Fight Aging! Newsletter, June 1st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 31, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Analysis of the Gray Whale Transcriptome in the Context of Longevity
Much of the comparative biology of aging involves study of long-lived mammals in an attempt to understand which mechanisms determine species longevity. It is possible that a better understanding of this biochemistry might form the basis for therapies, though this is by no means guaranteed. It is quite possible that mechanisms of species longevity will be very difficult to move between species, or to influence in another species without negative consequences. The past few decades of research into mimicking the beneficial responses to exercise and calorie restriction well illustrate that reworking the engines of metabolism i...
Source: Fight Aging! - May 26, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 18th 2020
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function.
On Nutraceutical Senolytics
https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/
Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therap...
Source: Fight Aging! - May 17, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Early Life Epigenetic Changes can Set the Stage for Later Life Metabolic Dysfunction
Epigenetic markers on DNA determine the pace and timing of protein production, and are thus one of the important influences on cell and tissue function. Cells adjust their epigenetic programs in response to the surrounding environment, but alterations can be lasting. It is thought that environmental influences on epigenetic programming of cellular behavior that occur in childhood set the stage for faster or slower onset of metabolic dysfunction in later life, once cell and tissue damage starts to accumulate. Researchers here provide a proof of principle of this process in rats.
Environmental exposures during early...
Source: Fight Aging! - May 15, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
We Need to Fix COVID-Damaged Care Sites and Give the Country Better Care and Universal Coverage in the Process
By GEORGE HALVORSON
The COVID crisis has shown us clearly that major portions of the American care system are extremely dysfunctional and some are now badly broken. We need to put in place a cash flow for American health care that can help our care sites survive and ultimately thrive, and we need to put that approach to save the sites in place now because a vast majority of hospitals and medical practices are badly damaged and some are financially crippled and even destroyed by their response to the crisis.
We have learned a lot in the COVID crisis that we need to use now in building our next steps and our collective...
Source: The Health Care Blog - May 9, 2020 Category: Consumer Health News Authors: matthew holt Tags: COVID-19 Featured Health Policy OP-ED George Halvorson Medicare Advantage Medicare Advantage for All Source Type: blogs
The Constitutional Case for the Fed ’s Treasury Backstops
George SelginOne of the more controversial provisions of the CARES Act consists ofthe $454 billion it allows the U.S. Treasury to devote to " backstopping " (that is, to supply partial funding for) the Federal Reserve ' s emergency lending.In a previous post, I argued that these Treasury backstops help to preserve the " boundary line " separating fiscal from monetary policy. I ' ve since engaged ina spirited Twitter exchangewith Peter Conti-Brown, Dan Awrey, and Kate Judge —all legal scholars specializing in monetary policy. That exchange inspires me to offer this more complete, but qualified, defense of the Treasury ' s...
Source: Cato-at-liberty - April 13, 2020 Category: American Health Authors: George Selgin Source Type: blogs
Fight Aging! Newsletter, March 30th 2020
This study, for the first time, shows that transplantation of non-autologous mitochondria from healthy skeletal muscle cells into normal cardiomyocytes leads to short-term improvement of bioenergetics indicating "supercharged" state. However, over time these improved effects disappear, which suggests transplantation of mitochondria may have a potential application in settings where there is an acute stress.
Outlining Some of the Science Behind Partial Reprogramming at Turn.bio
https://www.fightaging.org/archives/2020/03/outlining-some-of-the-science-behind-partial-reprogramming-at-turn-bio/
Turn.bio is ...
Source: Fight Aging! - March 29, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
That Darn Coin
George SelginThey say that a bad penny always turns up. But when it comes to crises these days, it seems that what keeps turning up is a bad idea —namely, the idea of having the U.S. Mint strike one or more trillion-dollar platinum coins.As I explainedlast March, the idea, which was first broached in 2009 and has since become very popular among Modern Monetary Theorists, gained prominence in January 2013, whenthey and several more orthodox economists latched onto itas a way around that month ' sdebt ceiling crisis.Paul Krugman, who was one of the idea ' s proponents, observed:Should President Obama be willing to print a ...
Source: Cato-at-liberty - March 24, 2020 Category: American Health Authors: George Selgin Source Type: blogs
Government Policy and the COVID-19 Pandemic
Jeffrey Miron andErin PartinWhat actions, if any, should governments take in response to the COVID-19 (C ‑19) pandemic?Control of infectious diseases might seem to be a textbook case where private actions will not produce good outcomes for society overall. While individuals surely face incentives to avoid getting sick themselves (which helps limit spread of the disease), they might focus mainly on the private costs and benefits of going to work or attending a large gathering when sick. Likewise, while businesses and other private organizations have good reasons to adopt work from home and other social distancin...
