Etodolac Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Perioperative escape from dormancy of spontaneous micro-metastases: A role for malignant secretion of IL-6, IL-8, and VEGF, through adrenergic and prostaglandin signaling
Brain Behav Immun. 2023 Jan 13:S0889-1591(23)00005-3. doi: 10.1016/j.bbi.2023.01.005. Online ahead of print.ABSTRACTWe recently showed that a minimally-invasive removal of MDA-MB-231HM primary tumors (PTs) and elimination of their secreted factors (including IL-6, IL-8, VEGF, EGF, PDGF-aa, MIF, SerpinE1, and M-CSF), caused regression of spontaneous micro-metastases into a non-growing dormant state. To explore the underlying mechanisms and potential clinical ramifications of this phenomenon, we herein used the MDA-MB-231HM human breast cancer cell-line, in-vitro, and in vivo following orthotopic implantation in immune-defic...
Source: Brain, Behavior, and Immunity - January 16, 2023 Category: Neurology Authors: Rita Haldar Lee Shaashua Berger Ella Rossenne Arielle Radin Anabel Eckerling Elad Sandbank Erica K Sloan Steve W Cole Shamgar Ben-Eliyahu Source Type: research

Molecules, Vol. 28, Pages 235: Nanostructured Lipid Carriers (NLC)-Based Gel Formulations as Etodolac Delivery: From Gel Preparation to Permeation Study
In this study, an NSAID from the BCS class II, etodolac (ETD), was used. The nanostructured lipid carriers (NLC) obtained with ETD were incorporated into semi-solid forms (gels). Hydrogels with the suspended drug and oleogel were also prepared for comparison purposes. The obtained gels were tested in terms of pH, viscosity, rheological, mechanical, and bioadhesive properties. The release and permeation through membranes were also studied. All tested formulations were characterized by a pH below 7, which ensured the physiological state of the skin. The viscosities of all gels decreased with increasing shear rate, indicating...
Source: Molecules - December 28, 2022 Category: Chemistry Authors: Anna Czajkowska-Ko śnik Emilia Szyma ńska Katarzyna Winnicka Tags: Article Source Type: research

Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating
J Pain Palliat Care Pharmacother. 2022 Nov 15:1-6. doi: 10.1080/15360288.2022.2141413. Online ahead of print.ABSTRACT(Case 1) A 45-year-old male was diagnosed with prostate cancer. Treatment was administered using bicalutamide and leuprorelin acetate, while a transdermal fentanyl (TDF) was applied for pain relief. However, TDF continued to peel off owing to excessive sweating, even when reinforced by a protective layer. As such, TDF was discontinued and pain control was initiated using other medicines. Sweating occurred irregularly because of hot flashes, approximately four to five times per day. (Case 2) A 37-year-old mal...
Source: Journal of Pain and Palliative Care Pharmacotherapy - November 15, 2022 Category: Palliative Care Authors: Hidetoshi Ishii Hideya Kokubun Ken-Ichi Tabata Akifumi Kanai Source Type: research

Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating
J Pain Palliat Care Pharmacother. 2022 Nov 15:1-6. doi: 10.1080/15360288.2022.2141413. Online ahead of print.ABSTRACT(Case 1) A 45-year-old male was diagnosed with prostate cancer. Treatment was administered using bicalutamide and leuprorelin acetate, while a transdermal fentanyl (TDF) was applied for pain relief. However, TDF continued to peel off owing to excessive sweating, even when reinforced by a protective layer. As such, TDF was discontinued and pain control was initiated using other medicines. Sweating occurred irregularly because of hot flashes, approximately four to five times per day. (Case 2) A 37-year-old mal...
Source: Cancer Control - November 15, 2022 Category: Cancer & Oncology Authors: Hidetoshi Ishii Hideya Kokubun Ken-Ichi Tabata Akifumi Kanai Source Type: research

