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Effects of mycophenolate mofetil, methotrexate and pimecrolimus on cdk4 and p16 in erosive oral lichen planus
Conclusion: By decreasing the expression of cdk4 and p16, pimecrolimus, methotrexate, and mycophenolate mofetil decrease the malignant potential of OLP lesions. However, methorexate can be a better alternative in cases showing high cdk4 expression. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - December 9, 2021 Category: Dermatology Authors: Sinny Goel Nita Khurana Source Type: research

Matching-Adjusted Indirect Comparison of Crisaborole Ointment 2% vs. Topical Calcineurin Inhibitors in the Treatment of Patients with Mild-to-Moderate Atopic Dermatitis
ConclusionThe unanchored MAIC suggests that the odds of achieving an improvement in ISGA score is greater with crisaborole 2% than with pimecrolimus 1% or tacrolimus 0.03% in patients aged ≥ 2 years with mild-to-moderate AD. These results are consistent with findings from the previously published network meta-analysis, which used a different methodology for performing indirect treatment comparisons. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 8, 2021 Category: Dermatology Source Type: research

Re-Evaluating Limitations in Atopic Dermatitis Meta-Analysis Is Important in Interpreting its Results
AbstractA recently published systematic review and meta-analysis concludes that topical calcineurin inhibitors (TCIs) used in atopic dermatitis (AD) increase risk of lymphoma. We believe this study has weaknesses that have not been adequately addressed by the authors and its results must therefore be interpreted with caution. According to study results only pimecrolimus used for AD was statistically significantly associated with lymphoma, and not TCIs in general. Unclear participant baseline immunocompetence and short follow-up duration limit the study ’s ability to detect malignancy risk. AD has been linked to an increa...
Source: Dermatology and Therapy - November 17, 2021 Category: Dermatology Source Type: research

Pimecrolimus interferes the therapeutic efficacy of human mesenchymal stem cells in atopic dermatitis by regulating NFAT-COX2 signaling
CONCLUSIONS: Coadministration of pimecrolimus with hMSCs could interfere with the therapeutic efficacy of hMSCs in atopic dermatitis, and this is the first study that figured out the interaction of hMSCs with other drugs in cell therapy of atopic dermatitis. Therefore, this study might give rise to improvement of the clinical application of hMSCs therapy and facilitate the widespread application of hMSCs in clinical field.PMID:34454603 | DOI:10.1186/s13287-021-02547-8 (Source: Cell Research)
Source: Cell Research - August 29, 2021 Category: Cytology Authors: Nari Shin Namhee Jung Seung-Eun Lee Dasom Kong Nam Gyo Kim Myung Geun Kook Hwanhee Park Soon Won Choi Seunghee Lee Kyung-Sun Kang Source Type: research

26966 Tofacitinib treats unresponsive vitiligo and elevated thyroid peroxidase antibodies
A 56-year-old female presented with expanding vitiligo to 35% total body surface area (TBSA) despite treatment with alpha lipoic acid, vitamin C, vitamin E, polypodium leucotomus, topical pimecrolimus, narrowband ultraviolet B, and excimer laser for 2 months. Past medical history was pertinent for Hashimoto thyroiditis treated with levothyroxine with normal levels of thyroid stimulating hormone (TSH) and free thyroxine (FT4), psoriatic arthritis, alopecia, and localized psoriasis on the elbows. Notably, lab tests confirmed normal levels of serum TSH and FT4 but elevated thyroid peroxidase antibodies (TPO) of 795 and elevat...
Source: Journal of the American Academy of Dermatology - August 8, 2021 Category: Dermatology Authors: Angela Yen Moore, Samanna Maberry Source Type: research

Efficacy of topical non-steroidal immunomodulators in the treatment of oral lichen planus: a systematic review and meta-analysis
ConclusionsTopical tacrolimus and pimecrolimus are safe and effective alternatives for OLP treatment.Clinical relevanceTS are usually the first choice for OLP treatment. Because some oral lesions may have a low response to treatment with TS, more topical therapeutic options, such as TNSIs, should be considered before systemic steroids are used. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - August 3, 2021 Category: Dentistry Source Type: research

Effects of Intermittent Treatment with Topical Corticosteroids and Calcineurin Inhibitors on Epidermal and Dermal Thickness Using Optical Coherence Tomography and Ultrasound
Conclusions: MPA, HC, and PIM may be more suitable for repeated and prolonged treatment, especially in chronic diseases. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - July 8, 2021 Category: Dermatology Source Type: research

Topical epigallocatechin-3-gallate in the treatment of vitiligo
CONCLUSION: Findings of the study indicate that topical EGCG can be effective on treating vitiligo.PMID:34046892 | DOI:10.1111/ajd.13612 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - May 28, 2021 Category: Dermatology Authors: Wenting Hu Lingling Zhang Fuquan Lin Jiehao Lei Miaoni Zhou AiE Xu Source Type: research