Multimerization of Ebola GP Δmucin on protein nanoparticle vaccines has minimal effect on elicitation of neutralizing antibodies
Ebola virus (EBOV), a member of the Filoviridae family of viruses and a causative agent of Ebola Virus Disease (EVD), is a highly pathogenic virus that has caused over twenty outbreaks in Central and West Africa since its formal discovery in 1976. The only FDA-licensed vaccine against Ebola virus, rVSV-ZEBOV-GP (Ervebo®), is efficacious against infection following just one dose. However, since this vaccine contains a replicating virus, it requires ultra-low temperature storage which imparts considerable logistical challenges for distribution and access. Additional vaccine candidates could provide expanded protection to mi...
Source: Frontiers in Immunology - August 24, 2022 Category: Allergy & Immunology Source Type: research
He battled AIDS, COVID-19, and Trump. Now, Anthony Fauci is stepping down
Anthony Fauci, the renowned physician-scientist who has led the $6.3 billion National Institute of Allergy and Infectious Diseases (NIAID) for nearly 4 decades and since early 2020 has been the U.S. government’s voice of scientific reason during the COVID-19 pandemic, will step down from government service in December.
Fauci, 81, had said in
recent interviews
that he planned to retire from the government by the end of President Joe Biden’s administration, but did not give a date until today. He said in a
statement
that although leading NIAID “has been the honor of a lifetime,” he plans to ...
Source: Science of Aging Knowledge Environment - August 22, 2022 Category: Geriatrics Source Type: research
A platform technology for generating subunit vaccines against diverse viral pathogens
The COVID-19 pandemic response has shown how vaccine platform technologies can be used to rapidly and effectively counteract a novel emerging infectious disease. The speed of development for mRNA and vector-based vaccines outpaced those of subunit vaccines, however, subunit vaccines can offer advantages in terms of safety and stability. Here we describe a subunit vaccine platform technology, the molecular clamp, in application to four viruses from divergent taxonomic families: Middle Eastern respiratory syndrome coronavirus (MERS-CoV), Ebola virus (EBOV), Lassa virus (LASV) and Nipah virus (NiV). The clamp streamlines subu...
Source: Frontiers in Immunology - August 18, 2022 Category: Allergy & Immunology Source Type: research
Development and characterization of influenza M2 ectodomain and/or hemagglutinin stalk-based dendritic cell-targeting vaccines
A universal influenza vaccine is required for broad protection against influenza infection. Here, we revealed the efficacy of novel influenza vaccine candidates based on Ebola glycoprotein dendritic cell (DC)-targeting domain (EΔM) fusion protein technology. The four copies of ectodomain matrix protein of influenza (tM2e) or M2e hemagglutinin stalk (HA stalk) peptides (HM2e) were fused with EΔM to generate EΔM-tM2e or EΔM-HM2e, respectively. We demonstrated that EΔM-HM2e- or EΔM-tM2e-pseudotyped viral particles can efficiently target DC/macrophages in vitro and induced significantly high titers of anti-HA and/or anti...
Source: Frontiers in Microbiology - August 8, 2022 Category: Microbiology Source Type: research
Marburg virus disease: A deadly rare virus is coming
Biosci Trends. 2022 Jul 31. doi: 10.5582/bst.2022.01333. Online ahead of print.ABSTRACTTwo cases of the deadly Marburgvirus were reported in Ghana, which might be a new global virus alert following COVID-19 and novel monkeypox. Thus far, there is no vaccine or treatment for Marburg virus disease, which is a disease with a mortality rate as high as that of Ebola. Although now human infections with Marburgvirus occurred mainly in Africa, outbreaks were twice reported in Europe over the past 55 years. A concern is that globalization might promote its global viral transmission, just like what happened with COVID-19. The curren...
