Cellular Senescence as a Contributing Cause of Sarcopenia

Every age-related disease that can be linked to the chronic inflammation of aging is likely driven in part by the accumulation of senescent cells. This is not only a matter of senescent cells present in the organs affected by disease, but also involves the burden of cellular senescence throughout the body. When lingering in significant numbers, senescent cells cause harm via their inflammatory secretions, the senescence-associated secretory phenotype (SASP). Secreted inflammatory signals can travel widely through the body, rousing the immune system to overactivity, and changing cell behavior for the worse. Sarcopenia is the characteristic loss of muscle mass and strength that takes place with age. Linking sarcopenia to chronic inflammation, and indeed to senescent cells, is a new idea in the sense that the modern focus on cellular senescence in aging only began in earnest a decade ago or so (after another prior decade of a few voices trying to get more researchers to take it seriously). With the development of senolytic therapies to selectively destroy senescent cells in full swing for a few years now, scientists have been writing papers on the plausible role of cellular senescence in sarcopenia. Today's open access materials are an example of the type. Cellular Senescence in Sarcopenia: Possible Mechanisms and Therapeutic Potential Aging promotes most degenerative pathologies in mammals, which are characterized by progressive decline of function at mol...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs