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New Non-Steroidal Topical Therapies for Inflammatory Dermatoses-Part 3: Roflumilast
Skinmed. 2023 Sep 29;21(4):264-268. eCollection 2023.ABSTRACTTopical corticosteroids have remained the initial and long-term topical treatment option for inflammatory dermatitis conditions since the 1950s. A number of non-steroidal topicals for treatment of inflammatory dermatoses have been developed in the recent decades, such as topical calcineurin inhibitors (tacrolimus ointment and pimecrolimus cream), vitamin D analogues, and phophodiesterase-4 inhibitors (crisaborole), but none had the combination of broad therapeutic range, relatively rapid onset of action, tolerability, and wide-spread clinical success that allowed...
Source: Skinmed - September 29, 2023 Category: Dermatology Authors: Margaret DiRuggiero Elizabeth Mancuso-Stewart Douglas DiRuggiero Matt Zirwas Source Type: research

Association Between the Use of Topical Calcineurin Inhibitors and the Risk of Cancer Among Patients with Atopic Dermatitis: A Nationwide, Population-Based, Retrospective Cohort Study
Conclusions and RelevanceOur study found no evidence to support an association between TCI use and the risks of almost all cancers compared with TCS use in patients with AD, but physicians should be aware of potentially higher risks of leukemia with TCI use. This study represents the first population-based study focused on the cancer risk of TCI use among patients with AD in an Asian population. (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - September 1, 2023 Category: Dermatology Source Type: research

Netherton syndrome in a Bulgarian patient
This article is mainly focused on innovative therapeutic options, including modern medications such as dupilumab, infliximab, secukinumab, anakinra, omalizumab, and others. (Source: Wiener Medizinische Wochenschrift)
Source: Wiener Medizinische Wochenschrift - September 1, 2023 Category: General Medicine Source Type: research

Amicrobial pustulosis of the folds: long-term remission achieved with low dose dapsone and topical pimecrolimus
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361443.NO ABSTRACTPMID:37591283 | DOI:10.5070/D329361443 (Source: Dermatol Online J)
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Chrysa Brinia Aikaterini Tsiogka Eftychia Platsidaki Vasiliki Markantoni Stamatios Gregoriou Dimitris Rigopoulos Georgios Kontochristopoulos Source Type: research