Efficacy of ultramicronised diclofenac in patients with osteoarthritis - systematic review with network meta-analysis
CONCLUSIONS: Ultramicronised diclofenac demonstrated superior efficacy compared to other conventional anti-inflammatory drugs and placebo in relieving osteoarthritis pain.PMID:34859865 | DOI:10.26355/eurrev_202111_27252 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 3, 2021 Category: Drugs & Pharmacology Authors: G C de Campos E de Almeida Macedo A M Kummer M Papaleo Rosim M Millan Fachi L L Auletta Source Type: research
Efficacy of ultramicronised diclofenac in patients with osteoarthritis - systematic review with network meta-analysis
CONCLUSIONS: Ultramicronised diclofenac demonstrated superior efficacy compared to other conventional anti-inflammatory drugs and placebo in relieving osteoarthritis pain.PMID:34859865 | DOI:10.26355/eurrev_202111_27252 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - December 3, 2021 Category: Drugs & Pharmacology Authors: G C de Campos E de Almeida Macedo A M Kummer M Papaleo Rosim M Millan Fachi L L Auletta Source Type: research
Efficacy of ultramicronised diclofenac in patients with osteoarthritis - systematic review with network meta-analysis
CONCLUSIONS: Ultramicronised diclofenac demonstrated superior efficacy compared to other conventional anti-inflammatory drugs and placebo in relieving osteoarthritis pain.PMID:34859865 | DOI:10.26355/eurrev_202111_27252 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 3, 2021 Category: Drugs & Pharmacology Authors: G C de Campos E de Almeida Macedo A M Kummer M Papaleo Rosim M Millan Fachi L L Auletta Source Type: research
Efficacy of ultramicronised diclofenac in patients with osteoarthritis - systematic review with network meta-analysis
CONCLUSIONS: Ultramicronised diclofenac demonstrated superior efficacy compared to other conventional anti-inflammatory drugs and placebo in relieving osteoarthritis pain.PMID:34859865 | DOI:10.26355/eurrev_202111_27252 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - December 3, 2021 Category: Drugs & Pharmacology Authors: G C de Campos E de Almeida Macedo A M Kummer M Papaleo Rosim M Millan Fachi L L Auletta Source Type: research
Efficacy of ultramicronised diclofenac in patients with osteoarthritis - systematic review with network meta-analysis
CONCLUSIONS: Ultramicronised diclofenac demonstrated superior efficacy compared to other conventional anti-inflammatory drugs and placebo in relieving osteoarthritis pain.PMID:34859865 | DOI:10.26355/eurrev_202111_27252 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 3, 2021 Category: Drugs & Pharmacology Authors: G C de Campos E de Almeida Macedo A M Kummer M Papaleo Rosim M Millan Fachi L L Auletta Source Type: research
Efficacy of ultramicronised diclofenac in patients with osteoarthritis - systematic review with network meta-analysis
CONCLUSIONS: Ultramicronised diclofenac demonstrated superior efficacy compared to other conventional anti-inflammatory drugs and placebo in relieving osteoarthritis pain.PMID:34859865 | DOI:10.26355/eurrev_202111_27252 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - December 3, 2021 Category: Drugs & Pharmacology Authors: G C de Campos E de Almeida Macedo A M Kummer M Papaleo Rosim M Millan Fachi L L Auletta Source Type: research
Efficacy of ultramicronised diclofenac in patients with osteoarthritis - systematic review with network meta-analysis
CONCLUSIONS: Ultramicronised diclofenac demonstrated superior efficacy compared to other conventional anti-inflammatory drugs and placebo in relieving osteoarthritis pain.PMID:34859865 | DOI:10.26355/eurrev_202111_27252 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 3, 2021 Category: Drugs & Pharmacology Authors: G C de Campos E de Almeida Macedo A M Kummer M Papaleo Rosim M Millan Fachi L L Auletta Source Type: research
Preparation, in vitro and in vivo evaluation of Chitosan-Sodium alginate-Ethyl cellulose polyelectrolyte film as a novel buccal mucosal delivery vehicle
Eur J Pharm Sci. 2021 Nov 29:106085. doi: 10.1016/j.ejps.2021.106085. Online ahead of print.ABSTRACTThis paper describes the development of a film comprising chitosan (CS), sodium alginate (SA), and ethyl cellulose (EC) for buccal mucosal administration. A film of CS-SA unidirectional release drug-containing water-repellent layer EC was produced by interfacial reaction solvent-drying technique using self-made equipment. The CS-SA-EC film had superior mechanical properties compared to CS-EC and SA-EC films. The existence of the amide bond was confirmed by FT-IR. DSC confirmed that the drug was dispersed in the carrier mater...
