An Estrogen-Related Receptor Agonist Exercise Mimetic Performs Well in Mice
Researchers here demonstrate in mice an effective approach to mimicking some of the adaptive responses to exercise, and sustaining those responses over time. Exercise mimetics have undergone a sedate pace of development in comparison to the larger body of work on calorie restriction mimetics, intended to mimick some of the sweeping changes to metabolism that occur at low nutrient levels, and the field isn't yet as well established. Still, some interesting lines of work have emerged, such as the program noted here.
The new drug, known as SLU-PP-332, doesn't affect appetite or food intake. Nor does it cause mice to ...
Source: Fight Aging! - October 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Future Proofing Healthcare Automation
The following is a guest article by Niall O’Connor, Chief Technology Officer at Cohere Health
Constructing a Responsible AI Framework for Prior Authorization
The American healthcare system is on the precipice of a critically necessary digital transformation. Anyone who has experience with healthcare, even just as a consumer, knows technology and change are needed. A recent report found that 89% of healthcare organizations are still using fax machines and 39% are using pagers. It’s time to future-proof healthcare automation, and I’m not the only one suggesting that now is the time for a digital transformation in hea...
Source: EMR and HIPAA - September 27, 2023 Category: Information Technology Authors: Guest Author Tags: Administration AI/Machine Learning Health IT Company Healthcare IT Revenue Cycle Management AI Accountability Cohere Health Healthcare Automation Niall O’Connor Prior Authorization responsible AI Source Type: blogs
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
All Too Short Comments on the 10th Aging Research and Drug Discovery (ARDD) Meeting
I attended the 10th Aging Research and Drug Discovery (ARDD) conference in Copenhagen recently, alongside my Chief Scientific Officer at Repair Biotechnologies, Mourad Topors. If one wanted to take in all of the presentations and take notes, as I've done in the past, ARDD would be much more of a test of endurance than other longevity industry conferences. It is five 12 hour days, starting with networking at 8am, the last presentations going on past 8pm, and then socializing at nearby bars afterwards for the truly dedicated. This on top of jet lag for those coming in from the US in direction and Asia in the other. The inten...
Source: Fight Aging! - September 11, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Don ’ t disrupt success in Medicare
Each year, Congress goes through its annual budget process to determine how to spend more than $6 trillion on America’s priorities. This year, as part of the discussions on how to spend Medicare’s $900 billion budget, we are being told the Medicare Trust Fund, which is projected to spend $415 billion in 2023 for Part A expenditures, which
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Don’t disrupt success in Medicare originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 9, 2023 Category: General Medicine Authors: Theresa Forster and Logan Hoover Tags: Policy Palliative Care Source Type: blogs
The Cost of Cardiovascular Disease
Age-related disease places a huge financial burden on individuals and their caregivers; even the need for caregivers arises only because aging produces disability. Even only considering cardiovascular disease, the largest contribution to human mortality, the costs are enormous. This is a point often made by advocates arguing for greater institutional funding of ways to treat aging. Present levels of funding for research and development of means to reduce age-related disease are very low in comparison to the massive ongoing costs that result from age-related disease. It makes little sense for this to be the case in an age o...
Source: Fight Aging! - September 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Physical Fitness Correlates with a Lower Risk of Atrial Fibrillation and Stroke
As one might expect, people who better maintain physical fitness into later life exhibit lesser degrees of age-related disease. In this case, the correlation is specifically for forms of cardiovascular disease, but researchers have reported that numerous other improvements in health can be linked to greater fitness. Animal studies can and do show causation in this relationship between fitness and age-related disease. It is reasonable to believe that the human correlations also largely reflect a causal relationship. There are a great many good reasons to make the effort to better maintain physical fitness throughout life.
...
Source: Fight Aging! - August 29, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Short-Term Economic Argument for Undertaking Efforts to Treat Aging as a Medical Condition
The primary economic argument presently made for treating aging as a medical condition emerges from the fact that medical spending and medical research is largely entwined with government in much of the world; it is increasingly a public purse, not a collection of private purses. Politicians and bureaucrats care (to some degree) about avoiding the looming financial implosion that will result when present unsustainable spending policies run head-on into the demographic transition to a society in which an ever-larger proportion of people are old, suffering from age-related disease, and many of their expenses paid via entitle...
Source: Fight Aging! - July 20, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
The corporatization of medicine: Part One
This will be a multi-part series. The days of independent community hospitals and small
physician practices are just about over. Paul Starr ’s famous book The Social
Transformation of American Medicine tells the story
of rise of a “sovereign” medical profession, consisting largely of
entrepreneurs who owned their own individual or small group practices and made
their living as independent business people. They were generally suspi cious of
alternative models such as large group practice and salaried employment. But recent
decades have been marked by one overarching trend: the consolidation of the
medical institu...
Source: Stayin' Alive - July 20, 2023 Category: American Health Source Type: blogs
The Sweet Spot of Health Care Cost Containment
BY BEN WHEATLEY
As health care continues to move in the direction of unaffordability, policy makers are considering a range of options to bring down health care costs. The Health Affairs Committee on Health Care Spending and Value has identified four broad areas for reform, including administrative savings, price regulation and supports for competition, spending growth targets, and value-based payment. These measures appropriately target health care’s supply side and the excesses that exist in the health care system.
In this blog, I would like to highlight another avenue for savings: one that focuses on the demand ...
Source: The Health Care Blog - July 19, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Ben Wheatley Health Care Cost Containment Health care spending Source Type: blogs
The cost of costs
The reason insurers impose deductibles and copays is to discourage utilization. They believe, no doubt correctly, that if people have to spend their own money they may choose not to get as many medical services or buy as many medications. The problem with this reasoning is that people aren ’t wise shoppers for medicine. Now, I’ll be the first to shout it from the rooftops that as a nation, we spend far too much on medical services that are low value or worthless. In fact, I will do so (metaphorically) later in this book. But it’s not because consumers of medicine aren’t wise s hoppers, and making them pay out...
Source: Stayin' Alive - June 17, 2023 Category: American Health Source Type: blogs
Podcast Episode Recommendation: Dear Diabetes Podcast with hostess Rene é Rayles Episode 7
The Dear Diabetes Podcast with hostess Rene é Rayles is a relatively new podcast covering the subject of diabetes; it began quite recently on March 29, 2023. However, Reneé Rayles recently interviewed Civica, Inc. ' s current CEO Ned McCoy. Recall that on June 1, 2023, Ned McCoy succeeded Martin VanTrieste as Civica ' s President and CEO (see the press release athttps://www.businesswire.com/news/home/20220524005169/en/Civica-Announces-Leadership-Transition for details). She spoke with Mr. McCoy about the company ' s affordable insulin biosimilar effort, which is proceeding according to planCivica has released...
Source: Scott's Web Log - June 2, 2023 Category: Endocrinology Tags: 2023 Civica CivicaRx CivicaScript Dear Diabetes Podcast podcast episode recommendations Rene é Rayles Source Type: blogs
Unveiling the intricate link between housing costs and health care
While housing costs have escalated, health care costs have not been left behind. According to the National Health Expenditure Account (NHEA), health care spending grew 4.6 percent in 2019, reaching $3.8 trillion or $11,582 per person. The correlation between these two factors is multifaceted. When housing is unaffordable, it consumes a large chunk of a
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Unveiling the intricate link between housing costs and health care originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 29, 2023 Category: General Medicine Authors: Harvey Castro, MD, MBA Tags: Policy Public Health & Policy Source Type: blogs
