Fight Aging! Newsletter, March 7th 2022
This study estimates that prescreening with a 500 blood test could reduce by half both the cost and the time it takes to enroll patients in clinical trials that use PET scans. Screening with blood tests alone could be completed in less than six months and cut costs by tenfold or more, the study finds. Known as Precivity AD, the commercial version of the test is marketed by C2N Diagnostics. The current study shows that the blood test remains highly accurate, even when performed in different labs following different protocols, and in different cohorts across three continents.
xCT Knockout Modestly Extends Life in M...
Source: Fight Aging! - March 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Arguing for a Rate of Living View of Aging
The rate of living view of aging is one of the discarded historical hypotheses that occurred along the way to the modern competing ideas about why aging occurs, and why there are differences in longevity between species. Roughly, the rate of living hypothesis says that a faster metabolism means a shorter life, that underlying processes (such as accumulation of molecular damage) depend strongly on metabolic rate. This doesn't appear to be the case, however; setting aside more detailed considerations, there are enough exceptions to the rule, species with high metabolism and exceptional longevity, to sink the argument. It isn...
Source: Fight Aging! - March 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Cellular Senescence as a Contributing Cause of Sarcopenia
Every age-related disease that can be linked to the chronic inflammation of aging is likely driven in part by the accumulation of senescent cells. This is not only a matter of senescent cells present in the organs affected by disease, but also involves the burden of cellular senescence throughout the body. When lingering in significant numbers, senescent cells cause harm via their inflammatory secretions, the senescence-associated secretory phenotype (SASP). Secreted inflammatory signals can travel widely through the body, rousing the immune system to overactivity, and changing cell behavior for the worse.
Sarcopeni...
Source: Fight Aging! - February 7, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Depletion of Arginine as a Calorie Restriction Mimetic Strategy
Researchers have shown that depleting the amino acid arginine produces some of the effects of calorie restriction, including loss of fat tissue and upregulation of autophagy. In this open access paper, researchers use a few different approaches to this end to illustrate that this may be a viable strategy for improved health. As is the case for all calorie restriction mimetics, it is worth recalling that (a) effects on long-term health and life span in short-lived species are larger than those in long-lived species, and (b) the actual practice of calorie restriction will usually be more effective than an intervention that t...
Source: Fight Aging! - January 27, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Health and social care near the end of life: can policies reduce costs and improve outcomes?
European Observatory on Health Systems and Policies - This briefing reviews the evidence on health and social care needs and expenditures at the end of life. End of life costs are the main reason for high per person spending levels observed at older ages in many European countries. However, there is huge variation between individuals, with estimates suggesting that just ten per cent of people near the end of life are responsible for over 60 per cent of total end of life health and social care expenditures. High-cost individuals tend to be frail people with multiple chronic illnesses who use considerable hospital and ...
Source: Health Management Specialist Library - January 24, 2022 Category: UK Health Authors: The King ' s Fund Library Tags: Social care Source Type: blogs
Looking back to look forwards: what can we learn from data on the impacts of Covid-19 on councils in 2020 –21?
lnstitute for Fiscal Studies - The Covid-19 pandemic has led to substantial increases in councils ’ expenditure and falls in their locally generated revenue, especially from sales, fees and charges (SFCs) and commercial activity. This briefing examines impacts for English councils using outturns data for 2020–21, compares these with expectations based on ex ante and rapidly available indicat ors, and considers the implications for both councils’ current financial resilience and how the financial impacts of future extreme adverse shocks should be monitored.BriefingPress release (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - January 11, 2022 Category: UK Health Authors: The King ' s Fund Library Tags: Social care Source Type: blogs
The Top Seven Reasons to Oppose New Semiconductor Subsidies
Scott Lincicome and Ilana BlumsackAs the global semiconductorshortage persists, chipmakers have renewed theirefforts to convince Congress to hand them tens of billions of taxpayer dollars. Earlier this year, the U.S. Senatepassed a $52 billion subsidy package for this very purpose. Its fate remains unclear in the House of Representatives, but a vote on some sort of government support for domestic chip production is expected in the coming weeks (though perhaps after the new year). Before members vote again on any such subsidies, however, we provide below seven reasons why broad, strings-free subsidization of U.S. semiconduc...
