The Staggering Ongoing Cost of Failing to Aggressively Pursue the Development of Rejuvenation Therapies
No feasible amount of funding that could be devoted to the research and development of rejuvenation therapies would be too much. If near all other projects were dropped, and institutions radically retooled on a short term basis, then the world might be able to devote $300 billion per year into medical research and development aimed at aging. That is an unachievable upper bound, of course. Given a few decades in which to train new researchers while rapidly and radically expanding existing institutions, then humanity might start to approach that scale of expenditure. Realistically it will take 20-30 years following the first...
Source: Fight Aging! - September 24, 2021 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns.
First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Metabolism Declines in Late Life
The research noted here is one of many different views into the decline in cell and tissue activity that takes place in old age. One can look at the way in which cancer rates decline with age after peaking in the 60s and 70s, for example. Or the phenomenon of diminished protein synthesis in old tissues. Or reduced calorie intake in older people. Many of the manifestations of age are reactions to underlying causes. A general slowdown in cell activity has the look of something that depends upon environment, given the various studies showing that many types of cell taken from old individuals can still perform to youthful leve...
Source: Fight Aging! - August 20, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
America as an outlier: Paying more for less
According to the Organisation for Economic Co-operation and Development (OECD), the United States clearly stands out: we spend far more on health care per capita than any other country in the world, yet life expectancy is shorter than in other developed countries that spend far less. Despite having a higher total expenditure on health careRead more …America as an outlier: Paying more for less originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 14, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/leonard-wang-and-lily-nguyen" rel="tag" > Leonard Wang and Lily Nguyen < /a > < /span > Tags: Policy Public Health & Source Type: blogs
I Think We Need A Good Deal More Haste, More Thought And Less Speed With Vaccination Certificates.
This appeared a few days ago: Australian vaccination certificates easy to forge Chris Griffith · 8:46AM August 5, 2021 An online security firm specialising in identity protection has warned that the federal government ‘s digital Covid vaccination certificates will be easy to forge without better security. There is concern that vaccination certificates aka vaccination passports which currently include a person’s name, date of birth and document number can be easily altered and copied. The government made digit al certificates available in June and this week added the abil...
Source: Australian Health Information Technology - August 11, 2021 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Development of a Safe Mitochondrial Uncoupler, OPC-163493
We describe here the optimization process from initial screening hit compound to a liver-localized mitochondrial uncoupler OPC-163493, which recently demonstrated its potent antidiabetic and cardiovascular beneficial effects with acceptable safety.
Link: https://doi.org/10.1021/acsomega.1c01993 (Source: Fight Aging!)
Source: Fight Aging! - July 21, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
SENS Research Foundation Raises at Least $20 Million in the First Two Days of the Pulse Chain Airdrop
A warning: we're going to be talking about the strange world of blockchains and cryptocurrency today, about which I am far less informed than is the case for matters relating to aging. Blockchains are a way to solve problems in distributed collaboration, allowing enforcement of transactions and outcomes without the need for a trusted third party. Implementations to date, most notably Bitcoin and Ethereum, have used the cost of large amounts of computation as the barrier that prevents cheating, but that requires a collectively equally large ongoing expenditure on computation on the part of participants in the network. That ...
Source: Fight Aging! - July 19, 2021 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
The Trump Administration Actually Thought Imported Cars Were a “National Security” Threat (and the Courts Would’ve Let ‘Em Get Away With It)
Inu Manak andScott LincicomeDo you drive an imported car or one made here by a foreign‐owned company? If so, you may be a serious threat to national security –if a long‐awaited report from the Trump administration is to be believed.No, really.Last week, the Department of Commerce finally released itsreport on U.S. imports of automobiles and certain automotive parts, as part of the Trump administration ’s 2018investigation pursuant to Section 232 of the Trade Expansion Act of 1962. While the report was submitted to the president on February 17, 2019, it was not published in the Federal Register, as the la...
Source: Cato-at-liberty - July 15, 2021 Category: American Health Authors: Inu Manak, Scott Lincicome Source Type: blogs
U.S. R & D Spending Continues to Climb (Somebody Should Tell Congress)
Scott LincicomeAs I noted on Wednesday, the Senate is now considering “The United States Innovation and Competition Act of 2021” (formerly known as the “Endless Frontier Act”), which is primarily* intended to boost federal funding for research and development in the United States by tens of billions of dollars. If you were to listen to the bill’s advocates, you’d think that the United States was suffering from a dramatic decline in R&D spending over the last several decades, and that other countries — particularly China — had raced ahead. New data from the U.S. andNational Center for Science and Eng...
