Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways
CONCLUSIONS: Distinct immunologic ircAE endotypes suggest actionable targets for precision medicine-based interventions.PMID:38652814 | DOI:10.1158/1078-0432.CCR-23-3431 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 23, 2024 Category: Cancer & Oncology Authors: Mario E Lacouture Elena Goleva Neil Shah Veronica Rotemberg Lukas Kraehenbuehl Kwami F Ketosugbo Taha Merghoub Tara Maier Alexander Bang Stephanie Gu Trina Salvador Andrea P Moy Taras Lyubchenko Olivia Xiao Clifton F Hall Evgeny Berdyshev James Crooks Rya Source Type: research
Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways
CONCLUSIONS: Distinct immunologic ircAE endotypes suggest actionable targets for precision medicine-based interventions.PMID:38652814 | DOI:10.1158/1078-0432.CCR-23-3431 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Mario E Lacouture Elena Goleva Neil Shah Veronica Rotemberg Lukas Kraehenbuehl Kwami F Ketosugbo Taha Merghoub Tara Maier Alexander Bang Stephanie Gu Trina Salvador Andrea P Moy Taras Lyubchenko Olivia Xiao Clifton F Hall Evgeny Berdyshev James Crooks Rya Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
Evaluation on the traditional safe use of Kochiae Fructus oriented by antioxidant properties and oral safety of its ethanolic extract
Toxicon. 2024 Apr 18:107725. doi: 10.1016/j.toxicon.2024.107725. Online ahead of print.ABSTRACTKochiae Fructus (KF) is a traditional Chinese medicine, which has been used to delay aging and treat inflammation, such as rubella, eczema, cutaneous pruritus, etc. In order to fully understand the traditional medicinal value of KF, we evaluated the antioxidant properties and oral safety of its ethanolic extract. Considering flavonoids and phenolics in medicinal plants generally have strong antioxidant activity, we firstly detected the total flavonoids and phenolics contents of KFEE and its fractions. Secondly, we evaluated the a...
Source: Toxicon - April 20, 2024 Category: Toxicology Authors: Xuelin Chen Kun Zhang Hanlei Wang Xia Zhao Yumei Zhang Source Type: research
Halting the Vicious Cycle of Atopic Dermatitis: Empowered by Scientific Understanding
The progress in our understanding of atopic dermatitis (AD) (atopic eczema) in the last 10 years has been remarkable. Nearly half of the scientific papers ever published on AD have been written in the last 10 years. This contribution of knowledge, in parallel with technological and pharmaceutical progress, has transformed our ability to treat some of the most severe forms of AD. Notably, we have seen the advent of biologics such as the anti –IL-4 receptor biologic dupilumab (Simpson et al, 2016), 2 anti–IL-13 agents (tralokinumab [Wollenberg et al, 2021] and lebrikizumab [Silverberg et al, 2023]), and small-molecula...
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Authors: Sara J. Brown, Johann E. Gudjonsson Tags: Editorial Source Type: research
Correlation of Disease Severity, Proinflammatory Cytokines, and Reduced Brain Gray Matter Volumes in Patients with Atopic Dermatitis
Conclusion: Patients with AD demonstrated significant brain GM volume reduction in many brain regions, which is related to disease severity and proinflammatory cytokines.PMID:38634841 | DOI:10.1089/derm.2023.0340 (Source: Dermatitis)
Source: Dermatitis - April 18, 2024 Category: Dermatology Authors: Cheng-Yuan Li Wan-Chen Chang Mu-Hong Chen Pei-Chi Tu Tai-Li Chen Chih-Chiang Chen Yun-Ting Chang You-Yin Chen Ya-Mei Bai Source Type: research
Oral Tofacitinib in the Treatment of Moderate-to-Severe Chronic Hand Eczema: A Case Series
Dermatitis. 2024 Apr 17. doi: 10.1089/derm.2024.0032. Online ahead of print.NO ABSTRACTPMID:38634838 | DOI:10.1089/derm.2024.0032 (Source: Dermatitis)
Source: Dermatitis - April 18, 2024 Category: Dermatology Authors: Fangzhou Yu Donghong Du Zhaoxia Zhang Xiaofeng Shan Guangjin Wang Fangfang Bao Zhongxiang Shi Baoqi Yang Furen Zhang Source Type: research
Correlation of Disease Severity, Proinflammatory Cytokines, and Reduced Brain Gray Matter Volumes in Patients with Atopic Dermatitis
Conclusion: Patients with AD demonstrated significant brain GM volume reduction in many brain regions, which is related to disease severity and proinflammatory cytokines.PMID:38634841 | DOI:10.1089/derm.2023.0340 (Source: Dermatitis)
