Comparison of the effect of Naproxen, Etodolac and Diclofenac on postoperative sequelsfollowing third molar surgery: a randomised, double-blind, crossover study.
CONCLUSION: NSAIDs (Diclofenac, Naproxen and Etodolac) are somehow similarly effective for controlling pain and trismus following extraction of mandibular third molars but Diclofenac potassium surpasses others in reduction of swelling. PMID: 24316711 [PubMed - in process] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - December 2, 2014 Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research

Preadmission use of nonaspirin nonsteroidal anti-inflammatory drugs and 30-day stroke mortality
Conclusions: Preadmission use of COX-2 inhibitors was associated with increased 30-day mortality after ischemic stroke, but not hemorrhagic stroke. Use of nonselective NSAIDs at time of admission was not associated with mortality from ischemic stroke or intracerebral hemorrhage. (Source: Neurology)
Source: Neurology - November 24, 2014 Category: Neurology Authors: Schmidt, M., Hovath-Puho, E., Christiansen, C. F., Petersen, K. L., Botker, H. E., Sorensen, H. T. Tags: Outcome research, All Cerebrovascular disease/Stroke, All epidemiology, Cohort studies ARTICLE Source Type: research

Impact of N-Acetylcysteine and Etodolac Treatment on Systolic and Diastolic Function in a Rat Model of Myocardial Steatosis Induced by High-Fat-Diet.
Conclusions: Obesity is associated with diastolic dysfunction rather than systolic dysfunction. NAC may protect heart against diastolic dysfunction due to obesity. NAC and etodolac treatment improve systolic function, even in the absence of the systolic dysfunction. PMID: 25348332 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 28, 2014 Category: Endocrinology Authors: Topal AE, Akkoc H, Kelle I, Yilmaz S, Topal D, Akkus M Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Colonic diverticular hemorrhage associated with the use of nonsteroidal anti‐inflammatory drugs, low‐dose aspirin, antiplatelet drugs, and dual therapy
ConclusionsBesides alcohol and smoking, NSAIDs, low‐dose aspirin, and antiplatelet drugs are risk factors for diverticular bleeding. The magnitude of risk may differ between different kinds of NSAIDs and antiplatelet drugs, and dual therapy with NSAIDs or antiplatelet drugs increases the risk of bleeding. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - October 15, 2014 Category: Gastroenterology Authors: Naoyoshi Nagata, Ryota Niikura, Tomonori Aoki, Takuro Shimbo, Yoshihiro Kishida, Katsunori Sekine, Shohei Tanaka, Kazuhiro Watanabe, Toshiyuki Sakurai, Chizu Yokoi, Junichi Akiyama, Mikio Yanase, Masashi Mizokami, Naomi Uemura Tags: Gastroenterology Source Type: research

Effects of paracetamol and etodolac on plasma adrenaline levels of rats
Abstract Adrenaline, which is released from the adrenal medulla, is an important compound in the reaction of sympathetic nerve system. This hormone can increase the body’s normal metabolic rate up to 100 %, and thus improves the effectiveness of the whole body. It has been considered to be involved in the control of inflammation. Therefore, we investigated whether there are effects of paracetamol and etodolac on adrenaline levels of rats after oral administration. The rats were divided into three subgroups while analysing the effects of adrenaline on paracetamol and etodolac. The first group was the ...
Source: Medicinal Chemistry Research - September 26, 2014 Category: Chemistry Source Type: research

Enantioselective HPLC-DAD method for the determination of etodolac enantiomers in tablets, human plasma and application to comparative pharmacokinetic study of both enantiomers after a single oral dose to twelve healthy volunteers.
Abstract An enantioselective high performance liquid chromatographic method with diode array detection (HPLC-DAD) was developed and validated for the determination of etodolac enantiomers in tablets and human plasma. Enantiomeric separation was achieved on a Kromasil Cellucoat chiral column (250mm×4.6mm i.d., 5µm particle size) using a mobile phase consisting of hexane: isopropanol: triflouroacetic acid (90:10:0.1v/v/v) at a flow rate of 1.0mLmin(-1). The chromatographic system enables the separation of the two enantiomers and the internal standard within a cycle time of 8min. The resolution between the ...
Source: Talanta - September 1, 2014 Category: Chemistry Authors: Hewala II, Moneeb MS, Elmongy HA, Wahbi AA Tags: Talanta Source Type: research

Concentration of non-steroidal anti-inflammatory drugs in the pelvic floor muscles: an experimental comparative rat model.
CONCLUSION: Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle. PMID: 24954342 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 28, 2014 Category: Universities & Medical Training Authors: Chin HY, Changchien E, Lin MF, Chiang CH, Wang CJ Tags: Yonsei Med J Source Type: research

Colonic diverticular hemorrhage associated with the use of NSAIDs, low‐dose aspirin, antiplatelet drugs, and dual therapy
ConclusionsBesides alcohol and smoking, NSAIDs, low‐dose aspirin, and antiplatelet drugs are risk factors for diverticular bleeding. The magnitude of risk may differ between different kinds of NSAIDs and antiplatelet drugs, and dual therapy with NSAIDs or antiplatelet drugs increases the risk of bleeding. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - April 10, 2014 Category: Gastroenterology Authors: Naoyoshi Nagata, Ryota Niikura, Tomonori Aoki, Takuro Shimbo, Yoshihiro Kishida, Katsunori Sekine, Shohei Tanaka, Kazuhiro Watanabe, Toshiyuki Sakurai, Chizu Yokoi, Junichi Akiyama, Mikio Yanase, Masashi Mizokami, Naomi Uemura Tags: Clinical Gastroenterology Source Type: research

