Application of Design of Experiments ® Approach-Driven Artificial Intelligence and Machine Learning for Systematic Optimization of Reverse Phase High Performance Liquid Chromatography Method to Analyze Simultaneously Two Drugs (Cyclosporin A and Etodolac) in Solution, Human Plasma, Nanocapsules, and Emulsions
The objectives of current investigation are (1) to find out wavelength of maximum absorbance (λmax) for combined cyclosporin A and etodolac solution followed by selection of mobile phase suitable for the RP-HPLC method, (2) to define analytical target profile and critical analytical attributes (CAAs) for the analytical quality by design, (3) to screen critical method parameters with the help of full factorial design followed by optimization with face-centered central composite design (CCD) approach-driven artificial neural network (ANN)-linked with the Levenberg-Marquardt (LM) algorithm for finding the RP-HPLC conditions,...
Source: AAPS PharmSciTech - May 14, 2021 Category: Drugs & Pharmacology Authors: Syed Nazrin Ruhina Rahman Oly Katari Datta Maroti Pawde Gopi Sumanth Bhaskar Boddeda Abhinab Goswami Srinivasa Rao Mutheneni Tamilvanan Shunmugaperumal Source Type: research
Application of Design of Experiments ® Approach-Driven Artificial Intelligence and Machine Learning for Systematic Optimization of Reverse Phase High Performance Liquid Chromatography Method to Analyze Simultaneously Two Drugs (Cyclosporin A and Etodolac) in Solution, Human Plasma, Nanocapsules, and Emulsions
The objectives of current investigation are (1) to find out wavelength of maximum absorbance (λmax) for combined cyclosporin A and etodolac solution followed by selection of mobile phase suitable for the RP-HPLC method, (2) to define analytical target profile and critical analytical attributes (CAAs) for the analytical quality by design, (3) to screen critical method parameters with the help of full factorial design followed by optimization with face-centered central composite design (CCD) approach-driven artificial neural network (ANN)-linked with the Levenberg-Marquardt (LM) algorithm for finding the RP-HPLC conditions,...
Source: AAPS PharmSciTech - May 14, 2021 Category: Drugs & Pharmacology Authors: Syed Nazrin Ruhina Rahman Oly Katari Datta Maroti Pawde Gopi Sumanth Bhaskar Boddeda Abhinab Goswami Srinivasa Rao Mutheneni Tamilvanan Shunmugaperumal Source Type: research
Application of Design of Experiments ® Approach-Driven Artificial Intelligence and Machine Learning for Systematic Optimization of Reverse Phase High Performance Liquid Chromatography Method to Analyze Simultaneously Two Drugs (Cyclosporin A and Etodolac) in Solution, Human Plasma, Nanocapsules, and Emulsions
The objectives of current investigation are (1) to find out wavelength of maximum absorbance (λmax) for combined cyclosporin A and etodolac solution followed by selection of mobile phase suitable for the RP-HPLC method, (2) to define analytical target profile and critical analytical attributes (CAAs) for the analytical quality by design, (3) to screen critical method parameters with the help of full factorial design followed by optimization with face-centered central composite design (CCD) approach-driven artificial neural network (ANN)-linked with the Levenberg-Marquardt (LM) algorithm for finding the RP-HPLC conditions,...
Source: AAPS PharmSciTech - May 14, 2021 Category: Drugs & Pharmacology Authors: Syed Nazrin Ruhina Rahman Oly Katari Datta Maroti Pawde Gopi Sumanth Bhaskar Boddeda Abhinab Goswami Srinivasa Rao Mutheneni Tamilvanan Shunmugaperumal Source Type: research
Application of Design of Experiments ® Approach-Driven Artificial Intelligence and Machine Learning for Systematic Optimization of Reverse Phase High Performance Liquid Chromatography Method to Analyze Simultaneously Two Drugs (Cyclosporin A and Etodolac) in Solution, Human Plasma, Nanocapsules, and Emulsions
The objectives of current investigation are (1) to find out wavelength of maximum absorbance (λmax) for combined cyclosporin A and etodolac solution followed by selection of mobile phase suitable for the RP-HPLC method, (2) to define analytical target profile and critical analytical attributes (CAAs) for the analytical quality by design, (3) to screen critical method parameters with the help of full factorial design followed by optimization with face-centered central composite design (CCD) approach-driven artificial neural network (ANN)-linked with the Levenberg-Marquardt (LM) algorithm for finding the RP-HPLC conditions,...
Source: AAPS PharmSciTech - May 14, 2021 Category: Drugs & Pharmacology Authors: Syed Nazrin Ruhina Rahman Oly Katari Datta Maroti Pawde Gopi Sumanth Bhaskar Boddeda Abhinab Goswami Srinivasa Rao Mutheneni Tamilvanan Shunmugaperumal Source Type: research
Application of Design of Experiments ® Approach-Driven Artificial Intelligence and Machine Learning for Systematic Optimization of Reverse Phase High Performance Liquid Chromatography Method to Analyze Simultaneously Two Drugs (Cyclosporin A and Etodolac) in Solution, Human Plasma, Nanocapsules, and Emulsions
The objectives of current investigation are (1) to find out wavelength of maximum absorbance (λmax) for combined cyclosporin A and etodolac solution followed by selection of mobile phase suitable for the RP-HPLC method, (2) to define analytical target profile and critical analytical attributes (CAAs) for the analytical quality by design, (3) to screen critical method parameters with the help of full factorial design followed by optimization with face-centered central composite design (CCD) approach-driven artificial neural network (ANN)-linked with the Levenberg-Marquardt (LM) algorithm for finding the RP-HPLC conditions,...
