Cancers, Vol. 15, Pages 2972: Drug Repurposing in Oncology: A Systematic Review of Randomized Controlled Clinical Trials
Jorge Vicente-Romero
Quality pharmacological treatment can improve survival in many types of cancer. Drug repurposing offers advantages in comparison with traditional drug development procedures, reducing time and risk. This systematic review identified the most recent randomized controlled clinical trials that focus on drug repurposing in oncology. We found that only a few clinical trials were placebo-controlled or standard-of-care-alone-controlled. Metformin has been studied for potential use in various types of cancer, including prostate, lung, and pancreatic cancer. Other studies assessed the possible use of the an...
Source: Cancers - May 30, 2023 Category: Cancer & Oncology Authors: Ignatios Ioakeim-Skoufa Natalia Tobajas-Ramos Enrica Menditto Mercedes Aza-Pascual-Salcedo Antonio Gimeno-Miguel Valentina Orlando Francisca Gonz ález-Rubio Ana Fanlo-Villacampa Carmen Lasala-Aza Ewelina Ostasz Jorge Vicente-Romero Tags: Systematic Review Source Type: research
"Don't let it to air": A cautionary tale of the potential consequences of surgery of residual cancer
Brain Behav Immun. 2023 Apr 29;111:247-248. doi: 10.1016/j.bbi.2023.04.012. Online ahead of print.ABSTRACTIn this issue of the BBI, Haldar et al. demonstrate that major surgical stress from laparotomy caused a significant increase in post-operative metastatic burden in a mouse model of cancer. They identified this metastatic outbreak was driven by a novel mechanism of direct, surgery-induced activation of the primary tumour which, if left in situ, released pro-metastatic factors (IL-6, IL-8, and VEGF). Surgical stress induced significant changes in the transcriptional programming of the primary tumor, with marked activatio...
Source: Brain, Behavior, and Immunity - May 1, 2023 Category: Neurology Authors: Gayashan Tennakoon Rebecca Auer Source Type: research
"Don't let it to air": A cautionary tale of the potential consequences of surgery of residual cancer
Brain Behav Immun. 2023 Apr 29:S0889-1591(23)00110-1. doi: 10.1016/j.bbi.2023.04.012. Online ahead of print.ABSTRACTIn this issue of the BBI, Haldar et al. demonstrate that major surgical stress from laparotomy caused a significant increase in post-operative metastatic burden in a mouse model of cancer. They identified this metastatic outbreak was driven by a novel mechanism of direct, surgery-induced activation of the primary tumour which, if left in situ, released pro-metastatic factors (IL-6, IL-8, and VEGF). Surgical stress induced significant changes in the transcriptional programming of the primary tumor, with marked...
Source: Brain, Behavior, and Immunity - May 1, 2023 Category: Neurology Authors: Gayashan Tennakoon Rebecca Auer Source Type: research
"Don't let it to air": A cautionary tale of the potential consequences of surgery of residual cancer
Brain Behav Immun. 2023 Apr 29:S0889-1591(23)00110-1. doi: 10.1016/j.bbi.2023.04.012. Online ahead of print.ABSTRACTIn this issue of the BBI, Haldar et al. demonstrate that major surgical stress from laparotomy caused a significant increase in post-operative metastatic burden in a mouse model of cancer. They identified this metastatic outbreak was driven by a novel mechanism of direct, surgery-induced activation of the primary tumour which, if left in situ, released pro-metastatic factors (IL-6, IL-8, and VEGF). Surgical stress induced significant changes in the transcriptional programming of the primary tumor, with marked...
Source: Brain, Behavior, and Immunity - May 1, 2023 Category: Neurology Authors: Gayashan Tennakoon Rebecca Auer Source Type: research
"Don't let it to air": A cautionary tale of the potential consequences of surgery of residual cancer
Brain Behav Immun. 2023 Apr 29:S0889-1591(23)00110-1. doi: 10.1016/j.bbi.2023.04.012. Online ahead of print.ABSTRACTIn this issue of the BBI, Haldar et al. demonstrate that major surgical stress from laparotomy caused a significant increase in post-operative metastatic burden in a mouse model of cancer. They identified this metastatic outbreak was driven by a novel mechanism of direct, surgery-induced activation of the primary tumour which, if left in situ, released pro-metastatic factors (IL-6, IL-8, and VEGF). Surgical stress induced significant changes in the transcriptional programming of the primary tumor, with marked...
