Elucidating mechanistic insights into drug action for atopic dermatitis: a systems biology approach
Topical Betamethasone (BM) and Pimecrolimus (PC) are widely used drugs in the treatment of atopic dermatitis (AD). Though the biomolecules and biological pathways affected by the drugs are known, the causal in... (Source: BMC Dermatology)
Source: BMC Dermatology - February 7, 2018 Category: Dermatology Authors: Indhupriya Subramanian, Vivek K. Singh and Abhay Jere Tags: Research article Source Type: research
Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.
In conclusion, we here have identified two approved drugs as novel potent PXR inhibitors with differential receptor interaction profiles and gene selectivity in primary human hepatocytes.
PMID: 29356861 [PubMed - as supplied by publisher] (Source: Archives of Toxicology)
Source: Archives of Toxicology - January 22, 2018 Category: Toxicology Authors: Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B Tags: Arch Toxicol Source Type: research
Frontal Fibrosing Alopecia: A Retrospective Analysis of 72 Patients from a German Academic Center
Facial plast Surg DOI: 10.1055/s-0037-1615281Frontal fibrosing alopecia (FFA) describes the scarring, band-like recession of the frontotemporal hairline. Treatment is difficult, and currently, no evidence-based therapy exists. The purpose of this study is to report clinical features and treatment responses in a large cohort of patients with FFA. The authors analyzed a series of 72 patients with a clinical or histologic diagnosis of FFA. A total of 70 patients were female (97.2%), and 2 were male (2.8%). In females, the first onset of FFA was postmenopausal in 81.4% (n = 57). Documented eyebrow loss was present in 61.1%...
Source: Facial Plastic Surgery - December 26, 2017 Category: Cosmetic Surgery Authors: Heppt, Markus V. Letul é, Valerie Laniauskaite, Ieva Reinholz, Markus Tietze, Julia K. Wolff, Hans Ruzicka, Thomas Sattler, Elke C. Tags: Rapid Communication Source Type: research
Preparation and Characterization of Novel Pimecrolimus Nanoparticles for Therapy of Allergic Conjunctivitis
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - December 8, 2017 Category: Nanotechnology Authors: Li, Hongxia Wang, Weijian Xu, Xuelian Yin, Jiaqi Yu, Mian Zheng, Xue Wang, Cheng Tags: Articles Source Type: research
A 5 ‐year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal – author response
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - September 21, 2017 Category: Dermatology Authors: B. Sigurgeirsson, T. Luger Tags: Critically Appraised Research Paper Source Type: research
A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - author response.
PMID: 28940181 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 21, 2017 Category: Dermatology Authors: Sigurgeirsson B, Luger T Tags: Br J Dermatol Source Type: research
Granuloma Faciale Treatment: A Systematic Review.
Abstract
Granuloma faciale is an uncommon benign chronic dermatosis characterized by reddish-brown to violaceous asymptomatic plaques appearing predominantly on the face. The pathogenesis of granuloma faciale remains unclear, and it is frequently unresponsive to therapy. This systematic review aims to summarize all recent publications on the management of granuloma faciale. The publications are mainly individual case reports, small case series and a few retrospective studies. Treatment options included topical, intralesional and systemic corticosteroids, topical pimecrolimus and tacrolimus, topical and sys...
Source: Acta Dermato-Venereologica - September 7, 2017 Category: Dermatology Authors: Lindhaus C, Elsner P Tags: Acta Derm Venereol Source Type: research
A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal.
CONCLUSIONS: Sigurgeirsson et al. conclude that the long-term management of mild-to-moderate AD in children with both TCS and PIM is safe, and that PIM has similar efficacy to TCS. Further, they conclude that their data support the use of PIM as a first-line treatment of mild-to-moderate AD in children.
PMID: 28868633 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 4, 2017 Category: Dermatology Authors: Weidinger S, Baurecht H, Schmitt J Tags: Br J Dermatol Source Type: research
A 5 ‐year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal
ConclusionsSigurgeirsson et al. conclude that the long‐term management of mild‐to‐moderate AD in children with both TCS and PIM is safe, and that PIM has similar efficacy to TCS. Further, they conclude that their data support the use of PIM as a first‐line treatment of mild‐to‐moderate AD in children. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - September 4, 2017 Category: Dermatology Authors: S. Weidinger, H. Baurecht, J. Schmitt Tags: Critically Appraised Research Paper Source Type: research
A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - comment.
PMID: 28858382 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 31, 2017 Category: Dermatology Authors: Charman C Tags: Br J Dermatol Source Type: research
A 5 ‐year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal – comment
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - August 31, 2017 Category: Dermatology Authors: C. Charman Tags: Putting Papers into Practice Source Type: research
Treatment of oral lichen planus. Systematic review and therapeutic guide.
Authors: García-Pola MJ, González-Álvarez L, Garcia-Martin JM
Abstract
In this systematic review, 55 structured articles on the therapeutic efficacy against pain and clinical signs of oral lichen planus (OLP) were analysed. The literature search was developed according to the criteria of the PRISMA system, selecting the tests performed using one of the following methodological designs: drug (active ingredient) vs. drug in different excipient or concentration, drug vs. different active principle, drug vs. phytotherapy and drug vs. treatment with phototherapy. Based on the results, an algorithm is propose...
Source: Medicina Clinica - August 1, 2017 Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Treatment of Annular Elastolytic Giant Cell Granuloma With Topical Tretinoin.
We present a case of a 47-year-old woman with bilateral forearm lesions consistent with annular elastolytic giant cell granuloma who was successfully treated with topical tretinoin.</p> <p><em>J Drugs Dermatol. 2017;16(7):699-700.</em></p>.
PMID: 28697223 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 13, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Intense Pulsed Light and Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment for the Scarring Lesion of Discoid Lupus Erythematosus.
Authors: Byun YS, Son JH, Cho YS, Chung BY, Cho HJ, Park CW, Kim HO
Abstract
Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus that can cause permanent scarring. Treatment of DLE includes protection from sunlight and artificial sources of ultraviolet light, as well as systemic and topical medications. The first-line standard therapies are antimalarials and topical steroids. Other systemic therapies include systemic steroid, azathioprine, dapsone, and immunosuppressive agents. Topical tacrolimus and pimecrolimus have also been evaluated. Recent studies reported that several treatments, ...
Source: Annals of Dermatology - June 3, 2017 Category: Dermatology Tags: Ann Dermatol Source Type: research
Therapeutic effectiveness of calcineurin inhibitors in canine vesicular cutaneous lupus erythematosus.
CONCLUSIONS AND CLINICAL IMPORTANCE: These observations support CIs as the preferable therapeutic alternatives to long-term immunosuppression with oral glucocorticoids in dogs with VCLE.
PMID: 28439997 [PubMed - as supplied by publisher] (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - April 24, 2017 Category: Veterinary Research Authors: Banovic F, Robson D, Linek M, Olivry T Tags: Vet Dermatol Source Type: research
