Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating
J Pain Palliat Care Pharmacother. 2022 Nov 15:1-6. doi: 10.1080/15360288.2022.2141413. Online ahead of print.ABSTRACT(Case 1) A 45-year-old male was diagnosed with prostate cancer. Treatment was administered using bicalutamide and leuprorelin acetate, while a transdermal fentanyl (TDF) was applied for pain relief. However, TDF continued to peel off owing to excessive sweating, even when reinforced by a protective layer. As such, TDF was discontinued and pain control was initiated using other medicines. Sweating occurred irregularly because of hot flashes, approximately four to five times per day. (Case 2) A 37-year-old mal...
Source: Cancer Control - November 15, 2022 Category: Cancer & Oncology Authors: Hidetoshi Ishii Hideya Kokubun Ken-Ichi Tabata Akifumi Kanai Source Type: research

Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating
J Pain Palliat Care Pharmacother. 2022 Nov 15:1-6. doi: 10.1080/15360288.2022.2141413. Online ahead of print.ABSTRACT(Case 1) A 45-year-old male was diagnosed with prostate cancer. Treatment was administered using bicalutamide and leuprorelin acetate, while a transdermal fentanyl (TDF) was applied for pain relief. However, TDF continued to peel off owing to excessive sweating, even when reinforced by a protective layer. As such, TDF was discontinued and pain control was initiated using other medicines. Sweating occurred irregularly because of hot flashes, approximately four to five times per day. (Case 2) A 37-year-old mal...
Source: Journal of Pain and Palliative Care Pharmacotherapy - November 15, 2022 Category: Palliative Care Authors: Hidetoshi Ishii Hideya Kokubun Ken-Ichi Tabata Akifumi Kanai Source Type: research

Dual Delivery of Cyclosporin A and Etodolac Using Polymeric Nanocapsules in a Rabbit Eye Model: Ocular Biodistribution and Pharmacokinetic Study
Journal of Ocular Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Ocular Pharmacology and Therapeutics)
Source: Journal of Ocular Pharmacology and Therapeutics - November 10, 2022 Category: Opthalmology Authors: Syed Nazrin Ruhina Rahman Abhinab Goswami Amoolya Sree Aishwarya Jala Roshan M. Borkar Tamilvanan Shunmugaperumal Source Type: research

Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats
This study was aimed to clarify species differences in AG hydrolysis between human and rat liver microsomes (HLM and RLM).To evaluate the AG hydrolysis profile, and the contribution of β-glucuronidase and esterase towards AG hydrolysis in HLM and RLM, nonsteroidal anti-inflammatory drugs (NSAIDs) were used. AGs were incubated with 0.1 M Tris-HCl buffer (pH 7.4) and 0.3 mg/mL HLM or RLM in the absence or presence of β-glucuronidase inhibitor, D-saccharic acid 1,4-lactone (D-SL) and esterase inhibitor, phenylmethylsulfonyl fluoride (PMSF).AGs of zomepirac (ZOM-AG), mefenamic acid (MEF-AG), and etodolac (ETO-AG) showed sign...
Source: Xenobiotica - October 3, 2022 Category: Research Authors: Hiroyuki Ikuta Hiroaki Shimada Kenjiro Sakamoto Rena Nakamura Atsushi Kawase Masahiro Iwaki Source Type: research

Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats
This study was aimed to clarify species differences in AG hydrolysis between human and rat liver microsomes (HLM and RLM).To evaluate the AG hydrolysis profile, and the contribution of β-glucuronidase and esterase towards AG hydrolysis in HLM and RLM, nonsteroidal anti-inflammatory drugs (NSAIDs) were used. AGs were incubated with 0.1 M Tris-HCl buffer (pH 7.4) and 0.3 mg/mL HLM or RLM in the absence or presence of β-glucuronidase inhibitor, D-saccharic acid 1,4-lactone (D-SL) and esterase inhibitor, phenylmethylsulfonyl fluoride (PMSF).AGs of zomepirac (ZOM-AG), mefenamic acid (MEF-AG), and etodolac (ETO-AG) showed sign...
Source: Xenobiotica - October 3, 2022 Category: Research Authors: Hiroyuki Ikuta Hiroaki Shimada Kenjiro Sakamoto Rena Nakamura Atsushi Kawase Masahiro Iwaki Source Type: research

Application of ionic liquid to enhance the nose-to-brain delivery of etodolac
Eur J Pharm Sci. 2022 Sep 1:106290. doi: 10.1016/j.ejps.2022.106290. Online ahead of print.ABSTRACTThe purpose of this study was to enhance the delivery of Etodolac (ETD) to the brain through intranasal administration using an ionic liquid (IL) consisting of ETD and proline ethyl ester. The IL of ETD was prepared by mixing ETD with proline ethyl ester as a counterion in a molar ratio of 1:2.The formation of the IL was confirmed by differential scanning calorimetry (DSC), infrared spectroscopy (IR) and proton nuclear magnetic resonance (1H-NMR).The solubility of ETD in simulated nasal fluids was improved by approximately 20...
Source: European Journal of Pharmaceutical Sciences - September 4, 2022 Category: Drugs & Pharmacology Authors: Hiroaki Tanigawa Naoto Suzuki Toyofumi Suzuki Source Type: research

