2023.108671. Online ahead of print.ABSTRACTLegumains belonging to C_13 peptidase family of proteins, and are ubiquitously disseminated among all vertebrate and invertebrate organisms, and have been implicated in innumerable biological and cellular functionality. Herein, we characterized and evaluated immunoregulatory characteristics of Legumain-1 from Fasciola gigantica (Fg-LGMN-1) during its interaction with host immune cells. The isopropyl-ß-d-thiogalactopyranoside (IPTG) stimulated RFg-LGMN-1 protein was positively detected by rat serum containing anti-RFg-LGMN-1...
Source: Experimental Parasitology - December 11, 2023 Category: Parasitology Authors: Muhammad Ehsan Rui-Si Hu Meng Wang Jun-Ling Hou Muhammad Rashid Muhammad Irfan Malik Source Type: research

Immune modulation of goat monocytes by Fasciola gigantica Legumain-1 protein (Fg-LGMN-1)
Exp Parasitol. 2023 Dec 9:108671. doi: 10.1016/j.exppara.2023.108671. Online ahead of print.ABSTRACTLegumains belonging to C_13 peptidase family of proteins, and are ubiquitously disseminated among all vertebrate and invertebrate organisms, and have been implicated in innumerable biological and cellular functionality. Herein, we characterized and evaluated immunoregulatory characteristics of Legumain-1 from Fasciola gigantica (Fg-LGMN-1) during its interaction with host immune cells. The isopropyl-ß-d-thiogalactopyranoside (IPTG) stimulated RFg-LGMN-1 protein was positively detected by rat serum containing anti-RFg-LGMN-1...
Source: Experimental Parasitology - December 11, 2023 Category: Parasitology Authors: Muhammad Ehsan Rui-Si Hu Meng Wang Jun-Ling Hou Muhammad Rashid Muhammad Irfan Malik Source Type: research

Effects of temperature on the life history traits of intermediate host snails of fascioliasis: A systematic review
ConclusionWe concluded that understanding the impact of temperature on the growth, fecundity, and survival of IHS may broaden our knowledge of the possible effects of climate change and hence inform fascioliasis control programs. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - December 4, 2023 Category: Tropical Medicine Authors: Agrippa Dube Source Type: research