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs.
CONCLUSIONS: Meloxicam and etodolac were the drugs that have proven to be safer for short-term therapy in healthy dogs in relation to renal function. NSAIDs ketoprofen and nimesulide should be used judiciously in dogs with renal dysfunction, since there are promoted changes in renal function. PMID: 24316857 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - December 1, 2013 Category: Surgery Authors: Borges M, Marini Filho R, Laposy CB, Guimarães-Okamoto PT, Chaves MP, Vieira AN, Melchert A Tags: Acta Cir Bras Source Type: research

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The proto-oncogene beta-catenin is linked to an abnormal activation of the Wnt/beta-catenin-pathway and shows mutations in 50–90% of hepatoblastoma (HB). Corresponding, the recently published murine orthotopic HB model differs from the former subcutaneous model by nuclear beta-catenin distribution. As the nuclear localization of beta-catenin is considered to reflect a more aggressive tumor growth, the influence of beta-catenin inhibition on cell viability and drug-efficiency in HB cells was analyzed. Beta-catenin distribution in HB cells was analyzed by immunofluorescence. The influence of beta-catenin inhibitors Celecox...
Source: Journal of Pediatric Surgery - November 1, 2013 Category: Surgery Authors: Federico G. Seifarth Tags: International Abstracts of Pediatric Surgery Source Type: research

Mutual Amide Prodrug of Etodolac-glucosamine: Synthesis, Characterization and Pharmacological Screening
Preeti Pandey, S Pandey, Shaifali DubeyIndian Journal of Pharmaceutical Sciences 2013 75(4):406-412Etodolac, a nonsteroidal antiinflammatory drug, widely used in arthritis is associated with gastric ulceration and irritation due to presence of free carboxylic group. The current investigation reports synthesis of mutual amide prodrug of etodolac by masking free carboxylic group with glucosamine, a nutritional supplement for treatment of arthritis. Confirmation and characterization of the structure of the synthesized prodrug done by elemental and spectroscopy analysis, melting point, determination of migration parameters (R ...
Source: Indian Journal of Pharmaceutical Sciences - October 14, 2013 Category: Drugs & Pharmacology Authors: Preeti PandeyS PandeyShaifali Dubey Source Type: research

Increased gastric mucus secretion alleviates non-steroidal anti-inflammatory drug-induced abdominal pain.
In conclusion, the occurrence of NSAID-induced abdominal pain is associated with reduced levels of gastric mucus secretion rather than the occurrence of endoscopic mucosal injury. PMID: 24005244 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - September 9, 2013 Category: Research Authors: Iwabuchi T, Iijima K, Ara N, Koike T, Shinkai H, Ichikawa T, Kamata Y, Ishihara K, Shimosegawa T Tags: Tohoku J Exp Med Source Type: research

Etodolac activates and desensitizes transient receptor potential ankyrin 1
The transient receptor potential ankyrin 1 (TRPA1) channel is well known as a sensor to environmental irritant compounds, cold, and endogenous proalgesic agents. TRPA1 is expressed on sensory neurons and is involved in pain modulation. Etodolac is a cyclooxygenase (COX)‐2 inhibitor that belongs to the class of nonsteroidal anti‐inflammatory drugs (NSAIDs). A recent study indicates that etodolac inhibits allyl isothiocyanate (AITC)‐induced calcium influx in heterologous HEK293 cells and sensory neurons. To examine whether and how etodolac modulates the TRPA1 channels, we applied etodolac to TRPA1‐transfected HEK293 ...
Source: Journal of Neuroscience Research - August 30, 2013 Category: Neuroscience Authors: Shenglan Wang, Yi Dai, Yoko Kogure, Satoshi Yamamoto, Wensheng Zhang, Koichi Noguchi Tags: Research Article Source Type: research

Systematic Review of Nonsteroidal Anti‐Inflammatory Drug‐Induced Adverse Effects in Dogs
The aim of this systematic review was to identify, assess, and critically evaluate the quality of evidence of nonsteroidal anti‐inflammatory drug (NSAID)‐induced adverse effects in dogs. Original prospective studies published in peer‐reviewed journals in English (1990–2012) that reported data on the safety of NSAIDs administration in dogs were searched. For each study, design type (I, II, III, or IV) and assessment of quality (+, Ø, −) were rated. For each drug, quantity and consistency rating (***, **, *) and strength of evidence (high, moderate, low, or extremely low) were identified and evaluated. The strengt...
Source: Journal of Veterinary Internal Medicine - June 19, 2013 Category: Veterinary Research Authors: B.P. Monteiro‐Steagall, P.V.M. Steagall, B.D.X. Lascelles Tags: Review Source Type: research

Myocardial infarction and individual nonsteroidal anti‐inflammatory drugs meta‐analysis of observational studies
ConclusionsMost frequently NSAIDs used in clinical practice, except naproxen, are associated with an increased risk of AMI at high doses or in persons with diagnosed coronary heart disease. For diclofenac and rofecoxib, the risk was increased at low and high doses. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - April 25, 2013 Category: Drugs & Pharmacology Authors: Cristina Varas‐Lorenzo, Nuria Riera‐Guardia, Brian Calingaert, Jordi Castellsague, Francesco Salvo, Federica Nicotra, Miriam Sturkenboom, Susana Perez‐Gutthann Tags: Review Source Type: research