Ebola Vaccine Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Uganda struggles to contain Ebola variant with no approved vaccine
More than 50 cases have been identified so far in an outbreak linked to the Sudan variant of Ebola virus, which has no approved treatment or vaccine (Source: New Scientist - Health)
Source: New Scientist - Health - September 30, 2022 Category: Consumer Health News Source Type: research

Gene Therapy Cargos Based on Viral Vector Delivery
Curr Gene Ther. 2022 Sep 21. doi: 10.2174/1566523222666220921112753. Online ahead of print.ABSTRACTViral vectors have proven useful in a broad spectrum of gene therapy applications due to their possibility to accommodate foreign genetic material for both local and systemic delivery. The wide range of viral vectors has enabled gene therapy applications for both acute and chronic diseases. Cancer gene therapy has been addressed by delivery of viral vectors expressing anti-tumor, toxic, and suicide genes for destruction of tumors. Delivery if immunostimulatory genes such as cytokines and chemokines has also been applied for c...
Source: Current Gene Therapy - September 26, 2022 Category: Genetics & Stem Cells Authors: Kenneth Lundstrom Source Type: research

Neurological Effects of Monkeypox Largely Unknown, Review Finds
Much remains unknown about the long-term neurologic effects of monkeypox. In anarticle published today inJAMA Neurology, researchers from the National Institute of Neurological Disorders and Stroke (NINDS) and colleagues described how reports of complications from other orthopoxviruses, such as smallpox, may offer clues about the neurologic consequences of monkeypox.“Although the COVID-19 pandemic is the worst pandemic in a century, the recent past has seen several major pandemics, including Zika, Ebola, dengue, West Nile, and AIDS,” wrote B. Jeanne Billioux, M.D., of NINDS and colleagues. “A common thread to these p...
Source: Psychiatr News - September 20, 2022 Category: Psychiatry Tags: febrile seizures/encephalopathy headache JAMA Neurology monkeypox neurological problems smallpox transverse myelitis Source Type: research

Comparative immunogenicity analysis of intradermal versus intramuscular immunization with a recombinant human adenovirus type 5 vaccine against Ebola virus
In this study, we evaluated different vaccine routes for Ad5-EBOV delivery by comparing humoral and cellular responses, germinal center reactions, dendritic cell activation and antigen expression. Mice injected intramuscularly with the vaccine exhibited an advantage in antigen expression, leading to more robust germinal center and humoral responses, while intradermal injection recruited more migrating DCs and induced a more polyfunctional cellular response. Our study provides more data for future use of viral vector-based vaccines. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - August 31, 2022 Category: Allergy & Immunology Source Type: research

Viral vector and nucleic acid vaccines against COVID-19: A narrative review
After about 2 years since the first detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in Wuhan, China, in December 2019 that resulted in a worldwide pandemic, 6.2 million deaths have been recorded. As a result, there is an urgent need for the development of a safe and effective vaccine for coronavirus disease 2019 (COVID-19). Endeavors for the production of effective vaccines inexhaustibly are continuing. At present according to the World Health Organization (WHO) COVID-19 vaccine tracker and landscape, 153 vaccine candidates are developing in the clinical phase all over the world. Some n...
Source: Frontiers in Microbiology - August 31, 2022 Category: Microbiology Source Type: research

The Evolution of Medical Countermeasures for Ebola Virus Disease: Lessons Learned and Next Steps
Vaccines (Basel). 2022 Jul 29;10(8):1213. doi: 10.3390/vaccines10081213.ABSTRACTThe Ebola virus disease outbreak that occurred in Western Africa from 2013-2016, and subsequent smaller but increasingly frequent outbreaks of Ebola virus disease in recent years, spurred an unprecedented effort to develop and deploy effective vaccines, therapeutics, and diagnostics. This effort led to the U.S. regulatory approval of a diagnostic test, two vaccines, and two therapeutics for Ebola virus disease indications. Moreover, the establishment of fieldable diagnostic tests improved the speed with which patients can be diagnosed and publi...
Source: Cancer Control - August 26, 2022 Category: Cancer & Oncology Authors: Ian Crozier Kyla A Britson Daniel N Wolfe John D Klena Lisa E Hensley John S Lee Larry A Wolfraim Kimberly L Taylor Elizabeth S Higgs Joel M Montgomery Karen A Martins Source Type: research

Developing capacity for implementation and evaluation of vaccine trials in Uganda: Perspective of the Makerere University Walter Reed Project
Conclusion: Academia, through establishment of appropriate partnerships can contribute to the identification of solutions to complex public health challenges.Keywords: Vaccines; community participation; developing countries. (Source: African Health Sciences)
Source: African Health Sciences - August 26, 2022 Category: African Health Authors: Prossy Naluyima, Betty Mwesigwa, Allan Tindikahwa, Stephen Mugamba, Jude Thaddeus Ssensamba, Ezra Musingye, Grace Mirembe, Hannah Kibuuka, Fred Wabwire-Mangen Source Type: research

News at a glance: New gene therapy, Europe ’s drought, and a black hole’s photon ring
ARCHAEOLOGY Drought exposes ‘Spanish Stonehenge’ for study Scientists are rushing to examine a 7000-year-old stone circle in central Spain that had been drowned by a reservoir for decades and was uncovered after the drought plaguing Europe lowered water levels. Nicknamed the “Spanish Stonehenge”—although 2000 years older than the U.K. stone circle—the Dolmen of Guadalperal (above) was described by archaeologists in the 1920s. The approximately 100 standing stones, up to 1.8 meters tall and arranged around an oval open space, were submerged in the Valdecañas reservoir after the constructi...
Source: Science of Aging Knowledge Environment - August 25, 2022 Category: Geriatrics Source Type: research

Multimerization of Ebola GP Δmucin on protein nanoparticle vaccines has minimal effect on elicitation of neutralizing antibodies
Ebola virus (EBOV), a member of the Filoviridae family of viruses and a causative agent of Ebola Virus Disease (EVD), is a highly pathogenic virus that has caused over twenty outbreaks in Central and West Africa since its formal discovery in 1976. The only FDA-licensed vaccine against Ebola virus, rVSV-ZEBOV-GP (Ervebo®), is efficacious against infection following just one dose. However, since this vaccine contains a replicating virus, it requires ultra-low temperature storage which imparts considerable logistical challenges for distribution and access. Additional vaccine candidates could provide expanded protection to mi...
Source: Frontiers in Immunology - August 24, 2022 Category: Allergy & Immunology Source Type: research