The Current Pathogenicity and Potential Risk Evaluation of Marburg Virus to Cause Mysterious "Disease X"-An Update on Recent Evidences
Environ Health Insights. 2024 Mar 4;18:11786302241235809. doi: 10.1177/11786302241235809. eCollection 2024.ABSTRACTThe World Health Organization (WHO) defined Disease X as an upcoming disease with the potential to cause a pandemic. Pathogen X is responsible for Disease X. Marburg virus disease (MVD) is one of the diseases from the priority disease list published by WHO. Marburg virus is a filamentous, negative-sense RNA virus that belongs to the same filovirus family as the lethal Ebola virus. Since the first discovery of this virus in 1967, 17 outbreaks occurred sporadically till 2023. Rousettus aegyptiacus acts as the na...
Source: Environmental Health Insights - March 5, 2024 Category: Environmental Health Authors: Rahima Akter Mitu Md Rabiul Islam Source Type: research
Effects of Shock and Vibration on Product Quality during Last-Mile Transportation of Ebola Vaccine under Refrigerated Conditions
L. Bus-Jacobs et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - February 28, 2024 Category: Infectious Diseases Source Type: research
Viruses, Vol. 16, Pages 279: Bivalent VSV Vectors Mediate Rapid and Potent Protection from Andes Virus Challenge in Hamsters
nz Feldmann
Orthohantaviruses may cause hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome. Andes virus (ANDV) is the only orthohantavirus associated with human–human transmission. Therefore, emergency vaccination would be a valuable public health measure to combat ANDV-derived infection clusters. Here, we utilized a promising vesicular stomatitis virus (VSV)-based vaccine to advance the approach for emergency applications. We compared monovalent and bivalent VSV vectors containing the Ebola virus (EBOV), glycoprotein (GP), and ANDV glycoprotein precursor (GPC) for protective eff...
Source: Viruses - February 11, 2024 Category: Virology Authors: Joshua Marceau David Safronetz Cynthia Martellaro Andrea Marzi Kyle Rosenke Heinz Feldmann Tags: Article Source Type: research
The economic burden of Ebola virus disease: a review and recommendations for analysis
CONCLUSIONS: The severe impact of EVD puts pressure on governments and the international community for better resource utilization and re-allocation. Several technical and methodological issues related to economic evaluation of EVD remain to be addressed, especially for LMICs. We recommend conducting cost-of-sequelae and cost-of-distribution analyses in addition to adapting existing economic analytical methods to EVD. Characteristics of the affected regions should be considered to provide evidence-based economic plans and economic-evaluation of mitigations that enhance resource allocation for prevention and treatment.PMID:...
Source: Journal of Medical Economics - February 1, 2024 Category: Health Management Authors: Mavis Obeng-Kusi Jennifer Martin Ivo Abraham Source Type: research
News at a glance: Long-awaited malaria shots, risks of face recognition technology, and Japan ’s first moon landing
GLOBAL HEALTH
Long-awaited malaria shots rolled out
After a 60-year quest, the first-ever routine childhood malaria vaccinations—those given as part of the regular immunization schedule—were administered to infants and toddlers in Cameroon on 22 January. They received RTS,S or Mosquirix, made by GlaxoSmithKline and approved for general use in 2021 by the World Health Organization (WHO). The vaccine’s efficacy wanes substantially over time, but a 4-year pilot rollout required by WHO in Ghana, Kenya, and Malawi showed it slashed illness and death in young children. Nineteen other African countrie...
Source: Science of Aging Knowledge Environment - January 25, 2024 Category: Geriatrics Source Type: research
Prophylactic and therapeutic measures for emerging and re-emerging viruses: artificial intelligence and machine learning - the key to a promising future
ConclusionsThe present review not only highlighted public-health management models but also provide leads in potential therapeutic targets as well as vaccine/ antiviral candidates. To support the context, the issues with existing therapeutic strategies are also overviewed and the prospects were identified. This review discusses a wide range of applications of AI and ML pertaining to the clinical domain. (Source: Health and Technology)
Source: Health and Technology - January 24, 2024 Category: Information Technology Source Type: research
Impact of Ebola epidemics on the daily operation of existing systems in Eastern Democratic Republic of the Congo: a brief review
CONCLUSION: National leadership has not yet taken the lead in strategic, operational, or financial aspects. Therefore, national leaders should double their efforts and awareness to encourage local fundraising, sufficient budget al.location, infrastructure construction, equipment provision, and staff training, to effectively support a holistic approach in response to outbreaks, providing effective results, and all types of research activities.PMID:38240249 | DOI:10.1080/13696998.2024.2305009 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - January 19, 2024 Category: Health Management Authors: Daniel Mukadi-Bamuleka Antoine Nkuba-Ndaye Placide Mbala-Kingebeni Steve Ahuka-Mundeke Jean-Jacques Muyembe-Tamfum Source Type: research
Wisconsin bill to restrict pathogen studies worries scientists
A hearing this week in Wisconsin on a proposal to bar research that may make human pathogens more dangerous has scientists worried that such state bans would hamper a broad range of microbiology studies. Bills like Wisconsin’s could also conflict with or exceed new federal restrictions on so-called gain-of-function (GOF) research, due out any moment.
The Wisconsin bill is still early in the legislative process, and its prospects are uncertain. But the hearing gave a platform to a small, vocal group of scientists who want to forbid certain GOF studies. Several hold the controversial view that such research is to bla...
