Inhibition of macrophage MAPK/NF- κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis
Int Immunopharmacol. 2024 Apr 14;133:112038. doi: 10.1016/j.intimp.2024.112038. Online ahead of print.ABSTRACTAvailable online Atopic dermatitis (AD) is a chronic, persistent inflammatory skin disease characterized by eczema-like lesions and itching. Although topical steroids have been reported for treating AD, they are associated with adverse effects. Thus, safer medications are needed for those who cannot tolerate these agents for long periods. Mangiferin (MAN) is a flavonoid widely found in many herbs, with significant anti-inflammatory and immunomodulatory activities. However, the potential modulatory effects and mecha...
Source: International Immunopharmacology - April 15, 2024 Category: Allergy & Immunology Authors: Cheng Lu ShiJun Deng YanJiao Liu ShengJin Yang DingMei Qin LiJuan Zhang Rui-Rui Wang Yi Zhang Source Type: research
Matching-Adjusted Indirect Comparison of the Efficacy at Week 32 of Tralokinumab and Dupilumab in the Treatment of Moderate-to-Severe Atopic Dermatitis
ConclusionThe results of this analysis demonstrate that, in combination with TCS, tralokinumab and dupilumab have similar efficacy in the treatment of moderate-to-severe AD at 32 weeks of therapy. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 13, 2024 Category: Dermatology Source Type: research
Reappraising the Use of Systemic Immunomodulators for Psoriasis and Eczema in the Military
CONCLUSIONS: Systemic treatments have evolved to become highly specific for both eczema and psoriasis. These newer biologics and immunomodulators may be compatible with use in the deployed setting, especially those that have long dosing intervals and proven efficacy and safety. Of the biologics, dupilumab and risankizumab offer the best efficacy, safety, and dosing intervals for atopic dermatitis and psoriasis, respectively. Deucravcitinib is a recently FDA-approved oral immunomodulator for psoriasis that has an excellent safety profile and efficacy. Allowing the use of these medications on deployments will enable more peo...
Source: Military Medicine - April 12, 2024 Category: International Medicine & Public Health Authors: Alexius Russell Samantha Williamson Alexandra Rosenberg Sunghun Cho Source Type: research
Impact of Cosmetics and Cleansers in Atopic Dermatitis —How to Advise Patients
AbstractPurpose of ReviewAtopic dermatitis (AD) or eczema is a frequent chronic inflammatory skin disease. Taking care of the eczematous skin is important to reduce the inflammation and return it to a healthier looking nourished skin. Beyond recommending topical anti-inflammatory drugs and the use of emollients, recommendations on the correct use of other everyday skin products, as cleansers or make-up products, are lacking.Recent FindingsThe dry, itchy, and inflamed eczematous skin causes anxiety, poor self-image, low self-esteem, decreased social skills, and an overall decrease in a patients ’ quality of life. The use ...
Source: Current Treatment Options in Allergy - April 8, 2024 Category: Allergy & Immunology Source Type: research
Prenatal risk factors of indoor environment and incidence of childhood eczema in the Japan environment and children's study
In this study, we aimed to determine the indoor environmental factors that are associated with eczema in children up to 3 years of age, using national birth cohort data from the Japan Environment and Children's Study (JECS). Information on indoor environments and eczema symptoms until 3 years of age was collected using self-administered questionnaires to the mothers. A total of 71,883 and 58,639 mother-child pairs at 1.5- and 3-years-old, respectively, were included in the former analyses. To account for prenatal indoor risk factors, 17,568 (1.5-years-old) and 7063 (3-years-old) children without indoor mold and/or ETS expo...
Source: Environmental Research - April 6, 2024 Category: Environmental Health Authors: Yu Ait Bamai Chihiro Miyashita Atsuko Ikeda-Araki Keiko Yamazaki Sumitaka Kobayashi Sachiko Itoh Yasuaki Saijo Yoshiya Ito Eiji Yoshioka Yukihiro Sato Reiko Kishi Michihiro Kamijima Shin Yamazaki Yukihiro Ohya Nobuo Yaegashi Koichi Hashimoto Chisato Mori Source Type: research
Prenatal risk factors of indoor environment and incidence of childhood eczema in the Japan environment and children's study
In this study, we aimed to determine the indoor environmental factors that are associated with eczema in children up to 3 years of age, using national birth cohort data from the Japan Environment and Children's Study (JECS). Information on indoor environments and eczema symptoms until 3 years of age was collected using self-administered questionnaires to the mothers. A total of 71,883 and 58,639 mother-child pairs at 1.5- and 3-years-old, respectively, were included in the former analyses. To account for prenatal indoor risk factors, 17,568 (1.5-years-old) and 7063 (3-years-old) children without indoor mold and/or ETS expo...