Application of ionic liquid to enhance the nose-to-brain delivery of etodolac
Eur J Pharm Sci. 2022 Sep 1:106290. doi: 10.1016/j.ejps.2022.106290. Online ahead of print.ABSTRACTThe purpose of this study was to enhance the delivery of Etodolac (ETD) to the brain through intranasal administration using an ionic liquid (IL) consisting of ETD and proline ethyl ester. The IL of ETD was prepared by mixing ETD with proline ethyl ester as a counterion in a molar ratio of 1:2.The formation of the IL was confirmed by differential scanning calorimetry (DSC), infrared spectroscopy (IR) and proton nuclear magnetic resonance (1H-NMR).The solubility of ETD in simulated nasal fluids was improved by approximately 20...
Source: European Journal of Pharmaceutical Sciences - September 4, 2022 Category: Drugs & Pharmacology Authors: Hiroaki Tanigawa Naoto Suzuki Toyofumi Suzuki Source Type: research

Cardiovascular Risks of Diclofenac Versus Other Older COX-2 Inhibitors (Meloxicam and Etodolac) and Newer COX-2 Inhibitors (Celecoxib and Etoricoxib): A Series of Nationwide Emulated Trials
ConclusionsThe increased cardiovascular risks associated with diclofenac initiation were higher than for other older COX-2 inhibitors (meloxicam/etodolac) and comparable to coxibs (celecoxib/etoricoxib). (Source: Drug Safety)
Source: Drug Safety - July 31, 2022 Category: Drugs & Pharmacology Source Type: research

Comparative photo-oxidative degradation of etodolac, febuxostat and imatinib mesylate by UV-C/H < sub > 2 < /sub > O < sub > 2 < /sub > and UV-C/S < sub > 2 < /sub > O < sub > 8 < /sub > < sup > 2- < /sup > processes: Modeling, treatment optimization and biodegradability enhancement
Environ Res. 2022 May 12:113385. doi: 10.1016/j.envres.2022.113385. Online ahead of print.ABSTRACTThe pharmaceutical contamination in aquatic environment has arisen increasing concern due to its potentially chronic toxicity. In recent years, HO° and SO4°- based advanced oxidation processes (AOPs) have been widely applied in water and wastewater treatments due to their highly efficiency on contaminant removal. Here, the response surface modeling (RSM) was used to investigate the degradation of three typical pharmaceuticals (i.e., etodolac (ETD), febuxostat (FBU) and imatinib mesylate (IMT)) by UV/H2O2 and UV/S2O82- proces...
Source: Environmental Research - May 15, 2022 Category: Environmental Health Authors: Amin Samzadeh Mansooreh Dehghani Mohammad Ali Baghapour Aboolfazl Azhdarpoor Zahra Derakhshan Matija Cvetni ć Tomislav Bolan ča Stefanos Giannakis Ying Cao Source Type: research

Comparative photo-oxidative degradation of etodolac, febuxostat and imatinib mesylate by UV-C/H < sub > 2 < /sub > O < sub > 2 < /sub > and UV-C/S < sub > 2 < /sub > O < sub > 8 < /sub > < sup > 2- < /sup > processes: Modeling, treatment optimization and biodegradability enhancement
Environ Res. 2022 May 12:113385. doi: 10.1016/j.envres.2022.113385. Online ahead of print.ABSTRACTThe pharmaceutical contamination in aquatic environment has arisen increasing concern due to its potentially chronic toxicity. In recent years, HO° and SO4°- based advanced oxidation processes (AOPs) have been widely applied in water and wastewater treatments due to their highly efficiency on contaminant removal. Here, the response surface modeling (RSM) was used to investigate the degradation of three typical pharmaceuticals (i.e., etodolac (ETD), febuxostat (FBU) and imatinib mesylate (IMT)) by UV/H2O2 and UV/S2O82- proces...
Source: Environmental Research - May 15, 2022 Category: Environmental Health Authors: Amin Samzadeh Mansooreh Dehghani Mohammad Ali Baghapour Aboolfazl Azhdarpoor Zahra Derakhshan Matija Cvetni ć Tomislav Bolan ča Stefanos Giannakis Ying Cao Source Type: research

Non-steroidal anti-inflammatory drugs (NSAIDs), pain and aging: Adjusting prescription to patient features
Biomed Pharmacother. 2022 Apr 19;150:112958. doi: 10.1016/j.biopha.2022.112958. Online ahead of print.ABSTRACTA narrative review of papers published from January 2011 to December 2021, after a literature search in selected databases using the terms "pharmacokinetics", "ibuprofen", "diclofenac", "acemetacin", "naproxen", "etodolac" and "etoricoxib" was performed. From 828 articles identified, only eight met the inclusion criteria. Selective COX-2 inhibitors are associated with higher cardiovascular risk, while non-selective COX inhibitors are associated with higher gastrointestinal risk. NSAIDs with lower renal excretion wi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 22, 2022 Category: Drugs & Pharmacology Authors: Hugo Ribeiro In ês Rodrigues Leonardo Napole ão Lu ís Lira Denise Marques Manuel Ver íssimo Jos é Paulo Andrade Mar ília Dourado Source Type: research

Etodolac enhances the radiosensitivity of irradiated HT-29 human colorectal cancer cells
CONCLUSION: Applying ET in a concentration-dependent manner had an incremental effect on the amount of apoptosis and cell death induced by radiation.PMID:35319403 | DOI:10.2174/1874471015666220321143139 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - March 23, 2022 Category: Radiology Authors: Zahra Shaghaghi Nasim Zarei Polgardani Sahar Abbasi Hajar Albooyeh Leila Dastranj Soghra Farzipour Maryam Alvandi Source Type: research