Source: Cato-at-liberty - May 21, 2021 Category: American Health Authors: Scott Lincicome Source Type: blogs
American Chipmakers Innovate While Congress Debates Subsidizing Them
Scott LincicomeThe Senate this week has begun considering the “The United States Innovation and Competition Act of 2021, ” which — among many other things — appropriates $52 billion in subsidies for U.S. semiconductor manufacturing facilities and research and development. The stated justification for the bill, according to the fact sheet that accompanied the legislation, is “to encourage the development of domestic semiconductor manufacturing capabilities and ensure the U.S. stay on the cutting‐edge of the industry with R&D ” and to counter China, which is “aggressively investing over $150 billion in...
Source: Cato-at-liberty - May 20, 2021 Category: American Health Authors: Scott Lincicome Source Type: blogs
Trustbusters or Business ‐Busters?
Jeffrey Miron andPedro Braga SoaresIn a recent opinionpiece, Senator Josh Hawley claims that America ’s economy is witnessing a widespread take ‐over from monopolies – big tech, big pharma, big finance, and more. These companies, the story goes, then harness their market power to foist ideological progressive agendas on an unwilling public.This narrative is misleading at best. First, big is not synonymous with bad. Concentration can arise out of competitive markets for legitimate reasons. Innovative companies can – and should – expand their market share by delivering better products at lower costs. I...
Source: Cato-at-liberty - May 4, 2021 Category: American Health Authors: Jeffrey Miron, Pedro Braga Soares Source Type: blogs
The New Deal and Recovery, Part 13: Fear Itself (Continued)
George Selgin(This post continuesmy discussion of the " regime uncertainty " hypothesis, according to which theNew Deal hampered recovery by causing businessmen to fear policy changes that might render their investments unprofitable.)Insull ' s MonstrosityThe 1935 Revenue Act wasn ' t the only measure that had businessmen and investors shuddering that August. Less than a week after it became law, FDR signed the still-more controversialPublic Utility Holding Company Act, granting the SEC the power to break up the nation ' s utility holding companies.On the eve of the Depression,Paul Mahoney explains, most U.S. electric and ...
Source: Cato-at-liberty - April 30, 2021 Category: American Health Authors: George Selgin Source Type: blogs
How Much Do You Want To Exercise Right Now? Researchers Are Studying People ’s In-The-Moment Motivation To Be Active
By Emma Young
Think back to the last time that you did some exercise. What exactly prompted you to get up and do it? Was it because it was scheduled? Or because you felt a strong urge to engage in some physical activity (or maybe a bit of both)?
Traditionally, researchers have explored a person’s general disposition to exercise, and looked at strategies to increase their exercise levels over a week, a month, or longer. However, a team led by Matt Stults-Kolehmainen at Yale University, Yale-New Haven Hospital and Columbia University argues in new work in Frontiers in Psychology that it’s also crucial to consider ...
Source: BPS RESEARCH DIGEST - April 26, 2021 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Sport Source Type: blogs
My Oral Testimony to the Alaska Senate Labor and Commerce Committee
Jeffrey A. SingerI gave oral testimony to the Alaska Senate Labor and Commerce Committee today regarding legislation it is considering that would repeal the state ’s Certificate of Need (CON) laws. These laws require health care facilities to obtain permission in order to open, expand, or add new equipment to health care facilities within the state. CON laws were originally encouraged by federal legislation passed during the Nixon administration, providing grants to states to set up CON commissions, under the misguided belief that restricting the growth of new or existing health care facilities would reduce health care e...
Source: Cato-at-liberty - April 21, 2021 Category: American Health Authors: Jeffrey A. Singer Source Type: blogs
Corporate Reinvestment
Peter Van DorenThe Washington Post recentlyreported on an analysis by Oren Cass of corporate profits and their division between dividends, stock repurchases, and reinvestment. The report argues that profits are being dispersed to shareholders through dividends and stock repurchases rather than reinvested. The result is reduced economic growth and fewer opportunities for American workers.Two papers I review inRegulation examine the issue. The first paper confirms that payouts to shareholders (rather than retention of earnings within the firm) are larger now than in the past. In the 2000s, annual aggregate inflation ‐...
Source: Cato-at-liberty - April 9, 2021 Category: American Health Authors: Peter Van Doren Source Type: blogs