Source: Cato-at-liberty - December 17, 2021 Category: American Health Authors: Scott Lincicome, Ilana Blumsack Source Type: blogs
Mike Lee Proposes Paring Back Protectionism to Address Port Woes
Colin GrabowOne unpleasant discovery for many Americans during 2021 has been thewoeful state of the country ’s ports, which have struggled to accommodate a deluge of demand for imported goods. To address these shortcomings, the Biden administration and much of Congress have —to the surprise of only the grossly naïve—largely centered their efforts around increased spending.Included in the Infrastructure Investment and Jobs Act passed last month was $17.1 billion for ports, of which more than $11.5 billion will be focused on new construction. That money, onearticle says, “appears set to literally reshape ports ...
Source: Cato-at-liberty - December 15, 2021 Category: American Health Authors: Colin Grabow Source Type: blogs
BDNF is Important in Muscle Function, Not Just in Brain Function
BDNF levels decline with age. Much of the focus on BDNF has been its role in neurogenesis in the brain. Interventions such as exercise and reversing (or compensating for) the aging of the gut microbiome can boost BDNF levels and cognitive function in animal studies. For a different view on the relevance of BDNF, researchers here report on their investigations of the role of BDNF in muscle tissue, finding that it can upregulate the mitochondrial quality control mechanism of mitophagy, improving muscle function. They also note that obesity can harm muscle tissue function by reducing BDNF levels and thereby causing a loss of ...
Source: Fight Aging! - December 6, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Left behind: a decade of intergenerational unfairness
This report used 31 indicators to investigate how the position of young people has changed in the labour market, housing, higher education, government expenditure, wealth and expenditure, physical and mental health, political representation and the environment. In all policy areas, except for the environment, the position of younger people has either declined or stagnated over the past ten years.ReportPress release (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - November 22, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Equality and diversity Source Type: blogs
About Your Proposal for Better Payment Arrangements: Does it Pass the Market Test?
Lawrence H. WhiteMany economists acknowledge that ordinary private goods and services need to “pass the market test”—generate revenue in excess of expenses—to show that consumers’ benefits (revealed by a willingness to pay) exceed producers’ outlays. But they make an exception when it comes to monetary instruments and payment systems. They imagine that they know what arrangements are efficient, without evidence from market tests.Such an attitude implies that we needn ’t, and therefore shouldn’t, tolerate experimentation and entrepreneurship in money and payments. What payment products are to be available, a...
Source: Cato-at-liberty - October 21, 2021 Category: American Health Authors: Lawrence H. White Source Type: blogs
Drug expenditure dynamics 1995 –2020: understanding medicine spending in context
This report includes estimates of total drug spending, including hospitals and net of discounts and rebates. These estimates have been based on official statistics from government agencies in the countries where available, in some cases not previously published internationally.ReportMore detail (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - October 18, 2021 Category: UK Health Authors: The King ' s Fund Library Source Type: blogs
Ninth Circuit: Oakland Can ’t Sue Wells Fargo Over Risky Mortgages
Walter OlsonIn a welcome development, a unanimous en banc panel of the Ninth Circuit has called what we may hope is a permanent halt to a reckless campaign under which city governments have sought to mulct bank shareholders by way of a strained theory of fair ‐housing liability.Following the housing bust of the late 2000s, some American cities signed up with contingency ‐fee plaintiff’s counsel to sue bank lenders on a highly ambitious legal theory: by extending too many risky loans to minority borrowers on dangerous terms (e.g., low ‐money‐down loans with adjustable inte...
Source: Cato-at-liberty - October 11, 2021 Category: American Health Authors: Walter Olson Source Type: blogs
Societal Resilience Requires a Public Health Focus
We must make a serious commitment to increase financial resources and provide better analytics for real world evidence/real time data in support of public health.John Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.Public health has been underfunded for decades. That neglect has had a profound impact since the COVID-19 pandemic has taken hold, and awakened policy makers and thought leaders to the need for more investment.Consider the statistics: The U.S. spends about $3.6 trillion each year on healthbut less th...
Source: Life as a Healthcare CIO - October 6, 2021 Category: Information Technology Source Type: blogs
Fight Aging! Newsletter, September 27th 2021
This study provides causal evidence of a lipoprotein-Aß /capillary axis for onset and progression of a neurodegenerative process.
The Staggering Ongoing Cost of Failing to Aggressively Pursue the Development of Rejuvenation Therapies
https://www.fightaging.org/archives/2021/09/the-staggering-ongoing-cost-of-failing-to-aggressively-pursue-the-development-of-rejuvenation-therapies/
No feasible amount of funding that could be devoted to the research and development of rejuvenation therapies would be too much. If near all other projects were dropped, and institutions radically retooled on a short term basi...
Source: Fight Aging! - September 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
