Drug-induced liver injury (DILI) ascribed to non-steroidal anti-inflammatory drugs (NSAIDs) in the USA-Update with genetic correlations
CONCLUSIONS: Despite prevalent use, NSAID-DILI is infrequent in the United States. Diclofenac is the most commonly implicated, and adherence to warnings of risk and close observation are recommended. The increased frequency of HLA-B*35:03 and DRB1*04:03, driven by diclofenac, suggests the importance of immune-mediated responses.PMID:38451034 | DOI:10.1111/liv.15892 (Source: Cancer Control)
Source: Cancer Control - March 7, 2024 Category: Cancer & Oncology Authors: Herbert L Bonkovsky Marwan Ghabril Paola Nicoletti Andrew Dellinger Robert J Fontana Huiman Barnhart Jiezhun Gu Ann K Daly Guruprasad P Aithal Elizabeth J Phillips David E Kleiner US DILIN Investigators Source Type: research

Modeling Path Importance for Effective Alzheimer's Disease Drug Repurposing
Pac Symp Biocomput. 2024;29:306-321.ABSTRACTRecently, drug repurposing has emerged as an effective and resource-efficient paradigm for AD drug discovery. Among various methods for drug repurposing, network-based methods have shown promising results as they are capable of leveraging complex networks that integrate multiple interaction types, such as protein-protein interactions, to more effectively identify candidate drugs. However, existing approaches typically assume paths of the same length in the network have equal importance in identifying the therapeutic effect of drugs. Other domains have found that same length paths...
Source: Pacific Symposium on Biocomputing - December 31, 2023 Category: Bioinformatics Authors: Shunian Xiang Patrick J Lawrence Bo Peng ChienWei Chiang Dokyoon Kim Li Shen Xia Ning Source Type: research

Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide
Chem Biol Interact. 2023 Jul 25:110644. doi: 10.1016/j.cbi.2023.110644. Online ahead of print.ABSTRACTCytochrome P450 4A11 (CYP4A11) has many endogenous and exogenous compounds containing a carboxyl group in their structure as substrates. If drugs with this characteristic potently attenuate the catalytic function of CYP4A11, drug-drug interactions may occur. Acidic non-steroidal anti-inflammatory drugs (NSAIDs) possess a carboxylic acid in their structure. However, it remains unclear whether these drugs inhibit CYP4A11 activity. The present study examined the inhibitory effects of acidic NSAIDs on CYP4A11 activity using hu...
Source: Chemico-Biological Interactions - July 27, 2023 Category: Molecular Biology Authors: Hisataka Itoh Naho Yamashita Shinobu Kamijo Kazufumi Masuda Hisato Kato Satoshi Yamaori Source Type: research

Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide
Chem Biol Interact. 2023 Jul 25;382:110644. doi: 10.1016/j.cbi.2023.110644. Online ahead of print.ABSTRACTCytochrome P450 4A11 (CYP4A11) has many endogenous and exogenous compounds containing a carboxyl group in their structure as substrates. If drugs with this characteristic potently attenuate the catalytic function of CYP4A11, drug-drug interactions may occur. Acidic non-steroidal anti-inflammatory drugs (NSAIDs) possess a carboxylic acid in their structure. However, it remains unclear whether these drugs inhibit CYP4A11 activity. The present study examined the inhibitory effects of acidic NSAIDs on CYP4A11 activity usin...
Source: Chemico-Biological Interactions - July 27, 2023 Category: Molecular Biology Authors: Hisataka Itoh Naho Yamashita Shinobu Kamijo Kazufumi Masuda Hisato Kato Satoshi Yamaori Source Type: research

EE88 Cost-Effectiveness Analysis of Etodolac and Aceclofenac in Low Back Pain
Over the decades, low back pain (LBP) has emerged as a serious health concern. According to WHO statistics 80% of individuals will experience at least one episode of LBP at some point throughout their lifetime. This present study aims to determine the cost-effectiveness of Etodolac and Aceclofenac in LBP. (Source: Value in Health)
Source: Value in Health - June 1, 2023 Category: International Medicine & Public Health Authors: N. Satheesan, R. Thomas, S. Sukumaran Source Type: research