Source: Science of Aging Knowledge Environment - January 12, 2024 Category: Geriatrics Source Type: research
GSE232633 Identification of early gene expression profiles governing long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo
In this study, we comprehensively investigated transcriptome profiles at 0, 3 hours, 1 and 7 days after vaccination with Ad26.ZEBOV and MVA-BN-Filo. Three hours after Ad26.ZEBOV injection, we observed an increase in gene abundance related to antigen presentation, sensing, and T- and B-cell receptors. The highest response occurred one day after Ad26.ZEBOV injection, with an increase in the expression of genes for interferon-induced antiviral molecules, monocyte activation, and sensing receptors. This response was mainly shaped by the HESX1, ATF3, ANKRD22, and ETV7 transcription factors. A plasma-cell signature was observed ...
Source: GEO: Gene Expression Omnibus - January 11, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Refined innate plasma signature after rVSV ΔG-ZEBOV-GP immunization is shared among adult cohorts in Europe and North America
ConclusionEleven additional biomarkers refined the previously found 5-biomarker Geneva signature. The refined signature better discriminated between different doses, was strongly associated with the risk of adverse events and with antibody responses and was validated in a separate cohort. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 3, 2024 Category: Allergy & Immunology Source Type: research
Longitudinal assessment of an Ebola vaccine trial understanding among healthcare providers in the Democratic Republic of the Congo
CONCLUSION: We observed a significant decline in the informational knowledge of informed consent, specifically in terms of basic knowledge on the study vaccine and trial procedures. As participant safety and understanding is a paramount ethical concern for researchers, it is crucial for participants to fully comprehend the study's objectives and potential risks. Therefore, our findings suggest the need for clinical researchers to re-explain participants to optimize the protection of their rights and wellbeing during the research.PMID:38163747 | DOI:10.1016/j.vaccine.2023.12.076 (Source: Vaccine)
Source: Vaccine - January 1, 2024 Category: Allergy & Immunology Authors: Tr ésor Zola Matuvanga Ynke Larivi ère Gwen Lemey Bernard Isekah Osang'ir Joachim Mari ën Solange Milolo Rachel Meta Junior Matangila Vivi Maketa Patrick Mitashi Jean-Pierre Van Geertruyden Hypolite Muhindo-Mavoko Pierre Van Damme Source Type: research
Longitudinal assessment of an Ebola vaccine trial understanding among healthcare providers in the Democratic Republic of the Congo
CONCLUSION: We observed a significant decline in the informational knowledge of informed consent, specifically in terms of basic knowledge on the study vaccine and trial procedures. As participant safety and understanding is a paramount ethical concern for researchers, it is crucial for participants to fully comprehend the study's objectives and potential risks. Therefore, our findings suggest the need for clinical researchers to re-explain participants to optimize the protection of their rights and wellbeing during the research.PMID:38163747 | DOI:10.1016/j.vaccine.2023.12.076 (Source: Vaccine)
Source: Vaccine - January 1, 2024 Category: Allergy & Immunology Authors: Tr ésor Zola Matuvanga Ynke Larivi ère Gwen Lemey Bernard Isekah Osang'ir Joachim Mari ën Solange Milolo Rachel Meta Junior Matangila Vivi Maketa Patrick Mitashi Jean-Pierre Van Geertruyden Hypolite Muhindo-Mavoko Pierre Van Damme Source Type: research
GSE242207 Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSV ΔG-ZEBOV-GP
Contributors : Eleonora Vianello ; Josefine Persson ; Bj örn Andersson ; Suzanne van Veen ; Thomaz Lüscher Dias ; Francesco Santoro ; Malin Östensson ; Ogonna Obudulu ; Christopher Agbajogu ; Sara Torkzadeh ; Helder Nakaya ; Donata Medaglini ; Claire-Anne Siegrist ; Tom M Ottenhoff ; Ali M HarandiSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe characterized the extracellular miRNAs, isolated from serum-derived extracellular vesicles (EV), induced by vaccination against Ebola.We identified early miRNA signatures associated with the ZEBOV-specific IgG antibody res...
Source: GEO: Gene Expression Omnibus - December 18, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Trends of measles in Tanzania: a five-year review of case-based surveillance data, 2018-2022
Vaccines provide a safe and cost-effective solution to vaccine-preventable infectious diseases. However, vaccine-preventable infectious diseases still pose a serious public health threat especially in the world's poor regions[1]. In sub-Saharan Africa, this burden is further aggravated by the occurrence of concurrent epidemics such as Coronavirus Disease 2019 (COVID-19), Ebola virus disease, monkeypox, and measles overstretching the already weak public health system[2]. In addition to human conflicts, natural disasters, vaccine hesitancy, and the COVID-19 pandemic has disrupted routine immunisation services leaving million...
Source: International Journal of Infectious Diseases - December 17, 2023 Category: Infectious Diseases Authors: Fausta Michael, Mariam M. Mirambo, Gerald Misinzo, Omary Minzi, Medard Beyanga, Delphinus Mujuni, Florence S Kalabamu, Elias N Nyanda, Mary Mwanyika-Sando, Daniel Ndiyo, Richard Kasonogo, Abbas Ismail, Andrew Bahati, Farida Hassan, Elangiringa Kaale, John Source Type: research