Source: Cato-at-liberty - March 23, 2020 Category: American Health Authors: Jeffrey Miron, Erin Partin Source Type: blogs
Trajectories of Exercise and Mortality in Late Life
Greater physical activity correlates well with lower mortality in later life. Given the way that human data is collected, and the way in which epidemiological studies are carried out, it is hard to determine causation, however. Is it that exercise is protective, or is it that more robust people both live longer and exercise more often? Fortunately the equivalent animal studies on exercise are unambiguous, and show that exercise does in fact act to improve long-term health and reduce premature mortality. Here, researchers expand on the existing evidence by focusing on trends in physical exercise in later life, and how those...
Source: Fight Aging! - March 23, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Promising Hub For Digital Health: Kazakhstan
Sharing borders with Russia, China, Kyrgyzstan, Uzbekistan, and Turkmenistan, you find the world’s largest landlocked country, the Republic of Kazakhstan. Conversely, with its population of over 18 million spanning across an area of 2,724,900 km², the country also has one of the lowest population densities worldwide, at less than 6 people per square kilometre.
Being a relatively new republic and with its widespread inhabitants, Kazakhstan poses as an adequate hub for digital health to expand. Such a young republic’s ministry of health can develop around newer technologies and strategies brought forth with the adven...
Source: The Medical Futurist - March 12, 2020 Category: Information Technology Authors: Prans Tags: Future of Medicine Healthcare Policy digital health digital health strategy health policy Source Type: blogs
Handouts, Helicopters, Hong Kong Dollars, and Hogwash
George SelginThis morning, upon logging in to my Twitter account, I found it brimming with reports that the Hong Kong government was about to embark upon an unprecedented experiment with helicopter money. " Helicopter Money is Here, " blurtsanFT Alphavilleheadline. " Hong Kong Embraces Helicopter Money, "saysZero Hedge. The foreign press has also chimed in: " Helicopter Money Comincia a Hong Kong, " writesItalian financial journalist Maurizio Blondet.In typically understated fashion,Zero Hedge' s report concludes thus:So Hong Kong is about to unleash the mother of all stagflations on its people—who were already on the br...
Source: Cato-at-liberty - February 26, 2020 Category: American Health Authors: George Selgin Source Type: blogs
Productivity of the English National Health Service: 2017/18 update
This report updates the Centre for Health Economics ’ time-series of NHS productivity growth for the period 2016/17 to 2017/18. Between 2016/17 and 2017/18, NHS productivity grew by 1.26 per cent when using the mixed measure of NHS input growth, which includes a direct (volume) growth measure for NHS staff and an indirect (based on expenditure data ) growth measure for materials and capital. The report also considers a range of alternative scarios including using a fully indirect measure of growth inputs.ReportCentre for Health Economics - news (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - February 25, 2020 Category: UK Health Authors: The King ' s Fund Library Tags: NHS finances and productivity Source Type: blogs
Correction of Mitochondrial Dysfunction as an Approach to Treat Heart Failure
Mitochondria are the power plants of the cell, and when their activity falters, cell and tissue function suffers as a consequence. Unfortunately mitochondrial dysfunction is a feature of aging, and is connected to the progression and severity of numerous age-related conditions. The research here examines age-related mitochondrial decline in the context of heart failure. As is appropriate for this new era of intervention in the aging process, the focus is on what might be done about this. At the very least, the evidence suggests that even early approaches that can only somewhat restore mitochondrial function in the old, suc...
Source: Fight Aging! - February 21, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Strategic Pathologies and the 2021 Defense Budget
Brandon ValerianoIn the coming weeks the Cato Institute foreign policy team will release its strategic analysis of the 2021 Budget. The newly released Trump Administration budget for 2021 only continues to exemplify many of the budget pathologies we identify as challenges to constructing a viable national strategy for defense. Instead of making hard choices, tepid moves are made that do not suit overall U.S. strategic posture.The 2021 Defense budget alone requests $636 billion, an increase from $633 billion enacted by the 2020 National Defense Authorization Act.While not a dramatic increase from the 2020 request,...
Source: Cato-at-liberty - February 11, 2020 Category: American Health Authors: Brandon Valeriano Source Type: blogs
