NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells.
CONCLUSION: Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2 in HUVECs, which suggests that use of these NSAIDs may increase the effects of ionizing radiation and affect the risk of MI after radiation exposure to the heart.
PMID: 27687548 [PubMed - as supplied by publisher] (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - September 25, 2016 Category: Biochemistry Authors: Uehara Y, Murata Y, Shiga S, Hosoi Y Tags: Biochem Biophys Res Commun Source Type: research
Self-assembling organogels based on pluronic and lethicin for sustained release of etodolac: In vitro and in vivo correlation.
Abstract
Etodolac, a member of non steroidal anti-inflammatory drugs (NSAIDs), has a poor aqueous solubility. Long term administration of etodolac causes severe gastrointestinal disturbances such as peptic ulcer and bleeding. These disturbances could be overcome by alternative routes such as a topical administration. In the present study, pluronic lecithin organogels (PLOs) were prepared by simple mixing of pluronic solution with lecithin solution. Etodolac was loaded into the prepared gels or added during the gel formation. The physicochemical properties of the modified organogels were investigated by dif...
Source: Current Drug Delivery - September 1, 2016 Category: Drugs & Pharmacology Authors: Mohammed AM, Faisal W, Saleh KI, Osman SK Tags: Curr Drug Deliv Source Type: research
Abstract # 1731 Perioperative COX-2 inhibition and beta-adrenoceptor blockade in breast cancer patients improve markers of immunity and reduce inflammation and primary tumor epithelial-to-mesenchymal transition (EMT)
This study reports the first clinical test of combined blockade of these pathways using the beta-adrenergic blocker, propranolol, and the COX-2 inhibitor, etodolac. In a double-blind placebo-controlled clinical trial, 36 breast cancer patients were randomized to an 11-day oral drug treatment beginning five days before surgery. Blood samples were taken before treatment (T1), on the mornings before and after surgery (T2&T3), and after treatment cessation (T4), and excised tumors were collected. No adverse effects of drug treatment were reported. Among other findings, in the placebo group, (i) serum IL-6 and CRP level...
Source: Brain, Behavior, and Immunity - August 31, 2016 Category: Neurology Source Type: research
Development and Characterization of Multifunctional Directly Compressible Co-processed Excipient by Spray Drying Method.
Abstract
The present investigation was carried out to develop and characterize a multifunctional co-processed excipient for improving the compressibility of poorly compressible drugs. Etodolac was used as a model drug. Microcrystalline cellulose (MCC), lactose monohydrate (lactose), and StarCap 1500 (StarCap) were selected as components of the co-processed excipient. The spray drying method was used for co-processing of excipients. D-optimal mixture design was applied to optimize the proportion of component excipients. Statistical analysis of the D-optimal mixture design revealed that all response variable...
Source: AAPS PharmSciTech - July 31, 2016 Category: Drugs & Pharmacology Authors: Chauhan SI, Nathwani SV, Soniwala MM, Chavda JR Tags: AAPS PharmSciTech Source Type: research
Etodolac: & #946;-cyclodextrin inclusion complex as a novel fluorescent chemosensor probe for Ba2+
(Source: Journal of Carbohydrate Chemistry)
Source: Journal of Carbohydrate Chemistry - July 21, 2016 Category: Chemistry Authors: Sivakumar, K. Parameswari, M. Stalin, T. Source Type: research
Spherical Agglomeration
of Platy Crystals: Curious
Case of Etodolac
Crystal Growth & DesignDOI: 10.1021/acs.cgd.6b00563 (Source: Crystal Growth and Design)
Source: Crystal Growth and Design - June 7, 2016 Category: Chemistry Authors: Supriya Jitkar, Rajesh Thipparaboina, Rahul B. Chavan and Nalini R. Shastri Source Type: research
"Missing Tooth" Multidomain Peptide Nanofibers for Delivery of Small Molecule Drugs.
This study establishes multidomain peptides as promising carriers for localized in situ delivery of small molecule drugs with poor water solubility.
PMID: 27253735 [PubMed - as supplied by publisher] (Source: Biomacromolecules)
Source: Biomacromolecules - June 1, 2016 Category: Biochemistry Authors: Li IC, Moore AN, Hartgerink JD Tags: Biomacromolecules Source Type: research
Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through β-adrenoceptors blockade and COX2 inhibition
Publication date: Available online 25 May 2016 Source:Brain, Behavior, and Immunity Author(s): Liat Sorski, Rivka Melamed, Pini Matzner, Hagar Lavon, Lee Shaashua, Ella Rosenne, Shamgar Ben-Eliyahu Liver metastases are a major cause of colorectal cancer death, and the perioperative period is believed to critically affect the metastatic process. Here we tested whether blocking excess release of catecholamines and prostaglandins during surgical procedures of different extent can reduce experimental liver metastasis of the syngeneic CT26 colon cancer in female and male BALB/c mice. Animals were either treate...
