Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

In conclusion, we here have identified two approved drugs as novel potent PXR inhibitors with differential receptor interaction profiles and gene selectivity in primary human hepatocytes.
PMID: 29356861 [PubMed - as supplied by publisher]

Source: Archives of Toxicology - January 22, 2018 Category: Toxicology Authors: Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B Tags: Arch Toxicol Source Type: research