Source: Dermatitis - April 18, 2024 Category: Dermatology Authors: Cheng-Yuan Li Wan-Chen Chang Mu-Hong Chen Pei-Chi Tu Tai-Li Chen Chih-Chiang Chen Yun-Ting Chang You-Yin Chen Ya-Mei Bai Source Type: research
Oral Tofacitinib in the Treatment of Moderate-to-Severe Chronic Hand Eczema: A Case Series
Dermatitis. 2024 Apr 17. doi: 10.1089/derm.2024.0032. Online ahead of print.NO ABSTRACTPMID:38634838 | DOI:10.1089/derm.2024.0032 (Source: Dermatitis)
Source: Dermatitis - April 18, 2024 Category: Dermatology Authors: Fangzhou Yu Donghong Du Zhaoxia Zhang Xiaofeng Shan Guangjin Wang Fangfang Bao Zhongxiang Shi Baoqi Yang Furen Zhang Source Type: research
Network Pharmacology Combined with Molecular Docking Approach to Investigate the Mechanism of ChuShiWeiLing Decoction Against Perianal Eczema
CONCLUSION: Our results indicated that the bioactives, potential targets, and molecular mechanism of CSWLD against PE.PMID:38629356 | DOI:10.2174/0113816128298780240329075340 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 17, 2024 Category: Drugs & Pharmacology Authors: Ying Liu Min Hao Xinyue Fang Yifei Qian Yahui Wang Shuai Yan Source Type: research
Network Pharmacology Combined with Molecular Docking Approach to Investigate the Mechanism of ChuShiWeiLing Decoction Against Perianal Eczema
CONCLUSION: Our results indicated that the bioactives, potential targets, and molecular mechanism of CSWLD against PE.PMID:38629356 | DOI:10.2174/0113816128298780240329075340 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 17, 2024 Category: Drugs & Pharmacology Authors: Ying Liu Min Hao Xinyue Fang Yifei Qian Yahui Wang Shuai Yan Source Type: research
Development of an indicator set for the evaluation of the quality of routine ambulatory health care for common disorders in children and adolescents
CONCLUSION: The consented QI set is currently being tested and can subsequently be used (possibly modified) to measure the quality of routine outpatient care for children and adolescents in Germany, in order to indicate the status quo and potential areas for improvement in outpatient care.PMID:38631959 | DOI:10.1016/j.zefq.2024.03.002 (Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen)
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - April 17, 2024 Category: Health Management Authors: Claudia Mehl Teresa M üller Thorsten Nau Christian Bachmann Max Geraedts Source Type: research
The Role of Inhalant Allergens on the Clinical Manifestations of Atopic Dermatitis
CONCLUSION: There is a significant relationship between exposures to inhalant allergens and AD. Inhalant allergens may aggravate AD symptoms by either bronchial provocation or direct skin contact. Sensitization of inhalant allergens, mainly house dust mites, follows a specific age-related pattern.PMID:38623643 | DOI:10.1177/19458924241246855 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 16, 2024 Category: ENT & OMF Authors: Jaekeun Jung Clinton W Enos Kent K Lam Joseph K Han Source Type: research
The Role of Inhalant Allergens on the Clinical Manifestations of Atopic Dermatitis
CONCLUSION: There is a significant relationship between exposures to inhalant allergens and AD. Inhalant allergens may aggravate AD symptoms by either bronchial provocation or direct skin contact. Sensitization of inhalant allergens, mainly house dust mites, follows a specific age-related pattern.PMID:38623643 | DOI:10.1177/19458924241246855 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 16, 2024 Category: ENT & OMF Authors: Jaekeun Jung Clinton W Enos Kent K Lam Joseph K Han Source Type: research
Inhibition of macrophage MAPK/NF- κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis
Int Immunopharmacol. 2024 Apr 14;133:112038. doi: 10.1016/j.intimp.2024.112038. Online ahead of print.ABSTRACTAvailable online Atopic dermatitis (AD) is a chronic, persistent inflammatory skin disease characterized by eczema-like lesions and itching. Although topical steroids have been reported for treating AD, they are associated with adverse effects. Thus, safer medications are needed for those who cannot tolerate these agents for long periods. Mangiferin (MAN) is a flavonoid widely found in many herbs, with significant anti-inflammatory and immunomodulatory activities. However, the potential modulatory effects and mecha...
Source: International Immunopharmacology - April 15, 2024 Category: Allergy & Immunology Authors: Cheng Lu ShiJun Deng YanJiao Liu ShengJin Yang DingMei Qin LiJuan Zhang Rui-Rui Wang Yi Zhang Source Type: research