Source: BioScience Trends - July 31, 2022 Category: Biomedical Science Authors: Fang Zhao Yun He Hongzhou Lu Source Type: research
Low Prevalence of Deletions of the pfhrp2 and pfhrp3 Genes in Plasmodium falciparum Parasites in Freetown, Sierra Leone in 2015
This study shows evidence of pfhrp2- and pfhrp3-deleted parasites in Freetown, Sierra Leone. Additional studies for more precise estimates of prevalence are warranted.PMID:35895430 | DOI:10.4269/ajtmh.22-0073 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - July 27, 2022 Category: Infectious Diseases Authors: Jessica N McCaffery Curtis S Huber Hindolo M Samai Eric Rogier Source Type: research
Low Prevalence of Deletions of the pfhrp2 and pfhrp3 Genes in Plasmodium falciparum Parasites in Freetown, Sierra Leone in 2015
This study shows evidence of pfhrp2- and pfhrp3-deleted parasites in Freetown, Sierra Leone. Additional studies for more precise estimates of prevalence are warranted.PMID:35895430 | DOI:10.4269/ajtmh.22-0073 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - July 27, 2022 Category: Tropical Medicine Authors: Jessica N McCaffery Curtis S Huber Hindolo M Samai Eric Rogier Source Type: research
Low Prevalence of Deletions of the pfhrp2 and pfhrp3 Genes in Plasmodium falciparum Parasites in Freetown, Sierra Leone in 2015
This study shows evidence of pfhrp2- and pfhrp3-deleted parasites in Freetown, Sierra Leone. Additional studies for more precise estimates of prevalence are warranted.PMID:35895430 | PMC:PMC9209925 | DOI:10.4269/ajtmh.22-0073 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - July 27, 2022 Category: Infectious Diseases Authors: Jessica N McCaffery Curtis S Huber Hindolo M Samai Eric Rogier Source Type: research
Low Prevalence of Deletions of the pfhrp2 and pfhrp3 Genes in Plasmodium falciparum Parasites in Freetown, Sierra Leone in 2015
This study shows evidence of pfhrp2- and pfhrp3-deleted parasites in Freetown, Sierra Leone. Additional studies for more precise estimates of prevalence are warranted.PMID:35895430 | PMC:PMC9209925 | DOI:10.4269/ajtmh.22-0073 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - July 27, 2022 Category: Tropical Medicine Authors: Jessica N McCaffery Curtis S Huber Hindolo M Samai Eric Rogier Source Type: research
Low Prevalence of Deletions of the pfhrp2 and pfhrp3 Genes in Plasmodium falciparum Parasites in Freetown, Sierra Leone in 2015
This study shows evidence of pfhrp2- and pfhrp3-deleted parasites in Freetown, Sierra Leone. Additional studies for more precise estimates of prevalence are warranted.PMID:35895430 | PMC:PMC9209925 | DOI:10.4269/ajtmh.22-0073 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - July 27, 2022 Category: Infectious Diseases Authors: Jessica N McCaffery Curtis S Huber Hindolo M Samai Eric Rogier Source Type: research
Low Prevalence of Deletions of the pfhrp2 and pfhrp3 Genes in Plasmodium falciparum Parasites in Freetown, Sierra Leone in 2015
This study shows evidence of pfhrp2- and pfhrp3-deleted parasites in Freetown, Sierra Leone. Additional studies for more precise estimates of prevalence are warranted.PMID:35895430 | PMC:PMC9209925 | DOI:10.4269/ajtmh.22-0073 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - July 27, 2022 Category: Tropical Medicine Authors: Jessica N McCaffery Curtis S Huber Hindolo M Samai Eric Rogier Source Type: research
Low Prevalence of Deletions of the pfhrp2 and pfhrp3 Genes in Plasmodium falciparum Parasites in Freetown, Sierra Leone in 2015
This study shows evidence of pfhrp2- and pfhrp3-deleted parasites in Freetown, Sierra Leone. Additional studies for more precise estimates of prevalence are warranted.PMID:35895430 | PMC:PMC9209925 | DOI:10.4269/ajtmh.22-0073 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - July 27, 2022 Category: Infectious Diseases Authors: Jessica N McCaffery Curtis S Huber Hindolo M Samai Eric Rogier Source Type: research