Source: Brain, Behavior, and Immunity - May 25, 2016 Category: Neurology Source Type: research
Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through β-adrenoceptors blockade and COX2 inhibition.
Abstract
Liver metastases are a major cause of colorectal cancer death, and the perioperative period is believed to critically affect the metastatic process. Here we tested whether blocking excess release of catecholamines and prostaglandins during surgical procedures of different extent can reduce experimental liver metastasis of the syngeneic CT26 colon cancer in female and male BALB/c mice. Animals were either treated with the beta-blocker, propranolol, the COX-2 inhibitor, etodolac, both drugs, or vehicle. The role of NK cells in controlling CT26 hepatic metastasis and in mediating the effect of the dr...
Source: Brain, Behavior, and Immunity - May 24, 2016 Category: Neurology Authors: Sorski L, Melamed R, Matzner P, Lavon H, Shaashua L, Rosenne E, Ben-Eliyahu S Tags: Brain Behav Immun Source Type: research
HPLC enantioseparation of racemic Bupropion, Baclofen and Etodolac: Modification of conventional ligand exchange approach by 'pre-column formation of chiral ligand exchange complexes'.
Abstract
Separation of racemic mixture of (RS)-Bupropion, (RS)-Baclofen and (RS)-Etodolac, commonly marketed racemic drugs, has been achieved by modifying the conventional ligand exchange approach. The Cu(II) complexes were first prepared with a few L-amino acids, namely, L-proline, L-histidine, L-phenylalanine, and L-tryptophan and to these was introduced mixture of enantiomer pair of (RS)-bupropion, or (RS)-baclofen or (RS)-etodolac. As a result, formation of a pair of diastereomeric complexes occurred by 'chiral ligand exchange' via the competition between the chelating L-amino acid and each of the two ...
Source: Biomedical Chromatography : BMC - April 22, 2016 Category: Biomedical Science Authors: Singh M, Bhushan R Tags: Biomed Chromatogr Source Type: research
Etodolac:β-cyclodextrin inclusion complex as a novel fluorescent chemosensor probe for Ba2+
(Source: Journal of Carbohydrate Chemistry)
Source: Journal of Carbohydrate Chemistry - April 13, 2016 Category: Chemistry Authors: Sivakumar, K.Parameswari, M.Stalin, T. Source Type: research
Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial
To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - April 12, 2016 Category: ENT & OMF Authors: J úlio César Silva de Oliveira, Gustavo Augusto Grossi de Oliveira, Ana Paula Farnezi Bassi Tags: Dentoalveolar surgery Source Type: research
Comparative assessment of ibuprofen and etodolac in edema, trismus and pain in lower third molar surgery: A randomized, clinical trial
To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus following extraction of lower-third molars. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - April 12, 2016 Category: ENT & OMF Authors: Júlio César Silva de Oliveira, Gustavo Augusto Grossi de Oliveira, Ana Paula Farnezi Bassi Source Type: research
Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial
To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - April 12, 2016 Category: ENT & OMF Authors: Júlio César Silva de Oliveira, Gustavo Augusto Grossi de Oliveira, Ana Paula Farnezi Bassi Tags: Dentoalveolar surgery Source Type: research
Stress impairs the efficacy of immune stimulation by CpG-C: Potential neuroendocrine mediating mechanisms and significance to tumor metastasis and the perioperative period
Publication date: Available online 2 March 2016 Source:Brain, Behavior, and Immunity Author(s): B. Levi, P. Matzner, Y. Goldfarb, L. Sorski, L. Shaashua, R. Melamed, E. Rosenne, G.G. Page, S. Ben-Eliyahu We recently reported that immune stimulation can be compromised if animals are simultaneously subjected to stressful conditions. To test the generalizability of these findings, and to elucidate neuroendocrine mediating mechanisms, we herein employed CpG-C, a novel TLR-9 immune-stimulating agent. Animals were subjected to ongoing stress (20-hrs of wet cage exposure) during CpG-C treatment, and antagoni...
Source: Brain, Behavior, and Immunity - March 3, 2016 Category: Neurology Source Type: research
