Economic evaluation of olmesartan/amlodipine fixed-dose combination for hypertension treatment in China.
CONCLUSIONS: Olmesartan/amlodipine fixed-dose combination confers better health outcomes and costs less compared with olmesartan and amlodipine free combination and valsartan/amlodipine fixed-dose combination and is cost-effective compared with amlodipine for hypertension treatment in China.
PMID: 31782677 [PubMed - as supplied by publisher] (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - November 30, 2019 Category: Health Management Tags: J Med Econ Source Type: research
Effects of amlodipine and valsartan on glibenclamide-treated streptozotocin-induced diabetic rats
This study examined the effects of amlodipine and valsartan on glibenclamide-treated streptozotocin-induced diabetic rats.Male albino rats (200–350 g) were fasted overnight and DM was induced by a single dose 40 mg/kg of streptozotocin (i.p.). After 48 h, DM was confirmed (blood sugar ≥200 mg/dl) and the animals were grouped into normal rats with no drug treatment, untreated diabetic animals and groups treated with glibenclamide, glibenclamide plus amlodipine, and glibenclamide plus valsartan. After six weeks treatment, animals were sacrificed under chloroform anaesthesia. Kidney, liver, lung, heart and blood w...
Source: Biomedicine and Pharmacotherapy - July 12, 2018 Category: Drugs & Pharmacology Source Type: research
Effects of amlodipine and valsartan on glibenclamide-treated streptozotocin-induced diabetic rats.
This study examined the effects of amlodipine and valsartan on glibenclamide-treated streptozotocin-induced diabetic rats. Male albino rats (200-350 g) were fasted overnight and DM was induced by a single dose 40 mg/kg of streptozotocin (i.p.). After 48 h, DM was confirmed (blood sugar ≥200 mg/dl) and the animals were grouped into normal rats with no drug treatment, untreated diabetic animals and groups treated with glibenclamide, glibenclamide plus amlodipine, and glibenclamide plus valsartan. After six weeks treatment, animals were sacrificed under chloroform anaesthesia. Kidney, liver, lung, heart and blood we...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Bolanle IO, Omogbai EKI, Bafor EE Tags: Biomed Pharmacother Source Type: research
Efficacy and effectiveness of valsartan/amlodipine and valsartan/amlodipine/hydrochlorothiazide in hypertension: randomized-controlled versus observational studies.
CONCLUSION: These findings demonstrate that the efficacy of Val/Aml and Val/Aml/HCTZ in RCTs was more pronounced compared with their effectiveness in RWE studies in different ethnic populations although the overall benefit was not different.
PMID: 29210288 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - December 8, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research
A comprehensive guidelines-based approach reduces cardiovascular risk in everyday practice: the VARO study.
CONCLUSIONS: The VARO study demonstrates that in daily practice settings, both individual risk factors and global cardiovascular risk are significantly improved through the systematic identification of high-risk individuals and their treatment in accordance with current guidelines using modern pharmacotherapy.
PMID: 28721135 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research
Development, validation and comparison of near infrared and Raman spectroscopic methods for fast characterization of tablets with amlodipine and valsartan.
The objective of this study was to develop, validate and compare NIR and Raman spectroscopic methods for fast characterization in terms of API content and tensile strength of fixed-dose combination tablets containing amlodipine and valsartan. For the APIs assay NIR-transmittance and Raman-reflectance methods were considered, whereas for the tensile strength assay Raman spectra were recorded in reflectance configuration and NIR spectra were recorded in both reflectance and transmittance. Multivariate calibration models (PLS) were built by applying different pre-processing methods (SNV, MSC, SD+SNV) on certain spectral regio...
Source: Talanta - March 29, 2017 Category: Chemistry Authors: Casian T, Reznek A, Vonica-Gligor AL, Van Renterghem J, De Beer T, Tomuță I Tags: Talanta Source Type: research
Effects of Amlodipine and Valsartan on Blood Pressure Variability and Pulse Wave Velocity in Hypertensive Patients.
CONCLUSIONS: All further strategies can effectively control BP. The combination treatment reduces both BPV and PWV noticeably, whereas double-dose amlodipine achieves the greatest BPV decrease and valsartan is best in controlling PWV.