Source: Environmental Research - April 6, 2024 Category: Environmental Health Authors: Yu Ait Bamai Chihiro Miyashita Atsuko Ikeda-Araki Keiko Yamazaki Sumitaka Kobayashi Sachiko Itoh Yasuaki Saijo Yoshiya Ito Eiji Yoshioka Yukihiro Sato Reiko Kishi Michihiro Kamijima Shin Yamazaki Yukihiro Ohya Nobuo Yaegashi Koichi Hashimoto Chisato Mori Source Type: research
A Protocol for the Automated Assessment of Cutaneous Pathology in a Mouse Model of Hemichannel Dysfunction
Methods Mol Biol. 2024;2801:177-187. doi: 10.1007/978-1-0716-3842-2_13.ABSTRACTIn this chapter, we provide detailed instructions to perform quantitative reflectance imaging in a mouse model of a rare epidermal disorder caused by hyperactive connexin 26 hemichannels. Reflectance imaging is a versatile and powerful tool in dermatology, offering noninvasive, high-resolution insights into skin pathology, which is essential for both clinical practice and research. This approach offers several advantages and applications. Unlike traditional biopsy, reflectance imaging is noninvasive, allowing for real-time, in vivo examination o...
Source: Mol Biol Cell - April 5, 2024 Category: Molecular Biology Authors: Chiara Peres Fabio Mammano Source Type: research
A Protocol for the Automated Assessment of Cutaneous Pathology in a Mouse Model of Hemichannel Dysfunction
Methods Mol Biol. 2024;2801:177-187. doi: 10.1007/978-1-0716-3842-2_13.ABSTRACTIn this chapter, we provide detailed instructions to perform quantitative reflectance imaging in a mouse model of a rare epidermal disorder caused by hyperactive connexin 26 hemichannels. Reflectance imaging is a versatile and powerful tool in dermatology, offering noninvasive, high-resolution insights into skin pathology, which is essential for both clinical practice and research. This approach offers several advantages and applications. Unlike traditional biopsy, reflectance imaging is noninvasive, allowing for real-time, in vivo examination o...
Source: Mol Biol Cell - April 5, 2024 Category: Molecular Biology Authors: Chiara Peres Fabio Mammano Source Type: research
Secondary Bacterial Infections in Patients with Atopic Dermatitis or Other Common Dermatoses
AbstractSecondary bacterial infections of common dermatoses such as atopic dermatitis, ectoparasitosis, and varicella zoster virus infections are frequent, withStaphylococcus aureus andStreptococcus pyogenes being the bacteria most involved. There are also Gram-negative infections secondary to common dermatoses such as foot dyshidrotic eczema and tinea pedis. Factors favoring secondary bacterial infections in atopic dermatitis, ectoparasitosis, and varicella zoster virus infections mainly include an epidermal barrier alteration as well as itch. Mite-bacteria interaction is also involved in scabies and some environmental fa...
Source: American Journal of Clinical Dermatology - April 5, 2024 Category: Dermatology Source Type: research
A systematic review investigating the proportion of clinical images shared in prospective randomized controlled trials involving patients with atopic dermatitis and systemic pharmacotherapy
J Dermatolog Treat. 2024 Dec;35(1):2338280. doi: 10.1080/09546634.2024.2338280. Epub 2024 Apr 3.ABSTRACTFor individuals with atopic dermatitis (AD), interpreting scientific papers that present clinical outcomes including the Eczema Area and Severity Index (EASI) and Investigators Global Assessment may be difficult. When compared to tabulated data and graphs, images from before and after treatment are often far more meaningful to these patients that ultimately will be candidates for the treatment. This systematic review focused on determining the frequency of clinical image sharing in AD research.Conducted in accordance wit...
Source: Journal of Dermatological Treatment - April 3, 2024 Category: Dermatology Authors: Sam Polesie Mikael Alsterholm Source Type: research