Source: AAPS PharmSciTech - May 14, 2021 Category: Drugs & Pharmacology Authors: Syed Nazrin Ruhina Rahman Oly Katari Datta Maroti Pawde Gopi Sumanth Bhaskar Boddeda Abhinab Goswami Srinivasa Rao Mutheneni Tamilvanan Shunmugaperumal Source Type: research
Effectiveness of transcutaneous electrical nerve stimulation as an adjunct to selected physical therapy exercise program on male patients with pudendal neuralgia: A randomized controlled trial
CONCLUSION: Adding TENS to physical therapy exercise program is more effective than physical therapy program alone in improving pain in male patients with pudendal neuralgia as measured by numerical pain rating scale and daily analgesic intake dose.PMID:33611923 | DOI:10.1177/0269215521995338 (Source: Clinical Rehabilitation)
Source: Clinical Rehabilitation - February 22, 2021 Category: Rehabilitation Authors: Marwa M Eid Mohamed F Rawash Moussa A Sharaf Hadaya Mosaad Eladl Source Type: research
Effectiveness of transcutaneous electrical nerve stimulation as an adjunct to selected physical therapy exercise program on male patients with pudendal neuralgia: A randomized controlled trial
CONCLUSION: Adding TENS to physical therapy exercise program is more effective than physical therapy program alone in improving pain in male patients with pudendal neuralgia as measured by numerical pain rating scale and daily analgesic intake dose.PMID:33611923 | DOI:10.1177/0269215521995338 (Source: Clinical Rehabilitation)
Source: Clinical Rehabilitation - February 22, 2021 Category: Rehabilitation Authors: Marwa M Eid Mohamed F Rawash Moussa A Sharaf Hadaya Mosaad Eladl Source Type: research
Enhanced oral bioavailability of Etodolac by liquisolid compact technique: optimisation, in-vitro and in-vivo evaluation.
CONCLUSION: The results indicated liquisolid compact technique to be a promising strategy to enhance the bioavailability of Etodolac.
PMID: 33106143 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 26, 2020 Category: Drugs & Pharmacology Authors: Pathak BK, Raghav M, Thakkar AR, Vyas BA, Shah PJ Tags: Curr Drug Deliv Source Type: research
Detection, transformation, and toxicity of indole-derivative nonsteroidal anti-inflammatory drugs during chlorine disinfection.
Abstract
As important emerging contaminants, nonsteroidal anti-inflammatory drugs (NSAIDs) are the most intensively prescribed pharmaceuticals introduced to drinking water due to their incomplete removal in wastewater treatment. While concentrations of NSAIDs in drinking water are generally low, they have been attracting increasing concern as a result of their disinfection byproducts (DBPs) generated in drinking water disinfection. In this work, detection methods were set up for four representative indole-derivative NSAIDs (indomethacin, acemetacin, sulindac, and etodolac) using ultra performance liquid ch...
Source: Chemosphere - October 22, 2020 Category: Chemistry Authors: Qiu J, Huang Y, Wu Y, Shi P, Xu B, Chu W, Pan Y Tags: Chemosphere Source Type: research
The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study.
CONCLUSIONS: Pain, edema and trismus after impacted third molars extraction were not influenced by gender.
PMID: 33037801 [PubMed - as supplied by publisher] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - October 11, 2020 Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research
Remdesivir-COVID-19: drug interactions in dentistry.
CONCLUSIONS: It is clinically necessary for oral health professionals to be aware of possible drug interactions that may occur between remdesivir and drugs commonly prescribed in dentistry in order to prevent adverse reactions that may even endanger the life of a patient with COVID-19.
PMID: 33015819 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - October 7, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Etodolac loaded solid lipid nanoparticle based topical gel for enhanced skin delivery
Publication date: Available online 5 October 2020Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Dilip K. Patel, Roohi Kesharwani, Vikas Kumar (Source: Biocatalysis and Agricultural Biotechnology)
Source: Biocatalysis and Agricultural Biotechnology - October 6, 2020 Category: Biotechnology Source Type: research
Solubility measurement, Hansen solubility parameter and thermodynamic modeling of etodolac in four binary solvents from 278.15 K to 323.15 K
Publication date: 15 November 2020Source: Journal of Molecular Liquids, Volume 318Author(s): Xiaoran Hu, Yanan Tian, Zidan Cao, Jiao Sha, Zibo Huang, Yu Li, Tao Li, Baozeng Ren (Source: Journal of Molecular Liquids)
Source: Journal of Molecular Liquids - September 13, 2020 Category: Molecular Biology Source Type: research
Solubility, Hansen solubility parameter and thermodynamic properties of etodolac in twelve organic pure solvents at different temperatures
Publication date: 10 October 2020Source: Journal of Molecular Liquids, Volume 316Author(s): Xiaoran Hu, Yi Gong, Zidan Cao, Zibo Huang, Jiao Sha, Yu Li, Tao Li, Baozeng Ren (Source: Journal of Molecular Liquids)
Source: Journal of Molecular Liquids - August 17, 2020 Category: Molecular Biology Source Type: research
[ASAP] Salts and Cocrystal of Etodolac: Advantage of Solubility, Dissolution, and Permeability
Crystal Growth& DesignDOI: 10.1021/acs.cgd.0c00313 (Source: Crystal Growth and Design)
Source: Crystal Growth and Design - June 2, 2020 Category: Chemistry Authors: Sunil K. Rai †, Suryanarayana Allu‡, and Ashwini K. Nangia*†‡ Source Type: research