PMID: 28104105 [PubMed - in process] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - December 31, 2016 Category: Journals (General) Authors: Shi R, Liu K, Shi D, Liu Q, Chen X Tags: Am J Med Sci Source Type: research
Quantitative model for the blood pressure ‐lowering interaction of valsartan and amlodipine
ConclusionPKPD models for SBP and DBP successfully described the time course of the antihypertensive effects of amlodipine and valsartan. An infra‐additive interaction between amlodipine and valsartan when used in combined administration was confirmed and quantified. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - October 2, 2016 Category: Drugs & Pharmacology Authors: Young ‐A Heo, Nick Holford, Yukyung Kim, Mijeong Son, Kyungsoo Park Tags: PHARMACOKINETIC DYNAMIC RELATIONSHIPS Source Type: research
Quantitative Model for the Blood Pressure Lowering Interaction of Valsartan and Amlodipine
ConclusionPKPD models for SBP and DBP successfully described the time course of the antihypertensive effects of amlodipine and valsartan. An infra‐additive interaction between amlodipine and valsartan when used in combined administration was confirmed and quantified. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - August 10, 2016 Category: Drugs & Pharmacology Authors: Young ‐A Heo, Nick Holford, Yukyung Kim, Mijeong Son, Kyungsoo Park Tags: PHARMACOKINETIC DYNAMIC RELATIONSHIPS Source Type: research
Endocan, a novel marker of endothelial dysfunction in patients with essential hypertension: comparative effects of amlodipine and valsartan.
Authors: Celık T, Balta S, Karaman M, Ahmet Ay S, Demırkol S, Ozturk C, Dınc M, Unal HU, Yılmaz MI, Kılıc S, Kurt G, Tas A, Iyısoy A, Quartı-Trevano F, Fıcı F, Grassı G
Abstract
Vascular inflammation plays an important role in the pathophysiology of hypertension and high levels of endocan may reflect ongoing vascular inflammation in hypertensive patients. In the present hypothesis-generating study, we aimed at investigating the comparative effects of amlodipine and valsartan on endocan levels in newly diagnosed hypertensive patients. The study population consisted of 37 untreated hypertensive pa...
Source: Blood Pressure - February 14, 2016 Category: Hematology Tags: Blood Press Source Type: research
Antihypertensive nano-ceuticales based on chitosan biopolymer: Physico-chemical evaluation and release kinetics
Publication date: 20 May 2016 Source:Carbohydrate Polymers, Volume 142 Author(s): Taskeen Niaz, Saima Shabbir, Shahid Manzoor, Asma Rehman, Abdur Rahman, Habib Nasir, Muhammad Imran Prime risk factor behind cardiovascular associated mortality and morbidity is hypertension. The main challenge with antihypertensive (AHT) drug therapy is their extreme hydrophobic nature and very low oral bio-availability; which result into higher dosage/frequency and associated side effects of drugs. The main objective of this study was to fabricate AHT nano-ceuticals in hydrophilic carriers of natural origin to improve drug...
Source: Carbohydrate Polymers - February 7, 2016 Category: Biomedical Science Source Type: research
Clinical Effectiveness, Safety and Tolerability of Amlodipine/Valsartan in Hypertensive Patients: the Indonesian Subset of the EXCITE Study.
CONCLUSION: Aml/Val SPC was effective for BP reductions and well tolerated in hypertensive patients, not adequately controlled by monotherapy, in a daily clinical setting in Indonesia.
PMID: 26586388 [PubMed - in process] (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - December 11, 2015 Category: Internal Medicine Tags: Acta Med Indones Source Type: research
Improvement in Hemodynamics After Methylene Blue Administration in Drug-Induced Vasodilatory Shock: A Case Report.
DISCUSSION: Methylene blue may improve hemodynamics in drug-induced vasodilatory shock and should be considered in critically ill patients poisoned with vasodilatory medications refractory to standard therapies.
PMID: 26310944 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - August 27, 2015 Category: Toxicology Authors: Laes JR, Williams DM, Cole JB Tags: J Med Toxicol Source Type: research
New methods for amlodipine and valsartan native spectrofluorimetric determination, with factors optimization study.
Abstract
Four native fluorescence methods were suggested for simultaneous determination of amlodipine (AML) and valsartan (VAL). These methods were based on excitation of both drugs at λex 300nm, in one step, to give maximum emission at λem 378 and 496nm for AML and VAL, respectively. The first method, single λex method, was used without any additions. The sensitivity of this method was further increased by the addition of hydroxy propylmethyl cellulose (HPMC) surfactant, β-cyclodextrin, or ferric oxide magnetite nanoparticles, in the other three methods. Different types of surfactants, and different c...
Source: Talanta - June 19, 2015 Category: Chemistry Authors: El-Kosasy AM, Tawakkol SM, Ayad MF, Sheta AI Tags: Talanta Source Type: research
Evening versus morning dosing of antihypertensive drugs in hypertensive patients with sleep apnoea: a cross-over study
Objective: Beneficial effects of continuous positive airway pressure (CPAP) on both blood pressure (BP) levels and variability have been documented in patients with obstructive sleep apnoea (OSA). We investigated the relevant impact of different dosing times of antihypertensive drugs beyond CPAP application.
Methods: In this prospective, cross-over trial, we included 41 patients with newly diagnosed hypertension and never treated OSA (apnoea-hypopnea index ≥15/h), without increased daytime somnolence (Epworth Score ≤10 points). Patients first received treatment with valsartan or with a fixed combination of amlodipine a...
Source: Journal of Hypertension - January 6, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research