Dual Delivery of Cyclosporin A and Etodolac Using Polymeric Nanocapsules in a Rabbit Eye Model: Ocular Biodistribution and Pharmacokinetic Study
Journal of Ocular Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Ocular Pharmacology and Therapeutics)
Source: Journal of Ocular Pharmacology and Therapeutics - November 10, 2022 Category: Opthalmology Authors: Syed Nazrin Ruhina Rahman Abhinab Goswami Amoolya Sree Aishwarya Jala Roshan M. Borkar Tamilvanan Shunmugaperumal Source Type: research

Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats
This study was aimed to clarify species differences in AG hydrolysis between human and rat liver microsomes (HLM and RLM).To evaluate the AG hydrolysis profile, and the contribution of β-glucuronidase and esterase towards AG hydrolysis in HLM and RLM, nonsteroidal anti-inflammatory drugs (NSAIDs) were used. AGs were incubated with 0.1 M Tris-HCl buffer (pH 7.4) and 0.3 mg/mL HLM or RLM in the absence or presence of β-glucuronidase inhibitor, D-saccharic acid 1,4-lactone (D-SL) and esterase inhibitor, phenylmethylsulfonyl fluoride (PMSF).AGs of zomepirac (ZOM-AG), mefenamic acid (MEF-AG), and etodolac (ETO-AG) showed sign...
Source: Xenobiotica - October 3, 2022 Category: Research Authors: Hiroyuki Ikuta Hiroaki Shimada Kenjiro Sakamoto Rena Nakamura Atsushi Kawase Masahiro Iwaki Source Type: research

Application of ionic liquid to enhance the nose-to-brain delivery of etodolac
Eur J Pharm Sci. 2022 Sep 1:106290. doi: 10.1016/j.ejps.2022.106290. Online ahead of print.ABSTRACTThe purpose of this study was to enhance the delivery of Etodolac (ETD) to the brain through intranasal administration using an ionic liquid (IL) consisting of ETD and proline ethyl ester. The IL of ETD was prepared by mixing ETD with proline ethyl ester as a counterion in a molar ratio of 1:2.The formation of the IL was confirmed by differential scanning calorimetry (DSC), infrared spectroscopy (IR) and proton nuclear magnetic resonance (1H-NMR).The solubility of ETD in simulated nasal fluids was improved by approximately 20...
Source: European Journal of Pharmaceutical Sciences - September 4, 2022 Category: Drugs & Pharmacology Authors: Hiroaki Tanigawa Naoto Suzuki Toyofumi Suzuki Source Type: research

Cardiovascular Risks of Diclofenac Versus Other Older COX-2 Inhibitors (Meloxicam and Etodolac) and Newer COX-2 Inhibitors (Celecoxib and Etoricoxib): A Series of Nationwide Emulated Trials
ConclusionsThe increased cardiovascular risks associated with diclofenac initiation were higher than for other older COX-2 inhibitors (meloxicam/etodolac) and comparable to coxibs (celecoxib/etoricoxib). (Source: Drug Safety)
Source: Drug Safety - July 31, 2022 Category: Drugs & Pharmacology Source Type: research

Comparative photo-oxidative degradation of etodolac, febuxostat and imatinib mesylate by UV-C/H 2 O 2 and UV-C/S 2 O 8 2- processes: Modeling, treatment optimization and biodegradability enhancement
Environ Res. 2022 May 12:113385. doi: 10.1016/j.envres.2022.113385. Online ahead of print.ABSTRACTThe pharmaceutical contamination in aquatic environment has arisen increasing concern due to its potentially chronic toxicity. In recent years, HO° and SO4°- based advanced oxidation processes (AOPs) have been widely applied in water and wastewater treatments due to their highly efficiency on contaminant removal. Here, the response surface modeling (RSM) was used to investigate the degradation of three typical pharmaceuticals (i.e., etodolac (ETD), febuxostat (FBU) and imatinib mesylate (IMT)) by UV/H2O2 and UV/S2O82- proces...
Source: Environmental Research - May 15, 2022 Category: Environmental Health Authors: Amin Samzadeh Mansooreh Dehghani Mohammad Ali Baghapour Aboolfazl Azhdarpoor Zahra Derakhshan Matija Cvetni ć Tomislav Bolan ča Stefanos Giannakis Ying Cao Source Type: research