Source: Brain, Behavior, and Immunity - May 1, 2023 Category: Neurology Authors: Gayashan Tennakoon Rebecca Auer Source Type: research
Towards the Development of Dual Hypouricemic and Anti-inflammatory Candidates: Design, Synthesis, Stability Studies and Biological Evaluation of Some Mutual Ester Prodrugs of Febuxostat-NSAIDs
Bioorg Chem. 2023 Mar 31;135:106502. doi: 10.1016/j.bioorg.2023.106502. Online ahead of print.ABSTRACTTreatment of gout involves two basic approaches: reducing the serum uric acid mainly by xanthine oxidase inhibitors (XOIs) and alleviating the intensity of the accompanying acute arthritic inflammation using non-steroidal anti-inflammatory drugs (NSAIDs). Febuxostat (FEB) is the first non-purine XOI approved for the treatment of hyperuricemia and gout. The present study aims at combining the hypouricemic effect of FEB and the anti-inflammatory (AI) properties of NSAIDs in a single entity by adopting the "mutual prodrug" ap...
Source: Bioorganic Chemistry - April 8, 2023 Category: Chemistry Authors: Aya Y Rashad Hoda G Daabees Mohamed Elagawany Mohamed Shahin Ahmed E Abdel Moneim Sherif A F Rostom Source Type: research
Interactions of Cyclodextrins and their Hydroxyl Derivatives with Etodolac: Solubility and Dissolution Enhancement
CONCLUSION: Superior dissolution enhancements of ETO were recorded for the FD mixture (up to 90% dissolved in less than 10 min). In conclusion, γ- and hydroxypropyl γ-derivative of cyclodextrins can be considered a promising excipient for enhancement of dissolution rates concerned for ETO.PMID:36959150 | DOI:10.2174/1567201820666230320164210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 24, 2023 Category: Drugs & Pharmacology Authors: Wesam W Mustafa Mouhamad Khoder Hamdy Abdelkader Richard Singer Raid Alany Source Type: research
Interactions of Cyclodextrins and their Hydroxyl Derivatives with Etodolac: Solubility and Dissolution Enhancement
CONCLUSION: Superior dissolution enhancements of ETO were recorded for the FD mixture (up to 90% dissolved in less than 10 min). In conclusion, γ- and hydroxypropyl γ-derivative of cyclodextrins can be considered a promising excipient for enhancement of dissolution rates concerned for ETO.PMID:36959150 | DOI:10.2174/1567201820666230320164210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 24, 2023 Category: Drugs & Pharmacology Authors: Wesam W Mustafa Mouhamad Khoder Hamdy Abdelkader Richard Singer Raid Alany Source Type: research
Interactions of Cyclodextrins and their Hydroxyl Derivatives with Etodolac: Solubility and Dissolution Enhancement
CONCLUSION: Superior dissolution enhancements of ETO were recorded for the FD mixture (up to 90% dissolved in less than 10 min). In conclusion, γ- and hydroxypropyl γ-derivative of cyclodextrins can be considered a promising excipient for enhancement of dissolution rates concerned for ETO.PMID:36959150 | DOI:10.2174/1567201820666230320164210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 24, 2023 Category: Drugs & Pharmacology Authors: Wesam W Mustafa Mouhamad Khoder Hamdy Abdelkader Richard Singer Raid Alany Source Type: research
Interactions of Cyclodextrins and their Hydroxyl Derivatives with Etodolac: Solubility and Dissolution Enhancement
CONCLUSION: Superior dissolution enhancements of ETO were recorded for the FD mixture (up to 90% dissolved in less than 10 min). In conclusion, γ- and hydroxypropyl γ-derivative of cyclodextrins can be considered a promising excipient for enhancement of dissolution rates concerned for ETO.PMID:36959150 | DOI:10.2174/1567201820666230320164210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 24, 2023 Category: Drugs & Pharmacology Authors: Wesam W Mustafa Mouhamad Khoder Hamdy Abdelkader Richard Singer Raid Alany Source Type: research
Interactions of Cyclodextrins and their Hydroxyl Derivatives with Etodolac: Solubility and Dissolution Enhancement