Source: European Journal of Pharmaceutical Sciences - December 2, 2021 Category: Drugs & Pharmacology Authors: Shuangqing Wang Zhonggao Gao Lei Liu Mingxin Li Along Zuo Jianpeng Guo Source Type: research
Preparation, in vitro and in vivo evaluation of Chitosan-Sodium alginate-Ethyl cellulose polyelectrolyte film as a novel buccal mucosal delivery vehicle
Eur J Pharm Sci. 2021 Nov 29:106085. doi: 10.1016/j.ejps.2021.106085. Online ahead of print.ABSTRACTThis paper describes the development of a film comprising chitosan (CS), sodium alginate (SA), and ethyl cellulose (EC) for buccal mucosal administration. A film of CS-SA unidirectional release drug-containing water-repellent layer EC was produced by interfacial reaction solvent-drying technique using self-made equipment. The CS-SA-EC film had superior mechanical properties compared to CS-EC and SA-EC films. The existence of the amide bond was confirmed by FT-IR. DSC confirmed that the drug was dispersed in the carrier mater...
Source: European Journal of Pharmaceutical Sciences - December 2, 2021 Category: Drugs & Pharmacology Authors: Shuangqing Wang Zhonggao Gao Lei Liu Mingxin Li Along Zuo Jianpeng Guo Source Type: research
Identification and drug-induced reversion of molecular signatures of Alzheimer ’s disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models
ConclusionsThe characterization of three AD mouse models at different disease stages provides an unprecedented view of AD pathology and how this differs from physiological aging. Moreover, our computational strategy to chemically revert AD signatures has shown that NSAID and anti-hypertensive drugs may still have an opportunity as anti-AD agents, challenging previous reports. (Source: Genome Medicine)
Source: Genome Medicine - October 26, 2021 Category: Genetics & Stem Cells Source Type: research
Application of Design of Experiments ® Approach-Driven Artificial Intelligence and Machine Learning for Systematic Optimization of Reverse Phase High Performance Liquid Chromatography Method to Analyze Simultaneously Two Drugs (Cyclosporin A and Etodolac) in Solution, Human Plasma, Nanocapsules, and Emulsions
The objectives of current investigation are (1) to find out wavelength of maximum absorbance (λmax) for combined cyclosporin A and etodolac solution followed by selection of mobile phase suitable for the RP-HPLC method, (2) to define analytical target profile and critical analytical attributes (CAAs) for the analytical quality by design, (3) to screen critical method parameters with the help of full factorial design followed by optimization with face-centered central composite design (CCD) approach-driven artificial neural network (ANN)-linked with the Levenberg-Marquardt (LM) algorithm for finding the RP-HPLC conditions,...
Source: AAPS PharmSciTech - May 14, 2021 Category: Drugs & Pharmacology Authors: Syed Nazrin Ruhina Rahman Oly Katari Datta Maroti Pawde Gopi Sumanth Bhaskar Boddeda Abhinab Goswami Srinivasa Rao Mutheneni Tamilvanan Shunmugaperumal Source Type: research
Application of Design of Experiments ® Approach-Driven Artificial Intelligence and Machine Learning for Systematic Optimization of Reverse Phase High Performance Liquid Chromatography Method to Analyze Simultaneously Two Drugs (Cyclosporin A and Etodolac) in Solution, Human Plasma, Nanocapsules, and Emulsions
The objectives of current investigation are (1) to find out wavelength of maximum absorbance (λmax) for combined cyclosporin A and etodolac solution followed by selection of mobile phase suitable for the RP-HPLC method, (2) to define analytical target profile and critical analytical attributes (CAAs) for the analytical quality by design, (3) to screen critical method parameters with the help of full factorial design followed by optimization with face-centered central composite design (CCD) approach-driven artificial neural network (ANN)-linked with the Levenberg-Marquardt (LM) algorithm for finding the RP-HPLC conditions,...
Source: AAPS PharmSciTech - May 14, 2021 Category: Drugs & Pharmacology Authors: Syed Nazrin Ruhina Rahman Oly Katari Datta Maroti Pawde Gopi Sumanth Bhaskar Boddeda Abhinab Goswami Srinivasa Rao Mutheneni Tamilvanan Shunmugaperumal Source Type: research