Cancers, Vol. 15, Pages 2972: Drug Repurposing in Oncology: A Systematic Review of Randomized Controlled Clinical Trials
Jorge Vicente-Romero Quality pharmacological treatment can improve survival in many types of cancer. Drug repurposing offers advantages in comparison with traditional drug development procedures, reducing time and risk. This systematic review identified the most recent randomized controlled clinical trials that focus on drug repurposing in oncology. We found that only a few clinical trials were placebo-controlled or standard-of-care-alone-controlled. Metformin has been studied for potential use in various types of cancer, including prostate, lung, and pancreatic cancer. Other studies assessed the possible use of the an...
Source: Cancers - May 30, 2023 Category: Cancer & Oncology Authors: Ignatios Ioakeim-Skoufa Natalia Tobajas-Ramos Enrica Menditto Mercedes Aza-Pascual-Salcedo Antonio Gimeno-Miguel Valentina Orlando Francisca Gonz ález-Rubio Ana Fanlo-Villacampa Carmen Lasala-Aza Ewelina Ostasz Jorge Vicente-Romero Tags: Systematic Review Source Type: research

"Don't let it to air": A cautionary tale of the potential consequences of surgery of residual cancer
Brain Behav Immun. 2023 Apr 29:S0889-1591(23)00110-1. doi: 10.1016/j.bbi.2023.04.012. Online ahead of print.ABSTRACTIn this issue of the BBI, Haldar et al. demonstrate that major surgical stress from laparotomy caused a significant increase in post-operative metastatic burden in a mouse model of cancer. They identified this metastatic outbreak was driven by a novel mechanism of direct, surgery-induced activation of the primary tumour which, if left in situ, released pro-metastatic factors (IL-6, IL-8, and VEGF). Surgical stress induced significant changes in the transcriptional programming of the primary tumor, with marked...
Source: Brain, Behavior, and Immunity - May 1, 2023 Category: Neurology Authors: Gayashan Tennakoon Rebecca Auer Source Type: research

"Don't let it to air": A cautionary tale of the potential consequences of surgery of residual cancer
Brain Behav Immun. 2023 Apr 29:S0889-1591(23)00110-1. doi: 10.1016/j.bbi.2023.04.012. Online ahead of print.ABSTRACTIn this issue of the BBI, Haldar et al. demonstrate that major surgical stress from laparotomy caused a significant increase in post-operative metastatic burden in a mouse model of cancer. They identified this metastatic outbreak was driven by a novel mechanism of direct, surgery-induced activation of the primary tumour which, if left in situ, released pro-metastatic factors (IL-6, IL-8, and VEGF). Surgical stress induced significant changes in the transcriptional programming of the primary tumor, with marked...
Source: Brain, Behavior, and Immunity - May 1, 2023 Category: Neurology Authors: Gayashan Tennakoon Rebecca Auer Source Type: research

"Don't let it to air": A cautionary tale of the potential consequences of surgery of residual cancer
Brain Behav Immun. 2023 Apr 29:S0889-1591(23)00110-1. doi: 10.1016/j.bbi.2023.04.012. Online ahead of print.ABSTRACTIn this issue of the BBI, Haldar et al. demonstrate that major surgical stress from laparotomy caused a significant increase in post-operative metastatic burden in a mouse model of cancer. They identified this metastatic outbreak was driven by a novel mechanism of direct, surgery-induced activation of the primary tumour which, if left in situ, released pro-metastatic factors (IL-6, IL-8, and VEGF). Surgical stress induced significant changes in the transcriptional programming of the primary tumor, with marked...
Source: Brain, Behavior, and Immunity - May 1, 2023 Category: Neurology Authors: Gayashan Tennakoon Rebecca Auer Source Type: research