CONCLUSION: Superior dissolution enhancements of ETO were recorded for the FD mixture (up to 90% dissolved in less than 10 min). In conclusion, γ- and hydroxypropyl γ-derivative of cyclodextrins can be considered a promising excipient for enhancement of dissolution rates concerned for ETO.PMID:36959150 | DOI:10.2174/1567201820666230320164210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 24, 2023 Category: Drugs & Pharmacology Authors: Wesam W Mustafa Mouhamad Khoder Hamdy Abdelkader Richard Singer Raid Alany Source Type: research
Interactions of Cyclodextrins and their Hydroxyl Derivatives with Etodolac: Solubility and Dissolution Enhancement
CONCLUSION: Superior dissolution enhancements of ETO were recorded for the FD mixture (up to 90% dissolved in less than 10 min). In conclusion, γ- and hydroxypropyl γ-derivative of cyclodextrins can be considered a promising excipient for enhancement of dissolution rates concerned for ETO.PMID:36959150 | DOI:10.2174/1567201820666230320164210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 24, 2023 Category: Drugs & Pharmacology Authors: Wesam W Mustafa Mouhamad Khoder Hamdy Abdelkader Richard Singer Raid Alany Source Type: research
Perioperative escape from dormancy of spontaneous micro-metastases: A role for malignant secretion of IL-6, IL-8, and VEGF, through adrenergic and prostaglandin signaling
Brain Behav Immun. 2023 Jan 13:S0889-1591(23)00005-3. doi: 10.1016/j.bbi.2023.01.005. Online ahead of print.ABSTRACTWe recently showed that a minimally-invasive removal of MDA-MB-231HM primary tumors (PTs) and elimination of their secreted factors (including IL-6, IL-8, VEGF, EGF, PDGF-aa, MIF, SerpinE1, and M-CSF), caused regression of spontaneous micro-metastases into a non-growing dormant state. To explore the underlying mechanisms and potential clinical ramifications of this phenomenon, we herein used the MDA-MB-231HM human breast cancer cell-line, in-vitro, and in vivo following orthotopic implantation in immune-defic...
Source: Brain, Behavior, and Immunity - January 16, 2023 Category: Neurology Authors: Rita Haldar Lee Shaashua Berger Ella Rossenne Arielle Radin Anabel Eckerling Elad Sandbank Erica K Sloan Steve W Cole Shamgar Ben-Eliyahu Source Type: research
Perioperative escape from dormancy of spontaneous micro-metastases: A role for malignant secretion of IL-6, IL-8, and VEGF, through adrenergic and prostaglandin signaling
Brain Behav Immun. 2023 Jan 13:S0889-1591(23)00005-3. doi: 10.1016/j.bbi.2023.01.005. Online ahead of print.ABSTRACTWe recently showed that a minimally-invasive removal of MDA-MB-231HM primary tumors (PTs) and elimination of their secreted factors (including IL-6, IL-8, VEGF, EGF, PDGF-aa, MIF, SerpinE1, and M-CSF), caused regression of spontaneous micro-metastases into a non-growing dormant state. To explore the underlying mechanisms and potential clinical ramifications of this phenomenon, we herein used the MDA-MB-231HM human breast cancer cell-line, in-vitro, and in vivo following orthotopic implantation in immune-defic...
Source: Brain, Behavior, and Immunity - January 16, 2023 Category: Neurology Authors: Rita Haldar Lee Shaashua Berger Ella Rossenne Arielle Radin Anabel Eckerling Elad Sandbank Erica K Sloan Steve W Cole Shamgar Ben-Eliyahu Source Type: research
Perioperative escape from dormancy of spontaneous micro-metastases: A role for malignant secretion of IL-6, IL-8, and VEGF, through adrenergic and prostaglandin signaling
Brain Behav Immun. 2023 Jan 13:S0889-1591(23)00005-3. doi: 10.1016/j.bbi.2023.01.005. Online ahead of print.ABSTRACTWe recently showed that a minimally-invasive removal of MDA-MB-231HM primary tumors (PTs) and elimination of their secreted factors (including IL-6, IL-8, VEGF, EGF, PDGF-aa, MIF, SerpinE1, and M-CSF), caused regression of spontaneous micro-metastases into a non-growing dormant state. To explore the underlying mechanisms and potential clinical ramifications of this phenomenon, we herein used the MDA-MB-231HM human breast cancer cell-line, in-vitro, and in vivo following orthotopic implantation in immune-defic...
Source: Brain, Behavior, and Immunity - January 16, 2023 Category: Neurology Authors: Rita Haldar Lee Shaashua Berger Ella Rossenne Arielle Radin Anabel Eckerling Elad Sandbank Erica K Sloan Steve W Cole Shamgar Ben-Eliyahu Source Type: research
